• Physical Therapy Rehabilitation Science
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• 제13권1호
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• pp.78-85
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• 2024

Objective: This Study aimed to examine the changes in muscle activity of trunk muscles by performing three squat exercises on normal adults. Design: cross-sectional study Methods: Thirty-two adult subjects participated in this study. General squat, overhead squat, and overhead squat combined with abdominal stabilization were randomly performed for 5 seconds, 3 times, to calculate the average muscle activation. Muscle activation was normalized using electrodes on the rectus abdominis, external oblique, internal oblique, and erector spinae muscles to measure maximum voluntary isometric contraction (MVIC) for 5 seconds, repeated 3 times each. Results: There was a significant difference in the mean and maximal muscle activity of the bilateral erector spinae (ES) when comparing the squat to the overhead squat (p<0.05). There was a significant difference (p<0.05) in the mean and maximal muscle activity of the bilateral external oblique (EO) when comparing the overhead squat to the overhead squat combined with the abdominal stabilization technique. When comparing the squat to the overhead squat with abdominal stabilization, there was a significant difference in the mean and maximum muscle activity of the bilateral RA, EO, and left Internal oblique (IO) (p<0.05), and there was a significant difference in the maximum muscle activity of the bilateral erector spinae (ES) (p<0.05). Post hoc tests showed significant differences between squatting methods for the RA, EO, IO, and ES (p<0.017). Conclusion: The results of this study showed that squats combined with abdominal stabilization were more effective at activating core muscles than squats or overhead squats alone.

• Tuberculosis and Respiratory Diseases
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• 제87권1호
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• pp.52-64
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• 2024

Chronic respiratory diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and respiratory infections injure the alveoli; the damage evoked is mostly irreversible and occasionally leads to death. Achieving a detailed understanding of the pathogenesis of these fatal respiratory diseases has been hampered by limited access to human alveolar tissue and the differences between mice and humans. Thus, the development of human alveolar organoid (AO) models that mimic in vivo physiology and pathophysiology has gained tremendous attention over the last decade. In recent years, human pluripotent stem cells (hPSCs) have been successfully employed to generate several types of organoids representing different respiratory compartments, including alveolar regions. However, despite continued advances in three-dimensional culture techniques and single-cell genomics, there is still a profound need to improve the cellular heterogeneity and maturity of AOs to recapitulate the key histological and functional features of in vivo alveolar tissue. In particular, the incorporation of immune cells such as macrophages into hPSC-AO systems is crucial for disease modeling and subsequent drug screening. In this review, we summarize current methods for differentiating alveolar epithelial cells from hPSCs followed by AO generation and their applications in disease modeling, drug testing, and toxicity evaluation. In addition, we review how current hPSC-AOs closely resemble in vivo alveoli in terms of phenotype, cellular heterogeneity, and maturity.

• IMMUNE NETWORK
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• 제19권1호
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• pp.7.1-7.11
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• 2019

Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disorder that affects mainly salivary and lacrimal glands, but its cause remains largely unknown. Clinical data indicating that SS occurs in a substantial proportion of patients with lupus points to common pathogenic mechanisms underlying the two diseases. To address this idea, we asked whether SS develops in the lupus-prone mouse strain sanroque (SAN). Owing to hyper-activation of follicular helper T (Tfh) cells, female SAN mice developed lupus-like symptoms at approximately 20 wk of age but there were no signs of SS at that time. However, symptoms typical of SS were evident at approximately 40 wk of age, as judged by reduced saliva flow rate, sialadenitis, and IgG deposits in the salivary glands. Increases in serum titers of SS-related autoantibodies and numbers of autoantibody-secreting cells in cervical lymph nodes (LNs) preceded the pathologic manifestations of SS and were accompanied by expansion of Tfh cells and their downstream effector cells. Thus, our results suggest that chronic dysregulation of Tfh cells in salivary gland-draining LNs is sufficient to drive the development of SS in lupus-prone mice.

• Clinical Endoscopy
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• 제56권3호
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• pp.283-289
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• 2023

Gastrointestinal (GI) bleeding is one of the most common conditions among patients visiting emergency departments in Korea. GI bleeding is divided into upper and lower GI bleeding, according to the bleeding site. GI bleeding is also divided into overt and occult GI bleeding based on bleeding characteristics. In addition, obscure GI bleeding refers to recurrent or persistent GI bleeding from a source that cannot be identified after esophagogastroduodenoscopy or colonoscopy. The small intestine is the largest part of the alimentary tract. It extends from the pylorus to the cecum. The small intestine is difficult to access owing to its long length. Moreover, it is not fixed to the abdominal cavity. When hemorrhage occurs in the small intestine, the source cannot be found in many cases because of the characteristics of the small intestine. In practice, small-intestinal bleeding accounts for most of the obscure GI bleeding. Therefore, in this review, we introduce and describe systemic approaches and examination methods, including video capsule endoscopy and balloon enteroscopy, that can be performed in patients with suspected small bowel bleeding in clinical practice.

• Clinical Endoscopy
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• 제56권3호
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• pp.333-339
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• 2023

Background/Aims: Intragastric balloon (IGB) is the only available endoscopic bariatric and metabolic therapy in Korea. End-ball (Endalis) has the longest history of clinical use among the IGBs available in Korea. However, little clinical data on this system have been reported. In this study, we aimed to evaluate the efficacy and safety of End-ball in Korea. Methods: We performed a retrospective cohort study of patients who underwent IGB insertion (End-ball) from 2013 to 2019. Demographic and anthropometric data were collected. The efficacy and safety of IGB treatment were analyzed. Results: In total, 80 patients were included. Mean age was 33.7 years and 83.8% were female. Initial body mass index was 34.48±4.69 kg/m². Body mass index reduction was 3.72±2.63 kg/m² at the time of IGB removal. Percent of total body weight loss (%TBWL) was 10.76%±6.76%. Percentage excess body weight loss was 43.67%±27.59%. Most adverse events were minor, and 71.4% of participants showed nausea, vomiting, or abdominal pain. Conclusions: IGB treatment showed good efficacy and safety profile in Korean patients with obesity. In terms of %TBWL and percentage excess body weight loss, the efficacy was similar to that in the Western population.

• Clinical Endoscopy
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• 제56권4호
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• pp.391-408
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• 2023

With an aging population, the number of patients with difficulty in swallowing due to medical conditions is gradually increasing. In such cases, enteral nutrition is administered through a temporary nasogastric tube. However, the long-term use of a nasogastric tube leads to various complications and a decreased quality of life. Percutaneous endoscopic gastrostomy (PEG) is the percutaneous placement of a tube into the stomach that is aided endoscopically and may be an alternative to a nasogastric tube when enteral nutritional is required for four weeks or more. This paper is the first Korean clinical guideline for PEG developed jointly by the Korean College of Helicobacter and Upper Gastrointestinal Research and led by the Korean Society of Gastrointestinal Endoscopy. These guidelines aimed to provide physicians, including endoscopists, with the indications, use of prophylactic antibiotics, timing of enteric nutrition, tube placement methods, complications, replacement, and tube removal for PEG based on the currently available clinical evidence.

• Clinical Endoscopy
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• 제56권4호
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• pp.470-478
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• 2023

Background/Aims: Metachronous recurrence incidences and risk factors following endoscopic submucosal dissection (ESD) for gastric adenocarcinoma and dysplasias were investigated. Methods: Retrospective review of electronic medical records of patients who underwent gastric ESD at The Catholic University of Korea, Yeouido St. Mary's Hospital. Results: A total of 190 subjects were enrolled for analysis during the study period. The mean age was 64.4 years and the male sex occupied 73.7%. The mean observation period following ESD was 3.45 years. The annual incidence rate of metachronous gastric neoplasms (MGN) was about 3.96%. The annual incidence rate was 5.36% for the low-grade dysplasia group, 6.47% for the high-grade dysplasia group, and 2.74% for the EGC group. MGN was more frequent in the dysplasia group than in the EGC group (p<0.05). For those with MGN development, the mean time interval from ESD to MGN was 4.1 (±1.8) years. By using the Kaplan-Meier model, the estimated mean MGN free survival time was 9.97 years (95% confidence interval, 8.53-11.40) The histological types of MGN were not related to the primary histology types. Conclusions: MGN following ESD developed in 3.96% annually and MGN was more frequent in the dysplasia group. The histological types of MGN did not correlate with those of primary neoplasm.

• Clinical Endoscopy
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• 제56권5호
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• pp.604-612
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• 2023

Background/Aims: We developed a new endoscopic submucosal dissection (ESD) simulator and evaluated its efficacy and realism for use training endoscopists. Methods: An ESD simulator was constructed using polyvinyl alcohol hydrogel sheets and compared to a previous ESD simulator. Between March 1, 2020, and December 30, 2021, eight expert endoscopists from three different centers analyzed the procedure-related factors of the simulator. Five trainees performed gastric ESD exercises under the guidance of these experts. Results: Although the two ESD simulators provided overall favorable outcomes in terms of ESD-related factors, the new simulator had several benefits, including better marking of the target lesion's limits (p<0.001) and overall handling (p<0.001). Trainees tested the usefulness of the new ESD simulator. The complete resection rate improved after 3 ESD training sessions (9 procedures), and the perforation rate decreased after 4 sessions (12 procedures). Conclusions: We have developed a new ESD simulator that can help beginners achieve a high level of technical experience before performing real-time ESD procedures in patients.

• Journal of Hospice and Palliative Care
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• 제9권2호
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• pp.93-100
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• 2006

목적: 본 연구는 말기 암 환자의 호스피스 완화의료에 대한 의사들의 태도에 대하여 알아보고자 하였다. 방법: 서울과 경지지역의 종합병원에 근무하는 전문의를 대상으로 호스피스 완화의학 연구회에서 자체 개발한 설문지를 이용하여 말기 암 환자에서 호스피스 완화의료에 대한 태도를 조사하였다. 설문지는 총 17문항으로 구성되었다. 수집된 자료는 실수, 중앙값과 백분율로 분석되었다. 결과: 총 81명(남자 46명, 여자 35명)이 설문지에 응답하였으며 나이의 중앙값은 35세였다. 내과가 36명(44.4%)으로 가장 많았다. 전문의 경력의 중앙값은 4년이었다. 1주일에 진료를 하는 환자 수는 거의 환자를 보지 않는 경우가 43명(53.2%)으로 가장 많았다. 호스피스 완화의료의 정확한 정의를 알고 있는 의사수는 37명(45.6%)이었다. 호스피스 완화의료의 필요성에 대하여 80명(98.8%)이 필요하다고 응답하였고 이 중에 73명(91.2%)이 완화의학 전문의가 필요하다고 응답하였다. 말기 암 환자에 대하여 적극적으로 호스피스 완화의료에 의뢰하겠는가에 대한 질문에 55명(67.9%)이 그렇게 하겠다고 응답하였으며 이 중 17명(30.9%)은 주저한 경험이 있는데 이유로 가족의 반대가 6명(35.3%)으로 가장 많았으며 다음으로 '환자를 포기하는 것 같아서'로 응답한 의사가 4명(23.5%)이었다. 적극적으로 호스피스 완화의료에 의뢰하지 않은 22명(27.2%)에 대하여 이유로 '환자를 포기하는 느낌'과 기타 사항으로 '절차를 모른다'가 각각 6명(27.2%)으로 가장 많았다. 37명(45.7%)의 의사가 임종 전 3개월에 호스피스 완화의료를 받는 것이 가장 좋다고 응답하였으며 가장 도움을 받는 것은 정신적, 심리적 조절이라고 응답한 의사가 58명(71.6%)으로 가장 많았다. 결론: 대부분의 의사들이 호스피스 완화의료의 필요성은 인식하고 있으나 말기 암 환자에 대한 호스피스 완화의료에 의뢰하는 적극적인 자세는 부족하였다. 의사들에게 지속적인 호스피스 완화의료에 대한 교육과 정보, 홍보가 필요하리라고 생각된다.

• Journal of Hospice and Palliative Care
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• 제16권3호
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• pp.175-182
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• 2013

목적: 말기암환자의 영성은 호스피스완화의료에서 중요하게 고려되어야 할 영역이지만 아직 이에 대한 연구자료가 부족하다. 따라서 이번 연구에서는 호스피스 병동에 입원해 있는 말기 암환자들을 대상으로 영적 안녕과 통증, 불안 및 우울과의 연관성에 대하여 살펴보았다. 방법: 서울소재 일개 대학병원에 입원해 있는 환자를 대상으로 연구자와 연구간호사가 연구에 동의한 50명의 환자에게 자기 기입식 설문지를 배부하는 방법으로 설문을 시행하였다. 영적 안녕지수의 측정은 Functional Assessment of Chronic-Illness Therapy-Spirituality (FACIT-Sp)의 영적 상태 12문항을 이용하였으며 병원 우울불안지수는 Hospital anxiety and depression scale (HADS), 통증지수의 측정은 BPI-K를 이용하였다. 수집된 자료는 Spearmans' rank test, T-test, univariate and multivariate regression analysis를 이용하여 분석하였다. 결과: 영적 안녕은 평균 통증 강도(r=-0.283, P<0.05), 불안 하부척도(HADS-A)(r=-0.613, P<0.05), 우울 하부척도(HADS-D)(r=-0.526, P<0.05)와 상관관계를 보였다. 다른 변수들의 영향을 보정한 뒤에도 영적 안녕은 종교유무(OR=9.193, 95% CI=4.158~14.229, P<0.001)와 불안하부척도(OR=-1.03, 95% CI=-1.657~-0.403, P=0.002)와 유의한 상관관계를 보였다. 결론: 말기암환자의 영적 안녕감은 통증, 우울, 불안 점수와 유의한 상관관계를 가졌으며 종교가 있고 우울지수가 낮은 경우 영적 안녕감의 증가와 유의한 상관관계를 가졌다. 추후 전향적 연구를 통한 영적 말기암환자의 영적 중재 및 영적 지지에 대한 노력이 필요할 것으로 생각된다.