• 한국언어정보학회지:언어와정보
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• 제3권1호
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• pp.39-63
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• 1999

Korean manner-of-motion verbs have different characteristics from locomotion verbs syntactically and semantically, and they are aptly encoded as having the primitive semantic element MOVE, not GO of Jackendoff(1990)'s Conceptual Semantics framework. This point is shown on the basis of their behavior, the inability to take the Goal 'NP-lo' phrases, the Purposive 'S-le' clauses, the 'NP-ey' phrases, and the atelic interpretation. It is further shown that the apparent locomotion verb behavior of some manner-of-motion verbs, 'exocentric' phenomenon in their meaning composition, is merely a transferred aspect of manner-of-motion verbs. Three kinds of strategies, transformational, quasi-transformational, and lexical ones, are examined to describe this phenomenon, and the lexical one is determined to be the most appropriate. The remaining part of this paper pursues the possibility of adopting Tenny's(1987, 1994) 'Aspectual Interface Hypothesis' in establishing an argument linking system with special attention to 'measuring-out', but concludes that the hypothesis can be accepted only in a restricted part of verbs, and with a modified notion of measuring-out like Jackendoff's(1996).

• 생약학회지
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• 제53권4호
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• pp.181-191
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• 2022

As the incidence of skin cancer increases every year, non-surgical treatment methods for cancer are being sought. Esculetin, a natural dihydroxy coumarin, is attracting attention as a therapeutic agent for certain diseases, such as cancer, based on its broad pharmacological activity. In this study, the anticancer ability of esculetin was evaluated using the epidermoid carcinoma cell line A431. As a result of evaluating the apoptosis ability of esculetin by MTT assay, apoptosis was observed in a time-concentration-dependent manner regardless of the presence or absence of FBS. As a result of quantitative real-time PCR, esculetin reduced cyclin D1 mRNA in a time-concentration-dependent manner. In addition, as a result of western blotting, esculetin significantly inhibited phosphorylation of ERK, JNK, and p38 in a concentration-dependent manner. The results of this study suggest that esculetin has the potential to be used as an effective natural medicine for the treatment of skin cancer.

• Journal of Korean Neurosurgical Society
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• 제64권6호
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• pp.933-943
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• 2021

Objective : Percutaneous pedicle screw (PPS) fixation is a needle based procedure that requires fluoroscopic image guidance. Consequently, radiation exposure is inevitable for patients, surgeons, and operation room staff. We hypothesize that reducing the production of radiation emission will result in reduced radiation exposure for everyone in the operation room. Research was performed to evaluate reduction of radiation exposure by modifying imaging manner and mode of radiation source. Methods : A total of 170 patients (680 screws) who underwent fusion surgery with PPS fixation from September 2019 to March 2020 were analyzed in this study. Personal dosimeters (Polimaster Ltd.) were worn at the collar outside a lead apron to measure radiation exposure. Patients were assigned to four groups based on imaging manner of fluoroscopy and radiation modification (pulse mode with reduced dose) : continuous use without radiation modification (group 1, n=34), intermittent use without radiation modification (group 2, n=54), continuous use with radiation modification (group 3, n=26), and intermittent use with radiation modification (group 4, n=56). Post hoc Tukey Honest significant difference test was used for individual comparisons of radiation exposure/screw and fluoroscopic time/screw. Results : The average radiation exposure/screw was 71.45±45.75 µSv/screw for group 1, 18.77±11.51 µSv/screw for group 2, 19.58±7.00 µSv/screw for group 3, and 4.26±2.89 µSv/screw for group 4. By changing imaging manner from continuous multiple shot to intermittent single shot, 73.7% radiation reduction was achieved in the no radiation modification groups (groups 1, 2), and 78.2% radiation reduction was achieved in the radiation modification groups (groups 3, 4). Radiation source modification from continuous mode with standard dose to pulse mode with reduced dose resulted in 72.6% radiation reduction in continuous imaging groups (groups 1, 3) and 77.3% radiation reduction in intermittent imaging groups (groups 2, 4). The average radiation exposure/screw was reduced 94.1% by changing imaging manner and modifying radiation source from continuous imaging with standard fluoroscopy setting (group 1) to intermittent imaging with modified fluoroscopy setting (group 4). A total of 680 screws were reviewed postoperatively, and 99.3% (675) were evaluated as pedicle breach grade 0 (<2 mm). Conclusion : The average radiation exposure/screw for a spinal surgeon can be reduced 94.1% by changing imaging manner and modifying radiation source from real-time imaging with standard dose to intermittent imaging with modified dose. These modifications can be instantly applied to any procedure using fluoroscopic guidance and may reduce the overall radiation exposure of spine surgeons.

• 대한한방부인과학회지
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• 제36권3호
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• pp.1-24
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• 2023

Objectives: Boeum-jeon (BEJ) is a herbal formula composed 8 Korean medicinal herbs and is traditionally used to treat inflammatory diseases. In this study, the authors tried to confirm the antioxidant efficacy of BEJ and its anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Methods: In this experiment, results of BEJ on the following two were measured as follows: (1) Antioxidant effects was measured by DPPH Radical scavenging Activity, ABTS Radical scavenging Activity. (2) Anti-Inflammatory effects were evaluated by the production amount of ROS, NO, Cytokine (PGE2, IL-1β, IL-6, TNF-α), COX-2, iNOS, TNF-α, IL-1β, IL-6, HO-1, NQO1 (the previous seven are "mRNA Expression"), COX-2, iNOS, TNF-α, IL-1β, IL-6, HO-1, NQO1, NRF2 (the previous eight are "Protein Expression") ERK, JNK, p38 (the previous three are "Protein Phosphorylation") in LPS-stimulated RAW 264.7 cells. Results: The experimental measurement results are as follows: (1) DPPH Radical scavenging Activity, ABTS Radical scavenging Activity increased in a concentration -dependent manner in the BEJ-treated group. (2) As a result of measuring anti-inflammatory efficacy, the production of ROS, NO, and Cytokine (PGE2, TNF-α, IL-1β, IL-6) in the BEJ-administered group was significantly reduced compared to the control group. (3) Among mRNA Expression levels, COX-2, iNOS, IL-1β, IL-6 and TNF-α was significantly decreased in a concentration-dependent manner than in the control group, and HO-1 and NQO1 were significantly increased in a concentration -dependent manner than in the control group. (4) Among the Protein Expression levels, COX-2, iNOS, IL-1β, IL-6 and TNF-α was significantly decreased in a concentration -dependent manner compared to the control group, and HO-1, NQO1 and NRF2 was significantly increased in a concentration-dependent manner compared to the control group. (5) As a result of Protein Phosphorylation, ERK, p38 and JNK was significantly decreased compared to the control group in a concentration-dependent manner. Conclusions: Boeum-jeon has been experimentally confirmed to have antioxidant and anti-inflammatory effects, and if the evidence for efficacy is reinforced through further studies such as in vivo studies and clinical trials in the future, it can be effectively used to treat various inflammatory diseases such as bladder inflammation and chronic pelvic inflammation.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 II
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• pp.775-778
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• 2003

In this paper, we report our quantum mechanical approach for the analysis of FinFET in a self-consistent manner. The simulation results are carefully investigated for FinFET with an electrical channel length(Leff) of 30nm and with a fin thickness(Tsi) of 10～35nm. We also demonstrated the differences in the simulations for the classical and quantum-mechanical simulation approaches, respectively. These simulation results also imply that it is necessary to solve the coupled Poisson and Schrodinger equations in a self-consistent manner for analyzing the sub-30nm MOSFETS including FinFET.

• 대한음성학회지:말소리
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• 제45호
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• pp.23-33
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• 2003

This is a study on perception errors of Korean stops in word initial position. This study will show how listeners perceive manipulated Korean stops through two experiments and I will analyze why they are confused. In addition, 1 will show those perception errors not only reflect the relationship between the place and manner of articulation but also ate deeply related to the length of aspiration.

• 음성과학
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• 제5권2호
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• pp.27-40
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• 1999

This study is concerned with articulatory and acoustic experiments about the change of the stop /t/ into its counterpart affricate before derivational and inflectional suffixes beginning with /(h)i/. The present phonetic results show that the stop consonant is articulatorily and acoustically completely neutralized into the underlying plain affricate. Thus this study provides another instance of complete neutralization of manner of articulation in Korean in addition to Kim and Jongman (1996).

• 한국측량학회:학술대회논문집
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• 한국측량학회 2003년도 춘계학술발표회 논문집
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• pp.479-484
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• 2003

The renewal of digital map takes much time and the manual process. LiDAR data allows reduction of time, automatic manner, and acquisition of the precise position. So it is used to renew the digital map of 1:5,000 scale. From the accuracy test results using aerial imagery and digitizing, renewal of digital map are feasible in automatic manner to some extent.

• 동의생리병리학회지
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• 제16권5호
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• pp.893-898
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• 2002

Citri Reticulatae Viride Pericarpium extract(CRVP) have been used in oriental medicine for many centuries as a therapeutic agent for smoothing the liver and regulating the circulation of qi, and promoting digestion and removing stagnated food. The effects of CRVP on the inhibition of brain damage in cerebral ischemia is not known. Therefore, this Study was designed to investigate the cerebral protective effects of CRVP on the transient cerebral ischemia using modern techniques, and further to provide the possibility of scientification of oriental medicine. The size of cerebral infarct size was measured by morphometry, and brain edema was measured by morphometry and brain water content determination. The results were a$ follows ; 1. Water fraction of CRVP was reduced infect area of rats brain slices which were subjected to a transient cerebral ischemia in a dose-dependent manner. 2. Methylene chloride fraction and hexane fraction of CRVP was significantly reduced infarct area of rats brain slices which were subjected to a transient cerebral ischemia in a dose-dependent manner. 3. Methylene chloride fraction and hexane fraction of CRVP was significantly reduced infarct volume of rats brain which was subjected to a transient cerebral ischemia in a dose-dependent manner. 4. Methylene Chloride fraction and hexane fraction of CRVP was significantly decreased brain edema induced by a transient cerebral ischemia in a dose-dependent manner. 5. Methylene chloride fraction and hexane fraction of CRVP was significantly decreased brain water content of rats which were subjected to a transient cerebral ischemia. It is suggested that CRVP has an anti-ischemic effect through the inhibition of brain damage in a transient cerebral ischemia, and that in future further development of main effective constituent in CRVP can provide a novel therapeutic strategy for cerebral ischemia.

• 정보처리학회논문지B
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• 제17B권1호
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• pp.23-30
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• 2010

본 논문에서는 가수 생활 50주년으로 인기를 누리고 있는 국민 여성 가수인 이미자와 패티김에 대해 사상체질 기반의 분석 방법을 적용하여 이들의 음악적 특징을 추출하였다. 이를 위해 사상의학에서 제시하고 있는 사상체질 분류 방법 중에서 얼굴 및 음성을 통해 체질을 분류하는 용모사기론적 방법을 적용하였다. 따라서 용모사기론적 방법을 공학적으로 적용하여 동일한 연령대의 음성 및 얼굴 영상의 비교 분석을 통해 사상체질 분류 결과를 정량적으로 도출하였다. 또한 실험 결과를 이미자와 패티김에게 적용하여 동일한 실험 결과값을 확인하고 이를 기반으로 두 여성 가수에 대한 사상체질 기반의 음색 특징 및 얼굴 형태의 비교 분석을 통해 그 음악적 특징을 분석하였다.