• Title/Summary/Keyword: Malignancy

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Spontaneous Tumor Lysis Syndrome Presenting Acute Kidney Injury with Extreme Hyperuricemia and Urinary Stone: A Rare Case of Spontaneous Tumor Lysis Syndrome

  • Kim, Seong Heon;Yang, Eu Jeen;Lim, Young Tak;Kim, Su Young
    • Childhood Kidney Diseases
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    • v.21 no.1
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    • pp.31-34
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    • 2017
  • Tumor lysis syndrome is a serious complication of malignancy, resulting from the massive and rapid release of cellular components into the blood. Generally, it occurs after initiation of chemotherapy. The onset of spontaneous tumor lysis syndrome (STLS) before anti-cancer treatment is rare and occurs mostly in Burkitt lymphoma and non-Hodgkin's lymphoma. There are only a few case reports in children. Here, we report a case of STLS secondary to T-cell acute lymphoblastic leukemia (ALL), which presented with urinary stone and subsequent acute kidney injury with severe hyperuricemia. Occult malignancy should be considered in case of unexplained acute kidney injury with extreme hyperuricemia.

Adenocarcinoma with Pleomorphic adenoma of the Parotid gland - A case report - (혼합종과 병존한 이하선의 악성 선암 그예)

  • Yoon Jung-Han;JeGal Young-Jong
    • Korean Journal of Head & Neck Oncology
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    • v.5 no.1
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    • pp.21-25
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    • 1989
  • It is frequently difficult to assess the presence of malignancy in patients with parotid tumor, because of unreliable diagnostic tools and riskful preoperative biopsy, In our case, a parotid adenocarcinoma and pleomorphic adenoma was revealed on permanent histologic section, which was made a impression as pleomorphic adenoma on preoperative Tru-Cut biopsy and intraoperative frozen section, So, the most accurate diagnosis of the parotid malignancy is a complete removal of tumor tissue, accompanied with permanent histologic section.

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Teratomas in Children (소아 기형종의 임상적 분석)

  • Jung, Poong-Man;Lee, Jong-In
    • Advances in pediatric surgery
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    • v.5 no.1
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    • pp.1-14
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    • 1999
  • Among 60 children with teratoma, forty-three (71.7 percent) were girls and 17 (28.3 percent) boys, Primary sites were sacrococcygeal in 30 patients (50 percent), retroperitoneal in 12 (20 percent), ovarian in 11 (18.3 percent), testicular in 3 (5 percent), and one in each of nasopharyngeal, gastric, hepatic and pancreatic (1.6 percent, respectively). Fifty-five (91.7 percent) teratomas were benign and 5 (8.3 percent) malignant. Malignant teratomas W8,re detected only in the sacrococcygeal region (16.7 percent). Age greater than 2 mouths at diagnosis, presence of urinary or colonic obstructive symptoms, multiple masses and elevated serum alpha-fetoprotein were indicators of malignancy in the sacrococcygeal region. Tumor size, presence of calcification, and gross apperance (cystic or solid) did not correlate with malignancy. Thirteen (21.7 percent) cases were associated with other anomalies. For the immature teratoma, operative resection without adjuvant chemotherapy was adequate treatment. Three patients with malignant tumors survived, one who received chemotherapy survived 3 years and the others without chemotherapy survived for 5 and 10 years.

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Clinical Experience of Squamous Cell Carcinoma in a Pressure Sore at Sacrum (천골부에 발생한 압박궤양에서 발생한 상피세포암의 치험례)

  • Cheon, Ji-Seon;Yang, Jeong-Yeol
    • Archives of Reconstructive Microsurgery
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    • v.15 no.2
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    • pp.107-110
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    • 2006
  • Malignancy in a chronic pressure sore is rare among Marjolin's ulcers. Carcinomas arising in pressure sores are highly aggressive and usually fatal. Although carcinomas in pressure sores are generally well-differentiated squamous carcinomas, they can show quite an aggressive course and do not respond either to chemotherapy or radiotherapy. The mortality rate is high despite wide surgical resection. Extensive surgical excisions with wide surgical margins are necessary and elective lymph node dissection should be considered for optimal therapy. We report a squamous carcinoma arising in a pressure sore. The related literature was reviewed.

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Craniospinal Metastasis from a Metastasizing Mixed Tumor of Salivary Gland : Unusual Presentation

  • Ye, Hyun-Hee;Cho, Chang-Won;Jeon, Mi-Young;Kim, Dae-Jo
    • Journal of Korean Neurosurgical Society
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    • v.41 no.3
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    • pp.186-189
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    • 2007
  • Metastasizing mixed tumors [MMT] of salivary glands are inexplicably metastasize maintaining benign histology. There is no pathologic and flow cytometric analysis criteria to predict the metastasis. MMT is known to metastasize by local implantation, vascular and lymphatic embolization after multiple surgery to local recurrences of primary tumor. However, multiple metastasis including cranium and spine occurred even without surgery to the primary tumor in this case. No pathological evidence of malignancy could be found in both primary and metastatic tumor. MMT is considered as an low grade malignancy based on clinical behavior rather than histologic evidence, such as low mortality rate, long delay of metastasis after primary lesion. Cranial metastasis is also extremely rare and only two cases have been reported. We report this unusual case with a literature review.

An Unusual Presentation of Rectal Carcinoma in a Child

  • Tiwari, Charu;Zadpe, Ashish;Rathi, Pravin;Shah, Hemanshi
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.21 no.1
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    • pp.72-75
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    • 2018
  • Colorectal carcinoma is a well-known malignancy in adults. However, it is rare in children. Besides, it also has different behaviour in paediatric age-group and usually presents with non-specific symptoms like abdominal pain, weight loss, and anaemia. This usually leads to delay in diagnosis. Adenocarcinoma in children has unfavourable tumour histology (mucinous subtype) and advanced disease stage at presentation which lead to poorer prognosis in children. Family history, genetic typing and sibling screening are essential components of management as this malignancy is frequently seen associated with hereditary syndromes. We describe a case of unusual presentation of rectal carcinoma in a 12-year-old girl.

Clinical Application of F-18 FDG PET(PET/CT) in Malignancy of Unknown Origin (원발부위미상암에서 F-18 FDG PET (PET/CT)의 임상 이용)

  • Kim, Byung-Il
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.sup1
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    • pp.162-165
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    • 2008
  • Diagnosis of primary origin site in the management of malignancy of unknown origin (MUO) is the most important issue. According to the histopathologic subtype of primary lesion, specialized treatment can be given and survival gain is expected. F-18 FOG PET (PET/CT) has been estimated as useful in detection of primary lesion with high sensitivity and moderate specificity. F-18 FDG PET (PET/CT) study before conventional studies is also recommended because it has high diagnostic performance compared to conventional studies. Although there has few data, F-18 FDG PET (PET/CT) is expected to be useful in diagnosis of recurrence, restaging, evaluation of treatment effect, considering that PET (PET/CT) has been reported as useful in other malignancies.

$^{18}F-FDG-PET/CT$ in Renal Cell Carcinoma (신세포암에서 $^{18}F-FDG-PET/CT$)

  • Jeon, Tae-Joo
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.sup1
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    • pp.126-129
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    • 2008
  • Renal cell carcinoma is the most common histological type of renal malignancy, predominant in men and the primary treatment modality of this tumor is surgery. The role of diagnostic imaging in the management of this tumor is the evaluation of extent of disease as well as the detection and characterization of renal mass. US has long been a routine screening tool for kidney but tomographic imaging modalities such as CT and MRI begin to be also commonly used these days. On the other hand, the sensitivity of $^{18}F-FDG-PET$ in detection of renal mass is relatively low because of inherent limitation caused by FDG excretion pathway despite avid uptake of FDG to tumor cell per se. Many studies revealed FDG PET scan could play an important role in detection of metastatic lesions although the sensitivity for the detection of primary lesion is not so high. Furthermore, development of PET/CT scanner will make it possible to expand the indication of FDG PET scan in this malignancy.

Clinical Investigation of Incidentally Found Thyroid Carcinoma in Mass Screening (집단 검진에서 발견된 갑상선 우연암종에 대한 임상적 고찰)

  • 김은서;장항석
    • Korean Journal of Bronchoesophagology
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    • v.7 no.2
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    • pp.168-173
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    • 2001
  • Background and Objectives: The introduction of highly sensitive imaging techniques has made it possible to detect many non-palpable nodules, or“incidentaloma”in the thyroid. Discovery of these lesions raises concerns about their malignancy, but the optimal strategy for managing these lesions has not been clearly established. This study was designed to evaluate the usefulness of ultrasonographic exam with new diagnostic criteria and presume the value of mass screening for thyroid cancer. Materials and Methods : Mass screening for thyroid cancer were carried out in conjunction with mass screening for breast cancer. The subjects were 630 women aged 30 years or over. Thyroid glands were examined with 10 MHz transducer ultrasonography by one radiologist. Needle aspiration biopsy were performed when suspicious of malignancy under the new diagnostic criteria. Results and Conclusion : The new ultrasonographic criteria to diagnose thyroid cancer provided useful information and ensured more accurate evaluation. 7 cases of thyroid cancer were discovered and successfully managed. It should be further demonstrated that there is sufficient value of mass screening for thyroid cancer to perform it independently despite early cancer detection.

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