• 한국지반신소재학회논문집
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• 제19권4호
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• pp.41-50
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• 2020

콘크리트 구조물의 균열은 장기간 지속 시 철근의 부식을 촉진시키므로 구조적 사용성을 보장하고 열화를 방지하기 위해 정기적인 현장 점검이 필수적이다. 대부분의 시설물 안전점검은 육안 검사에 의존하고 있어 비용과 시간 소모가 심하고 점검자에 따라 결과의 신뢰도 차이가 발생한다. 본 연구에서는 카메라로 촬영된 균열의 이미지 분석을 통해 콘크리트 균열의 폭과 길이를 측정하는 장치로서 안전진단 및 유지관리에 사용할 수 있는 휴대용 측정 장치를 개발하였다. 이 장치는 측정자가 육안으로 발견한 균열을 가까운 거리 (3m) 이내에서 촬영하고 레이저 거리측정으로 단위 픽셀크기를 정확히 산정하여, 본 연구에서 개발한 이미지 처리 알고리즘으로 균열 길이와 폭을 자동으로 산정할 수 있다. 측정결과 실험에 적용한 균열 이미지를 이용하여 3m 거리 이내에서 0.3mm 균열의 길이 측정은 약 10% 오차 범위에서 측정 가능하였다. 균열 폭의 경우 이진화 과정에서 진동 및 Blurring에 의한 주변픽셀을 검출해 과대평가되는 경향을 나타내었으나, 균열 폭 감소함수를 적용하여 효과적으로 보정할 수 있었다.

• 한국가축번식학회지
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• 제9권2호
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• pp.133-139
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• 1985

An immunoassay may be defined as an analytical procedure involving the competitive reaction between a limiting concentration of specific antibody and two populations of antigen, one of which is labelled or immobillized. The advent of immunoassay has revolutionised our knowledge of reproductive physiology and the practice of veterinary and clinical medicine. Radioimmunoassay (RIA) was the first of these methods to be developed, which meausred the analyte with good sensitivity, accuracy and precision (1,2). The essential components of RIA are:-(i) a limited concentration of antibodies, (ii) a reference preparation, and (iii) an antigen labelled with a radioisotope (usually tritium or iodine-125). Most procedures invelove isolating the antibody-bound fraction and measuring the amount of labelled antigen. Good facilities are available for scintilltion counting, data reduction nd statistical analysis. RIA is undergoing refinement through:-(i) the introduction of new techniques to separate the antibody-bound and free fractions which minimize the misclassification of labelled antigen into these compartments, and the amount of non-specfic binding. (3), (ii) the development of non-extration for the measurement of haptens (4), (iii) the determination of a, pp.rent free (i.e. non-protein bound) analytes (5), and (iv) the use of monoclonal antibodies(6). In 1968, Miles and Hales introduced in important new type of immunoassay which they termed immunora-diometric assay (IRMA) based on t도 use of isotopically labelled specific antibodies(7) in a move from limited to excess reagent systems. The concept of two-site IRMAs (with a capture antibody on a solid-phase, and a second labelled antibody to a different antigenic determinant of the analyte) has enabled the development of more sensitive and less-time consuming methods for the measurement of protein hormones ovar wide concentration of analyte (8). The increasing use of isotopic methos for diverse a, pp.ications has exposed several problems. For example, the radioactive half-life and radiolysis of the labelled reagent limits assay sensitivity and imposes a time limit on the usefulness of a kit. In addition, the potential health hazards associated with the use and disposal of radioactive cmpounds and the solvents and photofluors necessary for liquid scientillation counting are incompatable with the development of extra-laboratory tests. To date, the most practical alternative labels to radioisotopes, for the measurement of analytes in a concentration > 1 ng/ml, are erythrocytes, polystyrene particiles, gold sols, dyes and enzymes or cofactors with a visual or colorimetric end-point(9). Increased sensitivity to<1 pg/ml may be obtained with fluorescent and chemiluminescent labels, or enzymes with a fluorometric, chemiluminometric or bioluminometric end-point. The sensitivity of any immunoassay or immunometric assay depends on the affinity of the antibody-antigen reaction, the specific activity of the label, the precision with which the reagents are manipulated and the nonspecific background signal (10). The sensitivity of a limited reagent system for the measurement of haptens or proteins is mainly dependent upon the affinity of the antibodies and the smalleest amount of reagent that may be manipulated. Consequently, it is difficult in practice to improve on the sensitivity obtained with iodine-125 as the label. Conversely, with excess reagent systems for the measurement of proteins it is theoretically possible to increase assay sensitivity at least 1000 fold with alternative luminescent labels. To date, a 10-fold improvement has been achieved, and attempts are being made to reduce the influence of other variables on the specific signal from the immunoreaction.

• 한국건설관리학회논문집
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• 제24권4호
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• pp.3-13
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• 2023

본 연구는 국내에서 주로 사용되는 습식 도로절단기와 비산먼지 저감을 위해 개발된 슬러지 흡입식 도로절단기(이하 자동식 도로절단기)의 작업생산성을 비교 분석하여 자동식 도로절단기의 성능 및 활용성을 검증하는 것을 목적으로 한다. 이를 위해 먼저 국내에서 주로 사용되는 습식 수동식 도로절단기와 자동식 도로절단기의 개발 현황을 조사하고, 도로 절단 작업을 세부적으로 분석하였다. 또한, 동일한 조건의 테스트베드에 두 장비를 적용하여 깊이별 절단 시간을 측정하여, 표준절단 성능을 도출하였다. 하지만 테스트베드에서 측정된 데이터는 실제 도로절단 현장의 다양한 변수를 반영하지 못한다는 한계가 있다. 따라서 본 연구에서는 현장 조사를 통해 데이터를 수집하여 절단 거리와 시간 사이의 상관성을 분석한 후, 단순회귀분석을 통해 도로절단기 생산성 산정모델을 제시하였다. 회귀식에서 도출된 값을 테스트베드에서 도출한 표준절단 성능과 비교 분석한 결과, 회귀분석식을 통해 도출한 절단 성능은 표준절단 성능과 유사한 경향을 보였다. 마지막으로, 정량적으로 측정하기는 어려우나 생산성에 영향을 주는 세가지 세부작업에 대해 정성적으로 비교 분석하여 개발된 자동식 도로절단기의 활용성을 검증하였다.

• 대한치과보철학회지
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• 제49권1호
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• pp.38-48
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• 2011

연구 목적: 본 연구는 고정성 국소의치 제작을 위한 상악 좌측 제2소구치 및 제2대구치의 지대치 삭제에 대하여 인체공학적으로 안정된 진료 자세를 확립하고, 치과의사의 일반적 작업 자세와 비교, 분석하고 인체공학적으로 안정된 자세의 임상적용 가능성을 알아보고 이를 이용하여 향후 치과의사 교육의 기초 자료로 활용하기 위함이다. 연구 재료 및 방법: 상악 좌측 고정성 국소의치를 위한 인체공학적으로 안정된 자세를 고안하고 임상 경력 3-6년의 보철과 전공의 과정에 있는 치과의사 8명을 선정하여 임의의 자세로 상악 좌측 고정성 부분의치 지대치 삭제를 시행하고 연구 대상자들에게 인체공학적으로 안정된 자세를 교육하고 연구 대상들에게 인체공학적으로 안정된 자세로 상악 좌측 고정성 국소의치 지대치 삭제를 시행하였다. 임의의 자세로 삭제 시행한 치아와 인체공학적으로 안정된 자세로 삭제 시행한 치아를 KHDP 3-dimensional measuring device를 사용하여 계측해 교합면 삭제량, 변연의 폭경, 변연의 깊이 축면 경사도. 그리고 삭제시간을 측정 비교하였다. 모든 계측된 결과를 윈도우즈용 SPSS 통계 프로그램 (ver. 18.0, SPSS, Chicago, IL, USA)을 이용하여 교합면 삭제량, 변연의 폭 및 깊이, 축면 경사도, 치아 삭제 시간을 평균값 및 표준편차 분석하고 T-test를 Random Position 와 Home Position에 따른 차이 검정하였다. 결과: 와(fossa) 부위에서의 교합면 삭제량은 상악 좌측 제2소구치 및 제2대구치 모두에서 지시삭제량에 비해 적었으며, 교두정에서의 삭제량은 지시삭제량 1.7 mm에비해 많았으나, Random position과 Home position간에 유의차는 없었다 (P > .05). 변연 폭의 삭제량은 상악 좌측 제2소구치 및 제2대구치 모두에서 지시삭제량에 비해 많았으며, Random position과 Home position간에 유의차는 없었다 (P > .05). 변연 깊이의 삭제량은 상악 좌측 제2소구치 및 제2대구치 모두에서 Random position이 Home position에 비하여 지시삭제량보다 깊었다 (P < .05). 축면경사각은 상악 좌측 제2소구치 및 제2대구치 모두에서 Home position의 축면 경사각이 Random position의 축면경사각보다 작았으나 유의차는 없었다 (P > .05). 피어슨 상관분석 결과, Random position에서 교합면 삭제량, 변연 깊이, 축면경사각은 서로에게 영향을 주고 있었으나, Home position에서는 측정결과 들이 거의 독립적으로 서로에게 영향을 주지 않았다 (P < .05). Home position 삭제 횟수가 많아질수록 삭제소요 시간은 줄어들었고, 이는 실험에 참여한 8명 모두에서 Random position 삭제시간과 비슷해지거나 더 짧았다. 결론: 고정성 국소의치를 위한 상악 좌측 제2소구치 및 제2대구치 삭제의 경우, 교합면 삭제량, 변연의 폭, 변연의 깊이, 축면 경사각에 있어서 Home position과 Random position 간에는 큰 차이가 없었다. 삭제시간, 인접치 인접면 손상 정도는 Home position이 Random position보다 적었다. 또한 자세분석을 한 결과 Home position이 Random position에 비하여 곧은 자세로 인체에 무리를 주지 않았다. 따라서 인체공학적으로 안정된 자세인 Home position의 임상적용 가능성이 높다고 생각된다.

• 한국직업건강간호학회지
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• 제4권호
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• pp.5-29
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• 1995

Occupational health services in Korea have been operated as dual types : one is operated by occupational health care manager and the other is health care agency without their own personnel. The performance of occupational health service should be different due to the variety of characteristics of health care manager and workplace, qualification of health care manager. This study is to analyze performance of occupational health care services with a particular consideration of job performance shape and efficiency, based on comparing those two types of health care management to show on the basic data for the settlement of more qualitative health care management system at workplace. For this study, total 391 places in Seoul and Inchon city area ; 154 places (39.4%) managed by designated health care manager and 237 places (60.6%) by the agency with their commission are selected as research samples. Tools for data collection are questionnares that have been investigated during the period of 20 September 1993-20 December 1993. Those data are compared with percentiles, mean, standard deviation and B/C ratio using SPSS PC program. Conclusions observed from the tests and each comparison could be summerized as follows : 1. Occupational health care have been accomplished at workplaces with designated people than with agencies people, and coverage rate of the occupational health care services has differences, due to management types. The reason of these results is due to visit only one or two times monthly by the agencies, while their own health care manager obsess, at the workplaces all the times. 2. Most of the expense for environmental control of all health care services expenditures shows that there is almost no fundamental improvement because more expenses are needed for procuring personal protective equipment and measuring work environment instead of environmental improvement. 3. It is investigated how much the cost of occupational health care services needs per worker, and calculated how much the cost needs per service hour per worker. The results from this show that the cost of occupational health services at workplaces with their own managers used less than the cost of health care agencies, eventually the former gives better services with less cost than the latter. 4. Benefit/Cost ratio is also produced by total benefit/total cost. The result from the above way reads 4.57 as a whole, while their own manager having workplaces reads 4.82 and the agencies do l.56. Even if their own manager performing workplaces spent more cost, this system produces more benefit than the agencies management. 5. The B/C ratio for medical organization such as local clinic, health care center and pharmacy shows more than or equal to at the workplaces controlled by the agencies. It is inferred that benefit would be much less than the cost used, with so being inefficient. 6. It is assumed that the efficiency ratio of health education is equal to reduction rate of workers medical organization visit. Estimated reduction rate 5%, 10%, 15%, show that the efficiency ratio of health education have an effect on producing benefits. It is estimated that more benefit can be produced if more qualitative education will be provided for enhancing health care efficiency. 7. Results of this study cannot be generalized because there are large scale of deviation in case of workplaces with less than 300 full time workers, but B/C ratio reads 2.69 as a whole and 3.25 at workplaces with their own health care manager are higher than 1.63 at the workplaces manged by the agencies. Finally, all the benefit concerning health care services could not be quantified, measured and shown on the value of money. This is a reason that a considerable part of benefits are so underestimated. This is also thought that measurement tools should be developed for measuring benefits of health care services with a comprehensive quantification. in the future. It is also expected that efficiency of occupational health care services should be investigated using cost-effectiveness analysis.

• 한국조경학회지
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• 제48권5호
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• pp.80-88
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• 2020

2019년 3월 미세먼지 비상저감조치가 일주일 동안 발령되면서, 미세먼지로 인한 국민의 불안감은 점차 가중되고 있다. 본 연구는 공기정화식물이 적용된 바이오필터의 다중이용시설 내 적용성 평가를 위해 입자상 오염원의 실내 연속방출환경을 조성하여 오염원 저감효과에 대한 측정방법을 제안하고, 시스템의 실내공기질 개선 여부를 확인할 수 있는 기초연구를 진행하였다. 강의실을 대상으로 춘절기에 모니터링 1시간 전 모기향을 오염원으로 배경농도를 조성한 후, 스케줄에 따라 2시간 관수, 1시간 송풍하여 미세먼지의 저감능을 확인하였으며, 바이오필터 2m 전방에 PM₁₀, PM_2.5 및 온습도 센서를 설치하고, 3개 송풍구 중 중앙에 풍속 프로브를 설치하여 시계열 모니터링을 수행하였다. 바이오필터에 구비된 총 3개소의 송풍구 평균 면풍속은 0.38±0.16 m/s로 댐퍼 면적이 제외된 송풍구별 면적 0.29m×0.65m을 적용한 총 공조풍량이 776.89±320.16㎥/h로 산출되었다. 시스템 가동으로 평균온도 21.5~22.3℃, 평균상대습도 63.79~73.6%를 유지하여, 선행연구의 다양한 조건별 온습도 범위에 부합하는 것으로 판단된다. 시스템 공조부 구동을 통해 급격하게 상대습도를 상승시키는 효과를 효율적으로 운용할 경우, 계절에 따른 실내 미세먼지 저감과 적정한 상대습도 확보도 가능할 것으로 판단된다. 미세먼지 농도는 바이오필터 시스템 가동 전의 모든 주기에서 상승 현상이 동일하게 집계되었으며, 시스템 가동 후 1주기 송풍구간(B-1, β=-3.83, β=-2.45)에서 미세먼지(PM₁₀)는 최대 28.8% 수준인 560.3㎍/㎥, 초미세 먼지(PM_2.5)는 최대 28.0% 수준인 350.0㎍/㎥까지 저감되었다. 이후 미세먼지(PM₁₀, PM_2.5)의 농도는 2주기 송풍구간 감소(B-2, β=-5.50, β=-3.30)로 각각 최대 32.6% 수준인 647.0㎍/㎥, 32.4% 수준인 401.3㎍/㎥까지 저감되었고, 3주기 송풍구간감소(B-3, β=5.48, β=-3.51)로 최대 30.8% 수준인 732.7㎍/㎥, 31.0% 수준인 459.3㎍/㎥까지 저감된 것으로 확인되었다. 본 연구는 식생 바이오필터의 다중이용시설 내 설치와 유관한 관련 표준 및 규정을 참조하여, 객관적인 성능평가환경의 구축 방안을 제시할 수 있었다. 이를 통해 일반 강의실 환경 내에 보다 객관화된 모니터링 인프라를 조성하여, 상대적으로 신뢰성 있는 데이터 확보가 가능했던 것으로 판단된다.

• Asia pacific journal of information systems
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• 제20권3호
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• pp.139-166
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• 2010

The supply chain management (SCM) systems have emerged as strong managerial tools for manufacturing firms in enhancing competitive strength. Despite of large investments in the SCM systems, many companies are not fully realizing the promised benefits from the systems. A review of literature on adoption, implementation and success factor of IOS (inter-organization systems), EDI (electronic data interchange) systems, shows that this issue has been examined from multiple theoretic perspectives. And many researchers have attempted to identify the factors which influence the success of system implementation. However, the existing studies have two drawbacks in revealing the determinants of systems implementation success. First, previous researches raise questions as to the appropriateness of research subjects selected. Most SCM systems are operating in the form of private industrial networks, where the participants of the systems consist of two distinct groups: focus companies and vendors. The focus companies are the primary actors in developing and operating the systems, while vendors are passive participants which are connected to the system in order to supply raw materials and parts to the focus companies. Under the circumstance, there are three ways in selecting the research subjects; focus companies only, vendors only, or two parties grouped together. It is hard to find researches that use the focus companies exclusively as the subjects probably due to the insufficient sample size for statistic analysis. Most researches have been conducted using the data collected from both groups. We argue that the SCM success factors cannot be correctly indentified in this case. The focus companies and the vendors are in different positions in many areas regarding the system implementation: firm size, managerial resources, bargaining power, organizational maturity, and etc. There are no obvious reasons to believe that the success factors of the two groups are identical. Grouping the two groups also raises questions on measuring the system success. The benefits from utilizing the systems may not be commonly distributed to the two groups. One group's benefits might be realized at the expenses of the other group considering the situation where vendors participating in SCM systems are under continuous pressures from the focus companies with respect to prices, quality, and delivery time. Therefore, by combining the system outcomes of both groups we cannot measure the system benefits obtained by each group correctly. Second, the measures of system success adopted in the previous researches have shortcoming in measuring the SCM success. User satisfaction, system utilization, and user attitudes toward the systems are most commonly used success measures in the existing studies. These measures have been developed as proxy variables in the studies of decision support systems (DSS) where the contribution of the systems to the organization performance is very difficult to measure. Unlike the DSS, the SCM systems have more specific goals, such as cost saving, inventory reduction, quality improvement, rapid time, and higher customer service. We maintain that more specific measures can be developed instead of proxy variables in order to measure the system benefits correctly. The purpose of this study is to find the determinants of SCM systems success in the perspective of vendor companies. In developing the research model, we have focused on selecting the success factors appropriate for the vendors through reviewing past researches and on developing more accurate success measures. The variables can be classified into following: technological, organizational, and environmental factors on the basis of TOE (Technology-Organization-Environment) framework. The model consists of three independent variables (competition intensity, top management support, and information system maturity), one mediating variable (collaboration), one moderating variable (government support), and a dependent variable (system success). The systems success measures have been developed to reflect the operational benefits of the SCM systems; improvement in planning and analysis capabilities, faster throughput, cost reduction, task integration, and improved product and customer service. The model has been validated using the survey data collected from 122 vendors participating in the SCM systems in Korea. To test for mediation, one should estimate the hierarchical regression analysis on the collaboration. And moderating effect analysis should estimate the moderated multiple regression, examines the effect of the government support. The result shows that information system maturity and top management support are the most important determinants of SCM system success. Supply chain technologies that standardize data formats and enhance information sharing may be adopted by supply chain leader organization because of the influence of focal company in the private industrial networks in order to streamline transactions and improve inter-organization communication. Specially, the need to develop and sustain an information system maturity will provide the focus and purpose to successfully overcome information system obstacles and resistance to innovation diffusion within the supply chain network organization. The support of top management will help focus efforts toward the realization of inter-organizational benefits and lend credibility to functional managers responsible for its implementation. The active involvement, vision, and direction of high level executives provide the impetus needed to sustain the implementation of SCM. The quality of collaboration relationships also is positively related to outcome variable. Collaboration variable is found to have a mediation effect between on influencing factors and implementation success. Higher levels of inter-organizational collaboration behaviors such as shared planning and flexibility in coordinating activities were found to be strongly linked to the vendors trust in the supply chain network. Government support moderates the effect of the IS maturity, competitive intensity, top management support on collaboration and implementation success of SCM. In general, the vendor companies face substantially greater risks in SCM implementation than the larger companies do because of severe constraints on financial and human resources and limited education on SCM systems. Besides resources, Vendors generally lack computer experience and do not have sufficient internal SCM expertise. For these reasons, government supports may establish requirements for firms doing business with the government or provide incentives to adopt, implementation SCM or practices. Government support provides significant improvements in implementation success of SCM when IS maturity, competitive intensity, top management support and collaboration are low. The environmental characteristic of competition intensity has no direct effect on vendor perspective of SCM system success. But, vendors facing above average competition intensity will have a greater need for changing technology. This suggests that companies trying to implement SCM systems should set up compatible supply chain networks and a high-quality collaboration relationship for implementation and performance.

• 대한화학회지
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• 제55권3호
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• pp.463-471
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• 2011

[ $N_2O_2$ ] 시프염기 리간드인 N,N'-bis(4-methoxysalicylidene) phenylendiamine(4-$CH_3O$-salphen)을 합성하였다. 분광광도법으로 4-$CH_3O$-salphen을 이용하여 수용액 중의 Fe(II)와 Fe(III)이온의 분리 정량실험을 위하여, 리간드 농도는 $4.0{\times}10^{-4}\;M$, DMF 용매와 물의 비율은 70/30(v/v), pH는 3.4~3.8 범위, 온도는 $55^{\circ}C$에서 1 시간 정도를 물 중탕하여 결과를 얻었다. 시료의 예비 산화 및 환원 전처리는 $5.0{\times}10^{-4}\;M$ 농도의 $H_2O_2$와 $NH_2OH{\cdot}HCl$을 사용하여 단일 원자가 상태의 시료를 만들어 사용하였다. 이때 Fe(II)와 Fe(III) 이온의 정량은 434 nm와 456 nm에서 흡광도를 측정하였다. 이상의 최적화된 실험조건을 이용하여 약수, 온천수, 바닷물 및 하수 처리장의 처리수를 채취하여 Fe(II)와 Fe(III) 이온을 각각 정량 분석한 결과는 측정 평균값이 표준 값에 대하여 2.00~6.90% 범위에서 잘 일치 하였고, 정량검출한계는 Fe(II)의 경우 27.9 ng/mL이었고, Fe(III)은 55.8 ng/mL이었다.

• 대한약침학회지
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• 제5권2호
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• pp.120-136
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• 2002

Objectives : The purpose of this study is to investigate Acute and Subacute Toxicity, and Anti-cancer Effect of H Herbal-acupuncture on mice and rats. Methods : Balb/c mice were injected intraperitoneally with H Herbal-acupuncture for $LD_{50}$ and acute toxicity test. Sprague-Dawley rats were experimented in the same way for subacute toxicity test. H Herbal-acupuncture was injected into abdomen of mice having S-180 cancer cell line. Result : 1. During the test, $LD_{50}$ could not be counted since there was no expired subjects. 2. In an acute toxicity test, the loss of motility and reflex action was observed, but weight increased in the treatment group, compared with those in the normal group (P<0.05). 3. In an acute toxicity test of serum biochemical values of mice, glucose increased in the treatment group II while total cholesterol was increased in the all treatment groups (P<0.05). 4. In a subacute toxicity test, a little loss of motility and reflex action was observed in the treatment group. Weight of mice in the treatment group decreased on the 28th day. 5. In a subacute toxicity test, liver weight was decreased but lung weight of mice increased in the all treatment groups (P<0.05). 6. As a result of measuring Complete Blood Count test (CBC) of rat, HCT was decreased in treatments even though it was not significant, compared with the normal group (P<0.05). 7. In a serum biochemical value test of subacute toxicity, total protein and albumin decreased in the all treatment groups. Creatinine, glucose, GOT increased in the treatment group I compared with the control group. Alkaline phos-phatase decreased in treatment II group, compared with the control group (P<0.05). 8. Median survival time that was measured in the rats treated with sarcoma-180 cancer cell Median decreased in the treatment group, compared with the control group (P<0.05). 9. Natural killer cell activity showed significant reduction at 100:1 and 10:1 E/T ratio while it increased at 50:1 E/T ratio. It is inferred that there was an error in the experiment (P<0.05). 10. In an interleukin-2 productivity test, even though it decreased in lung cancer, and increased in abdomen cancer, but it was only a small difference (P<0.005). 11. After injecting B16F10 cell into a capillary vessel of C57BL/6 mice and generating metastasized lung cancer, the lung was examined with the naked eye. It was not possible to see metastasized cancer in the all groups on the seventh day but the cancer was viewed on the fourteenth day. The number and volume of metastasized cancer in the treatment group enlarged in the treatment group, compared with the control group. Conclusion : According to the results, H herbal-acupuncture took no effects in cancer.

• 한국임상약학회지
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• 제20권2호
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• pp.159-164
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• 2010

Radiofrequency ablation (RA) is being used to manage atrial fibrillation (AF) with patients failed at the $1^{st}$-line anti-arrhythmic medications. Patients undergoing this procedure are at increased risk of thromboembolism after ablation, and anticoagulation management surrounding the ablation remains controversial. Although no conclusive recommendations can be made, published guidelines and data support therapeutic anticoagulation with warfarin. The purpose of this study was to analyze effectiveness of current therapy and to find factors fluctuate International Normalized Ratio (INR) values in patients undergone RA followed by anticoagulation service (ACS). Retrospective review was conducted utilizing database in a hospital. Among 110 patients under warfarin around ablation between January 2006 to September 2007, 54 patients were selected and allocated into 2 groups: Group A included 47 who discontinued warfarin after ablation, while 7 in B continued the medication. Information on demographics, amount and length of warfarin dosing, INR values and measuring frequencies, and the causing factors on INR fluctuation were abstracted. Differences were analyzed using chi-squared test, Fisher's Exact test, and unpaired Student t-test. Mean amount of warfarin before and after surgery was 4.0 mg, 4.1 mg in Group A and was 5.1 mg, 4.6 mg in Group B, respectively. Average duration of warfarin doing before ablation was 73.7 days in Group A, 129.9 days in B with no significant difference (p = 0.312). The duration time of warfarin on groups after ablation lasted several months. The number of checking INRs was 4.1 and 7.6, respectively. Inter-individual variability of INR fluctuations were $2.1{\pm}0.6$ in Group A and $2.2{\pm}0.7$ in B which were not significantly different (p = 0.062). 164 cases of decreased INR were: 'omission in taking medication, stressfulness and headache, 'increased intake of high vitamin K foods', 'lifestyle change of increased physical activities', and 'increase of food-intakes'. To the contrary, 36 cases of increased INR were: 'reduce of food-intake', 'use of non-prescription drugs', 'reduction in physical activities', and 'excessive restriction on food-intake', consecutively. In conclusion, the study validated therapeutic outcomes of RA patients who we treated with standard guideline and demonstrated 9 factors of INR fluctuations in the patient. A well-trained, pharmacist-monitored anticoagulation service could reduce the risk of adverse effects and prevent complications in patients with AF around RA operation.