• Title/Summary/Keyword: Mdm2

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Calculation of Anchor's Terminal Velocity in the Water and Onshore Dropped Heights Using MDM Technique

  • Shin, Mun-Beom;Seo, Young-Kyo
    • Journal of Advanced Research in Ocean Engineering
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    • v.3 no.2
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    • pp.59-65
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    • 2017
  • When an anchor is dropped into the sea, there exists a danger of collision on the pipeline and subsea cables in the seabed. This collision could cause huge environmental disasters and serious economic losses. In order to secure the safety of subsea structures such as pipelines and subsea cables from the external impact, it is necessary to estimate the exact external force through the anchor's terminal velocity on the water. FLUENT, a computational fluid dynamic program, was used to acquire the terminal velocity and drag coefficient computation. A half-symmetry condition was used in order to reduce the computational time and a moving deforming mesh technique also adapted to present hydrostatic pressure. The results were examined with the equation based on Newton's Second Law to check the error rate. In this study, three example cases were calculated by stockless anchors of 5.25 ton, 10.5 ton, and 15.4 ton, and for the onshore experiment dropped height was back calculated with the anchor's terminal velocity in the water.

External Store Separation Analysis Using Moving and Deforming Mesh Method (이동변형격자 기법을 활용한 외부장착물 분리운동 해석)

  • Ahn, Byeong Hui;Kim, Dong-Hyun
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.27 no.4
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    • pp.9-20
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    • 2019
  • A military aircraft generally includes external stores such as fuel tanks or external arming, depending on the purpose of the operation. When a store is dropped from a military aircraft at high subsonic, transonic, or supersonic speeds, the aerodynamic forces and moments acting on the store can be sufficient to send the store back into contact with the aircraft. This can cause damage to the aircraft and endanger the life of the crew. In this study, time accurate computational fluid dynamics (CFD) with dynamic moving grid (moving and deformable mesh, MDM) technique has been used to accurately calculate store trajectories. For the verification of the present numerical approach, a wind tunnel test model for the wing-pylon-finned store configuration has been considered and analyzed. The comparison results for the ejected store trajectories between the present numerical analysis and the wind tunnel test data at the Mach number of 0.95 and 1.2 are presented. It is also importantly shown that the numerical parameter of MDM technique gives significant effect for the calculated store trajectory in the low-supersonic flow such as Mach 1.2.

EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development

  • Kim, Byeong-Seong;Ko, Hyo Rim;Hwang, Inwoo;Cho, Sung-Woo;Ahn, Jee-Yin
    • BMB Reports
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    • v.54 no.8
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    • pp.413-418
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    • 2021
  • ErbB3-binding protein 1 (EBP1) is a multifunctional protein associated with neural development. Loss of Ebp1 leads to upregulation of the gene silencing unit suppressor of variegation 3-9 homolog 1 (Suv39H1)/DNA (cytosine 5)-methyltransferase (DNMT1). EBP1 directly binds to the promoter region of DNMT1, repressing DNA methylation, and hence, promoting neural development. In the current study, we showed that EBP1 suppresses histone methyltransferase activity of Suv39H1 by promoting ubiquitin-proteasome system (UPS)-dependent degradation of Suv39H1. In addition, we showed that EBP1 directly interacts with Suv39H1, and this interaction is required for recruiting the E3 ligase MDM2 for Suv39H1 degradation. Thus, our findings suggest that EBP1 regulates UPS-dependent degradation of Suv39H1 to govern proper heterochromatin assembly during neural development.

A Case Study on Implementation of Mobile Information Security (모바일 정보보안을 위한 실시간 모바일 기기 제어 및 관리 시스템 설계.구현 사례연구)

  • Kang, Yong-Sik;Kwon, Sun-Dong;Lee, Kang-Hyun
    • Information Systems Review
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    • v.15 no.2
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    • pp.1-19
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    • 2013
  • Smart working sparked by iPhone3 opens a revolution in smart ways of working at any time, regardless of location and environment. Also, It provide real-time information processing and analysis, rapid decision-making and the productivity of businesses, including through the timely response and the opportunity to increase the efficiency. As a result, every company are developing mobile information systems. But company data is accessed from the outside, it has problems to solve like security, hacking and information leakage. Also, Mobile devices such as smart phones belonging to the privately-owned asset can't be always controlled to archive company security policy. In the meantime, public smart phones owned by company was always applied security policy. But it can't not apply to privately-owned smart phones. Thus, this paper is focused to archive company security policy, but also enable the individual's free to use of smart phones when we use mobile information systems. So, when we use smart phone as individual purpose, the normal operation of all smart phone functions. But, when we use smart phone as company purpose like mobile information systems, the smart phone functions are blocked like screen capture, Wi-Fi, camera to protect company data. In this study, we suggest the design and implementation of real time control and management of mobile device using MDM(Mobile Device Management) solution. As a result, we can archive company security policy and individual using of smart phone and it is the optimal solution in the BYOD(Bring Your Own Device) era.

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SNU AGN Monitoring Project (SAMP) using reverberation mapping of luminous AGNs

  • Jeon, Yiseul;Woo, Jong-Hak
    • The Bulletin of The Korean Astronomical Society
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    • v.41 no.1
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    • pp.70.4-71
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    • 2016
  • The links between super-massive black hole masses and their host galaxy properties are observed, indicating that black hole growth and host galaxy evolution are closely related. Reverberation mapping, which uses the time delay from the central black hole to broad line regions, is one of the best methods to estimate masses of black holes of active galactic nuclei (AGNs). However, only masses of about 50 black holes have been determined in reverberation mapping studies so far, and most of them are limited to optical luminosities below 10^45 erg/s due to the challenges of long-term time domain observations in both photometry and spectroscopy. In this project, we expand reverberation mapping samples to higher luminosities of > 10^44.5 erg/s at 0.1 < z < 0.35, that have expected time lags of 40 - 250 light days. Photometric (using LOAO 1-m and MDM 1.3-m) and spectroscopic (using MDM 2.4-m and Lick 3-m) monitoring campaigns are being conducted for a 3 year duration and 20 day cadence. Precedent photometric observations in 2015B show some targets with variability and follow-up spectroscopic observations are on-going. In this presentation, we introduce our project, present reverberation mapping simulation results, and preliminary results on photometry. These reverberation mapping masses of relatively high luminous AGNs will provide a strong constraint on black hole mass calibration, e.g., the single-epoch mass estimation.

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Regulation of cellular functions of p53 by ubiquitination (유비퀴틴화에 의한 세포 내 p53의 기능 조절)

  • Jung, Jin-Hyuk;Lee, Joon-Young;Lee, Sun-Mi;Choe, Tae-Boo;An, Sung-Kwan
    • KSBB Journal
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    • v.24 no.3
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    • pp.217-226
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    • 2009
  • p53 undergoes various post-translational modifications, including phosphorylation, ubiquitination, sumoylation, acetylation, methylation, and poly(ADP-ribosyl)ation. Modification of p53 widely affects to various functions of p53. Acetylation and phosphorylation of p53 have been studied for regulating its transcriptional activity which is observed in various stress condition. Otherwise, ubiquitination of p53 by Mdm2 has been well-studied as a canonical ubiquitin-mediated proteasomal degradation pathway. Moreover several investigators have recently reported that ubiquitination of p53 modulates not only its proteasome-dependent degradation by poly-ubiquitination but also its localization and transcriptional activity by mono-ubiquitination which usually does not serve the proteasome dependent degradation. Here we review recent studies on the cellular functions of p53 regulated by post-translational modifications, particularly focusing on mechanisms of ubiquitination.

Movement of Applied Nutrients Through Soils By Irrigation 1. Movement of nutrients to the amount of water applied (관개수(灌漑水)에 의한 시비양분(施肥養分)의 토양중(土壤中) 이동(移動)에 관(關)한 연구(硏究) 1. 관수량(灌水量)에 따른 양분(養分) 이동(移動))

  • Ryu, Kwan-Shig;Yoo, Sun-Ho;Song, Kwan-Cheol
    • Korean Journal of Soil Science and Fertilizer
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    • v.24 no.2
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    • pp.102-108
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    • 1991
  • A field experiment with microplots(D.20cm, L. 85cm) was conducted to obtain quantitative information on the downward movement of nutrients applied to the soils by different amount of irrigation water. The microplots were installed by embedding PVC column(D. 20cm, L. 90cm) filled with sieved soils in the field. Urea, fused and superphosphate, and KCl were broadcasted over the soil in the microplots and surface layer was covered with lime-amended soils. Microplots were removed 1 week after water application and analysed for Cl, $NH_4$ and $NO_3-N$, Bray 1-P and exchangeable cations of Ca, Mg, and K in each segment. Effect of irrigation rate on the movement of these ions were evaluated with the mean downward movement(MDM) determined with nutrient concentration of each segment and the distance to the segment from the site fertilized. For the nutrient studied, MDM was linearly related to the amount of water applied. When one pore volume of water needed for 0.1 bar soil moisture tension was applied, MDM(cm), computed as the piston front of applied water advanced 10cm, was found to be in the order; Cl, 7.52>Inorganic N, 6.03> K, 3.50> Mg, 2.69>Ca, 1.19>P, 0.29. After the downward movement of applied nutrients soil pH seemed to decrease with irrigation in the surface layer(0-15cm) and increase in the subsurface layer. It was also found that ammonium-nitrogen evolved from urea hydrolysis was more effective in raising the subsoil pH rather than the exchangeable Ca and Mg.

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Innovation Strategy for Engineering Plant Product Lifecycle Management based on Master Data Management, Project Management and Quality Management (기준정보 관리와 과제관리 및 품질관리 중심의 플랜트 PLM 혁신전략)

  • Myung, Sehyun
    • Korean Journal of Computational Design and Engineering
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    • v.21 no.2
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    • pp.170-176
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    • 2016
  • PLM system has been widely used in whole industry. Specially, in case of the company that constructs the engineering plant, PLM can be a key success tool for the innovation with ERP and Enterprise IT Systems. This paper describes the innovation strategy for engineering plant PLM including Master Data management, EPC project management, full 3D modeling and quality management.

Variability test of 9 AGNs slected from The Seoul Natioanl University AGN Monitoring Project

  • Cho, Wanjin;Woo, Jong-Hak;Son, Donghoon;Bae, Hyun-Jin;Jeon, Yiseul;Le, Huynh Anh;Park, Songyoun;Shin, Jaejin;Kim, Minjin;Park, Daeseong;Sung, Hyun-il;Gallo, Ellena;Hodges-Kluck, Edmund;Barth, Aaron;Treu, Tommaso;Malkan, Matt;Bennert, Vardha Nicola
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.2
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    • pp.76.4-77
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    • 2017
  • We have been performing a long term AGN Monitoring project, to measure the time lag of H beta line with respect to AGN optical continuum based on the reverberation mapping method. From October 2015, 69 AGNs have been monitored with BVR band photometry, using the MDM 1.3m & 2.4m and LOAO 1m telescopes, and long-slit spectroscopy, using the Lick 3m and MDM 2.4m telescopes. In this poster, we report the preliminary results of the variability study of a subsample of 9 AGNs, particularly with a few of tentative time rag measurements between B band magnitude and H beta luminosity based on the 1st year data set from February 2016 - January 2017.

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