• 정신신체의학
• /
• 제3권1호
• /
• pp.81-90
• /
• 1995

It is essential in evaluating the chronic pain patients that the physician obtain a multiple causative factors including organic, psychological, and socioenvironmental factors. Though these multiple factors are involved in the development of chronic pain syndrome, chronic pain syndrome is not only the sum of the interaction of all of these factors, but is also influenced by the sequelae of chronic pain, which again are organic, psychological, and socioenvironmental in nature. Therefore a systemic approach is probably the best way to asses the role of all of these factors. Furthermore, this approach can provide a framework for understanding chronic pain syndrome, for assessing chronic pain syndrome, for the rational management of chronic pain syndrome, and for the development and testing of hypotheses.

• 상하수도학회지
• /
• 제28권1호
• /
• pp.125-134
• /
• 2014

6 sigma is a management innovation strategy which improves most of all managerial processes including transactional and project based operations such as marketing, purchasing, accounting, and construction. Even though 6 sigma is trying to solve problems from the customer's viewpoint in the scientific manner, project leader feels some difficulties in implementation because of several reasons. Especially the difficulties are prevalent in construction site. This paper investigates the cause of the difficulties through questionnaires, analyzes the investigation results, and verifies the critical success factors of 6 sigma implementation. Factor analysis has been usually employed in reducing quantity of data and summarizing information chaos. In this study, several variables from questionnaires are grouped into just only four factors by the process of factor analysis. The critical success factors are extracted as project management system, implementation mechanism, site condition, and project ownership. Some ideas for each individual success factor are suggested, which are expected to be useful in successful implementation of 6 Sigma in construction site.

• Advances in Traditional Medicine
• /
• 제10권1호
• /
• pp.37-43
• /
• 2010

Palmitic acid (PA) is one of free fatty acids, which is found from Gaultheria itoana Hayata and Sarcopyramis nepalensis. Although PA has a variety of pharmacological effects including mediates hypothalamic insulin resistance, induces IP-10 expression, and promote apoptotic activities, the anti-inflammatory mechanism of PA in mouse peritoneal macrophages remains unclear. In this study, we showed that PA exerted an anti-inflammatory action through suppression the production of tumor necrosis factor-$\alpha$, interleukin-6, cyclooxygenases-2 and nitric oxide in lipopolysaccaride-stimulated mouse peritoneal macrophages. Our study suggests an important molecular mechanism of PA, which might explain its beneficial effect in the regulation of inflammatory reactions.

• 한국정밀공학회지
• /
• 제14권11호
• /
• pp.42-49
• /
• 1997

The extent of absorption and transmitance of the light that passes through some material is changed as the wavelength of the light varies, and which makdes it possible to estimate characteristics of the material. Spectrometer is a measurement system that can analyze the characteristics of material by using this principle. Its application field is so wide that it can be applied to all the arease that are concerned with analyzing materials : biological, environmental, medical and chemical area etc. This study is focused on developing precision sine drive mechanism for grating monochromator which is the most important part of the spectrometers. It is designed to be simple in struicture. It is achieved to derive basic principles to manipu- late precision sine drive mechanism : it should be aligned with a condition that .beta. , the angle between grat- ing normal and grating rod should be the same as .gamma. , the one between moving nut's normal and sliding guide. And also, it's found that the mis-alignments of the grating and mirrors are not the main factor in guaranteeing the linearity of sine drive mechanism. Performance evaluation is achieved by a standard sample by comparing experimental results with standard values. It results in wavelength accuracy of .+-. 0.5nm and resolution of 1nm. Conclusively, it can be verified that the sine drive mechanism developed in this study is not only simple in structure, but also stable and excellent in performanes.

• International Journal of Computer Science & Network Security
• /
• 제23권8호
• /
• pp.63-76
• /
• 2023

Identity and access management in cloud computing is one of the leading significant issues that require various security countermeasures to preserve user privacy. An authentication mechanism is a leading solution to authenticate and verify the identities of cloud users while accessing cloud applications. Building a secured and flexible authentication mechanism in a cloud computing platform is challenging. Authentication techniques can be combined with other security techniques such as intrusion detection systems to maintain a verifiable layer of security. In this paper, we provide an interactive, flexible, and reliable multi-factor authentication mechanisms that are primarily based on a proposed Authentication Method Selector (AMS) technique. The basic idea of AMS is to rely on the user's previous authentication information and user behavior which can be embedded with additional authentication methods according to the organization's requirements. In AMS, the administrator has the ability to add the appropriate authentication method based on the requirements of the organization. Based on these requirements, the administrator will activate and initialize the authentication method that has been added to the authentication pool. An intrusion detection component has been added to apply the users' location and users' default web browser feature. The AMS and intrusion detection components provide a security enhancement to increase the accuracy and efficiency of cloud user identity verification.

• 대한한방부인과학회지
• /
• 제18권4호
• /
• pp.119-135
• /
• 2005

Purpose : This study was investigated, in order to improve that reliability of disease mechanism diagnosis, which were used for the object diagnosis of Oriental medicine in the dept. of Oriental OB&GY, Oriental Medical hospital of Dong-Eui University, amend to a disease mechanism item of Questionnaires and indexes of disease mechanism, we were thought that the results were more pointed to the condition of appropriate disease mechanism, as a result of put a results of Questionnaires and belongs to indexes of disease mechanism together, we　suggested to call it a　'weight of disease mechanism', because It was possible to　mark a different degrees of indexes of disease mechanism in the same points.　Methods : We analyzed the results of Questionnaires about 3354 outpatients who　had OB&GY disease in the Oriental Medical hospital of Dong-Eui University from April 2000 to March 2004. Results : 1. weight of disease mechanism is 10 score according to disease mechanism score and the standard of reliability. 2. The standard of reliability is same 11 disease mechanism item except stagnated blood, cold syndrome, dry- ness, phlegm. Conclusion : Weight of disease mechanism which show satisfaction the conditions of standard of reliability, appear the results of Questionnaires, against previous study investigated reliability of Questionnaires make it through the standard of reliability.

• Molecules and Cells
• /
• 제46권12호
• /
• pp.727-735
• /
• 2023

Stem cells require high amounts of energy to replicate their genome and organelles and differentiate into numerous cell types. Therefore, metabolic stress has a major impact on stem cell fate determination, including self-renewal, quiescence, and differentiation. Lysosomes are catabolic organelles that influence stem cell function and fate by regulating the degradation of intracellular components and maintaining cellular homeostasis in response to metabolic stress. Lysosomal functions altered by metabolic stress are tightly regulated by the transcription factor EB (TFEB) and TFE3, critical regulators of lysosomal gene expression. Therefore, understanding the regulatory mechanism of TFEB-mediated lysosomal function may provide some insight into stem cell fate determination under metabolic stress. In this review, we summarize the molecular mechanism of TFEB/TFE3 in modulating stem cell lysosomal function and then elucidate the role of TFEB/TFE3-mediated transcriptional activity in the determination of stem cell fate under metabolic stress.

• Molecules and Cells
• /
• 제28권5호
• /
• pp.495-499
• /
• 2009

Although insulin-like growth factor-I (IGF-I) and androgen receptor (AR) are well known effectors of skeletal muscle, the molecular mechanism by which signaling pathways integrating AR and IGF-I in skeletal muscle cells has not been previously examined. In this study, the role of PI3K/Akt on IGF-I-induced gene expression and activation of AR in skeletal muscle cells was investigated. C2C12 cells were treated with IGF-I in the absence or presence of inhibitors of PI3K/Akt pathway (LY294002 and Wortmannin). Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression. Furthermore, IGF-I-induced AR mRNA and skeletal ${\alpha}-actin$ mRNA were blocked by LY294002 or Wortmannin. Confocal images showed that IGF-I-induced AR translocation from cytosol to nucleus was inhibited significantly in response to treatment with LY294002 or Wortmannin. The present results suggest that modulating effect of IGF-I on AR gene expression and activation in C2C12 mouse skeletal muscle cells is mediated at least in part by the PI3K/Akt pathway.

• 대한의생명과학회지
• /
• 제27권4호
• /
• pp.248-254
• /
• 2021

Ulcerative colitis (UC), chronic inflammatory bowel disease, is characterized by severe inflammation in the colon. Tea is one of the most popular beverages consumed worldwide. Pu-erh tea, a unique Chinese tea produced by microbial activities, possesses a broad range of health-promoting effects, including anti-aging, anti-Alzheimer's disease, antioxidation and anti-obesity. However, the inhibitory effect of Pu-erh tea on intestinal inflammation and the underlying mechanism remain unclear. The present study was designed to evaluate the regulatory effect of Pu-erh tea extract (PTE) on dextran sulfate sodium (DSS)-induced colitis clinical signs by analyzing the weight loss and colon length in mice. The inhibitory effects of PTE on inflammatory mediators, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, and the activation of nuclear factor-κB (NF-κB) were also determined in DSS-treated colitis tissue. We observed that PTE treatment significantly inhibited the DSS-induced clinical symptoms of weight loss, decrease,in colon length, and colon tissue damage in mice. Moreover, PTE attenuated the DSS-induced levels of IL-6 and TNF-α in colon tissue. We also demonstrated the anti-inflammatory mechanism of PTE by suppressing the activation of NF-κB in DSS-treated colon tissues. Collectively, the findings provide experimental evidence that PTE may be effective in preventing and treatment of intestinal inflammatory disorders, including UC.

• Toxicological Research
• /
• 제11권1호
• /
• pp.117-125
• /
• 1995

In order to examine the mechanism of asbestos clastogenicity, CHO cells were treated with chrysotile and crocidolite. Crocidolite and chrysotile were able to induce lipid peroxidation in a dose dependent manner. Ultrafiltrate of culture media from CHO cells treated with chrysotile/crocidolite induced sister chromatid exchange in CHO cells. Ultrafiltrate of culture media from CHO cells treated with chrysotile induced chromosome aberration but it was not statistically significant. Simultaneous treatment of 3-Aminobenzamide (3-AB) or cytosine arabinoside (Ara C) with crocidolite had no effect on the frequency of chromosome aberration by crocidolite whetease posttreatment of caffeine significantly increased the chromosomel aberration by crocidolite. This indicated that DNA damage by asbestos took place at late stage of cell cycle. The results suggested that the ultrafiltrate of media contained clastogenic factor (CF) and lipid peroxidation might be involved in the formation of CF.