• 대한의생명과학회지
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• 제17권2호
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• pp.167-171
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• 2011

[ ${\alpha}$ ]synuclein (${\alpha}$-syn) is implicated in the pathogenesis of Parkinson's disease (PD) and other related diseases. We have previously reported that ${\alpha}$-syn binds to the cell membranes in a transient and reversible manner. However, little is known about the physiologic function and/or consequence of this association. Here, we examined whether chemically induced perturbations to the cellular membranes enhance the binding of ${\alpha}$-syn, based on hypothesis that ${\alpha}$-syn may play a role in maintenance of membrane integrity or repair. We induced membrane perturbations or alterations in ${\alpha}$-syn-overexpressing human neuroblastoma cells (SH-SY5Y) by treating the cells with hydrogen peroxide ($H_2O_2$) or oleic acid. In addition, membranes fractionated from these cells were perturbed by treating them with proteinase K or chloroform. Dynamic interaction of ${\alpha}$-syn to the membranes was analyzed by the chemical cross-linking assay that we developed in the previous study. We found that membrane interaction of ${\alpha}$-syn was increased upon treatment with membrane-perturbing reagents in a dose and time dependent manner. These results suggest that perturbations in the cellular membranes cause increased binding of ${\alpha}$-syn, and this may have significant implication in the physiological function of ${\alpha}$-syn in cells.

• 한국도로학회논문집
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• 제11권3호
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• pp.33-40
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• 2009

폐타이어 고무분말은 도로 유지 및 보수제로 아스팔트 바인더의 개질제로 사용되고 있다. 도로보수제인 폐타이어 고무분말 개질 아스팔트 (crumb rubber modified asphalt, CRMA) 실란트에 필요한 접착특성은 저온에서 아스팔트 바인더의 취성과 접착파괴특성 때문에 주목받고 있다. 본 연구에서는 저온에서 CRMAs의 개질제로서 유연제의 영향을 조사하였다. 저온에서 CRMAs의 특성은 침입도, 연화점, 인장 및 인장접착시험을 통하여 측정하였다. 유연제를 도입한 CRMAs에서 CR과 아스팔트바인더의 연성변형이 증가함에 따라 인장접착강도와 변형률이 증가하였다. 저온영역에서 CRMAs의 인장특성과 접착특성은 유연제의 함량이 중요한 요소임을 발견하였다.

• 센서학회지
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• 제14권3호
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• pp.198-205
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• 2005

Recently, the systems using multiple sensors such as magnetic, acoustic and pressure sensor are used for detection of underwater objects or vehicles. Those systems have difficulty of maintenance and repair because they operate underwater. Thus, this paper describes a hybrid detection system with long term operating reliability. This has a multi-signal transmission structure to have a high reliability. First, a signal transmission & receiving part, which transfers data from underwater sensors to land and receive control message from land through optical cable, has 4 multi-path. Second, the nodes for signal transmission are connected dually each other with single-hop construction and sensors are connected to a couple of neighboring nodes. This enables the output signal to transmit from a node to the next node and the next but one node together. Also, the signal from a sensor can be transmitted to two nodes at the same time. Therefore, the system with this construction has high reliability in long term operation because it makes possible to transmit sensor data to another node which works normally although a transmission node or cable in system have some faults.

• 한국가스학회지
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• 제11권3호
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• pp.56-63
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• 2007

오늘날 고객의 요구는 보다 더 다양해지고 있고, 시장 환경이 급속히 변화함에 따라 기업의 모든 활동은 고객중심으로 이루어지고 있다. 최근 제품 및 서비스의 품질 향상을 위해 변화혁신 활동을 추진한 기업이 늘어나고 있는 실정이다. 본 연구는 도시가스 공급시설을 효율적으로 보수하기 위하여 6시그마 기법을 이용하여 공급시설 건전성에 영향을 주는 핵심인자를 도출하였으며, Risk 인자는 정량적인 평가를 통하여 시그마 값을 산출하였고, 근본원인 및 해결안을 도출, 새로운 프로세스를 적용하여 통계적 공정관리를 실행하였다. 도시가스 공급시설의 안전관리는 위험을 정량화하여 통계적인 공정관리를 통하여 산포를 줄이고, 품질관리 비용을 제거해서 효율적인 경영관리가 가능하며, 6시그마 이용 기법의 정착과 효율적인 운용의 확산을 통해 과학적인 안전관리가 가능할 것으로 기대된다.

• 한국IT서비스학회지
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• 제1권1호
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• pp.81-117
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• 2002

The generalization of Internet use has been spreaded all over the world and impacted company to introduce intranet and extranet for their operation which dealt with electronic commerce. For these reason, endeavor of implementation of web site system is promotioned and enhanced the possibility of adaptation range for the view of company. Dramatic competition which company faced with the use of internet and request from all over the world made company brought company to various and different type of level. It is necessary to develop website system with experty knowledge to satisfy customer needs. To deal with this situation, works from the level of government should proposed to spread whole country business which propelled through kyungnam mechanic industry information promotion center. With strategic proposal concerning district characteristics to adapt electronic commerce successfully, information promotion should performed. Support of government is needed continuously to realize infra of ASP composed of 4,877 mechanic industry company. It might be possible to deal with international rapid change with cooperation of company and government related department.

• 한국기계가공학회지
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• 제20권10호
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• pp.102-111
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• 2021

Maintainability is a major design parameter that includes availability as well as reliability in a RAM (reliability, availability, maintainability) analysis, and is an index that must be considered when developing a system. There is a lack of awareness of the importance of predicting and analyzing maintainability; therefore, it is dependent on past-experience data. To improve the utilization rate, maintainability must be managed as a key indicator to meet the user's requirements for failure maintenance time and to reduce life-cycle costs. To improve the maintainability-prediction accuracy in the detailed design stage, we present a maintainability-prediction method that applies Method B of the Military Standardization Handbook (MIL-HDBK-472) Procedure V, as well as a Korean maintainability-prediction software package that reflects the system complexity.

• 한국인터넷방송통신학회논문지
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• 제19권2호
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• pp.193-201
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• 2019

본 연구는 우리 군의 무기체계 도입 후 체계 업체가 CSP( Concurrent Spare Parts)지원 이후 우리 군이 운용유지 기간 해외에서 도입된 장비의 정비 지원 장비 품목의 해외 상업 구매 시 부품 무응찰 품목 조달 문제에 대한 내부적 요인과 외부적 요인의 각 기관별 수행 과정 및 수행된 사업들을 통해 파악된 노후화된 장비의 해외 부품 조달에 있어 입찰 참여자가 없는 부품의 무응찰 발생의 근본 원인을 보다 정밀하게 파악 및 진단함으로써, 향후 해외 도입 장비의 수리 부속 부품 조달시 부품 소요량 판단을 각 군이 보다 정확하게 소요량, 획득 기점을 예측 함으로 부품의 무응찰 발생률을 줄이고 이로 인한 장비 가동률 저하 문제와 미래의 부품가격 상승을 사전에 예방하고 효율적인 업무를 하기 위한 발전 방향을 제시하는데 그 목적을 둔다.

• 융복합기술연구소 논문집
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• 제10권1호
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• pp.25-29
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• 2020

Magnetic gears of non-contact power type have great advantages in terms of maintenance and repair than mechanical gears, and are used in various ways. Harmonic gears can derive a higher gear ratio than conventional gears through power transmission through a unique rotation mechanism. Magnetic harmonic gears, in which the gear teeth of the harmonic gears are replaced with magnets, have the advantages of both gears, but are difficult to implement and practical, so many studies are being conducted. In this study, we check whether the results of various types of magnetic gears can be applied to harmonic gears. By applying the axial type magnetic gear to the harmonic gear, the characteristic analysis is conducted to see if the result comparable to the existing radial type magnetic harmonic gear is obtained.

• Smart Structures and Systems
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• 제21권6호
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• pp.741-749
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• 2018

Structural health monitoring (SHM) systems are necessary to achieve smart predictive maintenance and repair planning as well as they lead to a safe operation of mechanical structures. In the context of vibration-based SHM the measured structural responses are employed to draw conclusions about the structural integrity. This usually leads to a mathematically illposed inverse problem which needs regularization. The restriction of the solution set of this inverse problem by using prior information about the damage properties is advisable to obtain meaningful solutions. Compared to the undamaged state typically only a few local stiffness changes occur while the other areas remain unchanged. This change can be described by a sparse damage parameter vector. Such a sparse vector can be identified by employing $L_1$-regularization techniques. This paper presents a novel framework for damage parameter identification by combining sparse solution techniques with an Extended Kalman Filter. In order to ensure sparsity of the damage parameter vector the measurement equation is expanded by an additional nonlinear $L_1$-minimizing observation. This fictive measurement equation accomplishes stability of the Extended Kalman Filter and leads to a sparse estimation. For verification, a proof-of-concept example on a quadratic aluminum plate is presented.

• Journal of Electrical Engineering and Technology
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• 제12권1호
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• pp.466-471
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• 2017

Pantograph must be correctly attached to catenary to continuously supply stable power to railway vehicle, and the device used here is Auxiliary Air Compressor (ACM). The existing ACM used the DC motor that included commutator and brush. Since maintenance and repair by mechanical friction are essential for the DC motor, BLDC motor studies have been conducted to improve this. A three-phase BLDC motor does $120^{\circ}$ two-phase commutation through hall sensors in general. However, since hall sensor is vulnerable to heat and can run only when all three sensors work normally, sensorless control method has been studied to solve this. Using back EMF Zero Crossing Point (ZCP) detection method, this paper will introduce a stable switching sensing method that has a non-commutation area in a low speed zone.