• Journal of Korean Medical classics
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• v.22 no.3
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• pp.321-336
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• 2009

Objectives : The purpose of our study was to discuss about the scholarship value and contents of the transcription of Correction of the Classic of Materia Medica that was obtained recently. Methods : We analysed the transcription of Correction of the Classic of Materia Medica itself and compared form and matter with Shennong's Classic of Materia Medica[神農本草經], Compendium of Materia Medica[本草綱目]. Results : 1. It is obvious that the transcription of Correction of the Classic of Materia Medica is one of the book works of Lee Gyujun. 2. The transcription of Correction of the Classic of Materia Medica was written to recover the original figure of Shennong's Classic of Materia Medica standing on Compendium of Materia Medica. Lee Gyujun corrected qi, flavor and main effects of herbs according to his medical sight, and classified herbs into three grade. Conclusions : The transcription of Correction of the Classic of Materia Medica is not an original book but an interim book on working process. But it reflects the medical sight of Lee Gyujun and the medical level of those days sufficiently. Also it is the only study of Shennong's Classic of Materia Medica in Chosun dynasty.

• Journal of Ginseng Research
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• v.14 no.2
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• pp.210-212
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• 1990

• Proceedings of the Ginseng society Conference
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• 1990.06a
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• pp.68-70
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• 1990

• Journal of Ginseng Research
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• v.14 no.2
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• pp.285-290
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• 1990

Ando et al found the root of Ginseng contained an active peptide which had anti-lipolysis funrtion when they studied effective components of Ginseng to cure diabetes mellitus in 1980. In recent years we were making lots of the researches on the Ginseng polypeptide. We obtained a 14 peptide which could decrease levels of blood sugar and hepatic glycogen. However, amino acid composition of the peptide differs from one reported by Ando et al. The results of its purification, structure and functure and function were reported in this paper.

• Journal of Ginseng Research
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• v.44 no.5
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• pp.673-679
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• 2020

Background: Panax notoginseng saponin (PNS) is the extraction from the roots and rhizomes of Panax notoginseng (Burk.) F. H. Chen. PNS is the main bioactive component of Xuesaitong, Xueshuantong, and other Chinese patent medicines, which are all bestselling prescriptions in China to treat cardiocerebrovascular diseases. Notoginsenoside R₁ and ginsenoside Rg₁, Rd, Re, and Rb₁ are the principal effective constituents of PNS, but a systematic research on the rare saponin compositions has not been conducted. Objective: The objective of this study was to conduct a systematic chemical study on PNS and establish the HPLC fingerprint of PNS to provide scientific evidence in quality control. In addition, the cytotoxicity of the new compounds was tested. Methods: Pure saponins from PNS were isolated by means of many chromatographic methods, and their structures were determined by extensive analyses of NMR and HR-ESI-MS studies. The fingerprint was established by HPLC-UV method. The cytotoxicity of the compounds was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5 -diphenyltetrazolium bromide assay. Results and Conclusion: Three new triterpenoid saponins (1-3) together with 25 known rare saponins (4-28) were isolated from PNS, except for the five main compounds (notoginsenoside R1 and ginsenoside Rg1, Rd, Re, and Rb1). In addition, the HPLC fingerprint of PNS was established, and the peaks of the isolated compounds were marked. The study of chemical constituents and fingerprint was useful for the quality control of PNS. The study on antitumor activities showed that new Compound 2 exhibited significant inhibitory activity against the tested cell lines.

• Journal of Korean Medical classics
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• v.24 no.5
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• pp.107-118
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• 2011

Classified Emergency Materia Medica is a pharmacopoeia published by the government of the Song(宋) dynasty. After publishment, it had a decisive effect on East-Asian herbology of China, Korean & Japan. Sakae Miki(三木榮), Tameto Okanisi(岡西爲人) wrote papers on the subjects of type, publishing process, bibliographic terms of Classified Emergency Materia Medica published in the early and middle years of Joseon Dynasty. Moreover, Sakae Miki claimed that Classified Emergency Materia Medica from China had been a standard of herbology of Joseon Dynasty since its publishment, and herbology based on materia medica from countryside(鄕藥) also had occupied a part of herbology in Joseon Dynasty. Nevertheless the specific influences, from Classified Emergency Materia Medica to the medical books of Joseon Dynasty which established the herbology based on materia medica from countryside has never been handled so far. So I would like to investigate the influence of Classified Emergency Materia Medica to Joseon Dynasty, through a comparison with literature review. The main literatures for comparison are two representative medical books of Joseon Dynasty, Compendium of Prescriptions from the Countryside(1433) & Treasured Mirror of Eastern Medicine(1613), especially focusing on the pharmacognostic parts. The main comparing points on researching literatures will be the following: publication year of books; order of herbs; and quotations. This paper will show which edition of Classified Emergency Materia Medica was utilized to publish two medical books of Joseon Dynasty, and the process how Korean herbology based on materia medica from countryside was transformed after accepting Chinese herbology.

• Journal of Ginseng Research
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• v.42 no.3
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• pp.277-287
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• 2018

Background: Temperature is an essential condition in red ginseng processing. The pharmacological activities of red ginseng under different steam temperatures are significantly different. Methods: In this study, an ultrahigh-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry was developed to distinguish the red ginseng products that were steamed at high and low temperatures. Multivariate statistical analyses such as principal component analysis and supervised orthogonal partial least squared discrimination analysis were used to determine the influential components of the different samples. Results: The results showed that different steamed red ginseng samples can be identified, and the characteristic components were 20-gluco-ginsenoside Rf, ginsenoside Re, ginsenoside Rg1, and malonyl-ginsenoside Rb1 in red ginseng steamed at low temperature. Meanwhile, the characteristic components in red ginseng steamed at high temperature were 20R-ginsenoside Rs3 and ginsenoside Rs4. Polar ginsenosides were abundant in red ginseng steamed at low temperature, whereas higher levels of less polar ginsenosides were detected in red ginseng steamed at high temperature. Conclusion: This study makes the first time that differences between red ginseng steamed under different temperatures and their ginsenosides transformation have been observed systematically at the chemistry level. The results suggested that the identified chemical markers can be used to illustrate the transformation of ginsenosides in red ginseng processing.

• Natural Product Sciences
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• v.1 no.1
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• pp.61-65
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• 1995

A new triterpenoid saponin named Mussaendoside F(1), along with five known compounds (2-6) were isolated from aerial part of Mussaenda pubescens.

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.69-73
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• 1993

• Advances in Traditional Medicine
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• v.5 no.2
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• pp.156-159
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• 2005

The protective effect of Naoxingtong (NXT) on rat cerebral microvascular endothelial cell (rCMEC) was investigated. rCMEC was injured in vitro by incubating for 4 hours at 100% NO in a hypoxia chamber. After treated with NXT-containing serum, the cellular viability rate (90.3%) was significantly elevated when compared with that of control group and the inhibitive rate of lactic dehydrogenase activity (9.2%) was far lower than the control group with dose-dependent effect. The results indicate that NXT can increase viability of rCMEC, and protect cell membrane from injury during hypoxia.