• 대한후두음성언어의학회지
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• 제24권1호
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• pp.41-46
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• 2013

Background & Objectives : The Speech Handicap Index (SHI) is used to assess speech problem of head and neck cancer patients. The aim of this preliminary study was to evaluate the reliability and validity the Korean version SHI. Materials and Methods : Sixteen patients with oral cavity cancer and 26 normal control were participated in the study. Test-retest reliability of the Korean version of SHI was completed by 20 out of 42 subjects after 2weeks. Mann-Whitney U test was used to compare the Korean version of SHI scores between normal population and patients group. The relationship between the Korean version of SHI and diadochokinesis (DDK) was investigated using Spearman correlation coefficients. Results : The Korean version of SHI provided a high internal consistency (${\alpha}$=0.99) and test-retest reliability (Spearman rho 0.98). The mean SHI scores [total (T), speech (S), and psychosocial (P)] in normal population were 0.8 (T), 0.2 (S) and 0.4 (P), whereas those in patients group were 58.1 (T), 27.9 (S) and 27.0 (P) respectively. There were significant differences in total SHI score as well as in all of the sub-SHI scores between two groups. Moreover, significant correlation between the Korean version of SHI parameters (T, S, P) and sequential motion rate (SMR) were yielded in patients group. Conclusion : The Korean version of SHIwas reliable and valid. It can be useful as a supplementary clinical tool for diagnosing and measuring treatment efficacy of speech problems related to oral cavity cancer.

• Journal of Nutrition and Health
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• 제38권10호
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• pp.880-894
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• 2005

The purposes of this study were to a) measure the IC identified of CFMC (contract foodservice management company) ,b) examine IC circumstance of CFMC, c) evaluate practically IC measurement tool of CFMC, and d) present information for selecting an adequate CFMC to clients. The questionnaires of IC measurement were handed out to 108 CFMCs, there composing of main office employees, foodservice managers, customers, and clients of 207 school,38 hospital, and 86 husiness/industry foodservices. The statistical data analysis was completed using SPSS Win (ver 12.0) for descriptive analysis, t-test, Mann-Whitney U test. First, CFMCs had operational experience for an average of 8 years and 8 months, and served an average of 38,540 meals a day. Most of the respondent companies specialized in the school foodservice field and managed an average of 66 clients for the contract period of 2 years and 3 months. Second, the respondent companies had gotten a score of 77.78 points for the total average, 77.7 points in the large enterprise group and 78.1 points in the small and medium-sized enterprise group. Therefore, the minimum number of points for the accrediting license on Qualification is suggested to be over 70 out of a 100 point scale; this study would be serve as reference for the certification license on qualification. On the level of evaluation category, the scores were 14.15 to 20 points on $\ulcorner$finance$\urcorner$, 19.24 to 25 points on $\ulcorner$customer$\urcorner$, 19.33 to 25 points on $\ulcorner$process$\urcorner$, 14.31 to 20 points on $\ulcorner$human resource$\urcorner$, and 8.6 to 10 point on $\ulcorner$renewal and development$\urcorner$ . $\ulcorner$Renewal and development$\urcorner$ and $\ulcorner$customer focus$\urcorner$ received better grades than other evaluation categories. Third, $\ulcorner$Finance$\urcorner$ indicated similar distribution overall. Small and medium-sized companies had lower grades than large companies on 'market ability' of $\ulcorner$customer$\urcorner$ , but, clients of small and medium-sized companies had higher grade for 'client satisfaction' than large companies. Most of the companies supported 'infrastructure support for foodservice operation' of $\ulcorner$process$\urcorner$ by the main office of CFMCs, but, the branch chain offices of CFMCs were not applied efficiently. Large companies made more effort to improve the 'employee ability' of $\ulcorner$human focus$\urcorner$ than small and medium-sized CFMC. The 'research and development cost' of $\ulcorner$renewal and development$\urcorner$ was increased compared to the previous year. In conclusion, if CFMCs were to perform self-evaluation and a routine checkups by utilizing CFMC's IC measuring tool, improvements in CFMC operational capacities as well as foodservice quality can be noted. (Korean J Nutrition 38(10)'880$\sim$894,2005)

• Journal of Korean Neurosurgical Society
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• 제30권2호
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• pp.201-206
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• 2001

Objective : The purpose of this study was to assess the complications, duration of admission, cost effectiveness, radiologic stabilization of the anterior cervical bone fusion in the treatment of cervical disc disease with and without plating. Materials and Methods : Fifty-two surgically treated patients for cervical disc disease were reviewed. Group I consisted of consecutive treated patients with iliac auto-bone graft without instrumentation after anterior cervical discectomy. Group II consisted of consecutive treated patients with iliac autologous-bone graft with CASPER cervical plate fixations. Radiologic fusion was decided when loss of end plate boundary between graft bone and vertebral body and immobile, maintenance of the disc space were evident on simple dynamic plain films. The patients were discharged after the stabilization of cervical motion by films was of tained. These groups were analysed multiple variably with Mann-Whitney U-test. Results : Group I consisted of 18 patients, group II consisted of 34 patients. Mean age was $49.0{\pm}8.1years$, mean duration of admission was $17.27{\pm}10.51days$, mean costs for treatment was $1,970,000{\pm}475,000won$. In group I, mean age was 47.7(34-60) years, 16 patients had undergo on one-level operation, 2-patients had undergo on two-level operation, mean duration of admission was $28.7{\pm}10.4days$, mean costs for treatment was $2,194,473{\pm}561,639won$. The periods of stabilization was $6.6{\pm}3.36weeks$ on radiologic study. Mean periods of out patient follow up was 16.8(6-64) weeks after discharge. Mean period of radiologic follow up was 17.3(4-6) weeks after surgical operation. In group II, mean age was 49.7(37-62) years and 18 patients one-level operation, 14- patients had undergo on two-level operation and 2-patients three-level operation. Mean duration of admission was $11.24{\pm}3.29days$, mean costs for treatment was $1,850,823{\pm}389,372won$. The periods of stabilization was $5.88{\pm}7.07weeks$ on radiologic study. Mean period of out patients follow up was 16.7(4-60) weeks after discharge. Mean period of radiologic follow up was 12.4(3-52) weeks after surgical operation. The duration of admission showed statistical significance in Group II but other items showed no significant difference between two groups. Conclusions : The more economic, early life return and effective method of cervical disc disease in our series were evident in patients who had undergone, iliac bone graft and plate fixations after anterior discectomy.

• Restorative Dentistry and Endodontics
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• 제30권1호
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• pp.7-15
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• 2005

이 연구의 목적은 상아질 접착제의 사용 여부에 따른 근관 밀폐효과를 비교 평가하기 위해 40개의 단근치를 근관 성형 후 20개씩 두군으로 나누었다. 1군은 근관 충전시에 상아질 접착제를 사용하지 않았으며 2군은 상아질 접착제를 사용하였다. 근첨에서 1.5 mm (Level 1), 2.0 mm (Level 2), 2.5 mm (Level 3) 떨어진 부위의 평균 누출률을 측정하였다. 1. 두군의 평균 누출률은 치경부로 향하면서 감소하였다. 2. Level 1에서 1군과 2군의 평균 누출률은 차이가 없었다 (p > 0.05) .3. Level 2와 3에서 2군의 평균 누출률은 1군보다 낮았으며, 통계학적으로 유의차를 나타내었다 (p < 0.05) .연구결과 상아질 접착제를 사용하여 근관 충전하는 경우 치근단 누출을 감소시킬 수 있을 것으로 판단된다.

• Restorative Dentistry and Endodontics
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• 제26권3호
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• pp.191-199
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• 2001

목적 - 기질금속단백분해효소(matrix metalloproteinase)는 조직의 염증 및 치유과정에서 숙주세포에서 생성, 분비되어 세포외기질(extracellular matrix)의 분해에 작용한다. 다양한 염증반응에 기질금속단백분해효소가 중요한 역할을 하는것으로 보고되고 있으나 치수 및 치근단 질환에서의 그 역할은 거의 알려져 있지 않은 상태이다. 본 연구에서는 염증이 있는 사람의 치수 및 치근단 조직을 채취하여 Enzymeimmunoassay 및 면역조직화학적 검색을 통해 제1형, 2형, 3형 기질금속단백분해효소의 수준 및 그 분포를 측정하여 치수 및 치근단 병소에서 이 효소의 작용을 알아보는 것을 목적으로 한다. 방법 - 연구재료는 근관치료를 위해 서울대학교 병원 치과 진료부 보존과에 내원한 환자를 대상으로 34개의 치아에서 통상의 근관치료 중 발수한 치수조직과 치근단 수술중 얻은 치근단 병소(n=10)를 이용하였다. 치수는 발수 전에 임상진단을 통해 급성 치수염(n=12), 만성 치수염(n=12), 정상 치수(n=10)로 구분하고 정상치수로 진단된 것을 대조군으로 설정하였다. 채취된 표본은 둘로 나누어 절반은 30분 이내에 5$\mu\textrm{m}$ 두께로 동결절단을 시행하여 조직표본을 제작하였고 deep freezer에 보관하였다가 헤마톡실린-에오신 염색 및 면역조직화학적 검색을 시행하였다. 나머지 조직은 ELISA를 위해 액체 질소에 보관하였다. ELISA를 시행하기전 표본의 단백질 정량을 시행하여 모든 표본의 단백질 양을 50mg/$\mu\textrm{l}$로 일치시키고 Amersham사의 ELISA kit를 사용하여 제1형, 2형, 3형의 기질금속단백분해효소의 양을 측정하였으며 그 결과를 Mann-Whitney U test를 사용하여 각 군간의 통계학적 유의성을 검증하였다. 결과 1. ELISA의 결과 제1형 기질금속단백분해효소의 농도는 모든 실험군에서 대조군보다 유의성있게 높게 나타났다.(p<.05). 또한 급성치수염군의 제1형 기질금속단백분해효소의 농도가 다른 실험군보다 유의성있게 높았다(p<.05). 2. 제2형 기질금속단백분해효소의 경우 급성치수염군과 대조군에서만 유의성있는 차이를 보였다(p<.05). 3. 제3형 기질금속단백분해효소의 경우 급성치수염군에서 대조군이나 만성치수염군보다 유의성 있는 높은 수치를 보였다(p<.05). 4. 면역조직화학검색 결과 염증성 치수에 존재하는 급성 및 만성염증세포 주위로 기질금속단백분해효소에 대한 면역 반응이 존재하였으며 주로 제1형과 제3형 기질금속단백분해효소의 경우 대식세포 및 림파구 주위로 강한 발색제의 침윤양상이 관찰되었다. 5. 치근단병소의 면역조직화학적 검색 결과 만성염증 세포 주변으로 미약한 발색제의 침윤양상이 관찰되었다.

• Restorative Dentistry and Endodontics
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• 제36권1호
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• pp.59-65
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• 2011

연구목적: 본 연구의 목적은 서로 다른 기하학적 형태를 가진 3가지 Ni-Ti 파일, 즉 K3, NRT, Profle을 사용하여 레진 블록으로 제작된 만곡 근관에서의 apical transportation 양상 및 working length 변화를 서로 비교하는 것이다. 연구 재료 및 방법: 실험 방법은 30개의 레진 블록을 Schneider technque을 사용하여 만곡도 측정 후 각 group당 임의로 10개씩 배분하였다. 이를 각 Ni-Ti 파일을 사용하여 crown down technique으로 근관 성형하였다. 이의 분석을 위해 double radiograph superimposition method (Backman CA 1992)를 사용하고, 분석의 정확성과 일관성을 위해 특별히 고안된 jig, digital X-ray 및 apical transportation의 측정 시 CAD/CAM software를 이용하였다. Apical transportation 양은 '근단공-0.5 mm'부위로부터 0, 1, 3, 5 mm에서 측정 하였으며, working length 변화는 근관 성형 전후의 working length 변화를 측정하였다. 또 통계 처리는 각 group의 apical transportation 양과 working length 변화를 Kruskal-Wallis One Way Analysis로 분석 후 다중 비교는 Mann-Whitney U-test를 사용하였다. 결과: 각 group간 working lengh 변화 및 0, 1, 3 mm 부위에서의 apical transportation 측정 값 사이에는 유의할만한 차이가 관찰되지 않았으나(p = 0.924), 5 mm 부위에서는 K3와 Profile사이에 유의할 만한 차이가 있었다(p = 0.027). 결론: 서로 다른 기하학적인 형태를 가진 3가지 Ni-Ti 파일의 apical transportation 및 working length 변화 정도 평가시, 본 연구의 범위 내에서는 3가지 파일 모두 유의할 만한 차이를 보이지 않은 가운데 본래의 근관 형태를 잘 유지한다고 할 수 있다.

• 대한감각통합치료학회지
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• 제17권2호
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• pp.18-30
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• 2019

목적 : 발달지연 아동을 대상으로 Ayres 감각통합중재를 적용하여 감각처리능력과 운동발달에 미치는 영향을 알아보고자 하였다. 연구방법 : 만 3-5세의 발달지연 아동을 대상으로 실험군 9명과 대조군 8명이 본 연구에 참여하였고 Short Sensory Profile(SSP), Peabody Developmental Motor Scale-2(PDMS-2)를 사용하였다. 실험군은 Ayres의 중심원리에 따른 개별 감각통합치료를 40분씩, 주 2회, 8주간 총 16회기를 실시하였다. 분석은 SPSS 24.0 의 카이스퀘어 검정, 맨휘트니 U검정, 윌콕슨 부호순위 검정, Cohen's d 검정으로 하였다. 연구결과 : Ayres의 감각통합중재를 실시한 실험군은 중재를 실시하지 않은 대조군에 비해 감각처리능력은 전체 점수와 움직임 민감성, 청각 여과하기, 낮은 에너지/허약함에서 통계적으로 유의한 차이가 나타났다(p<.05). 실험군과 대조군의 운동발달은 대근육운동발달지수, 소근육운동발달지수, 전체운동발달지수 모두 통계적으로 유의한 차이가 나타났다(p<.05). 결론 : Ayres의 감각통합중재는 발달지연 아동의 감각처리능력과 운동발달에 긍정적인 영향을 미쳤다.

• 재활복지공학회논문지
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• 제8권2호
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• pp.109-118
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• 2014

본 연구는 급성기 뇌졸중 환자에서 연하장애 재활치료를 받은 환자와 받지 않은 환자의 회복정도를 비교하기 위함이다. 뇌졸중으로 진단받고 연하장애를 가지는 환자(n=98)에서 치료를 받은 군과 받지 않은 군으로 나누어 실험군과 대조군사이 연하장애 재활치료중재전-후 비교 연구 설계에 의해 실험군(n=52)에는 8주간의 연하장애 재활치료를 시행하였고 대조군(n=46)에는 아무런 처치를 하지 않았다. 두 집단 모두를 대상으로 중재 전-후 Video Fluoroscopy Swallowing Study(VFSS), Dysphagia Outcome and Severity Scale(DOSS), Dysphagia Severity Scale(DSS), Functional Outcome Swallowing Scale(FOSS)로 평가를 하였으며 평가값의 변화량은 paired t-test 및 ANCOVA를 통해 분석 하였다. 실험군의 중재전-중재후의 점수 변화비교에서 DOSS를 제외한 나머지 평가도구에서 연하기능이 회복되었다(p<0.05). 대조군의 전-후의 점수 변화비교에서는 모든 평가도구에서 점수값의 변화가 통계학적으로 유의하여 연하기능의 유의한 변화가 있었다(p<0.05). 실험군과 대조군 각각의 2차 평가를 비교한 결과 DOSS를 제외한 나머지 평가도구에서 변화가 통계학적으로 유의한 수준을 보였다(p<0.05). 본 연구 결과 대상자들은 평균적으로 급성기 8주 동안 연하기능의 회복을 보였고, 대조군에서는 세 평가도구 모두에서 유의하게 평가항목간의 점수가 상승하였다. 대상군들의 전-후 검사값의 차를 비교하였을 때 대조군에서 더 높은 점수의 상승을 보여 시간의 경과에 따른 자연적 신경학적 회복을 시사했다.

• Journal of Periodontal and Implant Science
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• 제51권4호
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• pp.264-275
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• 2021

Purpose: Periodontitis is considered a local risk factor for medication-related osteonecrosis of the jaws (MRONJ). However, little is known about the progression of periodontitis in the presence of zoledronic acid (ZOL). The aim of this study was to evaluate the effects of the systemic use of ZOL on the progression of experimental periodontitis (EP) in rats, as ZOL could modulate the progression of periodontitis and concomitantly cause MRONJ in individuals with periodontitis. Methods: Forty-eight male Wistar rats were randomly distributed in 6 groups (n=8 each). To induce EP, ligatures were placed around the right first mandibular molars. Three groups were treated with ZOL (0.15 mg/kg/week, intraperitoneal), and 3 with 0.9% saline solution (controls). In the ZOL/Lig30 and ZOL/Lig 15 groups, after 4 weeks of treatment with ZOL, EP was induced and euthanasia was performed after 30 and 15 days of EP induction, respectively. In both groups, the animals continued to receive ZOL after EP until the end of the experiment. In the Lig/ZOL group, EP was induced first, and 15 days later, ZOL was administered for 8 weeks, with euthanasia 1 week after the last dose. After euthanasia, the mandibles were evaluated using micro-computed microtomography (micro-CT) and histomorphometry. Bone loss was measured, and the presence of osteonecrosis was evaluated histologically. The data were evaluated using the Student t-test and the Mann-Whitney test, with a significance level of 5%. Results: In the Lig/ZOL group, micro-CT revealed less alveolar bone resorption in the distal root (P<0.01) than in the control group (Lig/Con). Histomorphometric analysis confirmed less alveolar bone resorption in the Lig/ZOL group (P=0.001). Histologically, osteonecrosis was more common in the ZOL groups. Conclusion: ZOL decreased alveolar bone resorption in rats with EP. However, it presented a higher risk for MRONJ.

• Journal of Korean Academy of Oral Health
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• 제41권1호
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• pp.22-27
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• 2017

Objectives: Dental plaque is composed of 700 bacterial species. It is known that some oral microorganisms produce porphyrin, and thus, they emit red fluorescence when illuminated with blue light at a specific wavelength of <410 nm. Porphyromonas gingivalis belongs to the genus Porphyromonas, which is characterized by the production of porphyrin. The aim of this study was to evaluate red fluorescence emission of some oral microorganisms interacting with P. gingivalis. Methods: Five bacterial strains (P. gingivalis, Streptococcus mutans, Lactobacillus casei, Actinomyces naeslundii, and Fusobacterium nucleatum) were used for this study. Tryptic soy agar medium supplemented with hemin, vitamin K3, and sheep blood was used as a growth medium. The fluorescence emission of bacterial colonies was evaluated under 405 nm-wavelength blue light using a Quantitative Light-induced Fluorescence Digital (QLF-D) camera system. Each bacterium was cultured alone and co-cultured in close proximity with P. gingivalis. The red/green (R/G) ratio of fluorescence image was calculated and the differences of R/G ratio according to each growth condition were compared using the Mann-Whitney test (P<0.05). Results: Single cultured S. mutans, L. casei and A. naeslundii colonies emitted red fluorescence (R/G ratio=$2.15{\pm}0.06$, $4.31{\pm}0.17$, $5.52{\pm}1.29$, respectively). Fusobacterium nucleatum colonies emitted green fluorescence (R/G ratio=$1.36{\pm}0.06$). The R/G ratios of A. naeslundii and F. nucleatum were increased when P. gingivalis was co-cultured with each bacterium (P<0.05). In contrast, the R/G ratios of S. mutans and L. casei were decreased when P. gingivalis was co-cultured with each bacterium (P=0.002, 0.003). Conclusions: This study confirmed that P. gingivalis could affect the red fluorescence of other oral bacteria under 405 nm-wavelength blue light. Our findings concluded that P. gingivalis has an important role for red fluorescence emission of dental biofilm.