Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Craniospinal Metastasis from a Metastasizing Mixed Tumor of Salivary Gland : Unusual Presentation

  • Ye, Hyun-Hee (Departments of Neurosurgery, Maryknoll Medical Center) ;
  • Cho, Chang-Won (Departments of Neurosurgery, Maryknoll Medical Center) ;
  • Jeon, Mi-Young (Departments of Pathology, Maryknoll Medical Center) ;
  • Kim, Dae-Jo (Departments of Neurosurgery, Maryknoll Medical Center)
  • Published : 2007.03.30
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Abstract

Metastasizing mixed tumors [MMT] of salivary glands are inexplicably metastasize maintaining benign histology. There is no pathologic and flow cytometric analysis criteria to predict the metastasis. MMT is known to metastasize by local implantation, vascular and lymphatic embolization after multiple surgery to local recurrences of primary tumor. However, multiple metastasis including cranium and spine occurred even without surgery to the primary tumor in this case. No pathological evidence of malignancy could be found in both primary and metastatic tumor. MMT is considered as an low grade malignancy based on clinical behavior rather than histologic evidence, such as low mortality rate, long delay of metastasis after primary lesion. Cranial metastasis is also extremely rare and only two cases have been reported. We report this unusual case with a literature review.

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References

  1. Chen KTK : Metastasizing pleomorphic adenoma of the salivary gland. Cancer 42 : 2407-2411, 1978 https://doi.org/10.1002/1097-0142(197811)42:5<2407::AID-CNCR2820420542>3.0.CO;2-Y
  2. Collina G, Eusibi V, Carasoli PT : Pleomorphic adenoma with Lymphnode Metastases Report of two cases. Path Res Pract 184 : 188-193, 1989 https://doi.org/10.1016/S0344-0338(89)80119-0
  3. Cresson DH, Goldsmith M, Askin FB, Reddick RL, Postma DS, Siegal GP : Metastasizing Pleomorphic adenoma with Myoepithelial cell predominance. Path Res Pract 186 : 795-800; discussion 801-802, 1990 https://doi.org/10.1016/S0344-0338(11)80273-6
  4. el-Naggar A, Batsakis JG, Kessler S : Benign metastatic mixed tumours or unrecognized salivary carcinomas? J Laryngol Otol 102 : 810-812, 1988 https://doi.org/10.1017/S0022215100106528
  5. Fugimura M, Sugawara T, Seki H, Otawara Y, Sakuma T, Nakano Y, et al : Carcinomatous change in the cranial metastasis from a metastasizing mixed tumor of the salivary gland. Neurol Med Chir (Tokyo) 37 : 546-550, 1997 https://doi.org/10.2176/nmc.37.546
  6. Girson M, Mendelsohn DB, Burns D, Mikey B : Histologically benign pleomorphic adenoma of the calvaria. AJNR Am J Neuroradiol 12 : 193-196, 1991
  7. Juan R : Major and minor salivary gland : Rosai and Ackerman's Surgical Payhology, 9th ed. : Mosby, 2004, Vol1, pp873-916
  8. Marioni G, Marino F, Stramare R, Marcheese-Ragona R, Staffieri A : Benign metastasizing pleomorphic adenoma of the parotid gland : a clinicopathologic puzzle. Head Neck 25 : 1071-1076, 2003 https://doi.org/10.1002/hed.10319
  9. Morrison PD, McMullin JP : A case of metastasizing benign pleomorphic adenoma of the parotid. Clin Oncol 10 : 173-176, 1984 https://doi.org/10.1016/S0936-6555(98)80063-0
  10. Pinto de Moraes H, Herrera GA, Mendonca AM, Estrela RR : Metastatic Malignant Mixed tumor of the skin. Appl Pathol 4 :199-208, 1986
  11. Schreibstein JM, Tronic B, Tarlov E, Hybels RL : Benign metastasizing pleomorphic adenoma. Otolaryngol Head Neck Surg 112 : 612-615, 1995 https://doi.org/10.1016/S0194-5998(95)70222-9
  12. Sim DW, Maran AG, Harris D : Metastatic salivary pleomorphic adenoma. J Laryngol Otol 104 : 45-47, 1990 https://doi.org/10.1017/S0022215100111776
  13. Wenig BM, Hitchcock CL, Ellis GL, Gnepp DR : Metastasizing mixed tumor of salivary glands. A clinicopathologic and flow cytometric analysis. Am J Surg Pathol 16 : 845-858, 1992 https://doi.org/10.1097/00000478-199209000-00003
  14. Youngs GR, Scheuer PJ : Histologically benign mixed parotid tumour with hepatic metastasis. J Pathol 109 : 171-172, 1973 https://doi.org/10.1002/path.1711090211