• Korean Chemical Engineering Research
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• v.57 no.1
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• pp.118-123
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• 2019

In this study, the electrochemical characteristics of Graphite/Silicon/Pitch anode composites were analyzed to improve the low theoretical capacity of graphite as a lithium ion battery. The Graphite/Silica composites were synthesized by bonding silica onto polyvinylpyrrolidone coated graphite. The surface of used silica was treated with (3-Aminopropyl)triethoxysilane(APTES). Graphite/Silicon/Pitch composites were prepared by carbonization of petroleum pitch, the fabrication processes including the magnesiothermic reduction of nano silica to obtain silicon and varying the mass ratio of silica. The Graphite/Silicon/Pitch composites were analysed by XRD, SEM and XRD. Also the electrochemical performances of Graphite/Silicon/Pitch composite as the anode of lithium ion battery were investigated by constant current charge/discharge, rate performance, cyclic voltammetry and electrochemical impedance tests in the electrolyte of $LiPF_6$ dissolved in organic solvents (EC:DMC:EMC=1:1:1 vol%). The Graphite/Silicon/Pitch anode composite (silica 28.5 in weight) has better capacity (537 mAh/g). The cycle performance has an excellent capacity retention to 30th cycle of 95% and the retention rate capability of 98% in 0.1 C/0.2 C.

• Journal of Life Science
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• v.28 no.12
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• pp.1455-1460
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• 2018

Due to a rapidly expanding aging population, the incidence of degenerative bone disease has increased, and efforts to handle the issue using regenerative medicine have become more important. In order to control various bone diseases such as osteoarthritis and osteoporosis, regenerative medicine utilizing adult stem cells has been extensively studied. And it is now clear that the mitochondrial energy metabolism, oxidative phosphorylation, is important for the process of stem cell differentiation. Interestingly, a recent study reported that salicylate promotes mitochondrial biogenesis by regulating the expression of $PGC-1{\alpha}$ in murine cells. However, the possible effects of salicylate on osteogenic differentiation through increased mitochondrial biogenesis in stem cells remain unknown. Thus, here we investigated whether salicylate could influence osteogenic differentiation and mitochondrial biogenesis of periosteum-derived mesenchymal stem cells (POMSCs). We found that salicylate treatments of POMSCs undergoing osteogenic differentiation increased the activity of alkaline phosphatase, a well-known early marker of bone cell differentiation. In addition, we observed that mitochondrial mass was increased by salicylate treatments in POMSCs. Together, these results indicate that salicylate can enhance osteogenic differentiation and mitochondrial biogenesis in POMSCs. Therefore, the findings in this study suggest that small molecules augmenting mitochondrial function such as salicylate can be a novel modulator for osteogenic differentiation and regenerative medicine.

• Journal of Energy Engineering
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• v.27 no.4
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• pp.27-35
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• 2018

The passive containment cooling system (PCCS) has been designed to remove the released decay heat during the accident by means of the condensation heat transfer phenomenon to guarantee the safety of the nuclear power plant. The heat removal performance of the PCCS is mainly governed by the condensation heat transfer of the steam-air mixture. In this study, the heat removal performance of the PCCS was evaluated by using the MARS-KS code with a new empirical correlation for steam condensation in the presence of a noncondensable gas. A new empirical correlation implemented into the MARS-KS code was developed as a function of parameters that affect the condensation heat transfer coefficient, such as the pressure, the wall subcooling, the noncondensable gas mass fraction and the aspect ratio of the condenser tube. The empirical correlation was applied to the MARS-KS code to replace the default Colburn-Hougen model. The various thermal-hydraulic parameters during the operation of the PCCS follonwing a large-break loss-of-coolant-accident were analyzed. The transient pressure behavior inside the containment from the MARS-KS with the empirical correlation was compared with calculated with the Colburn-Hougen model.

• Journal of Platform Technology
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• v.6 no.4
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• pp.59-68
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• 2018

The objective of this study is to develop an embedded antenna structure with NFC and WPC composite functions. By selecting stable materials, the optimal component ratio of the polymer sheet was determined. The low cost embedded winding method compared to the existing FPCB was devised. During the winding process, characterization and process technology were developed. We also fabricated a ferrite mold to process the WPC grooves and developed the process technology for optimizing the WPC antenna. The following conclusions were obtained. (1) Optimum composition ratio was derived as Fe 87.5%, Si 7%, Al 5.5% and selected as the final material. (2) Optimal sheet conditions were derived from the experimental evaluation method and the experimental design method through the combination test of the optimized sheet and the conventional mass production FPCB. (3) According to coil diameter and inner diameter, Q value fluctuation, resistance value and efficiency fluctuation are obtained. Therefore, the most suitable coil condition is selected and Rx matching is performed. (4) The EMV load modulation test and the cognitive distance test of the polymer sheet and the ferrite sheet showed that the recognition distance of the polymer sheet at 1k and 4K was 32-33 mm and the recognition distance of the ferrite sheet at the same condition was 30-31 mm.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.78-85
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• 2019

Membrane proteins are involved in many common diseases, including heart disease and cancer. In various disease states, such as cancer, abnormal signaling pathways that are related to the membrane proteins cause the cells to divide out of control and the expression of membrane proteins can be altered. Membrane proteins have the hydrophobic environment of a lipid bilayer, which makes an analysis of the membrane proteins notoriously difficult. Therefore, this study evaluated the efficacy of two different methods for optimal membrane protein extraction. High-speed centrifuge and reagent-based method with a -/+ filter aided sample preparation (FASP) were compared. As a result, the high-speed centrifuge method is quite effective in analyzing the mitochondrial inner membranes, while the reagent-based method is useful for endoplasmic reticulum membrane analysis. In addition, the function of the membrane proteins extracted from the two methods were analyzed using GeneGo software. GO processes showed that the endoplasmic reticulum-related responses had higher significance in the reagent-based method. An analysis of the process networks showed that one cluster in the high-speed centrifuge method and four clusters in the reagent-based method were visualized. In conclusion, the two methods are useful for the analysis of different subcellular membrane proteins, and are expected to assist in selecting the membrane protein extraction method by considering the target subcellular membrane proteins for study.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.1
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• pp.161-170
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• 2019

Multi-product mass production small and medium enterprise factories have a wide variety of products and a large number of products, wasting manpower and expenses for inventory management. In addition, there is no way to check the status of inventory in real time, and it is suffering economic damage due to excess inventory and shortage of stock. There are many ways to build a real-time data collection environment, but most of them are difficult to afford for small and medium-sized companies. Therefore, smart factories of small and medium enterprises are faced with difficult reality and it is hard to find appropriate countermeasures. In this paper, we implemented the contents of extension of existing inventory management method through character extraction on label with barcode and QR code, which are widely adopted as current product management technology, and evaluated the effect. Technically, through preprocessing using OpenCV for automatic recognition and classification of stock labels and barcodes, which is a method for managing input and output of existing products through computer image processing, and OCR (Optical Character Recognition) function of Google vision API. And it is designed to recognize the barcode through Zbar. We propose a method to manage inventory by real-time image recognition through Raspberry Pi without using expensive equipment.

• Journal of the Korean Geotechnical Society
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• v.35 no.1
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• pp.5-15
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• 2019

In this study, the in situ deformation moduli, which were measured by borehole loading tests at basaltic rock masses located in the northeastern onshore and offshore and the northwestern onshore of Jeju Island, were examined in relation to RQD and RMR. The measured deformation moduli were also compared with the estimated deformation moduli from conventional empirical formulas using RQD and RMR. In addition, the measured deformation moduli were analyzed with respect to both the velocity ratio ($V_P/V_S$) and dynamic Poisson's ratio, which were obtained from the elastic wave velocities measured by velocity logging tests. As results, with only RQD, it was inappropriate to evaluate the quality of the Jeju island basaltic rock masses, which are characterized by vesicular structures, to select a measurement method of in situ deformation moduli, and to estimate the deformation moduli. On the other hand, it was desirable to evaluate the quality of the Jeju Island basaltic rock masses, and to estimate the deformation moduli by using RMR. The conventional empirical formulas using RMR overestimated the deformation moduli of the Jeju Island basaltic rock masses. There was qualitative consistency in the relation between velocity ratio and deformation moduli. To estimate appropriately the deformation moduli of the Jeju Island basaltic rock masses, empirical formulas were proposed as the function of RMR and velocity ratio, respectively.

• Biomolecules & Therapeutics
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• v.29 no.6
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• pp.685-696
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• 2021

In this study, we investigated the inhibitory effect of 5-aminolevulinic acid (ALA), a heme precursor, on inflammatory and oxidative stress activated by lipopolysaccharide (LPS) in RAW 264.7 macrophages by estimating nitric oxide (NO), prostaglandin E2 (PGE2), cytokines, and reactive oxygen species (ROS). We also evaluated the molecular mechanisms through analysis of the expression of their regulatory genes, and further evaluated the anti-inflammatory and antioxidant efficacy of ALA against LPS in the zebrafish model. Our results indicated that ALA treatment significantly attenuated the LPS-induced release of pro-inflammatory mediators including NO and PGE2, which was associated with decreased inducible NO synthase and cyclooxygenase-2 expression. ALA also inhibited the LPS-induced expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, reducing their extracellular secretion. Additionally, ALA abolished ROS generation, improved the mitochondrial mass, and enhanced the expression of heme oxygenase-1 (HO-1) and the activation of nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in LPS-stimulated RAW 264.7 macrophages. However, zinc protoporphyrin, a specific inhibitor of HO-1, reversed the ALA-mediated inhibition of pro-inflammatory cytokines production and activation of mitochondrial function in LPS-treated RAW 264.7 macrophages. Furthermore, ALA significantly abolished the expression of LPS-induced pro-inflammatory mediators and cytokines, and showed strong protective effects against NO and ROS production in zebrafish larvae. In conclusion, our findings suggest that ALA exerts LPS-induced anti-inflammatory and antioxidant effects by upregulating the Nrf2/HO-1 signaling pathway, and that ALA can be a potential functional agent to prevent inflammatory and oxidative damage.

• Particle and aerosol research
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• v.16 no.4
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• pp.131-140
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• 2020

Air pollutants emitted from chimneys of coal-fired power plants are considered to be a major source of fine particulate matter in the atmosphere. In order to manage fine particle in the chimney of a coal-fired power plant, it is necessary to know the concentration of fine particle emitted in real time, but the current system is difficult. In this study, a real-time measurement system for chimney fine particle was developed, and measurements were performed on six coal-fired power plants. Through the measurements, the mass concentration distribution according to the particle size could be secured. All six chimneys showed bimodal distribution, and the count median diameters of each mode were 0.5 and 1.1 ㎛. In addition, it was compared with the gravimetric measurement method, and it was determined that the relative accuracy for PM10 was within 20%, and the value measured using the developed measuring instrument was reliable. Finally, three power plants were continuously measured for one month, and as a result of comparing the concentration of PM10 according to the amount of power generation, it was confirmed that the PM10 discharged from the chimney increased in the form of an exponential function according to the amount of power generation.

• (The)Study of the Eastern Classic
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• no.55
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• pp.59-84
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• 2014

This research is an attempt to newly interpret his academic evaluation and understand Seo Kye Bak Se-Dang's Sa Byeun Rok The Doctrine of the Mean. In academic world, his academic Characteristic was considered as anti-Neo-confucianism, out of Jung Ju Hak, out of Seong Ri Hak, and Sil Hak. His understanding of The Doctrine of the Mean was pretty critical, because he had unique academic characteristic to interpret Chinese classics rather than anti-Neo-confucianism, out of Jung Ju Hak, out of Seong Ri Hak, and Sil Hak. Especially, he took practical study with six Chinese classics as the central figure and it was a creative thing with philosophical method. He tried to find out original meaning which was essential thought of Confucianism, and pointed out disharmony for consistency about meaning of The Doctrine of the Mean when Jung Ja and Ju Ja interpreted The Doctrine of the Mean. It appeared as an effort of trying agreement between name and its duty, and role and function in things and act. In addition, he thought The Doctrine of the Mean as trying to follow nature, and it was the way of people to practice in bright side of mind. It is different from Ju Ja's thought which explains principle about people and things, and it has strong reality which is foundation of practice and allows dynamic energy of human life. Therefore, practice style of The Doctrine of the Mean develops filial duty as center of mass and appears manifestation of human's independence through how people pracice it. To sum up, he traced The Doctrine of the Mean as reality, practice, and physical science rather than ideal, theoretical, and metaphysical philosophy. It developed the spirit of study as understanding world as the center of human, thinking over the way of people, and studying the essence of Confucianism with practice of thought.