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The Distribution of C298T Polymorphism in the Oseteocalcin Gene from Korean Male Athletes and its Association with Bone Mineral Density  

Jung, In-Geun (College of Physical Education, Hanyang University)
Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University)
Kim, Ji-Young (Dept. of Life Science, Sahmyook University)
Oh, Sang-Duk (College of Physical Education, Hanyang University)
Ha, Nam-Joo (Dept. of Pharmacy, Sahmyook University)
Publication Information
YAKHAK HOEJI / v.50, no.1, 2006 , pp. 26-32 More about this Journal
Abstract
Osteocalcin is a vitamin K dependent and bone specific protein which plays an important role in the regulation of bone and calcium metabolism. In this study, we evaluated the relationship between the C298T polymorphism in the osteocalcin gene and bone mineral density (BMD) in Korean young men and their interaction with physical activity. BMDs of the femoral neck and lumbar spine were measured using dual energy X-ray absorptiometry, and the C298T polymorphism in the osteocalcin gene determined using polymerase chain reaction (PCR)-HindIII restriction fragment length polymorphism (RFLP) method. We did not observe any significant differences in the femoral neck and lumbar spine BMDs across genotypes of this polymorphism in controls, athletes or combined groups, respectively (P>0.05). Therefore, our data suggest that the C298T polymorphism in the osteocalcin gene is not a suitable genetic marker for the susceptibility to BMD.
Keywords
athletes; osteocalcin and polymorphism;
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