• Archives of Pharmacal Research
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• 제17권6호
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• pp.424-427
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• 1994

An acinomycin complex isolated from culture broth of a soil microorganism, SNUS 9305-011 has been examined by High performance liquid chromatography (HPLC). From the analysis of the fractions obtained by column chromatography of the ethyl acetate extract, three actinomycin components are confimed . The HPLC analysis is carried out with a CN-bonded nucleosil column. Comparison of the retention times of the components with those of actinomycin D, C complex, $X_{o{\beta}$, and V and suggests that they are different actinomycins. FBA mass spectra fo the coponents also shows different molecular ions from those of standards and other reported actionbmycins. The present work has demonstrated that actinomycin components can be separated by a CN-bonded HPLC column, and that ocmparison of their HPLC chormatograms with authentic smaples and information on their molecular ions can be successfully employed for indentification of actionmycins.

• Journal of Advanced Marine Engineering and Technology
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• 제24권1호
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• pp.94-103
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• 2000

This paper describes the model identification and the discrete-time sliding mode control of electro-hydraulic servo systems which are composed of servo valves, double-rod cylinder and load mass. The controlled plant is identified as a 3th-order discrete-time ARMAX model obtained from the prediction error algorithm, where a nominal model and modeling errors are zuantitatively constructed. The discrete sliding mode controller for 3th-order ARMAX model is designed in discrete-time domain, where all states are observed from Kalman filter. The discrete sliding mode controller has better tracking performance than that obtained from continuous-time sliding mode controller, in experiment.

• 약학회지
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• 제37권4호
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• pp.317-324
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• 1993

The metabolic profile of carbinoxamine, 2-[(4-chlorophenyl)-2-pyridinyi-methoxy] N, N-dimethylethanamine, was determined in rat urine. Urinary extracts obtained with or without enzyme hydrolysis were derivatized with MSTFA/TMSCI (N-methyl-N-trimethylsilyl trifluoroacetamide/Trimethylchlorosilane) and analyzed by GC/MSD. In rat urine, which obtained after oral treatment with carbinoxamine maleate, chlorobenzolyl pyridine, (4-chlorophenyl)-2-pyridinyl methanol : carbinol, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N-methylethanamine : norcarbinoxamine, 2-[(4-chlorophenyl)2-pyridinylmethoxy]ethanamine : bis-norcarbinoxamine and parent carbinoxamine were detected in free form. Norcarbinoxamine and bisnorcarbinoxamine were also detected in conjugated form(acetylation). These data suggest that in the rat, hydroxylation of either the benzyl or pyridinyl ring can occur during carbinoxamine elimination. O-demethylation and subsequent conjugation represents the primary pathway of carbinoxamine elimination in the rat.

• 대한기계학회논문집
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• 제16권11호
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• pp.2033-2048
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• 1992

본 연구에서는 탄성체 구조물로 형성된 응용에서 좀더 공통된 상황에 관한 것 이다.유일한 선형해석모델의 규명에 필요한 정보제공을 위하여 충분히 넓은 진동수 범위에 걸쳐 응답을 측정하고, 구조물을 기진시키는 것은 불가능하고 비경제적이며 또 는 일반적으로 바람직하지 못할 것으로 생각된다.

• 분석과학
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• 제5권3호
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• pp.333-338
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• 1992

녹차 중 탄닌성분들인 에피갈로카테킨, 에피갈로카테킨 갈레이트는 세파덱스 LH-20 컬럼에서 물-아세톤의 혼합용리에 의하여 신속하게 분리되어 용출하였다. 용출액은 280nm에서 흡광도의 변화를 측정한 결과 4개의 분획으로 검출되었다. 각 분획을 그대로 고속원자충격 질량분석장치에 도입하여 탄닌성분들을 동정할 수 있었다. 에피갈로카테킨, 에피갈로카테민 갈레이트는 역상 HPLC에서 용출된 피크면적으로 계산한 결과, 70% 이상의 높은 수율로 얻을 수 있었다. 본 방법에 의하여 보고된 방법들보다 탄닌성분들을 신속하게 동정할 수 있고, 고순도로 얻을 수 있었다.