• Biomedical Science Letters
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• v.17 no.2
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• pp.167-171
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• 2011

[ ${\alpha}$ ]synuclein (${\alpha}$-syn) is implicated in the pathogenesis of Parkinson's disease (PD) and other related diseases. We have previously reported that ${\alpha}$-syn binds to the cell membranes in a transient and reversible manner. However, little is known about the physiologic function and/or consequence of this association. Here, we examined whether chemically induced perturbations to the cellular membranes enhance the binding of ${\alpha}$-syn, based on hypothesis that ${\alpha}$-syn may play a role in maintenance of membrane integrity or repair. We induced membrane perturbations or alterations in ${\alpha}$-syn-overexpressing human neuroblastoma cells (SH-SY5Y) by treating the cells with hydrogen peroxide ($H_2O_2$) or oleic acid. In addition, membranes fractionated from these cells were perturbed by treating them with proteinase K or chloroform. Dynamic interaction of ${\alpha}$-syn to the membranes was analyzed by the chemical cross-linking assay that we developed in the previous study. We found that membrane interaction of ${\alpha}$-syn was increased upon treatment with membrane-perturbing reagents in a dose and time dependent manner. These results suggest that perturbations in the cellular membranes cause increased binding of ${\alpha}$-syn, and this may have significant implication in the physiological function of ${\alpha}$-syn in cells.

• International Journal of Highway Engineering
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• v.11 no.3
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• pp.33-40
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• 2009

The use of the crumb rubber as an asphalt binder modifier may contribute to road maintenance and repair. The adhesion properties of the crumb rubber modified asphalt (CRMA) sealant have attracted interest due to brittle and adhesion failure of asphalt binders at low temperatures. In this study, the influence of a flexibilizer as a modifier for CRMA at low temperatures was investigated. Their properties were measured using the penetration, the softening point, the tensile and tensile adhesion tests at low temperature. The tensile adhesion strength and the strain of CRMAs were increased with increasing ductile deformation of the CR and the asphalt binder in the flexiblizer modified CRMAs. It was found that the flexibilizer concentration was an important factor for tensile and adhesion properties of CRMAs at low temperatures.

• Journal of Sensor Science and Technology
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• v.14 no.3
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• pp.198-205
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• 2005

Recently, the systems using multiple sensors such as magnetic, acoustic and pressure sensor are used for detection of underwater objects or vehicles. Those systems have difficulty of maintenance and repair because they operate underwater. Thus, this paper describes a hybrid detection system with long term operating reliability. This has a multi-signal transmission structure to have a high reliability. First, a signal transmission & receiving part, which transfers data from underwater sensors to land and receive control message from land through optical cable, has 4 multi-path. Second, the nodes for signal transmission are connected dually each other with single-hop construction and sensors are connected to a couple of neighboring nodes. This enables the output signal to transmit from a node to the next node and the next but one node together. Also, the signal from a sensor can be transmitted to two nodes at the same time. Therefore, the system with this construction has high reliability in long term operation because it makes possible to transmit sensor data to another node which works normally although a transmission node or cable in system have some faults.

• Journal of the Korean Institute of Gas
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• v.11 no.3
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• pp.56-63
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• 2007

These days, needs and wants of the customers are getting diversified and the market is also changing rapidely. Many organizations are now attempting change and innovation activities to improve products and service quality. This study was performed to apply 6 sigma tools for the efficient repair management of city gas supply equipment. Vital few factors, RISK factors, sigma values, root causes. and solutions were derived by 6 sigma tools. We are performing statistical process control for the new process. Six sigma for city gas supply equipment safety management enabled to improve the business management for efficiency by reducing variation and eliminating cost for quality.

• Journal of Information Technology Services
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• v.1 no.1
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• pp.81-117
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• 2002

The generalization of Internet use has been spreaded all over the world and impacted company to introduce intranet and extranet for their operation which dealt with electronic commerce. For these reason, endeavor of implementation of web site system is promotioned and enhanced the possibility of adaptation range for the view of company. Dramatic competition which company faced with the use of internet and request from all over the world made company brought company to various and different type of level. It is necessary to develop website system with experty knowledge to satisfy customer needs. To deal with this situation, works from the level of government should proposed to spread whole country business which propelled through kyungnam mechanic industry information promotion center. With strategic proposal concerning district characteristics to adapt electronic commerce successfully, information promotion should performed. Support of government is needed continuously to realize infra of ASP composed of 4,877 mechanic industry company. It might be possible to deal with international rapid change with cooperation of company and government related department.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.10
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• pp.102-111
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• 2021

Maintainability is a major design parameter that includes availability as well as reliability in a RAM (reliability, availability, maintainability) analysis, and is an index that must be considered when developing a system. There is a lack of awareness of the importance of predicting and analyzing maintainability; therefore, it is dependent on past-experience data. To improve the utilization rate, maintainability must be managed as a key indicator to meet the user's requirements for failure maintenance time and to reduce life-cycle costs. To improve the maintainability-prediction accuracy in the detailed design stage, we present a maintainability-prediction method that applies Method B of the Military Standardization Handbook (MIL-HDBK-472) Procedure V, as well as a Korean maintainability-prediction software package that reflects the system complexity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.19 no.2
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• pp.193-201
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• 2019

The purpose of this study is to investigate the internal and extrnal factors of procurement of non-bid parts in the overseas militaries products for commercial purchase after deploy at Militaries. How we will continures to support of Primary of delivery to end users for all systems for maintenance support equipment products of Korean militaries. the purpose of this study is to propose a development direction for solving hard to find parts and non-bid products problem due to non-response of overseas repair parts suppliers.

• Journal of Institute of Convergence Technology
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• v.10 no.1
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• pp.25-29
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• 2020

Magnetic gears of non-contact power type have great advantages in terms of maintenance and repair than mechanical gears, and are used in various ways. Harmonic gears can derive a higher gear ratio than conventional gears through power transmission through a unique rotation mechanism. Magnetic harmonic gears, in which the gear teeth of the harmonic gears are replaced with magnets, have the advantages of both gears, but are difficult to implement and practical, so many studies are being conducted. In this study, we check whether the results of various types of magnetic gears can be applied to harmonic gears. By applying the axial type magnetic gear to the harmonic gear, the characteristic analysis is conducted to see if the result comparable to the existing radial type magnetic harmonic gear is obtained.

• Smart Structures and Systems
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• v.21 no.6
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• pp.741-749
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• 2018

Structural health monitoring (SHM) systems are necessary to achieve smart predictive maintenance and repair planning as well as they lead to a safe operation of mechanical structures. In the context of vibration-based SHM the measured structural responses are employed to draw conclusions about the structural integrity. This usually leads to a mathematically illposed inverse problem which needs regularization. The restriction of the solution set of this inverse problem by using prior information about the damage properties is advisable to obtain meaningful solutions. Compared to the undamaged state typically only a few local stiffness changes occur while the other areas remain unchanged. This change can be described by a sparse damage parameter vector. Such a sparse vector can be identified by employing $L_1$-regularization techniques. This paper presents a novel framework for damage parameter identification by combining sparse solution techniques with an Extended Kalman Filter. In order to ensure sparsity of the damage parameter vector the measurement equation is expanded by an additional nonlinear $L_1$-minimizing observation. This fictive measurement equation accomplishes stability of the Extended Kalman Filter and leads to a sparse estimation. For verification, a proof-of-concept example on a quadratic aluminum plate is presented.

• Journal of Electrical Engineering and Technology
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• v.12 no.1
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• pp.466-471
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• 2017

Pantograph must be correctly attached to catenary to continuously supply stable power to railway vehicle, and the device used here is Auxiliary Air Compressor (ACM). The existing ACM used the DC motor that included commutator and brush. Since maintenance and repair by mechanical friction are essential for the DC motor, BLDC motor studies have been conducted to improve this. A three-phase BLDC motor does $120^{\circ}$ two-phase commutation through hall sensors in general. However, since hall sensor is vulnerable to heat and can run only when all three sensors work normally, sensorless control method has been studied to solve this. Using back EMF Zero Crossing Point (ZCP) detection method, this paper will introduce a stable switching sensing method that has a non-commutation area in a low speed zone.