Browse > Article
http://dx.doi.org/10.3742/OPEM.2010.10.1.037

Palmitic acid inhibits inflammatory responses in lipopolysaccharide-stimulated mouse peritoneal macrophages  

Lee, Ju-Young (Department of Herb Science Shinsung College)
Lee, Hye-Ja (Department of Herb Science Shinsung College)
Jeong, Ji-Ahn (Department of Herb Science Shinsung College)
Jung, Ji-Wook (Department of Herbal Medicinal Resource, College of Health and Welfare, Daegu Haany University)
Publication Information
Advances in Traditional Medicine / v.10, no.1, 2010 , pp. 37-43 More about this Journal
Abstract
Palmitic acid (PA) is one of free fatty acids, which is found from Gaultheria itoana Hayata and Sarcopyramis nepalensis. Although PA has a variety of pharmacological effects including mediates hypothalamic insulin resistance, induces IP-10 expression, and promote apoptotic activities, the anti-inflammatory mechanism of PA in mouse peritoneal macrophages remains unclear. In this study, we showed that PA exerted an anti-inflammatory action through suppression the production of tumor necrosis factor-$\alpha$, interleukin-6, cyclooxygenases-2 and nitric oxide in lipopolysaccaride-stimulated mouse peritoneal macrophages. Our study suggests an important molecular mechanism of PA, which might explain its beneficial effect in the regulation of inflammatory reactions.
Keywords
Palmitic acid; Tumor necrosis factor-$\alpha$; Interleukin-6; Cyclooxygenases-2; Nitric oxide;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Stevens C, Walz G, Singaram C. (1992) Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease. Dig. Dis. Sci. 37, 818-826.   DOI
2 Grosjean SA, Arstall MA, Mitchell RN, Klappacher GW, Kelly RA, Pfeffer MA, Pfeffer JM. (1999) Inducible nitric oxide synthase and tumor necrosis factor in animal models of myocardial necrosis induced by coronary artery ligation or isoproterenol injection. J. Card. Fail. 5, 236-245.   DOI   ScienceOn
3 Wallace JL. (1999) Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal antiinflammatory drugs (NSAIDs). Am. J. Med. 107, 11S- 16S; discussion 16S-17S.   DOI   ScienceOn
4 Narumi S, Finke JH, Hamilton TA. (1990) Interferon gamma and interleukin-2 synergize to induce selective monokine expression in murine peritoneal macrophages. J. Biol. Chem., 265, 7036-7041.
5 Otta JC And Smith WL. (1995) Prostaglandin endoperoxide synthases-1 and -2. J. Lipid Mediat. Cell Signal. 12, 139-156.   DOI   ScienceOn
6 Parrillo JE. (1993) Pathogenetic mechanisms of septic shock. N. Engl. J. Med., 328, 1471-1477.   DOI   ScienceOn
7 Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P. (1994) Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc. Res. 28, 34-39.   DOI   ScienceOn
8 Vane JR, Bakhle YS and Botting RM. (1998) Cyclooxygenases 1 and 2. Annu. Rev. Pharmacol. Toxicol. 38, 97-120.   DOI   ScienceOn
9 Tegeder I, Pfeilschifter J, Geisslinger G. (2001) Cyclooxygenase- independent actions of cyclooxygenase inhibitors. FASEB J. 15, 2057-2072.   DOI   ScienceOn
10 Vallance P, Moncada S. (1993) Role of endogenous nitric oxide in septic shock. New Horiz. 1, 77-86.
11 Harbrecht BG., Billiar TR, StadlerA, Demetris AJ, Ochoa BJ, Curran RD, Simmons RL. (1992) Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia. Crit. Care Med. 20, 1568-1574.   DOI   ScienceOn
12 Wang YY, Chen HD, Liao M, Ruan HL, Pi HF, Zhang YH. (2009) Studies on the chemical constituents of Sarcopyramis nepalensis. Zhong Yao Cai. 32, 1395- 1397.
13 Weinberg JB, Misukonis MA, Shami PJ, Mason SN, Sauls DL, Smith GK, McDonald B, Bachus KE. (1995) Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. Blood 86, 1184-1195.
14 Beutler B. (2000) TNF, immunity and inflammatory disease: lessons of the past decade. Curr. Opin. Immuno. 12, 20-26.   DOI   ScienceOn
15 Belosludtsev K, Saris NE, Andersson LC, Belosludtseva N, Agafonov A, Sharma A, Moshkov DA, Mironova GD. (2006) On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and $Ca2^+$ in mitochondria. J. Bioenerg. Biomembr. 38, 113-120.   DOI
16 Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. (2009) Palmitic acid mediates hypothalamic insulin resistance by altering PKCtheta subcellular localization in rodents. J. Clin. Invest. 119, 2577-2589.   DOI   ScienceOn
17 Chen CY, Lin RJ, Huang JC, Wu YH, Cheng MJ, Hung HC, Lo WL. (2009) Chemical constituents from the whole plant of Gaultheria itoana Hayata. Chem. Biodivers 6, 1737-1743.   DOI   ScienceOn
18 Dinarello C A. (2000) Proinflammatory cytokines. Chest 118, 503-508.   DOI   ScienceOn
19 Leiro JM, Alvarez E, Arranz JA., Cano E, Orallo F. (2004) Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophages. Immunopharmacol. 4, 163-177.   DOI   ScienceOn
20 MacMicking J, Xie QW, Nathan C. (1997) Nitric oxide and macrophage function. Annu. Rev. Immunol. 15, 323-350.   DOI   ScienceOn
21 Beutler B. (1995) TNF, immunity and inflammatory disease, lessons of the past decade. J. Invest. Med. 43, 227-235.
22 Medzhitov R, Janeway CA Jr. (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 9, 295-298.
23 Minghetti L, Levi G. (1998) Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog. Neurobiol. 54, 99-125.   DOI   ScienceOn
24 Morita I, SchindlerM, Regier MK, Otto JC, Hori T, KeWitt DL and Smith WL. (1995) Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem. 270, 10902-10908.   DOI   ScienceOn
25 Pfeilschifter J, Muhl H. (1999) Immunopharmacology: anti-inflammatory therapy targeting transcription factors. Eur. J. Pharmacol. 30, 237-245.
26 Stark LA, Din FV, Zwacka RM, Dunlop MG. (2001) Aspirin-induced activation of the NF-kappaB signaling pathway: a novel mechanism for aspirinmediated apoptosis in colon cancer cells. FASEB J. 15, 1273-1275.   DOI