• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.8
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• pp.1883-1897
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• 1993

Interactive computer-aided analysis of mechanical systems has recently been undergoing an evolution due to highly efficient computer graphics. The industrial implementation of state-of-the-art analytical developments in mechanisms has been facilitated by computer-aided design packages because these rigid-body mechanism analysis programs dramatically reduce the time required for linkage design. This paper proposes a component modular approach to computeraided kinematic motion analysis for general planar multiloop mechanisms. Most multiloop mechanisms can be decomposed into serveral components. The kinematic properties (position, velocity, and acceleration) of every node can then be determined from the kinematic analysis of the corresponding component modules by a closed-form solution procedure. In this paper, 8 types of modules are defined and formulations for kinematic analysis of the component modules are derived. Then a computer-aided kinematic analysis program is developed using the proposed approach and the solution procedure of an example shows the effectiveness and accuracy on the approach.

• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.420-425
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• 2010

The antifungal effects and action mechanisms of styraxjaponoside A and B were investigated. Devoid of hemolytic effect, the compounds had significant effect against several human pathogenic fungal strains, with energy-independent manners. To understand the action mechanisms of the compounds, the flow cytometric analysis plotting the forward scatter and the side scatter, $DiBAC_4$(3) staining and DPH fluorescence analysis were conducted. The results indicated that the actions of the compounds were dependent upon the membrane-active mechanisms. The present study suggests that styraxjaponoside A and B exert their antimicrobial effects via membrane-disruptive mechanisms.

• Toxicological Research
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• v.17
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• pp.117-125
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• 2001

Envenoming by Russells viper causes a broad spectrum of renal impairment. Renal failure is an important complication in patients bitten by Russells viper. Experimental work in animals and in vitro has elucidated pathophysiological mechanisms that contribute to life threatening complications and have suggested possibilities for therapeutic intervention. The evidence in experimental animals regarding mechanisms of venom action in relation to changes in either extrarenal or intrarenal factors is presented. The cardiovascular system and renal hemodynamics are affected by venom. Reductions of renal function including renal hemodynamics are associated directly with changes in general circulation during envenomation. Possible endogenous mechanisms for releasing the hormone inducing renal vasoconstriction after envenomation are evident. Hormonal factor such as the catecholamine, prostaglandin and renin angiotensin systems induce these changes. Direct nephrotoxicity of venom action is studied in the isolated per-fused kidney. Characteristic polarization of the cell membrane, changes of mitochondrial activity and Na-K ATPase in renal tubular cells are observed. Changes in renal function and the cardiovascular system are observed of ter envenomation and are reversed by the administration of Russells viper antivenom (purified equine immunoglobulin, $Fab_2$ fragment). The neutralizing effects are more efficient when the intravenous injection of antivenom is given within 30 min after the envenomation.

• Structural Engineering and Mechanics
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• v.52 no.6
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• pp.1085-1098
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• 2014

Plastic mechanism analysis of structures subjected to large deformation has long been used in order to determine collapse mechanisms of steel structures, and the energy absorbed in plastic deformation during such collapses. In this paper the technique is applied to vehicle roof structures that undergo large plastic deformation as a result of rollover crashes. The components of such roof structures are typically steel spot-welded hat-type sections. Ten different deformation mechanisms are defined from investigations of real-world rollover crashes, and an analytical technique to determine the plastic collapse load and energy absorption of such mechanisms is determined. The procedure is presented in a generic manner, such that it may be applied to any vehicle structure undergoing a rollover induced collapse. The procedure is applied to an exemplar vehicle, in order to demonstrate its application in determining the energy absorbed in the deformation of the identified collapse mechanisms. The procedure will be useful to forensic crash reconstructionists, in order to accurately determine the initial travel velocity of a vehicle that has undergone a rollover and for which the post-crash vehicle deformation is known. It may also be used to perform analytical studies of the collapse resistance of vehicle roof structures for optimisation purposes, which is also demonstrated with an analysis of the effect of varying the geometric and material properties of the roof structure components of the exemplar vehicle.

• Journal of the Korean Society of Combustion
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• v.4 no.2
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• pp.63-74
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• 1999

The effects of EGR and premixedness on NO formation have been numerically investigated. The flame structure is classified into three categories; premixed flame($=1)$, rich/lean premixed flame(${\alpha}=0.6$ and 0.8) and diffusion flame(${\alpha}=0$). NO formation/destruction mechanisms are assorted to thermal, reburn and Fenimore mechanisms. The temperature of unburned gas is arranged to 298 and 500 K to have access to the condition in a real internal combustion engine. The results show that all three NO formation/destruction reaction rates in the fuel rich flame zone could be decreased by EGR for rich/lean premixed flames, while those in the fuel lean flame zone are not significantly changed. Near the stagnation plane, however, only the thermal NO reaction rate is decreased. The contribution of reburn and Fenimore mechanisms for the net NO production becomes less significant as the premixedness of a flame increases. The larger amount of NO reduction with EGR is expected under the higher temperature and/or higher fuel/air premixedness conditions due to the increased contribution of the thermal mechanism. The role of Fenimore and reburn mechanisms could be important for rich premixed and diffusion flames; therefore, the effect of EGR on NO reduction could vary with fuel/air premixedness. The premixedness of a partially premixed flame changes the flame structure and could affect the NO production characteristics.

• Geomechanics and Engineering
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• v.16 no.1
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• pp.35-47
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• 2018

This paper investigates the mechanisms of tunnel spalling and massive tunnel failures using fracture mechanics principles. The study starts with examining the fracture propagation due to tensile and shear failure mechanisms. It was found that, fundamentally, in rock masses with high compressive stresses, tensile fracture propagation is often a stable process which leads to a gradual failure. Shear fracture propagation tends to be an unstable process. Several real case observations of spalling failures and massive shear failures in boreholes, tunnels and underground roadways are shown in the paper. A number of numerical models were used to investigate the fracture mechanisms and extents in the roof/wall of a deep tunnel and in an underground coal mine roadway. The modelling was done using a unique fracture mechanics code FRACOD which simulates explicitly the fracture initiation and propagation process. The study has demonstrated that both tensile and shear fracturing may occur in the vicinity of an underground opening. Shallow spalling in the tunnel wall is believed to be caused by tensile fracturing from extensional strain although no tensile stress exists there. Massive large scale failure however is most likely to be caused by shear fracturing under high compressive stresses. The observation that tunnel spalling often starts when the hoop stress reaches $0.4^*UCS$ has been explained in this paper by using the extension strain criterion. At this uniaxial compressive stress level, the lateral extensional strain is equivalent to the critical strain under uniaxial tension. Scale effect on UCS commonly believed by many is unlikely the dominant factor in this phenomenon.

• Physical Therapy Korea
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• v.5 no.2
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• pp.106-117
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• 1998

The pain is common among individuals with physical disabilities. It can interfere with therapy since patients with pain can become uncooperative and reluctant to move. This paper reviews the natural physiological mechanisms that can reduce pain perception, and considers physiological mechanisms which contribute to clinical pain by describing how the pain system changes its sensitivity depending upon the body's needs. The peripheral and central mechanisms contributing to sensitised nociceptive system are described with reference to the symptoms of clinical pain such as hyperalgesia, allodynia sopntaneous 'on-going'-projected and referred pain. It is suggested that in some chronic pain the nociceptive system maintains a state of sensitivity despite the absence of on-going tissue damage and under such circumstances the nociceptive system itself may have become dysfunctional. Such situations are often initiated by damage to nervous tissue which results in changes in the activity and organization of neuronal circuits within the central nervous system. The ability of the nociceptive system to operate in a suppressed state is also discussed with reference to pain modulation. The physical therapist can help facilitate the activation of these mechanisms through a combination of noninvasive modalities, functional activities, and the therapeutic use of self.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.4
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• pp.503-513
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• 2007

The obese population has been increasing worldwide and obesity has become one of the socioeconomic problems. Obesity raises more concerns as more studies regarding its direct and indirect relativity to several diseases such as type II diabetes, hypertension, etc. are published. Since leptin, an important signal in the chronic control of food intake and energy expenditure, was discovered in 1994, there has been a great accumulation of knowledge on fighting obesity by facilitating pharmacological and nutritional strategies on the molecular level of the body weight control system. In particular, evidences are accumulating that particular food components affect our physiological function and gene expressions which are associated with body weight control. In this study, we review the four mechanisms for weight control and antiobesity functional agents such as HCA, L-carnitine, CLA, chitosan, calcium supplements capsaicin contained in red pepper, and oriental herbal mixture. We also describe about the efficacy and working mechanism of these functional agents on the basis of antiobesity mechanisms.

• The KIPS Transactions:PartC
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• v.11C no.6 s.95
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• pp.739-746
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• 2004

License mechanisms are the key elements in almost all DRM(digital rights management) systems. The license mechanisms are designed for the clear identification and enforcement of contents, principals, and usage rules in DRM systems. But current license mechanisms are lacking in the flexibility for the secure and efficient sharing of the contents among the members of a group such as a family or a part of an enterprise. This paper suggests a new license mechanism for efficient and secure sharing of contents in DRM systems among the members of a group. We named it member/group license mechanism. The mechanism extends the current license mechanisms by introducing new concepts such as group licenses, member licenses, and derivation relationships between licenses.

• BMB Reports
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• v.38 no.5
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• pp.507-516
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• 2005

Antimicrobial peptides (AMPs) have been isolated and characterized from tissues and organisms representing virtually every kingdom and phylum. Their amino acid composition, amphipathicity, cationic charge, and size allow them to attach to and insert into membrane bilayers to form pores by 'barrel-stave', 'carpet' or 'toroidal-pore' mechanisms. Although these models are helpful for defining mechanisms of AMP activity, their relevance to resolving how peptides damage and kill microorganisms still needs to be clarified. Moreover, many AMPs employ sophisticated and dynamic mechanisms of action to carry out their likely roles in antimicrobial host defense. Recently, it has been speculated that transmembrane pore formation is not the only mechanism of microbial killing by AMPs. In fact, several observations suggest that translocated AMPs can alter cytoplasmic membrane septum formation, reduce cell-wall, nucleic acid, and protein synthesis, and inhibit enzymatic activity. In this review, we present the structures of several AMPs as well as models of how AMPs induce pore formation. AMPs have received special attention as a possible alternative way to combat antibiotic-resistant bacterial strains. It may be possible to design synthetic AMPs with enhanced activity for microbial cells, especially those with antibiotic resistance, as well as synergistic effects with conventional antibiotic agents that lack cytotoxic or hemolytic activity.