• Title/Summary/Keyword: Makoto

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Simulated Annealing Approach to Evaluation of Maximum Number of Simultaneous Switching Gates

  • Seko, Tadashi;Ohara, Makoto;Kikuno, Tohru
    • Proceedings of the IEEK Conference
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    • 2000.07b
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    • pp.1084-1087
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    • 2000
  • This paper presents a new approach to evaluate the maximum number of simultaneous switching gates of a given combinational circuit. The new approach is based on an iterative method proposed by Sinogi et al. and applies a simulated annealing strategy to search jot a new solution. The experimental evaluation using ISCAS’85 benchmark circuits shows that the proposed approach has attained an excellent improvement compared with other rotated methods including the iterative method.

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NMR Analysis of Water-Soluble Silk Fibroin Powder

  • Makoto Demura;Tomoyasu Aizawa;Katsutoshi Nitta;Yeo, Joo-Hong;Lee, Kwang-Gill;Lee, Yong-Woo
    • Proceedings of the Korean Society of Sericultural Science Conference
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    • 2002.10a
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    • pp.99-99
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    • 2002
  • No Abstract, See Full Text

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Clinicopathological Significance of S100A10 Expression in Lung Adenocarcinomas

  • Katono, Ken;Sato, Yuichi;Jiang, Shi-Xu;Kobayashi, Makoto;Saito, Keita;Nagashio, Ryo;Ryuge, Shinichiro;Satoh, Yukitoshi;Saegusa, Makoto;Masuda, Noriyuki
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.1
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    • pp.289-294
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    • 2016
  • Background: S100A10, of the S100 protein family, is reported to be involved in cancer cell invasion and metastasis. The aims of the present study were to immunohistochemically examine S100A10 expression in surgically resected lung adenocarcinomas, and evaluate any relationships with clinicopathological parameters and prognosis of patients. Materials and Methods: S100A10 expression was immunohistochemically studied in 202 consecutive resected lung adenocarcinomas, and its associations with clinicopathological parameters were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of S100A10 expression on survival. Results: S100A10 expression was detected in 65 of the 202 (32.2%) lung adenocarcinomas, being significantly correlated with poorer differentiation (P =0.015), a higher pathological TNM stage (stages II and III) (P=0.004), more frequent and severe intratumoral vascular invasion (P=0.001), and a poorer prognosis (P=0.030). However, S100A10 expression was not an independent predictor of survival after controlling for clinicopathological factors. Conclusions: The present study reveals that S100A10 is expressed in a subset of lung adenocarcinomas, and this is related to some clinicopathological parameters, although further studies are required to confirm the correlation between S100A10 expression and prognosis of lung adenocarcinoma patients.

Deconstructive reading of Makoto Shinkai's : Stories of things that cannot meet without their names (해체로 읽는 신카이 마코토의 <너의 이름은. 군(君)の명(名)は.> : 이름 없이는 서로 만날 수 없는 사물들에 대해)

  • Ahn, Yoon-kyung;Kim, Hyun-suk
    • Cartoon and Animation Studies
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    • s.50
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    • pp.75-99
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    • 2018
  • Makoto Shinkai, an animated film maker in Japan, has been featured as a one-person production system and as a 'writer of light', but his 2016 release of "Your Name" was a departure from the elements that characterize his existing works. At the same time, by the combination of the traditional musubi(むすび) story, ending these, it was a big hit due to its rich narratives and attraction of open interpretation possibility. As it can be guessed from the title of this work, this work shows the encounter between the Japanese ancient language and the modern language in relation to the 'name', and presents the image that the role of the name(language) is repeatedly emphasized with various variations in events for the perfect 'encounter'. In this work, the interpretations of $Signifi\acute{e}$ for characters and objects are extended and reserved as a metaphorical role of the similarity, depending on the meaning of the subject which they touch. The relationship between words and objects analyzed through the structure of Signifiant and $Signifi\acute{e}$ is an epoch-making ideological discovery of modern times revealed through F. Saussure. Focusing on "the difference" between being this and that from the notion of Saussure, Derrida dismissed logocentrism, rationalism that fully obeyed the order of Logos. Likewise, dismissing the center, or dismissing the owner had emerged after the exclusive and closed principle of metaphysics in the west was dismissed. Derrida's definition of 'deconstruction' is a philosophical strategy that starts with the insight on the nature of language. 'Dissemination,' a metaphor that he used as a methodological concept to read texts acts as interpretation and practice (or play), but does not pursue an ultimate interpretation. His 'undecidability' does not start with infinity, but ends with infinity. The researcher testifies himself and identifies that we can't be an interpreter of the world because we, as a human are not the subject of language but a user. Derrida also interpreted the world of things composed of Signifiant and $Signifi\acute{e}$ as open texts. In this respect, this study aimed to read Makoto's works telling about the meeting of a thing and a thing with name as a guide, based on Derrida's frame of 'deconstruction' and 'dissemination.' This study intends to re-consider which relationship the Signifiant and $Signifi\acute{e}$ have with human beings who live in modern times, examine the relationship between words and objects presented in this work through Jacques Derrida's destruction and dissemination concepts, and recognize that we are merely a part of Signifiant and $Signifi\acute{e}$. Just as Taki and Mitsuha confirm the existence by asking each other, we are in the world of things, expecting musubi that a world of names calls me.

Human Arm Posture Control Using the Impedance Controllability of the Musculo-Skeletal System Against the Alteration of the Environments

  • Kim, Jaehyo;Makoto Sato;Yasuharu Koike
    • Transactions on Control, Automation and Systems Engineering
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    • v.4 no.1
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    • pp.43-48
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    • 2002
  • We show that humans execute the postural control ingeniously by regulating the impedance properties of the musculo-skeletal system as the motor command against the alteration of the environment. Adjusting muscle activity can control the impedance properties of the musculo-skeletal system. To quantify the changes in human arm viscoelasticity on the vertical plane during interaction with the environment, we asked our subject to hold an object. By utilizing surface electromyographic(EMG) studies, we determined a relationship between the perturbation and a time-varying muscle co-activation. Our study showed when the subject lifts the object by himself the muscle stiffness increases while the torque remains the same just before the lift-off. These results suggest that the central nervous system(CNS) simultaneously controls not only the equilibrium point(EP) and the torque, but also the muscle stiffness as themotor command in posture control during the contact task.

High-efficient Expression of Porcine IL-2 with Recombinant Baculovirus Infected Silkworm, Bombyx mori

  • Inumaru, Shigeki;KokuHo, Takehiro;Yada, Takashi;Kiuchi, Makoto;Miyazawa, Mitsusuhiro
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.5 no.2
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    • pp.146-149
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    • 2000
  • Biologically active porcine Interleukin-2(poIL-2) was produced from in vitro and in viva baculovirus expression system, namely the Autographa californica nuclear polyhedrosis virus (ACNPV)-cell culture system and the Hybrid nucler polthedrosis virus (HyNPV)-sillkworm larva system. The concentration of the recombinant poIL-2(rpoIL-2) in the larvae hemolymph was 1 to 3 mg/mL, which was about 7 to 20 times those of the cell culture systems. The level of this expression efficiency is equal to that with transgenic livestock, secretion products in milk.

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Direct Triazine Herbicide Detection Using a Self-Assembled Photosynthetic Reaction Center from Purple Bacterium

  • Nakamura, Chikashi;Hasegawa, Miki;Shimada, Kazumi;Shirai, Makoto;Miyake, Jun
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.5 no.6
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    • pp.413-417
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    • 2000
  • In this study, a direct detection system for triazine derivative herbicides was developed using the photosynthetic reaction center (RC) from the purple bacterium, Rhodobacter sphaeroides, and surface plasmon resonance (SPR) apparatus. The histidine-tagged RCs were immobilized on an SPR gold chip using nickel-nitrilotriacetic acid groups as a binder for one of the triazine herbicide, atrazine. The SPR responses were proportional to the sample concentrations of atrazine in the range 0.1-1 $\mu\textrm{g}$/mL. The sensitivity of the direct detection of atrazine using the RC-assembled sensor chip was higher than that using the antibody-immobilized chip. The other types of herbicides, DCMU or MCPP, were not detected with such high sensitivity. The results indicated the high binding selectivity of the RC complex.

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