• The Korean Journal of Nuclear Medicine
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• v.27 no.1
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• pp.59-64
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• 1993

To evaluate the usefulness and differences in diagnosing coronary artery disease (CAD) between men and women of intravenous dipyridamole $^{99m}Tc$-MIBI myocardial SPECT, we obtained $^{99m}Tc$-MIBI myocardial SPECT and compared with the findings of coronary angiographies. Ninety eight male and 37 female patients who underwent dipyridamole $^{99m}Tc$-MIBI myocardial imaging within one month of cardiac catheterization were studied. Scans were considered abnormal if perfusion defect was detected and the defect size was more than 12% for left anterior descending artery (LAD) and circumflex (LCX) and 8% for right coronary artery (RCA) territories. Lesions${\geqq}$50% luminal diameter narrowing were considered significant CAD. Overall sensitivity for detection of CAD was 94.3% in men and 96.4% in women; specificity was 70% in men and 52.6% in women (P=not significant, ns). Vessel-matched sensitivity was 75.3% in men and 72.7% in women (P=ns): specificity was 84.6% in men and 67.9% in women (P < 0.025). For individual coronary artery, the sensitivity in men and women was 87.7%, 81.8% for LAD; 78%, 83.3% for RCA and 52.2%, 46.7% for LCX (P=ns): the specificity was 80%, 40% for LAD (P<0.01), 82.5%, 68.4% for RCA, 88.9%, 86.4% for LCX (P=ns). The hemodynamic parameter after intravenous dipyridamole in men and women were significantly changed; the heart rate was increased and systolic, diastolic blood pressure was decreased. Adverse effects were reported in 58.8% of men and 72.7% in women (P=ns). The incidence of chest pain and headache were higher in women. There was no significant difference in the incidences of nausea, abdominal pain, dizziness, facial flushing, dyspnea. In conclusion, dipyridamole $^{99m}Tc$-MIBI myocardial SPECT is a safe, noninvasive test for evaluation of CAD. There was no gender difference to detect CAD, but more false-positive rate in women especially in the territory of LAD.

• 한국해양학회지
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• v.22 no.3
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• pp.143-152
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• 1987

The digital data were obtained using Kennedy 9000 magnetic tape deck which was connected to the SMS960 side scan sonar during the field operations. The data of three consecutive survey tracks near Seongsan-po, Cheju were used for the development of this study. The softwares were mainly written in Fortran-77 using VAX 11/780 MINI-COMPUTER (CPU Memory; 4MB). The established mapping system consists of the pretreatment and the digital processing of seafloor image data. The pretreatment was necessary because the raw digital data format of the field magnetic tapes was not compatible to the VAX system. Therefore the raw data were read by the personal computer using the Assembler language and the data format was converted to IBM compatible, and next data were communicated to the VAX system. The digital processing includes geometrical correction for slant range, statistical analysis and cartography of the seafloor image. The sound speed in the water column was assumed 1,500 m/sec for the slant range correction and the moving average method was used for the signal trace smoothing. Histograms and cumulative curves were established for the statistical analysis, that was purposed to classify the backscattering strength from the sea-bottom. The seafloor image was displayed on the color screen of the TEKTRONIX 4113B terminal. According to the brief interpretation of the result image map, rocky and sedimentary bottoms were very well discriminated. Also it was shown that the backscattered acoustic pressurecorrelateswith the grain size and sorting of surface sediments.

• Ecology and Resilient Infrastructure
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• v.2 no.1
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• pp.64-79
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• 2015

We investigated the tidal current, hydrographic data, and benthic environment of major sea cucumber (Holothuroidea, de Blainville, 1834) habitats in Baengnyeongdo, Jindo and Uljin to understand the optimal environmental or ecological habitat for sea cucumbers. The three study areas were characterized by a cold-water mass of temperatures ranging $12{\sim}18^{\circ}C$, with an active circulation between the surface and deep waters. According to an analysis of the tidal current map, a strong flow velocity of $100{\sim}120cm\;s^{-1}$ appeared in Baengnyeongdo and Jindo. The three sea cucumber habitats showed the common characters of a bottom sediment composed of sand-silt, a diverse seaweed colony and benthic organisms, and boulders and rocks which provide a hideout for the organisms. We aimed to draw the optimal habitat condition for sea cucumbers in Korea, and the result showed that the low water temperature, rapid water flow, active vertical mixing between surface and deep waters, bottom composed by sand-silt, large rocks, and diverse seaweed colony and benthic organism were important factors. The optimal habitat for Juvenile sea cucumbers was the intertidal areas characterized by a muddy bottom, reef, and seaweed. The optimal habitat for adult sea cucumbers was characterized by a place where sand and mud are mixed, and the body size of the sea cucumber was proportional to water depth, and the relatively large boulders and rocks compared to the intertidal area.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.48 no.4
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• pp.428-444
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• 2012

The species composition and seasonal variation of fisheries resources in Jinhae bay and Jinju bay, were studied using shrimp beam trawl through a year of 2010. During the study period, a total of 117 species were collected in Jinhae bay. Species included were 63 species in Pisces and 24 in Crustacea. And a total of 106 species were collected in Jinju bay. Species included were 57 species in Pisces and 31 in Crustacea. The dominant species were Zoarces gilli, Crangon hakodatei and Oratosquilla oratoria in Jinhae bay, and Crangon hakodatei, Leiognathus nuchalis and Charybdis bimaculata in Jinju bay. The samples were mainly grouped according to the location and season on the SOM. Group 1 with sample sites in Jinju bay, was characterized by high values of Parapenaeopsis tenella, Leiognathus nuchalis and Hexagrammos otakii. Group 2 with sample sites in April, were dominant Crangon hakodatei and Luidia quinaria. The samples in Group 3 were high values of Charybdis bimaculata and Pleuronichthys cornutus. Group 4 with sample sites in Jinhae bay, was characterized by high densities of Zoarces gilli and Pholis fangi. The dominant species, Crangon hakodatei, were catched egg-bearing females until June. Zoarces gilli and Leiognathus nuchalis were presented small size individuals during study period. It represented that study area is an important role in spawning and nursery ground for fisheries resources.

• Journal of the Korean Geographical Society
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• v.42 no.3 s.120
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• pp.344-354
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• 2007

Estuarine wetlands for 33 watersheds in the Han River estuary were delineated on topographic maps from the 1910s, 1970s, and 2000s. Then, these data were used to address the issue of spatial distribution and temporal variation. Watershed characteristics such as drainage density, location, watershed size, slope, and elevation were identified for each watershed to determine the relationship between watershed characteristics and spatial distribution of estuarine wetlands. The analysis of estuarine wetlands indicated that wetlands in the estuary had declined gradually between the 1910s and the 1970s, although most wetlands were lost since the 1970s mainly caused by the large development projects related to urban expansion in metropolitan Seoul. The sediment composition and formation processes of the wetlands differed with watershed location; mud flats dominate in the lower part of the estuary, and relatively more sandy and emergent-plant wetlands occur near the main channel and tributaries of the Han River. Relatively more estuary wetlands occur in large watersheds, which have high slopes and low elevations. Estuarine wetlands have been lost dramatically in the densely populated watershed regions (i.e., Han River Seoul, Han River Goyang, West Han River), while relatively more wetlands have remained in undeveloped regions, including the Lower Imjin River and Lower Han River. In particular, anthropogenic disturbance has played an important role in the loss of wetland through the conversion of wetland into agricultural and developed land.

• Geophysics and Geophysical Exploration
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• v.12 no.1
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• pp.69-76
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• 2009

We report an implementation of the Ground Penetrating Radar (GPR) survey at a site that corresponds to a ruined castle. The objective of the survey was to characterise buried archaeological structures such as walls and tiles in Van Khan Tooril's Ruin, Mongolia, by 2D and 3D GPR techniques. GPR datasets were acquired in an area 10mby 9 m, with 10 cm line spacing. Two datasets were collected, using GPR with 500MHz and 800MHz frequency antennas. In this paper, we report the use of instantaneous parameters to detect archaeological targets such as tile, brick, and masonry by polarimetric GPR. Radar polarimetry is an advanced technology for extraction of target scattering characteristics. It gives us much more information about the size, shape, orientation, and surface condition of radar targets. We focused our interpretation on the strongest reflections. The image is enhanced by the use of instantaneous parameters. Judging by the shape and the width of the reflections, it is clear that moderate to high intensity response in instantaneous amplitude corresponds to brick and tiles. The instantaneous phase map gave information about the location of the targets, which appeared as discontinuities in the signal. In order to increase our ability to interpret these archaeological targets, we compared the GPR datasets acquired in two orthogonal survey directions. A good correlation is observed for the alignments of reflections when we compare the two datasets. However, more reflections appear in the north-south survey direction than in the west-east direction. This is due to the electric field orientation, which is in the horizontal plane for north-south survey directions and the horizontally polarised component of the backscattered high energy is recorded.

• Korean Journal of Environment and Ecology
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• v.24 no.2
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• pp.186-193
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• 2010

In order to examine the traits of sluice gate water control, halophyte community formation and their inter-relations in Saemangeum, both water level condition and halophyte community formation were analyzed periodically and spatially on the topographic map with Surfer, Saemageum Spatial Analysis System, and related field reports. The traits of water level condition are that average water level in the growing period of halophytes was similar to annual average water level, annual low level and high level appeared in the growing period, and water level was usually maintained within a range of -1.0m~0.5m above mean sea level, but it has changed more frequently year by year. Routine water level control, natural disaster prevention, construction, and civil appeal took major percentages of the reasons for sluice gate's opening and shutting. Since 2007, not only the overall control frequency of sluice gate but also its control frequency for construction and natural disaster prevention have increased outstandingly. Halophyte community had formed at a rate of 1,209ha/year in the 4,315 ha land in 2008, 6.3 times larger than in 2005, and 2,382 ha above around 1.0m was estimated to be artificially vegetated, 89.1 % of the 2,673ha-size sown area. High water level was found to be a more possible determinant than average water level or low water level in halophyte community formation and it was thought to be secondary factors whether tillage was conducted or/and whether surface sealing formed.

• Molecules and Cells
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• v.41 no.9
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• pp.830-841
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• 2018

Recent studies have indicated that microRNAs (miRNAs) play an important role in hepatocellular carcinoma (HCC) progression. In this study, we showed that miR-766-3p was decreased in approximately 72% of HCC tissues and cell lines, and its low expression level was significantly correlated with tumour size, TNM stage, metastasis, and poor prognosis in HCC. Ectopic miR-766-3p expression inhibited HCC cell proliferation, colony formation, migration and invasion. In addition, we showed that miR-766-3p repressed Wnt3a expression. A luciferase reporter assay revealed that Wnt3a was a direct target of miR-766-3p, and an inverse correlation between miR-766-3p and Wnt3a expression was observed. Moreover, Wnt3a up-regulation reversed the effects of miR766-3p on HCC progression. In addition, our study showed that miR-766-3p up-regulation decreased the nuclear ${\beta}-catenin$ level and expression of Wnt targets (TCF1 and Survivin) and reduced the level of MAP protein regulator of cytokinesis 1 (PRC1). However, these effects of miR-766-3p were reversed by Wnt3a up-regulation. In addition, PRC1 upregulation increased the nuclear ${\beta}-catenin$ level and protein expression of TCF1 and Survivin. iCRT3, which disrupts the ${\beta}-catenin-TCF4$ interaction, repressed the TCF1, Survivin and PRC1 protein levels. Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.

• Journal of the Korean association of regional geographers
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• v.22 no.1
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• pp.211-224
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• 2016

Natural lakes are estimated in variety with that's function or value depending on age environment or geographical characteristics. There are many kind of natural lakes, but the kind of natural lake is limited in rivers in korea flowing into East Sea. However, Yeonho lake in Uljin has different geographical characteristics with oxbow lake or lagoon which is common in korea's river flowing into East Sea. Therefore the purpose of this study is to analyze geographical characteristics due to the process of Yeonho's formation. Further more research for protecting wetland is needed to adequately preserve, depending on the geomorpologic process. To analyze geographical characteristics, it was essential to compare and analyze topographical map of 1918 1956 2012 and I pictured estinated line of bedrock and longitudinal section of Nam-dae cheon(Riv) Yeonho cheon(Riv). In addition, I denoted flooded areas through design flood level of Nam-dae cheon(Riv) Yeonho cheon(Riv) and analyzed particle size distribution of deposited sediment due to consider deposit environment. The results of study are as follows. In conclusion, Yeonho lake is floodbasin which was not researched at river flowing into East Sea. Through this study, my opinion is that floodbasin can be formed in the river that is steep and short. I argue that preservation methods will be seeked by geomorphologic process of floodbasin and development of downtown.

• Journal of Korea Technology Innovation Society
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• v.15 no.2
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• pp.299-322
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• 2012

Biotechnology is considered a new propeller to national economic growth. Although BT-based converging technology is one of keywords in nowadays, few studies analyze the characteristics of Korean BT convergence market. This study has conducted the analysis of BT-based converging technology market by using patent database in KIPO (Korean Intellectual Property Office) from 2000 to 2010. We, especially, have classified BT convergence into homogeneous and heterogeneous ones, and compare the nature of BT convergence market with that of non-convergence one. To achieve the object of this study, the following methods are used: concentration across IPC technological classes; concentration of patenting activity across firms; PFS (Patent Family Size) index. Furthermore, according to FOS technology-industry table, we have intended to find new converging industry of BT heterogeneous converging technologies. As very few studies have focused on Korean converging technology market so far, this analysis is considered to be meaningful. It is found that the market of BT converging technology is rather robust than that of BT non-converging one, which refers that BT convergence shows the tendency of concentration towards few technologies by few conglomerate firms in Korea. Meanwhile, we have derived a BINET keyword map to research the convergence of sub-technologies in detail and the related industries. We expect the implications of this study to be utilized in establishing the BT-based converging technology policy.