• Environmental Analysis Health and Toxicology
• /
• 제8권3_4호
• /
• pp.33-41
• /
• 1993

This study was designed to determine the hemolytic mechanism of antitumor agent tetraphosphine platinum (II) complex (RC-1), which was synthesized recently. Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation, methemoglobin synthesis and hemolysis. And also treatment of radical scavengers showed the inhibitory effect of hemolysis and the decrease of malondialdehyde levels in RC-1 treated erythrocytes. So, the mechanism of hemolysis was considered to be the generation of free radicals, methemoglobin synthesis and the lipid peroxidation of phospholipid which composed of erythrocyte membrane.

• 대한기계학회논문집
• /
• 제17권6호
• /
• pp.1330-1341
• /
• 1993

본 연구에서는 회전대우(revolute joint)들로 이루어진 1자유도 평면기구들의 특성을 파악하고 그래이프이론(graph theory)을 이용하여 기구의 형태를 행렬로 표시 하여 체이터베이스에 저장하였다. 또한 기구의 특성중의 하나인 작업조건(function specification)에 따른 무오차점(precision point)의 최대 개수를 알아내는 프로그램 을 개발하여 이로써 얻은 정보를 또 다른 데이타베이스에 저장하였다. 이와같이 구축 된 데이터베이스들로부터 설계자의 요구에 적합한 기구를 선택하여 형태합성 문제를 해결하였다.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2010년도 추계학술대회 논문집
• /
• pp.865-866
• /
• 2010

• 한국CDE학회논문집
• /
• 제4권3호
• /
• pp.224-237
• /
• 1999

This paper proposes a case-based approach to the conceptual design of mechanism, especially of the generation of design alternatives in function generation and motion transmission tasks. The aim of this work is to generate and provide various design alternatives by utilizing the previous design concepts underling in the existing design cases. The approach is based on the basic idea that the whole design concepts or sub-concepts extracted from different design cases can be merged to generate a variety of new design alternatives. The notion of virtual function generator is introduced to conceptualize and represent all possible underlying design concepts in the prior design cases. The virtual function generators are extracted in advance from the existing mechanism and serve as new conceptual building blocks for the synthesis of mechanism. Various design alternatives are generated basically by merging tow virtual function generators that partially match the specified function. By utilizing the design concepts that have been effectively used in the previous design cases. he proposed approach could efficiently produce more feasible design concepts than from-scratch ones. The approach proposed in this paper is illustrated with a design example.

• 한국기계가공학회지
• /
• 제11권1호
• /
• pp.68-75
• /
• 2012

In this study, the optimal synthesis of planar steering mechanisms for vehicles is studied. The author minimized the steering error between two front wheels subject to the constraints of transmission angles. Nonlinear programming methods such as BFGS method and golden section search method are used for this optimization. As numerical examples, Ackermann's steering mechanism, 6-link and 10-link planar mechanism are adopted to check the usefulness of this method. Consequently, among the three optimized mechanisms, 10-link planar one conducts far more accurate performance subject to tight constraints of transmission angles.

• 한국정밀공학회지
• /
• 제12권6호
• /
• pp.80-86
• /
• 1995

A method of eliminating the branch problem in driving crank center point plane for 3 position synthesis of 4 bar mechanism is introduced. By studying various transformation characteristics from the circle point plane into the center poi t plane, the curves in the center point plane transformed from the filemon line in circle point plane are analytically obtained, which will seperate the whole center point plane into many sub-areas for the selec- tion of the center point of the driving crank. And a simple method to identify which of the sub-areas will cause the branch problem is also presented. The method will allow the selection of the center point of driving crank without the branch problem.

• Asian-Australasian Journal of Animal Sciences
• /
• 제18권1호
• /
• pp.133-140
• /
• 2005

Although amino acids are substrates for the synthesis of proteins and nitrogen-containing compounds, it has become more and more clear over the years that these nutrients are also extremely important as regulators of body protein turnover. The branched-chain amino acids (BCAAs) together or simply leucine alone stimulate protein synthesis and inhibit protein breakdown in skeletal muscle. However, it was only recently that the mechanism(s) involved in the regulation of protein turnover by BCAAs has begun to be defined. The acceleration of protein synthesis by these amino acids seems to occur at the level of peptide chain initiation. Oral administration of leucine to food-deprived rats enhances muscle protein synthesis, in part, through activation of the mRNA binding step of translation initiation. Despite our knowledge of the induction of protein synthesis by BCAAs, there are few studies on the suppression of protein degradation. The recent findings that oral administration of leucine rapidly reduced $N^{\tau}$-methylhistidine (3-methylhistidine; MeHis) release from isolated muscle, an index of myofibrillar protein degradation, indicate that leucine suppresses myofiblilar protein degradation. The details of the molecular mechanism by which leucine inhibits proteolysis is just beginning to be elucidated. The purpose of this report was to review the current understanding of how BCAAs act as regulators of protein turnover.

• 한국전기전자재료학회논문지
• /
• 제27권12호
• /
• pp.852-856
• /
• 2014

$BaTiO_3$ nano powder can be synthesized by hydrate salt method at $120^{\circ}C$ in air. Decreasing the thickness of thick film, the nano dielectric particle is needed in electronic ceramics. However, the synthesis of $BaTiO_3$ nano particle at low temperature in air and their mechanism were not reported enough. And ultrasonic treatment can be tried because of low temperature process in air. Therefore, in this study, the $BaTiO_3$ nano powder was synthesised with the synthesis time and ultrasonic treatment at $120^{\circ}C$ in air. In the synthesis process, the effects of process were evaluated. From the experimental observation, the synthesis mechanism was proposed. The homogeneous $BaTiO_3$ particle was synthesised by KOH salt solution at $120^{\circ}C$ for 1hour. It was conformed that the ultrasonic treatment effected on the increase of synthesis rate. After cutting the salt powder using FIB, $BaTiO_3$ nano particles observed homogeneously in the cross-section of the salt particle.

• Mycobiology
• /
• 제47권2호
• /
• pp.242-249
• /
• 2019

Betaine derivatives are considered major ingredients of shampoos and are commonly used as antistatic and viscosity-increasing agents. Several studies have also suggested that betaine derivatives can be used as antimicrobial agents. However, the antifungal activity and mechanism of action of betaine derivatives have not yet been fully understood. In this study, we investigated the antifungal activity of six betaine derivatives against Malassezia restricta, which is the most frequently isolated fungus from the human skin and is implicated in the development of dandruff. We found that, among the six betaine derivatives, lauryl betaine showed the most potent antifungal activity. The mechanism of action of lauryl betaine was studied mainly using another phylogenetically close model fungal organism, Cryptococcus neoformans, because of a lack of available genetic manipulation and functional genomics tools for M. restricta. Our genome-wide reverse genetic screening method using the C. neoformans gene deletion mutant library showed that the mutants with mutations in genes for cell membrane synthesis and integrity, particularly ergosterol synthesis, are highly sensitive to lauryl betaine. Furthermore, transcriptome changes in both C. neoformans and M. restricta cells grown in the presence of lauryl betaine were analyzed and the results indicated that the compound mainly affected cell membrane synthesis, particularly ergosterol synthesis. Overall, our data demonstrated that lauryl betaine influences ergosterol synthesis in C. neoformans and that the compound exerts a similar mechanism of action on M. restricta.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.339.2-339.2
• /
• 2002

Interest in the synthesis and chemistry of multidentate macrocyclic ligands is currently very high. Synthetic macrocycles arise from the fact that many biologically important molecules are metal complexes of macrocyclic organic systems: and in order to understand the mechanism of action of the naturally occurring complexes. chemists have resorted to the synthesis and study of so-called model systems. (omitted)