• Design & Manufacturing
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• 제2권3호
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• pp.1-5
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• 2008

Plastic parts are molded for the purpose of mass production in injection molding. Therefore designer is usually designing molds that has geometrically balanced hot runner lay-out for filling balance at cavities. Although, mold is manufactured with geometrically balanced runner lay-out, there are actually filling imbalances in cavities. These filling imbalances phenomenon are caused by complicated interaction between melt and mold. In this paper, filling imbalances for internal gear based on injection molding in hot-runner mold were investigated by CAE and injection molding experiences.

• 한국자동차공학회논문집
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• 제11권4호
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• pp.189-195
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• 2003

The steel wheels are widely used in the passenger cars because of their low cost of production although the aluminum wheels have many advantages in their performance and appearance. It is known that the steering wheel vibration with steel wheels is generated more often than one with aluminum wheels. Both the constant velocity driving test and the m up test are carried out in this study to analyze the causes and path of the steering wheel vibration generated from the steel wheels. And this study shows that the steering wheel vibration is affected by the fastening torque of the wheel mounting bolts between the steel wheel and the suspension disk.

• International Journal of Oral Biology
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• 제44권1호
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• pp.1-7
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• 2019

Osteoporosis is a common disease characterized by bone mass reduction, leading to an increased risk of bone fracture, and it is caused by an imbalance of osteoblastic bone formation and osteoclastic bone resorption. Current osteoporosis drugs aim to reduce the risk of bone fracture, either by increasing osteoblastic bone formation or decreasing osteoclastic bone resorption. However, osteoblasts and osteoclasts are closely coupled, such that any reagent altering the differentiation or activity of one eventually affects the other. This tight coupling between osteoblasts and osteoclasts not only limits the therapeutic efficacy but also threatens the safety of osteoporosis drugs. This review will discuss the biological mechanisms of action of currently approved medications for osteoporosis treatment, focusing on the osteoblast-osteoclast coupling.

• 한국게임학회 논문지
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• 제15권6호
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• pp.107-120
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• 2015

디지털 게임의 부분유료화 모델은 플레이어로 하여금 신규 게임 유입의 장벽을 낮추고 동시에 소액 결제를 통해 소비를 유도하여 안정적인 수익을 촉발한다는 점에서 게임 업계의 대표적인 수익모델로 평가받고 있다. 하지만 부분유료화를 통해 제공되는 서비스들의 종류와 적용 대상, 적용 양상이 다양해지면서 있는 플레이어들의 게임 플레이 경험에 불균형을 양산하는 문제를 만들고 있다. 이에 본 논문은 부분유료화의 개념과 특징을 정리하고, 획득방법, 지속성, 기능 발현 대상에 따라 2가지 유형, 7가지 세분류를 진행하였다. 이 과정을 통해 부분유료화 모델이 가지는 세 가지 문제점을 도출할 수 있었는데 첫째, 게임 플레이 경험의 불평등 유발, 둘째, 게임 세계 경제의 불균형 양산, 셋째 게임 플레이 지속성 파괴가 바로 그것이다. 본 논문에서는 이 세 가지 문제점을 구체적인 사례를 중심으로 설명하고 그 해결책을 제언하는 것을 목적으로 한다. 이러한 연구는 앞으로의 부분유료화 모델이 한국 게임 시장에 어떤 방식으로 적용되어야 하는지에 대한 지표를 제공한다는 점에서 의의를 찾을 수 있다.

• Tribology and Lubricants
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• 제35권1호
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• pp.44-51
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• 2019

The paper presents the rotordynamic performance measurements and model predictions of a fuel cell electric vehicle (FCEV) air compressor supported on gas foil bearings (GFBs). The rotor has an impeller on one end and a thrust runner on the other end. The front (impeller side) and rear (thrust side) gas foil journal bearings (GFJBs) are located between the impeller and thrust runner to support the radial loads, and a pair of gas foil thrust bearings are located on both sides of the thrust runner to support the axial loads. The test GFJBs have a partial arc shim foil installed between the top foil and bump strip layers to enhance hydrodynamic pressure generation. During the rotordynamic performance tests, two sets of orthogonally installed eddy-current displacement sensors measure the rotor radial motions at the rotor impeller and thrust ends. A series of speed-up and coast-down tests to 100k rpm demonstrates the dominant synchronous (1X) rotor responses to imbalance masses without noticeable subsynchronous motions, which indicates a rotordynamically stable rotor-GFB system. Finite element analysis of the rotor determines the rotor free-free (bending) natural modes and frequencies well beyond the maximum rotating frequency. The predicted damped natural frequencies and damping ratios of the rotor-GFB system reveal rotordynamic stability over the speeds of interest. The imbalance response predictions show that the predicted critical speeds and rotor amplitudes strongly agree with the test measurements, thus validating the developed rotordynamic model.

• Nutritional Sciences
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• 제4권1호
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• pp.34-38
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• 2001

The purpose of this study was to compare the energy expenditure of normal-weight and overweight Korean middle-aged women (40-60 yr). Middle-aged oveweight ($BMI\;{\geq}\;25$, n= 20) and normal-weight women were ($BMI\;{\leq}\;23$, n = 20) were recruited in Seoul. Anthropometric measurements, body composition, energy intake, daily activity time, and energy costs of some daily activities were measured. Energy expenditure at rest and while reading the newspaper, washing dishes, mopping the floor, and walking on a treadmill at 1.0, 2.0, 3.5mph were measured by indirect calorimeter and total daily energy expenditure was estimated by summation of energy costs of different activities. The overweight group had significantly higher values of body weight, triceps skinfold thickness, thigh circumference, waist circumference, hip circumference, BMI, WTR, WHR, body surface area, percentage body fat, fat mass, fat free mass (FFM), and muscle mass compared to normal-weight group. The energy intakes of both groups were close to RDA and other nutrient intake status was also satisfactory. There were no significant differences in intakes of energy and nutrients between the two groups. Overweight subjects showed lower energy expenditure per kg body weight for reading the newspaper, washing dishes and mopping the floor, and walking on a treadmill at 2.0 and 3.5 mph, however, energy expenditure per kg FFM did not differ between the two groups. Daily energy expenditure for all activities was significantly higher in the overweight compared to the normal-weight group due to higher body weight. Both overweight and normal-weight groups showed negative energy balance between energy intake and energy expenditure, and there was no significant difference in energy balance between the two roups. Total daily energy expenditure correlated highly with FFM and body surface area. The result of present study does not offer an explanation on the energy imbalance and weight gain of overweight women.

• 대한통합의학회지
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• 제7권4호
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• pp.283-290
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• 2019

Purpose : The purpose of this study was to find out how changes in body shape of obese patients could be affected by the combined management of diet and psychotherapy along with exercise therapy to control energy imbalance, the cause of obesity. Methods : In this study, the aerobic exercise program was conducted on 12 industrial workers of "D" company for a total of eight weeks for obese patients with a high body mass index (25 kg/㎡ or higher). The experimental group did not apply the program three times a week. The body type analysis was carried out using the body analyzer (Inbody 770, Inbody, Korea) and blood test and psychological test were performed after 8 weeks of exercise before and after exercise. Results : The results of the group showed a change in weight loss of 6.03 kg (p=.000) on average, which is nearly 10 % of the change in weight. It was also shown that the BMI (body mass index) decreased by 1.76 kg/㎡ (p=.000). Abdominal fat (AO) is also 0.14 % (p=.000), waist circumference (WC, 12.72 cm, p=.000), internal fat (VF, 25.12 %, p=.000), liver function levels AST (5.47 U/L, p=.04), ALT (13.64 U/L, p=.000), total cholesterol, pTC -14.22. Conclusion : Based on the results of this study, the obesity management program will be able to maximize the effects of obesity control if exercise programs and psychotherapy are combined.

• IMMUNE NETWORK
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• 제23권6호
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• pp.46.1-46.16
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• 2023

Autoimmune hepatitis (AIH) affects all age group and occurs mainly in women. Pyroptosis is a novel programmed cell death featured with cell bursting and release of proinflammatory cytokines. A deeper understanding of AIH pathogenesis will contribute to novel therapy for AIH patients. Here, we aimed to investigate the role of IL-17 in immune-mediated liver injury. The levels of cytokines were measured by ELISA, and mRNA levels of STAT3 and IFN gamma-inducible protein 16 (IFI16) were detected by PCR. Expressions of STAT3, IFI16, gasdermin D and cleaved caspase-1 were measured by western-blotting. Immunohistochemical staining and transmission electron microscopy were applied to evaluate liver histopathological changes of the treated mice. Our results showed that the levels of IFI16 was increased in hepatocytes treated with IL-17 protein, and further elevated after STAT3-overexpressed (STAT3-OE) lentivirus treatment. The levels of IFI16 were reduced in hepatocytes treated with IL-17 neutralizing Ab (nAb), but were significantly increased after STAT3-OE treatment. Pyroptosis was observed in hepatocytes treated with IL-17 protein, and further cell damage was observed after STAT3-OE lentivirus treatment. Liver damage was alleviated in mice treated with IL-17 nAb, however sever damage was experienced after STAT3-OE lentivirus treatment. A binding interaction between IFI16 and STAT3 was detected in IL-17 treated hepatocytes. Glutathione transaminase activity was enhanced in concanavalin A-induced AIH mice compared to the control group (p<0.01). IL-17 plays an important role in activating STAT3 and up-regulating IFI16, which may promote the pyroptosis in AIH-related liver injury through STAT3-IFI16 axis.

• 한국재난정보학회 논문집
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• 제2권1호
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• pp.139-155
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• 2006

Over the past two decades suicide terrorism has become an ever-widening phenomenon. When suicide terrorism was first introduced in the Middle East it seemed that this new phenomenon was invincible and that it might change the innate imbalance between terror groups and their rivalry governments. This did not in fact occur. Looking at history of terrorism, it can be seen that suicide attacks are in actuality a very old modus operandi. However, contemporary suicide terrorism differs from such historical tactics, just as the whole phenomenon of terrorism differs from ancient modes of warfare. Modern suicide terrorism is aimed at causing devastating physical damage. through which it inflicts profound fear and anxiety. Its goal is to produce a negative psychological effect on an entire population rather than just the victims of the actual attack. The relatively high number of casualties guaranteed in such attacks, which are usually carried out in crowded areas, ensures full media coverage. Thus, suicide terrorism, ranks with other spectacular modus operandi such as blowing up airplanes in mid air or the use of Weapons of Mass Destruction as a sure means to win maximum effect. For the purposes of this paper a suicide terror attack is defined as a politically motivated violent attack perpetrated by a self-aware individual (or individuals) who actively and purposely causes his own death through blowing himself up along with his chosen target. The perpetrator's ensured death is a precondition for the success of his mission. The greatest potential risk suicide terrorism may pose in future is if terrorists carry out operations combined with other spectacular tactics such as blowing up airplanes or the use of Weapons of Mass Destruction. Such a combination will increase immensely the death toll of a single terror attack and will have a shocking psychological effect on public moral. At this level suicide terrorism would constitute a genuine strategic threat and would probably be confronted as such. This study portrays a general overview of the modern history of suicide terror activity worldwide, focusing on its main characteristics and the various aims and motivations of the terror groups involved. In addition, This study provides an overview what is to be done to prevent such terrorist attacks.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2009년도 추계학술대회 논문집
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• pp.258-263
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• 2009

This paper describes an analysis of the stability and performance of a large-capacity flywheel energy storage system (FESS) supported by active magnetic bearings. We designed and manufactured the system that can store up to 5kWh of usable energy at the maximum speed of 18,000 rpm. In order to analyze the stability of the systems accurately, we derived a rigid body rotor model, flexible rotor model using finite-element method, and a reduced-order model using modal truncation. The rotor model is combined with those of active magnetic bearings, amplifiers, and position sensors, resulting in a system simulation model. This simulation model is validated against experimental measurements. The stability of the system is checked from the pole locations of the closed-loop transfer functions. We also investigated the sensitivity function to quantify the robustness of the systems to the disturbances such as mass imbalance and sensor noises.