• 국제초고층학회논문집
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• 제5권1호
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• pp.51-62
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• 2016

The concept of introducing viscous damping devices between outriggers and perimeter columns in tall buildings to provide supplementary damping and improve performance, reduce structural costs, and increase available usable area was developed and implemented by Smith and Willford (2007). It was recognized that the relative vertical movement that would occur between the ends of outriggers and columns, if they were not connected, could be used to generate damping. The movements, and correspondingly damping, can potentially be significantly increased by amplifying them using simple "mechanisms". The mechanisms also make it possible to increase the number of available dampers and thus further increase supplementary damping. The feasibility of mechanisms to amplify supplementary damping and enhance structural performance of tall, slender buildings is studied with particular focus on its efficacy in improving structural performance in wind loads.

• Earthquakes and Structures
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• 제10권2호
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• pp.351-366
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• 2016

The structural collapse of masonry structure under dynamic loading displays many possible failure mechanisms often related to interaction between structural components. Roof collapse is one of the major damage mechanisms observed in masonry structures during an earthquake. Better connection between the roof diaphragm and walls may be preventing roof collapse, but it can affect other failure mechanisms. In spite of this fact, less attention has been paid to the influence of the roof diaphragm effect on masonry structures and little research has been implemented in this field. In the present study, the roof diaphragm effect on the unreinforced masonry structure under dynamic loading has been experimentally investigated. Three one-quarter scale one-story adobe masonry house models with different roof conditions have been tested by subjecting them to sinusoid loading on a shaking table simulator. Phenomena such as failure pattern, dynamic performance of masonry structure were examined.

• Tuberculosis and Respiratory Diseases
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• 제79권4호
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• pp.248-256
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• 2016

Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first line treatment for advanced disease. They have led to a doubling of progression-free survival and an increase in overall survival by more than 2 years. However, emergence of resistant clones has become the primary cause for treatment failure, and has created a new challenge in the daily management of patients with EGFR mutations. Identification of mechanisms leading to inhibitor resistance has led to new therapeutic modalities, some of which have now been adapted for patients with unsuccessful tyrosine kinase inhibitor treatment. In this review, we describe mechanisms of tyrosine kinase inhibitor resistance and the available strategies to overcoming resistance.

• BMB Reports
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• 제48권4호
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• pp.223-228
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• 2015

The Drosophila lymph gland is the hematopoietic organ in which stem-like progenitors proliferate and give rise to myeloid-type blood cells. Mechanisms involved in Drosophila hematopoiesis are well established and known to be conserved in the vertebrate system. Recent studies in Drosophila lymph gland have provided novel insights into how external and internal stresses integrate into blood progenitor maintenance mechanisms and the control of blood cell fate decision. In this review, I will introduce a developmental overview of the Drosophila hematopoietic system, and recent understandings of how the system uses developmental signals not only for hematopoiesis but also as sensors for stress and environmental changes to elicit necessary blood responses. [BMB Reports 2015; 48(4): 223-228]

• 대한기계학회논문집A
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• 제26권6호
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• pp.1060-1068
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• 2002

Compound continuously variable transmission(CVT) mechanisms are proposed, which can offer a backward mode, a geared neutral, an underdrive mode and an overdrive mode. They are composed of a 2K-H I type differential gear unit, a V-belt type continuously variable unit(CVU), a few friction clutches and gears, and not required of a starting device as a torque converter. Compound CVT mechanisms developed here present two distinct operating modes which are a power circulation mode and a power split mode. The transition of two modes takes place at the particular CVU speed ratio. For these CVT mechanisms, performance analysis related to speed ratio, power ratio and efficiency are executed and proven by experimental studies.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.232-237
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• 2004

The tension behavior of Nicalon/CAS glass-ceramic matrix composites was investigated. Infrared (IR) thermography was employed for two different types of $Nicalon^{TM}/CAS$ composites, i.e., cross-ply and unidirectional specimens. During tensile testing, an IR camera was used for in-situ monitoring of progressive damages of $Nicalon^{TM}/CAS$ samples. The IR camera provided the temperature changes during tensile testing. Microstructural characterization using scanning electron microscopy (SEM) was performed to investigate the fracture mechanisms of $Nicalon^{TM}/CAS$ composites. In this investigation, the thermographic NDE technique was used to facilitate a better understanding of the fracture mechanisms of the $Nicalon^{TM}/CAS$ composites during tensile testing.

• Journal of Mechanical Science and Technology
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• 제20권12호
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• pp.2025-2033
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• 2006

This paper presents, the design of a latch mechanism for wafer containers in a standard mechanical interface environment. For an integrated circuits fabrication factory, the standard mechanical interfaced wafer container is an effective tool to prevent wafers from particle contamination during wafer storage, transporting or transferring. The latch mechanism inside the container door is used to latch and further seal the wafer container for safety and air quality. Kinematic characteristics of the mechanism are established by analyzing the required functions of the mechanisms. Based on these characteristics, a methodology for enumerating feasible latch mechanisms is developed. New mechanisms with one degree-of-freedom and up to five links are generated. An optimum design is also identified with respect to the criteria pertinent to the application. The computer-aided simulation is also built to verify the design.

• 한국자동차공학회논문집
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• 제19권4호
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• pp.64-71
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• 2011

Homogeneous charge compression ignition (HCCI) was the best concept able to provide low NOx and PM in diesel engine emissions. This new alternative combustion process was mainly controlled by chemical kinetics in comparison with the conventional combustion in internal combustion engine. In this paper, detailed kinetic reaction mechanisms of diesel surrogate was investigated to understand the diesel HCCI engine combustion. It was tested two existing mechanisms and two new mechanisms for the comparison of experimental result. The best mechanism for diesel surrogate was suggested through this comparison.

• 수산해양기술연구
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• 제40권2호
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• pp.161-165
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• 2004

The main goal of this work is to study the effect of glass fiber volume fraction on the result of tensile test with respect to glass fiber/polypropylene(GF/PP) composites. The tensile test and failure mechanisms of GF/PP composites were investigated in the fiber volume fraction range from 10% to 30%. The tensile strength and the fracture strength increased with the increasing of the fiber volume fraction in the tested range. Fiber pull-out and debonding of this composites increased with the fiber volume fraction in thc tested range. The major failure mechanisms were classified into the debonding, the fiber pull out, the delamination and the matrix deformation.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1997년도 추계학술대회
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• pp.41-46
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• 1997

Lower esophageal sphincter (LES) is characterized by the ability to maintain a sustained pressure, and to relax allowing the passage of a bolus, whereas the esophagus is normally relaxed and contracts only briefly when required to produce peristalsis (fig. 1). The neuromuscular mechanisms that participate in the physiological regulation of these functions are not well understood, but it is thought that LES tone is spontaneous and regulated mostly through myogenic mechanisms, whereas LES relaxation and esophageal contraction are induced by neural mechanisms. Gastroesophageal reflux represents the effortless movement of gastric contents from stomach to esophagus. Because this phenomenon occurs in virtually everyone multiple times every day and in the majority of people without clinical consequences, the reflux per se is not disease. However in some cases, it can be pathologic, producing symptoms and signs called gastroesophageal reflux disease (GERD), which mechanism is not well known. It may result in heart burn, chronic esophagitis, aspiration pneumonia, esophageal strictures, and Barrett's esophagus.