• BMB Reports
• /
• 제34권4호
• /
• pp.305-309
• /
• 2001

MatR in Rhizobium trifolii is a malonate-responsive transcription factor that regulates the expression of genes, matABC, enabling decarboxylation of malonyl-CoA into acetyl-CoA, synthesis of malonyl-CoA from malonate and CoA, and malonate transport. According to an analysis of the amino acid sequence homology, MatR belongs to the GntR family The proteins of this family have two-domain folds, the N-terminal helix-turn-helix DNA-binding domain and the C-terminal ligand-binding domain. In order to End the malonate binding site and amino acid residues that interact with RNA polymerase, a site-directed mutagenesis was performed. Analysis of the mutant MatR suggests that Arg-160 might be involved in malonate binding, whereas Arg-102 and Arg-174 are critical for the repression activity by interacting with RNA polymerase.

• 한국신재생에너지학회:학술대회논문집
• /
• 한국신재생에너지학회 2008년도 추계학술대회 논문집
• /
• pp.102-102
• /
• 2008

• 한국신재생에너지학회:학술대회논문집
• /
• 한국신재생에너지학회 2008년도 추계학술대회 논문집
• /
• pp.103-103
• /
• 2008

• 한국재료학회:학술대회논문집
• /
• 한국재료학회 1998년도 IUMRS-ICEM ABSTRACT BOOK
• /
• pp.42.2-42
• /
• 1998

• 한국전기전자재료학회논문지
• /
• 제28권6호
• /
• pp.400-402
• /
• 2015

The typical winter heating unit heating mat. The product is to be found in the development of new water heating mat today. The product that circulates the water through the hose inside the mat with your existing heating mat electric heated mat is different from boiling water. However, no clear standards for noise and safety, consumer choice is giving confusing information about the product is low. We were to develop a high heat retention and stability than conventional sleeping mats to produce creative than traditional hot mats, heated mats general comparison with experimental results is a more efficient heat retention mat is produced.

• 한국신재생에너지학회:학술대회논문집
• /
• 한국신재생에너지학회 2008년도 춘계학술대회 논문집
• /
• pp.397-397
• /
• 2008

• 한국재료학회:학술대회논문집
• /
• 한국재료학회 1997년도 한국재료학회 춘계학술발표회
• /
• pp.56-56
• /
• 1997

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권11호
• /
• pp.6433-6438
• /
• 2013

In hepatocellular cancer (HCC), lack of response to chemotherapy and radiation treatment can be caused by a loss of epigenetic modifications of cancer cells. Methionine adenosyltransferase 1A is inactivated in HCC and may be stimulated by an epigenetic change involving promoter hypermethylation. Therefore, drugs releasing epigenetic repression have been proposed to reverse this process. We studied the effect of the demethylating reagent 5-aza-2'-deoxycitidine (5-Aza-CdR) on MAT1A gene expression, DNA methylation and S-adenosylmethionine (SAMe) production in the HCC cell line Huh7. We found that MAT1A mRNA and protein expression were activated in Huh7 cells with the treatment of 5-Aza-CdR; the status of promoter hypermethylation was reversed. At the same time, MAT2A mRNA and protein expression was significantly reduced in Huh7 cells treated with 5-Aza-CdR, while SAMe production was significantly induced. However, 5-Aza-CdR showed no effects on MAT2A methylation. Furthermore, 5-Aza-CdR inhibited the growth of Huh7 cells and induced apoptosis and through down-regulation of Bcl-2, up-regulation of Bax and caspase-3. Our observations suggest that 5-Aza-CdR exerts its anti-tumor effects in Huh7 cells through an epigenetic change involving increased expression of the methionine adenosyltransferase 1A gene and induction of S-adenosylmethionine production.

• Composites Research
• /
• 제37권3호
• /
• pp.143-149
• /
• 2024

본 논문에서는 친환경 포장재인 골판지의 기계적 물성을 측정하고, 이를 LS-DYNA의 MAT_PAPER 모델에 적용하여 유한요소해석을 수행하였다. MAT_PAPER는 주로 종이의 거동을 모델링 하기 위한 재료모델이지만 본 연구를 통해 골판지에 대해서도 적용 가능함을 보였다. 인장, 압축, 전단 거동에 대하여 골판지의 방향별 기계적 물성을 측정 및 분석하고, 이를 바탕으로 6개의 항복면을 도출하여 MAT_PAPER 모델에 통합하였다. 재료시험 시편의 유한요소해석과 골판지 사각관의 저속 붕괴해석 결과를 각 실험 결과와 비교함으로써, 골판지의 거동을 등가적으로 잘 고려할 수 있음을 보였다. 그러나 해당 모델은 골판지의 변형률 속도효과를 고려하지 못하므로, 골판지의 원소재인 원심지의 고속물성을 측정하여 이를 보정하였으며, 이에 따라 골판지 사각관의 고속 압괴 실험 결과와 잘 일치함을 보였다.

• 한국농공학회논문집
• /
• 제54권1호
• /
• pp.99-108
• /
• 2012

Soil erosion and sediment from agricultural farmland has caused various negative impacts on environment in recent years. The effect of rice straw mat on soil erosion has been investigated by many researchers these days. In this study, the SWAT model was applied to Hongcheon watershed to evaluate SWAT flow and sediment, and the effect of rice straw mat on sediment yield at watershed outlet was evaluated. The Nash-Sutcliffe model efficiency (NSE) and coefficient of determination ($R^2$) values for flow simulation (calibration period) were 0.66 and 0.67, and the NSE values for sediment was 0.90. The calibrated parameters were used to analyze the reduction of sediment yield in the farmland with rice straw mat. Average daily sediment yield without rice straw mat was 49.8 ton/day and sediment yield with rice straw mat was 25.5 ton/day, and the reduction rate was 38.7 %. Also, average daily sediment yield with/without rice straw mat were 97.5 ton/day and 190.7 ton/day during the rainy season (Jun. 2008 - Aug. 2009), with the reduction rate 46.3 %.