• 대한화장품학회지
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• 제30권4호
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• pp.445-448
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• 2004

노화는 크게 내인성 노화와 광노화로 분류된다. 내인성 노화는 시간이 지남에 따라 진행되는 자연적인 노화이며, 광노화는 자외선에 우리 몸이 노출되면서 발생되는 노화 현상으로 주로 피부에서 잘 나타난다. 대표적인 노화 기작으로는 체내 활성 산소의 증가로 인한 생체 구성 성분의 퇴화를 들 수 있다. 따라서, 효과적인 노화 방지를 위해서는 활성 산소를 억제할 수 있는 항산화제를 지속적으로 공급해 주어야 한다. 본 논문에서는 천연 식물 성분인 예덕나무 피 추출물이 노화 방지에 매우 우수한 효과가 있다는 실험 결과들을 보여준다. 먼저, 예덕나무 피 추출물(Mallotus japonicus bark extracts)은 hydroxy radical scavenging activity와 SOD like activity를 가지고 있으며 과산화 수소에 의해 발생하는 피부 손상을 억제하는 효과가 매우 뛰어나다. 또한 광노화 방지 효과도 매우 뛰어나 자외선 조사에 의해 발생할 수 있는 피부 세포 손상을 억제하여 주며 자외선에 의한 유전자 변이도 억제해 주는 것으로 나타났다. 결론적으로, 예덕나무 피 추출물은 피부에서 일어날 수 있는 노화 현상을 억제하는데 매우 뛰어난 효과를 가진 물질로서 화장품 원료로서의 이용 가능성이 매우 높다.

• 한국식품과학회지
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• 제33권2호
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• pp.271-277
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• 2001

항균 활성이 우수한 예덕나무의 75% 에탄올 추출물을 용매 분획 후 일정 수준의 농도로 액체 배지(tryptic soy broth)에 첨가하여 L. monocytogenes 5 균주를 배양시킨 결과 헥산분획물 20 ppm에서 72시간 동안 증식 저해 효과를 나타내었다. 항균 활성이 우수한 예덕나무 헥산 분획물을 silica gel column chromatography로 1회 분획하여 항균 활성이 우수한 획분 M34를 얻었으며 M34 획분은 50 ppm 수준의 농도에서 실험 균주 모두 증식을 저해했다. 획분 M34를 2회 연속 분리하여 소 획분 M34-4-4를 얻은 후 액체 배지에 첨가하여 L. monocytogenes 2 균주를 접종한 후 72시간 배양한 결과 50 ppm 수준의 농도에서 증식 저해 효과가 나타났으며, M34-4-4을 구조 동정한 결과 linolenic acid로 확인되었다.

• 한국환경생태학회지
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• 제15권3호
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• pp.224-229
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• 2001

칠산도에서 확인된 관속식물은 37과 74속 71종 13변종으로 총 84종류였다. 꾸지뽕나무나 예덕나무가 출현하는 것으로 보아 남부아구에 속한다고 볼 수 있다 제1도는 밀사초와 사철쑥, 제2도는 밀사초, 제3도는 밀사초와 예덕나무, 제4도는 누리장나무 그리고 제6도는 참억새와 띠가 우점하였다.

• 생약학회지
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• 제51권2호
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• pp.115-121
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• 2020

Caenorhabditis elegans model system was used to investigate the antioxidant activity of methanol extract of Mallotus japonicus twigs. The ethyl acetate soluble fraction of the M. japonicus methanol extract showed the best DPPH radical scavenging activity. The ethyl acetate fraction was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans along with reactive oxygen species (ROS) level. In addition, to confirm that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the ethyl acetate fraction, SOD-3 expression was measured using a transgenic strain. As a result, the ethyl acetate fraction increased SOD and catalase activity, and decreased ROS accumulation in a dose-dependent manner. In addition, the ethyl acetate fraction-treated CF1553 worm showed higher SOD-3::GFP intensity than the control worm.

• 한국응용곤충학회지
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• 제52권2호
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• pp.93-100
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• 2013

방패광대노린재는 2012년 제주도, 진도, 통영, 광주, 태안에서 분포가 확인되었다. 성충은 6월 하순에서 7월 초순경에 예덕나무에 출현하며 10월 말까지 관찰이 가능하다. 실내 사육은 온도 $25^{\circ}C({\pm}2)$, 습도 65%(${\pm}2$), 광주기 16L:8D의 조건에서 성충의 암 수 형태 측정, 발육특성, 기주 및 산란선호성을 조사하였다. 체장(female: 26.20 mm, male: 23.88 mm), 체폭(female: 11.35 mm, male: 10.57 mm ), 두폭(female: 3.84 mm, male: 3.64 mm), 주둥이(female: 7.90 mm, male: 7.27 mm). 더듬이(female: 9.87 mm, male: 9.69 mm), 앞다리(female: 12.50 mm, male: 12.27 mm), 가운뎃다리(female: 14.61 mm, male: 13.12 mm), 뒷다리(female: 16.90 mm, male: 16.53 mm), 생체중(female: 0.46 g, male: 0.31 g)으로 각각 조사되었다. 우리나라에는 앞가슴등판 끝에 가시가 있는 개체가 있고, 가시의 유무는 마지막 5령 탈피시 생겨난다. 암 수 구분은 생식기와 배마디의 점무늬로 구별된다. 기주선호성은 예덕나무, 무늬예덕나무, 피마자, 털인동, 감귤나무, 느티나무의 열매, 엽병, 주맥, 가지를 흡즙하였다.

• 한국환경복원기술학회지
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• 제11권6호
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• pp.61-72
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• 2008

This study was carried out to analyze vegetation and soil characteristic of Osmanthus insularis community, Geomundo. The Osmanthus insularis community was classified into three subcommunities: Mallotus japonicus subcommunity, Ficus erecta subcommunity, Raphiolepis umbellata subcommunity. The importance value of Camellia japonica, Osmanthus insularis, Ligustrum japonicum, Litsea japonica Mallotus japonicus, Pinus thunbergii and Ficus erecta in Osmanthus insularis community were 76.11%, 75.91%, 37.24%, 21.99%, 18.35%, 17.64% and 11.91%, respectively. According to the DBH analysis. Osmanthus insularis showed formality distribution style among the entire community. Their dominance is expected to continue. But the young plant individual were low density, importance value reduced. In the study sites, soil organic matter, nitrogen, available phosphorous and soil pH were ranged from 19.11~24.62%, 0.73~1.18%, 11.61~27.98mg/kg and 6.11~6.37, respectively. According to the result of survey Osmanthus insularis individual, the female plants individual were 57.90%, the male plants individual were 42.10%.

• 생약학회지
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• 제31권3호
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• pp.351-356
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• 2000

The hepatoprotective effects of bergenin and its derivative, acetylbergenin, were evaluated against D-galactosamine-induced liver damage in rats. Bergenin is a C-glucoside of 4-O-methyl gallic acid that has been isolated from the cortex of Mallotus japonicus (Euphorbiaceae). Acetylbergenin was synthesized from acetylation of bergenin to increase lipophilic and physiological activities. Bergenin (50, 100 and 200 mg/kg) and acetylbergenin (25, 50 and 100 mg/kg) were administered orally once daily for successive 5 days after the injection of galactosamine (400 mg/kg, i.p.), respectively. The substantially elevated serum enzyme activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and ${\gamma}-glutamyltransferase$ due to galactosamine treatment were dose-dependently restored towards normalization by post-treatment with bergenin and acetylbergenin. Bergenin and acetylbergenin also significantly prevented the elevation of hepatic malondialdehyde formation and depletion of reduced glutathione content induced by galactosamine in a dose-dependent manner. In addition, the decreased activities of glutathione S-transferase and glutathione reductase were restored towards normalization. These results suggest that effects of bergenin and acetylbergenin may be related to complex mechanisms that involve prevention of lipid peroxidation and preservation of hepatic glutathione. The results of this study clearly indicate that bergenin and acetylbergenin have potent hepatotherapeutic action against galactosamine-induced hepatotoxicity in rats, and lipophilic acetylbergenin is more active in the antihepatotoxic effects against galactosamine than much less lipophilic bergenin.

• Biomolecules & Therapeutics
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• 제8권4호
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• pp.293-298
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• 2000

Bergenin is a C-glucoside of 4-O-methyl gallic acid that has been isolated from the cortex of Mallotus japonicus (Euphorbiaceae). Acetylbergenin was synthesized by acetylation from bergenin to increase lipophilic and physiological activities. The therapeutic effects of bergenin and acetylbergenin were evaluated against carbon tetrachloride ($CCl_4$)-induced hepatotoxicity in rats. Bergenin and acetylbergenin were administered orally once daily for successive 5 days, after the intraperitoneal injection of a mixture 0.5 m1/kg of $CCl_4$ in olive oil (1:1). The substantially elevated serum enzymatic activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and ${\gamma}$-glutamyltransferase induced by $CCl_4$ were restored towards normalization by posttreatment with bergenin and acetylbergenin. Bergenin and acetylbergenin also significantly prevented the elevation of hepatic malondialdehyde formation and depletion of glutathione content induced by $CCl_4$ in a dose dependent fashion. In addition, the decreased activities of glutathione S-transferase and glutathione reductase were restored towards normalization. These results suggest that therapeutic effects of bergenin and acetylbergenin may be related complex mechanisms that involve prevention of lipid peroxidation and preservation of hepatic GSH. The results of this study clearly indicate that bergenin and acetylbergenin have potent hepatothrapeutic action against $CCl_4$-induced hepatotoxicity in rats. In addition, acetylbergenin 50 mgHg showed almost the same levels of hepatoprotective activity as those of bergenin 100 mgAg, indicating the fact that lipophilic acetylbergenin is more effective in the hepatoprotective action against $CCl_4$ than bergenin.

• Biomolecules & Therapeutics
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• 제7권1호
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• pp.35-43
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• 1999

Hepatoprotective effects of Malloti cortex extract (MCE) from Mallotus japonicus against the carbon tetrachloride (CCl$_{4}$) and galactosamine (GalN) were investigated. Whereas serum aspartate aminotransferase and alanine aminotransferase levels were markedly elevated after CCl$_{4}$ and GalN administration, pretreatment and posttreatment with MCE before and after the injection of CCl$_{4}$ and GalN resulted in decreases in elevated serum aminotransferase activities. Whereas CCl$_{4}$ and GalN treatment caused 3~7 fold increases in sorbitol dehydrogenase and ${\gamma}$-glutamyltransferase activities, pretreatment and posttreatment with MCE resulted in the blocking of CCl$_{4}$ and GalN-induced liver toxicity. The hepatoprotective effect of MCE was in part due to MCE-induced elevation of hepatic glutathione levels. Pretreatment and posttreatment with MCE also reduced increased lipid peroxidation induced by CCl$_{4}$ and GalN. These results suggest that MCE may be useful for the prevention and therapy of hepatotoxic pathogenesis. It is presumed that protective and therapeutic effects of MCE due to be inducible glutathione S-transferase and glutathione reductase activities, involving in glutathione-medicated detoxication and maintainment of glutathione content, respectively.

• 한국산림과학회지
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• 제88권3호
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• pp.374-378
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• 1999

본(本) 연구(硏究)는 매자나무과(科)의 매발톱나무와 당매자나무 그리고 대극과(科)의 예덕나무와 사람주나무에 있어서 목부(木部) 방사조직(放射組織)내 에 천공(穿孔)을 지니는 방사조직(放射組織) 구성세포(構成細胞)가 존재(存在)함을 처음으로 보고(報告)하는 것으로써 천공(穿孔)을 지니는 이들 방사조직(放射組織) 세포(細胞)의 천공(穿孔)은 도관요소(導管要素)에 발달(發達)하는 천공(穿孔)과 동일(同一)하게 단일천공(單一穿孔)을 지니는 것으로 밝혀졌다.