• The Korean Journal of Pain
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• 제29권1호
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• pp.3-11
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• 2016

A nerve block is an effective tool for diagnostic and therapeutic methods. If a diagnostic nerve block is successful for pain relief and the subsequent therapeutic nerve block is effective for only a limited duration, the next step that should be considered is a nerve ablation or modulation. The nerve ablation causes iatrogenic neural degeneration aiming only for sensory or sympathetic denervation without motor deficits. Nerve ablation produces the interruption of axonal continuity, degeneration of nerve fibers distal to the lesion (Wallerian degeneration), and the eventual death of axotomized neurons. The nerve ablation methods currently available for resection/removal of innervation are performed by either chemical or thermal ablation. Meanwhile, the nerve modulation method for interruption of innervation is performed using an electromagnetic field of pulsed radiofrequency. According to Sunderland's classification, it is first and foremost suggested that current neural ablations produce third degree peripheral nerve injury (PNI) to the myelin, axon, and endoneurium without any disruption of the fascicular arrangement, perineurium, and epineurium. The merit of Sunderland's third degree PNI is to produce a reversible injury. However, its shortcoming is the recurrence of pain and the necessity of repeated ablative procedures. The molecular mechanisms related to axonal regeneration after injury include cross-talk between axons and glial cells, neurotrophic factors, extracellular matrix molecules, and their receptors. It is essential to establish a safe, long-standing denervation method without any complications in future practices based on the mechanisms of nerve degeneration as well as following regeneration.

• Environmental Analysis Health and Toxicology
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• 제24권2호
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• pp.169-178
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• 2009

To investigate the inhibitory effects of Peonia japonica water extract(PJWE) on skin wrinkle formation, skin wrinkles were induced by both the irradiation of UVB and the application of squalene monohydroperoxide to the backs of hairless mice for 4 weeks. And at the same time experimental materials were applied topically. Wrinkles for the control (C) group were formed as a pattern of deep furrows and thick crests. Whereas wrinkles for the positive control (PC, 0.01% retinoic acid) and experimental(E, PJWE) groups were formed as a pattern of shallow furrows and thin crests, which were similar to that of the normal(N) group. Collagen and elastic fibers in dermis of the PC and E groups were almost intact with a regular arrangement, which were similar to those of the N group. The activity of xanthine oxidase, the free radical generating enzyme, was significantly lower in the E group than the C and PC groups. The activities of superoxide dismutase and catalase, the free radical scavenging enzymes, were much higher in the E group than the C and PC groups and similar to the N group. As for the amount of matrix metalloproteinase-3(MMP-3) expression, PC and E groups were significantly lower than the C group. Therefore, PJWE could be very effective natural herbal material for the inhibition or improvement of wrinkle formation in hairless mice skin.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 하계학술대회 논문집 Vol.4 No.2
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• pp.1168-1171
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• 2003

In contrast to a conventional transformer, the flat transformer is made using a number of small ferrite cores. Two cores for transformer and one core for inductor, which composed one module. Many modules can be connected together to form a flat matrix transformer. This structural arrangement eliminates the single hot spot problem in conventional transformers and permits high current density pertains at high frequency. In this study, the ferrite magnetic cores of Mn-Zn system for the Flat transformer were manufactured and the electrical and magnetic characteristics of its tested. The power loss of sample FO2(Mn-Zn ferrite) sintered at $1350^{\circ}C$ was $350kW/m^3$ in test conditions of 250kHz, 200mT and $100^{\circ}C$, which showed the good power loss property in high frequency. The power loss of FO2 samples has been studied as a function of magnetic flux density and frequency. Steinmetz exponent was 2.82 at 250kHz and 2.73 at 500kHz. These results illustrated the switching of power loss mechanism in ferrite core from hysteresis losses to eddy current losses or others.

• 한국식품영양과학회지
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• 제13권4호
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• pp.459-468
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• 1984

The currently accepted model of membrane structure proposes a dynamic, asymmetric lipid matrix of phospholipids and cholesterol with globular proteins embedded across the membrane to various degrees. Most phospholipids are in the bilayer arrangement and also closely associated with integral membrane proteins or loosely associated with peripheral proteins. Biological functions of membrane, such as membrane-bound enzyme functions and transport systems, are influenced by the membrane physical properties, which are determined by fatty acid composition of phospholipids, polar head group composition and membrane cholesterol content. Polar and non-polar region of the phospholipid molecule can interact, with changes in the conformation of a membrane-associated protein altering either its catalytic activity or the protein's interaction with other membrane proteins. Mammalian dietary studies attempted to change the lipid composition of a few cell membranes have shown comparisons, using essential fatty acid-deficient diets. In recent years, Clandinin and a few other workers have pioneered the study proving the influence of dietary fat fed in a nutritionally complete diet on composition of phospholipid classes of cell membrane. Modulation caused by diet fat was rapid and reversible in phospholipid fatty acyl composition of membranes of cardiac mitochondria, liver cell, brain synaptosome and lymphocytes. These changes were at the same time, accompanied by variety of membrane associated functions controlled by membrane-bound enzymes, tranporter and receptor proteins. The findings suggest the basic concept of the necessity of dietary fatty acid balance if consistency of optimal membrane structural lipid composition is to be maintained, as well as the overall inadequacy of describing the nutritional-biochemical quality of a dietary fat solely by its content of linoleic acid. Furthermore, they give light on the possible application to clinical and preventive medicine.

• 한국지역지리학회지
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• 제6권3호
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• pp.169-184
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• 2000

미국의 씬씨내티 대도시지역을 대상으로 인자분석 및 Hot Spot 분석에 의해 산업 군집과 그것의 경계가 확인되어졌다. 전통적 투입 산출 접근법이 비공간적 산업 군집을 추출하는 반면 이 연구는 전통적 접근을 GIS 기법과 결합하여 경계를 설정한다. 투입 산출 산업 군집의 결과를 선도산업 부문과 결합하여 5개 선도 산업 군집을 추출하였는데 그것은 음식료품, 화학, 금속, 금속제품, 기계공업 부분이다. 그리고 Hot Spot 기법을 이용하여 연구지역의 산업 군집을 Arcview에 통합하여 시각화하였다. 산업 군집의 공간적 결합정도와 공간적 한계를 결정하는 것은 경제의 공간구조의 효율성을 측정하는 부가적 접근이 될 수 있다. 산업 군집과 산업의 공간적 군집 접근은 하나의 공장이나 기업의 수준보다 집계적인 차원에서 산업의 공간적 배열의 새로운 모형 개발 기초의 가능성을 제시한다.

• Composites Research
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• 제33권1호
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• pp.30-37
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• 2020

단방향 연속 섬유 강화 복합소재에 대하여 섬유 배열에 따른 응력 분포 양상을 연구하기 위해 단면 형상을 대표하는 체적 요소를 생성하였다. 대표 체적 요소에 횡방향 하중을 가하였을 때, 섬유와 기지재 강성의 차이로 인해 섬유 둘레에서 응력 집중 현상이 발생하며, 섬유 간 좁은 간격 때문에 집중된 응력이 중첩되며 섬유 주변에서 높은 응력이 구해질 것이라 쉽게 예측할 수 있다. 본 연구에서는 섬유 둘레 응력 증감이 단순히 섬유 간 간격 뿐 아니라 섬유의 상대적 위치가 하중 방향과 이루는 각도에 의해서도 결정됨을 보여준다. 정규 육각 구조를 가지는 대표 체적 요소의 중앙에 위치한 섬유를 다양한 방향으로 이동시키며 횡방향 하중을 가하여, 섬유 주변 응력이 증가하거나 감소하는 양상을 유한요소해석 기법을 이용해 측정하였다. 섬유 간 거리가 최소이면서 두 섬유의 중심을 잇는 선분의 방향이 하중 방향과 일치할 때 응력이 최대로 증가하였으며, 섬유 간 거리가 최소라 하더라도 하중 방향에 수직일 때 최대 응력은 오히려 감소한다는 것을 보여준다.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2005년도 춘계 학술대회
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• pp.231-238
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• 2005

본 연구에서는 유동저항이론을 기초로 하여 연속다공체, 분리단열망 및 연속다공체-분리단열망 공존암반과 같은 3가지 암반을 대상으로 암반 특성에 따른 지하수 유동저항 개념 모델링 및 관계식을 제안하였다. 정상상태조건에서 밀도변동은 고려하지 않았으며 유한 체적법을 이용하였다. 각종 물성치는 블록 중심에서 정의되고, flux는 블록면에서 정의되는 staggered 격자 체계하에서 모든 블록에 대해 Darcy 법칙이 적용되었다. 접촉면에서의 투수계수는 인접면 중심에서 정의된 물성치의 조화평균값을 사용하였다. 유동저항개념을 이용하여 인접한 블록간의 상대압력차와 flux의 관계를 표현하였다. 개개의 단열에서의 유동은 다공암반에서 이용된 방정식과 동일한 형태의 2차원 방정식으로 모사되었다. 본 논문에서 제안된 모델은 추후 다양한 암반 특성별 유동 모사 기법을 개발하는데 많은 기여를 할 것으로 기대된다.

• 치과방사선
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• 제25권2호
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• pp.483-499
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• 1995

Mandibular first molars of the rats were undertaken to observe the radiosensitivity of amelogenesis. Twenty four Sprague-Dawley rats received 396cGy radiation with the MK Cell irradiator using Cs-137, and twenty four rats served as control. They were devided into two groups; Group 1 which received radiation at the 14th day after gestation and group 2 which received radiation at the 19th day after gestation. Light Microscopy and Transmitted Electron Microscopy investigation was undertaken in the group 1 at the 15th, 18th, 20th, 22nd(2 days after birth), and 25th day(5 days after birth) after gestation, and in the group 2 at the 21th(birth day), 22nd(2 days after birth), and 25th(5 days after birth) day after gestation. The following histopathologic findings were obtained. 1. Compared with control group, experimental group showed a delayed formation of enamel and dentin due to slow rate of differentiation of undifferentiated mesenchymal cells. 2. In the experimental groups, the arrangement of the inner enamel epithelium was irregular and there were many vacuoles in the cytoplasm. There were dilated rER and mitochondria, increase of the intercellular space, and loss of the cellular polarity. 3. In the group 1, early enamel without Tomes' process, and early organic matrix was observed at the 25th day after gestation. 4. In the group 2, histopathologic changes were similar to those of the group 1, but the degree of changes was more severe than that of the group 1.

• 치과방사선
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• 제28권1호
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• pp.87-109
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• 1998

The present study was designed to elucidate the effects of the Co-60 γ irradiation and/or calcium­deficient diet on the dentin and cementum formation of rat molar. The pregnant three-week old Sprague­Dawley rats were used for the study. The experimental group was divided into two groups, irradiation/normal diet group and irradiation/calcium-deficient diet group. The control group was non­irradiation/normal diet group. The abdomen of the rats at the 19th day of pregnancy were irradiated with single absorbed dose of 350cGy. The rat pups were sacrificed on the 14th day after delivery and the maxillae including molar tooth germ were taken. The specimens including the 1st molar tooth germ were prepared to make tissue sections for light and transmission electron microscopy. Some of tissue sections for light microscopy were stained immunohistochemically with anti-fibronectin antibody. The results were as follows; 1. The Hertwig's epithelial root sheath cells, which are related to the differentiation of the tooth-forming cells, showed irregular cellular arrangement, decrease of intercellular junctional complex, and decreased immunoreactivity to the fibronectin after irradiation. These were more severe in the irradiation/calcium-deficient diet group. 2. The cementoblasts at the cementum-forming area showed chromatin clumpings after irradiation. The immu noreactivity to the fibronectin was weaken after irradiation, especially irradiation/calcium-deficient diet group. 3. The odontoblasts at the dentin-forming area showed increase of lysosomes in the cytoplasm and destruction of intercellular junctional complex. The irradiation/calcium-deficient diet group showed decrease of number and density of the electron dense particles and a large number of vacuoles scattered in the dentin matrix. The immunoreactivity was weaken.

• 방사선산업학회지
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• 제5권4호
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• pp.325-330
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• 2011

To predict the details of flow in industrial process unit, single photon emission computed tomography (SPECT) is a promising technique. Recently, industrial SPECT based on medical system has developed by researchers of the Korea Atomic Energy Research Institute (KAERI) and Hanyang University. In the present study, to confirm the effect of the number of detectors on image quality, and determine the optimal number of detectors in industrial SPECT, industrial SPECT system with various geometries were evaluated by the Monte Carlo simulation. CsI(Tl) detectors ($12mm{\times}12mm{\times}20mm$) with collimators (the geometric resolution of collimator $R_g$ was 4 cm at the center of the 30 cm diameter cylindrical vessel object) were modeled in a hexagonal array, and the point sources of $^{99m}Tc$, $^{68}Ga$, and $^{137}Cs$ were simulated at the center of the cylindrical vessel object using the MCNPX code. Then, the reconstruction images of each geometry were reconstructed using the expectation maximization (EM) algorithm. In this study, the reciprocity theorem was used to improve computation time required for system matrix of the EM algorithm. The result shows that the resolution of the reconstructed image was significantly improved by increasing the number of detectors in industrial SPECT system and more than 60 detectors will be required for the resolution of the reconstructed image.