• Asian-Australasian Journal of Animal Sciences
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• v.15 no.9
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• pp.1250-1256
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• 2002

A novel fine-mapping method exploiting linkage disequilibrium (LD) was applied to better refine the quantitative trait loci (QTL) positions for milk production traits on bovine chromosome 14 in the pedigree comprising 22 paternal half-sib families of a Black-and-White Holstein-Friesian grand-daughter design in the Netherlands for a total of 1,034 sons. The chromosome map was constructed with the 31 genetic markers spanning 90 Kosambi cM with the average inter-marker distance of 3.5 cM. The linkage analyses, in which the effects of sire QTL alleles were assumed random and the random factor of the QTL allelic effects was incorporated into the Animal Model, found the QTL for milk, fat, and protein yield and fat and protein % with the Lod scores of 10.9, 2.3, 6.0, 25.4 and 3.2, respectively. The joint analyses including LD information by use of multi-marker haplotypes highly increased the evidence of the QTL (Lod scores were 25.1, 20.9, 11.0, 85.7 and 17.4 for the corresponding traits, respectively). The joint analyses including DGAT markers in the defined haplotypes again increased the QTL evidence and the most likely QTL positions for the five traits coincided with the position of the DGAT gene, supporting the hypothesis of the direct causal involvement of the DGAT gene. This study strongly indicates that the exploitation of LD information will allow additional gains of power and precision in finding and localising QTL of interest in livestock species, on the condition of high marker density around the QTL region.

• Korean Journal of Poultry Science
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• v.35 no.4
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• pp.335-339
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• 2009

The very low density apolipoprotein-II (apoVLDL-II) gene is closely related with the constitution of the lipoprotein in various tissues. The apoVLDL-II gene have main functions for reducing fat elements from tissues and muscles. Previous results indicated that the polymorphisms in apoVLDL-II gene were positively related with growth and body composition traits in chicken. In this study, we analyzed previously identified apoVLDL-II gene polymorphisms using the PCR-RFLP method and investigated allele and genotype frequencies in three chicken breeds. Data indicated that Korean native chicken and Korean Oge chicken have similar B and F gene frequencies, indicating that this marker can be used for the improvement of growth and body composition traits in those breeds and can be used as marker assisted selection with further verifications.

• Journal of Ship and Ocean Technology
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• v.5 no.2
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• pp.50-61
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• 2001

In this paper, nonlinear interactions between water waves and a horizontally submerged circular cylinder are numerically simulated. In this case, the nonlinear interactions between them generated a wave breaking phenomenon. The wave breaking phenomenon plays an important role in the wave farce. Negative drifting forces are raised at shallow submerged cylinders under waves because of the wave breaking phenomenon. For the numerical simulation, a finite difference method based on the unsteady incompressible Navier-Stokes equations and the continuity equation is adopted in the rectangular grid system. The free surface is simulated with a computational simulation method of two-layer flow by using marker density. The results are compared with some existing computational and experimental results.

• 한국전산유체공학회:학술대회논문집
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• 2011.05a
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• pp.395-406
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• 2011

In this research a numerical simulation method is developed for moving body in free surface flows using fixed staggered rectangular grid system. The non-linear free surface near the body is defined by marker-density method. The body boundary is defined by line segment connecting the points where the body surface and grid line meet. Continuity equation and Navier-Stokes equations are used as governing equations and the equations are coupled with two-step projection method. The velocities and pressures of body boundary and free surface cells are calculated with simultaneous iterative method. To treat a body movement in a fixed grid system, the volume displaced by moving body is added to the divergence of the body boundary cell. For the verification of the present numerical method. vortex shedding period of advancing cylinder is calculated and the period is compared with existing experiment results. Moreover, added mass and damping coefficients of a vertically excited box are calculated and the computed results are compared with published experiment results. Impulsive pressure and water level variation due to sloshing phenomenon are simulated and the results are compared with published experiment results. Varying the plunger shape, the waves generated by plunging type wave maker are compared with the 2nd order Stokes wave theory The plunger shape generating the wave that shows the best agreement with the theory is represented.

• YAKHAK HOEJI
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• v.50 no.1
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• pp.26-32
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• 2006

Osteocalcin is a vitamin K dependent and bone specific protein which plays an important role in the regulation of bone and calcium metabolism. In this study, we evaluated the relationship between the C298T polymorphism in the osteocalcin gene and bone mineral density (BMD) in Korean young men and their interaction with physical activity. BMDs of the femoral neck and lumbar spine were measured using dual energy X-ray absorptiometry, and the C298T polymorphism in the osteocalcin gene determined using polymerase chain reaction (PCR)-HindIII restriction fragment length polymorphism (RFLP) method. We did not observe any significant differences in the femoral neck and lumbar spine BMDs across genotypes of this polymorphism in controls, athletes or combined groups, respectively (P>0.05). Therefore, our data suggest that the C298T polymorphism in the osteocalcin gene is not a suitable genetic marker for the susceptibility to BMD.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2006.11a
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• pp.261-264
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• 2006

This paper deal with development of dredging equipment that proper water head elimination method changing transitional dredging method. Numerical simulation and model test were accomplished for development of seabed sediment inhalation equipment using water head. Sediment elimination system by the difference of water head has been analysed by numerical method. Model test was achieved for inhalation equipment performance test using water head by primary design. Also sediment elimination system has designed and developed that doesn't occur secondary pollution phenomenon. To verify the numerical results are compared with experimental results.

• Journal of the East Asian Society of Dietary Life
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• v.17 no.1
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• pp.1-10
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• 2007

The effects of mulberry-leaf powder Tofu(MPT) on anthropometric measurements, including bone mineral density(BMD) in the right carpus, biochemical bone turnover markers, serum levels of lipids and macrominerals, were investigated in 30 smoking male adults who lived in Choongnam were given MPT(100 g/day) for 4 weeks. The average ages, number of smoked cigarettes and packyear were 22.38 years, 15.12/day and 3.54 years, respectively. The nutrient contents per 100 g MPT were 86.10 kcal energy, 8.98 g protein, 0.53 mg fiber, 211.33 mg Ca and 1.59 g fat. Anthropometric measurements, including dietary intake using the 24-hours recall method, carpal BMD using DEXA, serum levels of protein, albumin and glucose, lipid profiles (cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol) with Al(atherosclerosis index), HTR, CRF, LHBt, some biomarkers of BMD(serum alkaline phosphatase activity, osteocalcin, urinary DPD), and serum macrominerals(Ca, Ca/P ratio, Mg) and Pb were analyzed before and after consumption of MPT. After MPT consumption, dietary intakes of plant protein, total Ca and plant Ca increased significantly, but there were no significant differences in anthropometric measurements, BMD with bone metabolism markers, serum levels of protein, albumin or glucose, lipid profiles with AI, HTR, LHR and CRF.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.5
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• pp.617-623
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• 2008

A fine-mapping method exploiting linkage disequilibrium was used to detect quantitative trait loci (QTL) on the X chromosome affecting milk production, body conformation and productivity traits. The pedigree comprised 22 paternal half-sib families of Black-and-White Holstein bulls in the Netherlands in a grand-daughter design for a total of 955 sons. Twenty-five microsatellite markers were genotyped to construct a linkage map on the chromosome X spanning 170 Haldane cM with an average inter-marker distance of 7.1 cM. A covariance matrix including elements about identical-by-descent probabilities between haplotypes regarding QTL allele effects was incorporated into the animal model, and a restricted maximum-likelihood method was applied for the presence of QTL using the LDVCM program. Significance thresholds were obtained by permuting haplotypes to phenotypes and by using a false discovery rate procedure. Seven QTL responsible for conformation types (teat length, rump width, rear leg set, angularity and fore udder attachment), behavior (temperament) and a mixture of production and health (durable prestation) were detected at the suggestive level. Some QTL affecting teat length, rump width, durable prestation and rear leg set had small numbers of haplotype clusters, which may indicate good classification of alleles for causal genes or markers that are tightly associated with the causal mutation. However, higher maker density is required to better refine the QTL position and to better characterize functionally distinct haplotypes which will provide information to find causal genes for the traits.

• 한국전산유체공학회:학술대회논문집
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• 1996.05a
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• pp.85-92
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• 1996

Numerical simulations are made for the three-dimensional flow around a wing in ground effect craft haying the complex geometry. A numerical tool is developed for the primary design of hull and wing shape of practical Wing-In-Ground effect(WIG) stop. The finite-difference method is utilized to descretize the governing equations and pressure field is obtained by using Marker-And-Cell(MAC) method. The air and water flows are simultaneously simulated in the time-marching solution procedure for the Navier-Stokes equation. The porosity technique and the density function are devised for the implementation of the three-dimensional body-boundary and the free-surface conditions, respectively. In this paper, a craft is modeled simply by three blocks containing a wing mounted on a main body horizontally, with the endplate. The numerical calculations of a WIG advancing in a calm water are performed and the WIG-generated wave profiles are also obtained. In the final paper, details of the numerical methods employed for the present study and calculated results are discussed.

• Bulletin of the Society of Naval Architects of Korea
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• v.25 no.4
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• pp.13-27
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• 1988

Two version of the TUMMAC(Tokyo University Modified Marker-And-Cell) method, i.e., $TUMMAC-IV_{vm1}$ and TUMMAC-VI are applied to two water-wave problems. The ship wave of a Series 60 model($C_B=0.6$) and of the fore-body of a HSVA tanker model are simulated by the $TUMMAC-IV_{vm1}$ method are the results are compared with the experimental results. From the comparison with the experimental data it is ascertained that the $TUMMAC-IV_{vm1}$ method is useful for the analysis of the realized by the TUMMAC-VI method is useful for the analysis of the characteristics of nonlinear ship waves. Three-dimensional wave breaking is realized by the TUMMAC-VI method in the simulation of a flow about a vertical rectangular cylinder. From the results of this simulation, it is shown that the TUMMAC-VI method is very available for the simulation of 3-dimensional wave breaking phenomena.