• Journal of Microbiology and Biotechnology
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• v.4 no.4
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• pp.256-263
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• 1994

The aceB gene, encoding for malate synthase, one of the key enzymes of glyoxylate bypass, was isolated from a pMT1-based Corynebacterium glutamicum gene library via complementation of an Escherichia coli aceB mutant on an acetate minimal medium. The aceB gene was closely linked to aceA, separated by 598 base pairs, and transcribed in divergent direction. The aceB expressed a protein product of Mr 83, 000 in Corynebacterium glutamicum which was unusually large compared with those of other malate synthases. A DNA-sequence analysis of the cloned DNA identified an open-reading frame of 2, 217 base pairs which encodes a protein with the molecular weight of 82, 311 comprising 739 aminoo acids. The putative protein product showed only limited amino acid-sequence homology to its counteliparts in other organisms. The N-terminal region of the protein, which shows no apparent homology with the known sequences of other malate synthases, appeared to be responsible for the protein s unusually large size. A potential calciumbinding domain of EF-hand structure found among eukaryotes was detected in the N-terminal region of the deduced protein.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.8
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• pp.793-798
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• 2009

In this paper, the simulation and optimization of SRH (Surface Relief Hologram) masks for printing LCD gate patterns using TIR (Total Internal Reflection) holographic lithography was investigated. A simulation and optimization algorithm based on SDTA (Scalar Diffraction Theory Analysis) method was developed. The accuracy of the algorithm was compared to that of the RCWA (Rigorous Coupled Wave Analysis) method for estimating the Fresnel diffraction pattern of Cr amplitude masks for the given system geometry. In addition, the results from the optimization algorithm were validated experimentally. It was found that one to the most important conditions for the fabrication of SRH masks is to avoid nonlinear shape distortions of the resulting grating. These distortions can be avoided by designing SRH masks with recorded gratings having small aspect ratios of width versus depth. The optimum gap size between the Cr and SRH masks was found using the optimization algorithm. A printed LCD gate pattern with a minimum line width of $1.5{\mu}m$ exposed using the optimized SRH mask was experimentally demonstrated.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.255-255
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• 2020

아프리카 대륙에서 존재하는 가장 큰 사하라 사막(Sahara desert)의 면적은 지난 1세기 동안 기후변화로 인하여 10% 정도 증가하였고, 미래에도 기온상승으로 인하여 증가할 것으로 판단된다. 사하라 사막 면적의 증가로 인하여 아프리카의 자연식생과 수자원뿐만 아니라 아프리카에 거주하는 사람들의 삶에 많은 영향을 미치기에 사막의 면적 또는 경계선의 위치를 예측함은 매우 중요하다. 본 연구에서는 Coupled Model Intercomparison Project Phase 5 (CMIP5)의 36개 Global Climate Models (GCMs)과 ERA-interim 재분석 자료의 1979~2000년 강수 자료들을 이용하여 사헬(Sahel) 지대 서쪽(15W~15E, 10N~20N)과 동쪽(15E~35E, 10N~20N)의 강수량과 사막경계선을 비교하였다. 또한, 각 모델의 과거 모의 성능을 평가하여 미래 기후 예측성을 판단하고자 한다. 본 연구에서는 22년 평균 강수량이 200mm 이하인 지역을 사막이라 정의하고, 모델별로 연평균 강수량과 사막경계선에 대한 root mean square error(RMSE)를 산정하여 평가하였다. 또한, 습윤 정적 에너지(Moist. Static Energy; MSE), 바람(풍속 및 풍향) 자료를 이용하여 각 모델의 사막경계선의 오차에 대한 이유를 분석하였다. 이 연구를 바탕으로 하여 사헬 지대의 강수량 및 사막면적 모의의 불확실성 요소를 이해하고, 미래 상세 지역 수문기후 변화 예측에 활용 가능한 GCMs을 선별할 수 있을 것으로 판단한다.

• Proceedings of the Korean Society of Applied Entomolohy Conference
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• 2004.05a
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• pp.40-40
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• 2004

• JSTS:Journal of Semiconductor Technology and Science
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• v.6 no.3
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• pp.146-153
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• 2006

We have been investigating InGaAs HEMTs as a future high-speed and low-power logic technology for beyond CMOS applications. In this work, we have experimentally studied the role of the side-recess spacing $(L_{side})$ on the logic performance of 50 nm $In_{0.7}Ga_{0.3}As$ As HEMTs. We have found that $L_{side}$ has a large influence on the electrostatic integrity (or short channel effects), gate leakage current, gate-drain capacitance, and source and drain resistance of the device. For our device design, an optimum value of $L_{side}$ of 150 nm is found. 50 nm $In_{0.7}Ga_{0.3}As$ HEMTs with this value of $L_{side}$ exhibit $I_{ON}/I_{OFF}$ ratios in excess of $10^4$, subthreshold slopes smaller than 90 mV/dec, and logic gate delays of about 1.3 ps at a $V_{CC}$ of 0.5 V. In spite of the fact that these devices are not optimized for logic, these values are comparable to state-of-the-art MOSFETs with similar gate lengths. Our work confirms that in the landscape of alternatives for beyond CMOS technologies, InAs-rich InGaAs FETs hold considerable promise.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.27 no.4
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• pp.257-268
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• 2017

Objectives: This study was conducted to review the Toxic UseReduction Act of Massachusetts, USA, which has been evaluated as a successfulcase of a chemical reduction policy, and to search for ways to introduce it inKorea. Methods: We analyzed the implementation of the TURA by attending TUR Planning Course of the Toxic Use Reduction Institute in Massachusetts and researching the related literature. Results: As TURA took effect, the use of chemicals in Massachusetts was reduced, and cost savings were achieved in workplaces. The success factors for the legislation are considered to be support form the federal and state governments and the active participation of business and civic group. Domestic efforts to reduce toxic substances have already begun, so if the process of TURA is appropriately applied to domestic legislation of chemicals control, it would be expected to produce visible results. Therefore, we reviewed the 'Act on Chemicals Registration and Assessment', 'Act on Chemical Control' and 'Act on the Integrated Control of Pollutant-Discharging Facilities' and sought solution for applying TURA to each piece of legislation. For the first case, 'Toxic or Hazardous Substance List' and 'Establishment of Toxic Use Fee' is applicable. For the second case, 'Annual Toxic or Hazardous Substance Reports' is applicable. For the third case, 'Toxic Reduction Plans' and 'Toxics Use Reduction Institute and 'Toxic Use Reduction Planners' is applicable. Conclusions: The government should take notice appropriateness for the reduction of toxic chemicals and provide financial support. Businesses should invest in technologies that build trust with local communities, improve productivity, and reduce costs. Finally, civic group should cooperate with government and businesses.

• BMB Reports
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• v.41 no.8
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• pp.575-580
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• 2008

Thymocyte-specific transcriptional regulatory systems can be used to better understand the relationship between transcription and V(D)J recombination during early T cell development. In this study, we generated transgenic mice expressing the transactivator Gal4-VP16 or the Gal4 DNA binding domain (Gal4-DBD) under the control of the lck proximal promoter, which is only active in immature thymocytes. From these studies Gal4-VP16 and Gal4-DBD expression was shown to significantly alter thymic cellularity and differentiation without significantly changing the $CD3^+$ thymocyte distribution. Furthermore, the presence of Gal4-VP16 or Gal4-DBD in the transgenic thymocytes retarded the mobility of the Gal4 DNA binding motif as determined by a gel mobility shift assay, suggesting that the developmental alteration did not affect the functional property of the transgenic proteins. These results indicated that lck promoter-driven Gal4-VP16 or Gal4-DBD expression did not affect $CD3^+$ mature thymocytes, thus this system can be applied to study transcriptional regulation of transresponder genes in bigenic mouse model thymocytes.

• Journal of the Korean Ceramic Society
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• v.43 no.11 s.294
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• pp.746-750
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• 2006

NiO films and Ru co-sputtered NiO films were deposited by reactive magnetron sputtering for micro-solid oxide fuel cell anode applications. The deposited films were reduced to form porous films. The reduction kinetics of the Ru doped NiO film was more sluggish than that of the NiO film, and the resulting microstructure of the former exhibited finer pore networks. The possibility of using the films for the anodes of single chamber micro-SOFCs was investigated using an air/fuel mixed environment. It was found that the abrupt increase in the resistance is suppressed in the Ru co-sputtered film, as compared to undoped film.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3409-3416
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• 2023

Licensing the next-generation of nuclear reactor designs requires extensive use of Modeling and Simulation (M&S) to investigate system response to many operational conditions, identify possible accidental scenarios and predict their evolution to undesirable consequences that are to be prevented or mitigated via the deployment of adequate safety barriers. Deep Learning (DL) and Artificial Intelligence (AI) can support M&S computationally by providing surrogates of the complex multi-physics high-fidelity models used for design. However, DL and AI are, generally, low-fidelity 'black-box' models that do not assure any structure based on physical laws and constraints, and may, thus, lack interpretability and accuracy of the results. This poses limitations on their credibility and doubts about their adoption for the safety assessment and licensing of novel reactor designs. In this regard, Physics Informed Neural Networks (PINNs) are receiving growing attention for their ability to integrate fundamental physics laws and domain knowledge in the neural networks, thus assuring credible generalization capabilities and credible predictions. This paper presents the use of PINNs as surrogate models for accidental scenarios simulation in Nuclear Power Plants (NPPs). A case study of a Loss of Heat Sink (LOHS) accidental scenario in a Nuclear Battery (NB), a unique class of transportable, plug-and-play microreactors, is considered. A PINN is developed and compared with a Deep Neural Network (DNN). The results show the advantages of PINNs in providing accurate solutions, avoiding overfitting, underfitting and intrinsically ensuring physics-consistent results.

• Journal of the Korean Mathematical Society
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• v.39 no.2
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• pp.163-191
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• 2002

We introduce Clapp-Puppe type generalized Lusternik-Schnirelmann (co)category in a Quillen model category. We establish some of their basic properties and give various characterizations of them. As the first application of these characterizations, we show that our generalized (co)category is invariant under Quillen modelization equivalences. In particular, generalized (co)category is invariant under Quillen modelization equivalences. In particular, generalized (co)category of spaces and simplicial sets coincide. Another application of these characterizations is to define and study rational cocategory. Various other applications are also given.