• 대한통합의학회지
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• 제10권4호
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• pp.261-275
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• 2022

Purpose : According to the Korean Diabetes Association, the number of metabolic disease patients in Korea is approximately 14.97 million as of 2020;, the prevalence of diabetes among adults over 30 years old is 44.3 %, and the prevalence of diabetes in the elderly over 65 years old is 50.4%. These individuals exposed to the risk of complications. Therefore, the purpose of this study was to determine a distribution method for a customized fusion exercise marine healing program for metabolic disease patients. Methods : We have searched numerous papers concerning artificial intelligence (AI), virtual reality (VR), augmented reality (AR), and marine resources related to marine healing programs that can be introduced in marine healing centers for people with metabolic diseases Results : Through the production of various marine resources and evidence-based exercise programs, the provision of exercise programs using AI, and the development of exercise platforms using AR and VR, we were able to establish guidelines for how to operate marine healing programs at marine healing centers. Conclusion : Korea has much more diverse marine healing resources than other advanced countries in the marine healing industry. However, the development of these resources has only just begun. It is hoped that the studied marine healing program will be of great help to metabolic patients by creating contents that will be implemented in marine healing centers by using the cutting-edge technologies and various marine resources that Korea possesses.

• 대한통합의학회지
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• 제10권1호
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• pp.109-118
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• 2022

Purpose : The study to verify the effectiveness of the Soomchi combined marine healing program by analyzing the physical composition of the subjects, their blood lipids, and the effects of the program on their lung health-related variables, and heart rate variability variables. Methods : In the experiment, the Soomchi combined marine healing program was conducted for 5 hours a day, 5 days a week. on 15 participants. The results of their body composition, blood lipids, lactic acid, blood pressure, PEF, FEV1 and maximum oxygen intake were analyzed before and after the subjects completed the Soomchi program. For the statistical analysis, the mean and standard deviation (M±SD) of each variable were calculated using SPSS version 20 and an independent t-test was conducted to test for the amount of change in the participants before and after the Soomchi combined marine healing program. All significant levels were set to α=.05. As a result of the experiment Results : First, no statistically significant differences were found in the changes in body composition after the 5-day combined marine healing program was completed. Second, regarding the changes in blood component after the program was conducted, statistically significant differences were found in the lactic acid (p<.05). That is, the experimental group showed a significant decrease in lactic acid after the program whereas the control group showed a significant increase. Third, systolic blood pressure decreased significantly and while in PEF and FEV1 increased significantly in the experimental group after the program. Fourth, the LF of the control group significantly decreased after 5 days. Conclusion : After the Soomchi Lung Health Ocean Healing Program, positive physical changes were observed in the lung health variables and heart rate variability of the participants.

• 해양환경안전학회지
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• 제29권7호
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• pp.750-759
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• 2023

해양치유 프로그램에 대한 관심은 코로나19 팬데믹 이후 정부와 업계 실무자 모두에서 급속도로 증가하고 있다. 그러나 아직까지 소비자 관점에서 해양치유 프로그램이나 해양치유 체험에 대한 유용성, 만족도, 편익 등을 이해하고자 시도한 연구는 부족한 실정이다. 이에 이 논문에서는 후기수용모델을 적용하여 해양치유 프로그램 참여자의 지각된 유용성과 기대일치, 만족, 지속참여의도 간 관계를 구조적으로 분석하고자 하였다. 자료수집은 부산시 해양치유 프로그램 운영 기간인 2022년 9~10월까지 매 주말 사전 훈련된 면접원에 의한 면접조사 방식으로 실시하였고, 총 203부의 유효 표본을 분석에 활용하였다. 분석 결과 해양치유 프로그램에 대한 기대일치는 프로그램 참여자의 만족과 프로그램의 지각된 유용성에 긍정적인 영향을 미치는 것으로 나타났고, 해양치유 프로그램 참여자 만족은 프로그램 지속참여의도에 긍정적인 영향을 미치는 것으로 나타났다. 해양치유 프로그램에 대한 지각된 유용성 역시 프로그램 참여자 만족 및 지속참여의도에 긍정적인 영향을 미쳤다.

• 대한통합의학회지
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• 제8권1호
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• pp.37-45
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• 2020

Purpose : The purpose of this study is to verify the effectiveness of combined marine healing programs by analyzing the physical composition of elderly musculoskeletal and metabolic patients, the risk factors of metabolic syndrome and the effects of the inflammatory factors, the C -reactive protein (CRP). Methods : Individuals with musculoskeletal and metabolic diseases were identified, and marine healing programs were conducted for f our hours each day for two weeks with 11 elderly participants. A one-way RM ANOVA was conducted to determine the differences due to treatment with composite marine healing systems. The results are as follows. Results : After a two-week ocean healing program, weight decreased the most, while BMI also decreased and muscle mass increased. Waist circumference, a risk factor for metabolic syndrome and CRP, decreased, and CRP demonstrated a decreasing trend. Conclusion : The above results show that the two-week marine healing program has a positive effect on the body composition and inflammatory factors of elderly musculoskeletal and metabolic patients.

• 농업과학연구
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• 제51권1호
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• pp.9-23
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• 2024

This study investigates the physiological and psychological effects of a nature-based outdoor activity program in an environment reflecting the characteristics of forest and coastal areas on 30 firefighters (average age: 40.4 ± 9.8 years) who are frequently exposed to dangerous situations. Blood pressure, pulse pressure, and heart rate variability were used as physiological measurement indicators, and the Korean versions of PANAS (positive affect and negative affect schedule), WEMWBS (Warwick-Edinburgh mental well-being scale), and PRS (perceived restorativeness scale) were used as psychological measurement indicators. For four days and three nights, the participants experienced programs at Hallyeohaesang Nature Center and the surrounding mountains, seas, and islands, utilizing forest resources such as trekking on forest trails, walking barefoot, taking aromatic footbaths, meditating in forest oxygen domes, and lying on relaxation chairs, and programs utilizing marine resources such as taking a boat to an island, walking on forest trails with seascape views, and sailing on a yacht. Participants' systolic blood pressure and pulse pressure decreased, and participants' positive emotions increased and negative emotions decreased after the program. There was a statistically significant increase in mental well-being and perceived restorative environment. Through this study, it was found that nature-based outdoor activity programs based on forest and marine resources are effective in physiological and psychological stability of firefighters. It is hoped that the results of this study will be applied to other high-risk workers for PTSD, who have high stress levels, by combining forest healing and marine healing, and expanding the scope and diversity of programs in more diverse environments and conditions.

• 대한통합의학회지
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• 제9권4호
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• pp.139-147
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• 2021

Purpose : The purpose of this study is to verify the effectiveness of combined marine healing programs by analyzing the physical composition of metabolic patients, blood lipids and the effects of the inflammatory factors, the C -reactive protein(CRP). Methods : the combined marine treatment program was conducted for 6 hours a day, 5 days a week on the 10 adult patients with metabolic diseases and the results of their body composition, blood lipids and CRP were analyzed before and after the subjects completed the program. For the statistical analysis, the mean and standard deviation (M±SD) of each variable were calculated using SPSS version 20 and a paired t-test was conducted in order to test for the differences before and after the combined marine treatment program. All significant levels were set to 𝛼=.05. As a result of the experiment Results : First, regarding the changes in body composition and blood pressure after the 5-day combined marine treatment program was completed, there were statistically significant differences found in weight (p<.01) and systolic blood pressure (p<.05). Second, regarding the changes in blood lipids and CRP after the program was conducted, there were statistically significant differences found in total cholesterol (p<.05) while there was no statistically significant difference found in the variables of neutral fat, low-density lipoprotein cholesterol and CRP. Conclusion : the study results were integrated, the 5-day combined marine treatment program had a positive effect on weight, blood pressure and total cholesterol in the patients with metabolic diseases. Therefore, the short-term marine treatment program was thought to be effective for them. However, considering no significant differences were found in neutral fat, low-density lipoprotein cholesterol and CRP, further development and research on combined marine treatment programs should be conducted in the long term to create an effective program for patients with metabolic diseases.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2023년도 제68차 하계학술대회논문집 31권2호
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• pp.735-736
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• 2023

본 연구는 해양치유자원에서 효능을 입증된 시각적 및 청각적인 자원을 포함한 해양경관자원을 디지털화 한 디지털 해양치유프로그램을 제안하고자한다. 이 프로그램으로 해양치유의 간접경험과 해양치유자원에 대한 올바른 정보를 제공함으로써 해양치유에 대한 수요를 촉진하고 지역경제 활성화로 기여할 수 있다.

• BMB Reports
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• 제42권10호
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• pp.655-660
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• 2009

The potential anti-metastasis and anti-invasion activities of early growth response gene-1 (Egr-1) and claudin-3, a tight junction (TJ)-related protein, were evaluated using histone deacetylase (HDAC) inhibitors in human hepatocarcinoma cells. The results of wound healing and Transwell assays showed that HDAC inhibitors such as trichostatin A and sodium butyrate inhibited cell migration and invasion. HDAC inhibitors markedly induced Egr-1 expression during the early period, after which expression levels decreased. In addition, the down-regulation of snail and type 1 insulin-like growth factor receptor (IGF-1R) in HDAC inhibitor- treated cells induced the upregulation of thrombospondin-1 (TSP-1), E-cadherin and claudin-3. Cells transfected with Egr-1 and claudin-3 siRNA displayed significant blockage of HDAC inhibitor-induced anti-invasive activity. Collectively, these findings indicate that the up-regulation of Egr-1 and claudin-3 are crucial steps in HDAC inhibitor-induced anti-metastasis and anti-invasion.