• 한국신재생에너지학회:학술대회논문집
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• 2007.06a
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• pp.553-556
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• 2007

Hyundai${\cdot}$Kia Motors have developed PEMFC stack technologies for passenger car application in 1998. The developed 80kW class stack, which was installed Kia's Sportage FCV in 2005, has been modified for -10$^{\circ}C$ cold start-up and ensuring the stability and durability by using new technologies such as newly designed separator, manifold block, end plate, and so on. And also, the stack durability has been verified over 1,500hrs with the condition of combined vehicle driving mode. Hyundai${\cdot}$Kia Motors will keep continuing the stack R&D to reach the goal of FCV commercialization.

• Journal of the Korean Institute of Gas
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• v.16 no.3
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• pp.48-53
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• 2012

The purpose of this paper studies the failure cases including with system of liquefied phase injection in liquified petroleum gas vehicle. The first case, resulting with inspection the injector of LPG, it occasionally certified the injection damage phenomenon that the fuel efficiency(km/l) was decreased to 5% by carbon deposit with injector hole when the driver operates the vehicle. The second case, it certified the interference phenomenon of air flow with carbon deposit in ISA system control for idle speed of engine and throttle body suppling air into engine. As a result, the fuel efficiency was decreased 7%. The third case, the outer air during intake stroke was intermittently flowed in this gasket gap because of weaken adhesion power phenomenon for cylinder block by intake manifold gasket tearing. Consequentially, it certified the decrease for fuel efficiency to 3% by risen the amount of fuel injection as the air inflow quantity. These failure examples reduced the power performance of engine and the fuel efficiency of vehicle. It have to minimize of failure phenomenon preparing through quality management.

• Journal of Mechanical Science and Technology
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• v.17 no.10
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• pp.1563-1571
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• 2003

A fast response NO analyzer was applied to investigate the relation between cycle-by-cycle NO emissions and combustion chamber pressure. NO emissions were sampled at an isolated exhaust manifold of 4-stroke spark ignition engine to avoid the interference of exhaust gas from other cylinders. The linear correlation analysis was performed with collected data of NO emissions and combustion chamber pressure with respect to the various air-fuel mixture ratios and engine loads. The sampled data sets were obtained during 200 cycles at each operating condition. The results showed that there was a typical pattern in NO emissions from an exhaust port through a cycle. It was possible to set a block of crank angle in which the linear correlation coefficient between NO emissions and combustion chamber pressure was high. As the engine load increased, NO emissions were more dependent on combustion chamber pressure after TDC. It was also analyzed that the correlation between two parameters with respect to air-fuel mixture ratio tended to increase as mixture went leaner. Furthermore, this correlation coefficient for the mixture near the lean limit seemed to be kept high even though combustion was unstable.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.9
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• pp.1249-1255
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• 2010

An ultra high- pressure system generally consists of a hydraulic power unit, an oil supply unit, an electrical power supply device, and an electrical control device. The hydraulic power unit supplies the hydraulic power to the intensifier to create generate ultra high pressure. The intensifier amplifies increases the pressure using the oil supplied from by the hydraulic power unit. The electrical supply devices and control devices maintain are provided for the electric motors, valves, and sensors. In this study, instead of a flow-control device, a pressure-control type device was mounted on a manifold block in the hydraulic power unit instead of the flow-control type. A servo valve was fitted in the intensifier, and the performance characteristics of the intensifier varied according to the variations of in the pressure cycle and with the temperature of the operating oil in the hydraulic power unit.

• Journal of Life Science
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• v.28 no.4
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• pp.488-495
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• 2018

The p53 gene plays a critical role in the transcriptional regulation of cellular response to stress, DNA damage, hypoxia, and tumor development. Keeping in mind the recently discovered manifold physiological functions of p53, its involvement in the regulation of cancer is not surprising. In about 50% of all human cancers, inactivation of p53's protein function occurs either through mutations in the gene itself or defects in the mechanisms that activate it. This disorder plays a crucial role in tumor evolution by allowing the evasion of a p53-dependent response. Many recent studies have focused on directly targeting p53 mutants by identifying selective, small molecular compounds to deplete them or to restore their tumor-suppressive function. These small molecules should effectively regulate various interactions while maintaining good drug-like properties. Among them, the discovery of the key p53-negative regulator, MDM2, has led to the design of new small molecule inhibitors that block the interaction between p53 and MDM2. Some of these small molecule compounds have now moved from proof-of-concept studies into clinical trials, with prospects for further, more personalized anti-carcinogenic medicines. Here, we review the structural and functional consequences of wild type and mutant p53 as well as the development of therapeutic agents that directly target this gene, and compounds that inhibit the interaction between it and MDM2.