• Journal of Environmental Science International
• /
• v.9 no.5
• /
• pp.369-374
• /
• 2000

The estuary of Nakdong river is very influenced by the freshwater contained nutrients and organic materials. The response results of these influences are eutrophication and red tide outbreak in this region. Concentration of chlorophyll a was 0.78~62.55$\mu\textrm{g}$/L in February 1.20~21.29$\mu\textrm{g}$/L in April 1.88~188.35$\mu\textrm{g}$/L in June and 0.78~11.21$\mu\textrm{g}$/L in August respectively. The decrease of chlorophyll a is considered that residence time is shorten by increase of freshwater discharge and unfavorable growth condition of phytoplankton is created by diffusion of low salinity and increase of turbidity. The phytoplankton maximum region located inner side of this estuary during winter season whereas it was moved to outer side when mean discharge of the Nakdong risver was increased, Therefore the variation of phytoplankton maximum region was affected by input discharge from the Nakdong river basin.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.47 no.4
• /
• pp.316-326
• /
• 2011

In this study, the entrapped number is investigated on the UV light with different illuminance to fluorescent bait cage for swimming crab in order to find the appropriate illuminance which has the best attraction effect of fluorescent bait cage for pots. In addition, preference to the light, arrival time and residence time at light area are compared and analyzed to fluorescent bait cage and non-fluorescent bait cage for American lobster at the UV light and ordinary light according to the illuminance condition. Pot with red non-fluorescent bait cage at the no lighting (<0.01lux), pot with blue fluorescent bait cage at the 20W UV lighting (0.16lux) and pot with blue fluorescent bait cage at the 30W UV lighting (0.22lux) were soaked for 6 hours and the entrapped number of swimming crab was examined. The mean entrapped number of swimming crab in pot with red non-fluorescent bait cage at the no lighting (<0.01lux) was 1.0, but the mean entrapped number of swimming crab in pot with blue fluorescent bait cages at the 20W UV lighting (0.16lux) and 30W UV lighting (0.22lux) were 1.4 and 0.4, respectively (P<0.05). The rate of preference to the blue fluorescent bait cage at the UV lighting shows 1.6-4.8 times higher than that of preference to the red non-fluorescent bait cage at the ordinary lighting. In addition, The rate of preference to the blue fluorescent bait cage at the UV lighting is higher when the illuminance of ordinary light is same as or is lower than that of UV light (P<0.05). However, the preference to the light depending on gender shows no significant difference (P>0.05). The arrival time to UV light area of lobster is shown as 1.2-2.4 times faster than that to ordinary light area. Generally, it is shown that arrival time to UV light area is faster than the arrival time to ordinary light area when the illuminance of ordinary light is the same as or lower than that of UV light (P<0.05). However, arrival time to the light area depending on gender shows no significant difference (P>0.05). The residence time at UV light area of lobster is 1.2-1.7 times longer than that at ordinary light area. The residence time depending on different illuminance of ordinary light and genders showed no significant difference (P>0.05).

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.5
• /
• pp.3219-3221
• /
• 2013

Background: This study used receiver operating characteristic (ROC) curves to screen Surveillance, Epidemiology and End Results (SEER) skin melanoma data to identify and quantify the effects of socioeconomic factors on cause specific survival. Methods: 'SEER cause-specific death classification' used as the outcome variable. The area under the ROC curve was to select best pretreatment predictors for further multivariate analysis with socioeconomic factors. Race and other socioeconomic factors including rural-urban residence, county level % college graduate and county level family income were used as predictors. Univariate and multivariate analyses were performed to identify and quantify the independent socioeconomic predictors. Results: This study included 49,999 parients. The mean follow up time (SD) was 59.4 (17.1) months. SEER staging (ROC area of 0.08) was the most predictive foctor. Race, lower county family income, rural residence, and lower county education attainment were significant univariates, but rural residence was not significant under multivariate analysis. Living in poor neighborhoods was associated with a 2-4% disadvantage in actuarial cause specific survival. Conclusions: Racial and socioeconomic factors have a significant impact on the survival of melanoma patients. This generates the hypothesis that ensuring access to cancer care may eliminate these outcome disparities.

• Journal of Veterinary Science
• /
• v.22 no.5
• /
• pp.47.1-47.10
• /
• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.25 no.7
• /
• pp.895-904
• /
• 2001

Flow fields, temperature distributions, and particle trajectories in a 2-stage entrained-flow gasifier are calculated using a CFD code, FLUENT. Realizable k-$\xi$ model is used as a turbulent model. Because of swirling flow there appear recirculation regions near the burners. The characteristics of flow fields and temperature distributions in the gasifier are dependent on the swirl number of the system. Mean residence time of the particles in the reductor is inversely proportional to particle size, particle density and swirl number. As the swirl number is increasing, the particles injected from the combustor burners approach the wall near the combustor burners, which prevents the particles from entering the reductor and thus attatching the reductor wall. If the lower combustor burner angle is larger than the higher combustor burner angle for a given swirl number, the particles may move toward the reductor and cause ash/slag deposition problem.

• YAKHAK HOEJI
• /
• v.37 no.4
• /
• pp.383-388
• /
• 1993

Pharmacokinetics of aucubin, an irdoid glucoside, was compared in rats of experimental hepatic failure(EHF). EHF was induced by CCI$_{4}$ or D-galactosamine pretreatment. This work was designed to find out any differences in the pharmacokinetics of aucubin that may explain the different protective effect of aucubin on CCI$_{4}$- and galactosamine-induced EHF : aucubin reportedly protected CCI$_{4}$-inducing hepatotoxicity effectively, but did not for galactosamine-hepatotoxicity. EHF was induced by intraperitoneal injection Of CCI$_{4}$(0.9ml/kg) or galactosamine(250 mg/kg) to Wistar rats 24 hr before the pharmacokinetic study. The rats were fasted during the 24 hr. Aucubin was iv injected at a dose of 15 mg/kg and the plasma aucubin was assayed by HPLC. There were no significant differences in the pathophysiologies(body weight, liver weight, GTP, hematocrit, blood cell distrbution and plasma protein binding of aucubin) between the two EHF models except GOP which was significantly (p<0.05) higher in CCI$_{4}$-than in galactosamine-EHF. On the other hand, pharmacokinetics of aucubin such as total cleatance(CL$_{t}$), distribution volume at steady-state(Vd$_{ss}$), and mean residence time(MRT) differed significantly(p<0.05) between the models : for example, CL$_{t}$ was increased two fold by CCI$_{4}$, but not by galaclosamine ; Vd$_{ss}$, in galactosamine-EHF was higher than that in CCI$_{4}$-EHF ; MRT was decreased by CCI$_{4}$, but increased conversely by galactosamine. The increase of CL$_{t}$(and decrease of MRT) in rats of CCI$_{4}$-EHF was contrary to the general expectation for the hepatic failure : most of the hepatic failures have been known to decrease CL$_{t}$ of the administered drugs. Whether the difference in the pharmacokinetics is responsible for the different protective effect of aucubin against the two EHF models is of interest. However, much more studies on biliary excretion, urinary excretion, and hepatic uptake in cellular level should be preceded before any conclusions are made on the role of different pharmacokinetics on the different pharmacology of aucubin.

• Journal of Pharmaceutical Investigation
• /
• v.21 no.2
• /
• pp.73-78
• /
• 1991

The influence of different suppository bases on the rectal absorption and the dissolution rate of propranolol was investigated. The bioavailability of propranolol in rectal suppository was determined by comparing the area under the concentration-time curves(AUC) for oral administration with rectal suppositories in rabbits. The dissolution $rates(D_{20min})$ were higher in such order as tween (TWE), witepsol H-15(WIT), polyethylene glycol(PEG) suppository. The maximum blood concentrations $(C_{max})$ were 803.9 ng/ml for TWE suppository, 770.2 ng/ml for WIT suppository, 281.2 ng/ml for PEG suppository and 177.1 ng/ml for oral administration. The relative bioavailabilities were 233.5% for TWE suppository, 218.1% for TWE suppository, 191.3% for PEG suppository. The correlation between $D_{20min}$ and AUC, the time for dissolution in 75% and $C_{max}$, the mean dissolution time and the mean residence time showed significant linear relationship respectively.

• Korean Journal of Ecology and Environment
• /
• v.33 no.4 s.92
• /
• pp.342-349
• /
• 2000

This paper demonstrates the influence of intensity of the monsoon on morpho-hydrological fluctuations in Taechung Reservoir during 1993${\sim}$1994. During the study, hydrological variables including rainfall, inflow, and discharge volume showed distinct contrast between 1993 and 1994. Interannaul differences in rainfall occurred during the monsoon in July${\sim}$August monsoon and influenced inflow, discharge, and water residence time (WRT). Total inflow in 1993 was four times greater than that of 1994, and summer inflow in 1993 was 8 times greater than summer 1994. Annual Mean WRT was 93.2 d in 1993 vs. 158.6 d in 1994 and the largest differences occurred between monsoons of 1993 and 1994. Morphometric variables reflected the interannual contrasts of hydrology, so that in 1993 surface area, total volume, shoreline development, and mean depth increased consistently from premonsoon to postmonsoon and over this same period in 1994 they decreased. This outcome indicates that the area of shallow littoral zones in 1993 was greater than in 1994. Also, the drainage area to surface area (D/L) at 80 m MSL was 60.7 which was much greater than values in Soyang and Andong reservoirs and natural lakes world-wide. The morpho-hydrodynamic conditions seemed to influence in-reservoir nutrient concentration which is one of the most important factors regulating the eutrophication processes. I believe, under the maximum hydrodynamic fluctuations in Korean waterbodies during the monsoon, applications of mass balance models to man-made lakes for assessments of external loading should be considered because the models can be used under the seasonally stable inflow and water residence time.

• Korean Journal of Hydrosciences
• /
• v.6
• /
• pp.39-49
• /
• 1995

The surface hydrology of large land areas is susceptible to several preferred stable states with transitions between stable states induced by stochastic fluctuation. This comes about due to the close couping of land surface and atmospheric interaction. An interesting and important issue is the duration of residence in each mode. Mean transition times between the stable modes are analyzed for different model parameters or climatic types. In an example situation of this differential equation exhibits a bimodal probability distribution of soil moisture states. Uncertainty analysis regarding the model parameters is performed using a Monte-Carlo simulation method. The method developed in this research may reveal some important characteristics of soil moisture or precipitation over a large area, in particular, those relating to abrupt change in soil moisture or preciptation having extremely variable duration.

• Journal of Korea Water Resources Association
• /
• v.33 no.3
• /
• pp.375-382
• /
• 2000

The surface hydrology of large watershed is susceptible to several preferred stable states with transitions between stable states induced by stochastic fluctuations. This comes about due to the close coupling of land surface and atmospheric interaction. An interesting and important issue is the duration of residence in each mode. In this study, mean transition tunes between the stable modes are analyzed for the Han River Basin. On the basis of historical data, the nonlinear water balance model is calibrated for the Han River Basin. The transition times between the stable modes in the model are studied based on the stochastic representation of the physical processes and on the calibrated model parameters. This study has implications for prediction of the transition time between stable modes or residence times, that is, the time the system spends in a given stable modes, since this would be equivalent to predicting the duration of drought or wet conditions.