• YAKHAK HOEJI
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• v.36 no.6
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• pp.598-603
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• 1992

The purpose of this study was to assess the effect of three formulations; product A (polyethylene glycol was used as a main dispersing agent), product B (wax mixture was used as a main dispersing agent) and product C(silicon dioxide was used as a main dispersing agent) on bioavailability of acetaminophen soft gelatin capsules(softgels) and to develop an effective acetaminophen softgel which exhibits an excellent bioavailability. Acetaminophen softgels of various formulations were prepared as 4 minim round type by rotary die method. Four softgels of the three formulation (A, B, C), each of which contained 50 mg acetaminophen, were administered orally to 12 normal healthy rabbits using a three-way cross over design. Plasma acetaminophen concentrations were measured by HPLC. The results obtained in this study were as follows: 1. The Tmax rank order of acetaminophen softgel was C$(63.75{\pm}10.62\;min)$>A$(36.25{\pm}5.37\;min)$>B$(35{\pm}6.74\;min)$. 2. The decreasing Cmax order of softgel product was A$(93.51{\pm}0.55\;{\mu}g/ml)$>B$(3.16{\pm}0.37\;{\mu}g/ml)$>C$(2.6{\pm}0.55\;{\mu}g/ml)$. 3. The $[AUC]^{\infty}_0$ rank order for three acetaminophen softgel formulations was A $(14.89{\pm}1.56\;{\mu}g/ml{\cdot}min)$ >B$(14.39{\pm}1.43\;{\mu}g/ml{\cdot}min)$>C$(11.45{\pm}1.49\;{\mu}g/ml{\cdot}min)$. 4. Pharmacokinetic parameters such as Tmax, Cmax and $[AUC]^{\infty}_0$ of product A and B did not differ significantly(p>0.05). On the other hand, those of product C were significantly different(p>0.05).

• The Korean Society of Law and Medicine
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• v.23 no.2
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• pp.67-96
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• 2022

"Aid in Dying" means that when a decision-making patient suffers from an incurable disease, a drug that can speed up death is prescribed by a doctor and used to lead to death. Since the suspension of life-sustaining treatment was institutionalized based on human dignity and patient autonomy, the question of whether assisted death can be legally justified in relation to the right to receive medical help to shorten one's life to die with dignity has recently been actively discussed. In Korea, since the suspension of life-sustaining treatment was institutionalized by the enactment of the Life-sustaining Treatment Decision Act in 2016, an amendment to the Life-sustaining Treatment Act was recently proposed to legalize Aid in Dying. The global trend is that human "Right to Die" is discussed in the division of life and death, from the suspension of life-sustaining treatment to assisted death, and again in the order of euthanasia. In this paper, we started discussing dignified death and institutionalized patients' right to self-determination, looked at the controversy in the United States, which legislated assisted death in many states since the 2000s, and analyzed the main contents of California's End of Life Option Act and the data after enforcement. The strict requirements for Aid in Dying, such as voluntary confirmation of patients' intentions and doctors' obligation to provide information, and the results of California's Aid in dying system, composed of relatively diverse races, were reviewed.

• The Journal of Advanced Prosthodontics
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• v.10 no.2
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• pp.79-84
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• 2018

PURPOSE. All-ceramic restorations required extensive tooth preparation. The purpose of this in vitro study was to investigate a minimally invasive preparation and thickness of monolithic zirconia crowns, which would provide sufficient mechanical endurance and strength. MATERIALS AND METHODS. Crowns with thickness of 0.2 mm (group 0.2, n=32) or of 0.5 mm (group 0.5, n=32) were milled from zirconia and fixed with resin-based adhesives (groups 0.2A, 0.5A) or zinc phosphate cements (groups 0.2C, 0.5C). Half of the samples in each subgroup (n=8) underwent thermal cycling and mechanical loading (TCML)(TC: $5^{\circ}C$ and $55^{\circ}C$, $2{\times}3,000cycles$, 2 min/cycle; ML: 50 N, $1.2{\times}10^6cycles$), while the other samples were stored in water ($37^{\circ}C/24h$). Survival rates were compared (Kaplan-Maier). The specimens surviving TCML were loaded to fracture and the maximal fracture force was determined (ANOVA; Bonferroni; ${\alpha}=.05$). The fracture mode was analyzed. RESULTS. In both 0.5 groups, all crowns survived TCML, and the comparison of fracture strength among crowns with and without TCML showed no significant difference (P=.628). Four crowns in group 0.2A and all of the crowns in group 0.2C failed during TCML. The fracture strength after 24 hours of the cemented 0.2 mm-thick crowns was significantly lower than that of adhesive bonded crowns. All cemented crowns provided fracture in the crown, while about 80% of the adhesively bonded crowns fractured through crown and die. CONCLUSION. 0.5 mm thick monolithic crowns possessed sufficient strength to endure physiologic performance, regardless of the type of cementation. Fracture strength of the 0.2 mm cemented crowns was too low for clinical application.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.15 no.3
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• pp.44-51
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• 2016

This paper presents the characteristics of the energy absorption in an expansion tube type impact absorber that is applied to a high weight drop tester and the use of a response surface methodology to predict the impact energy absorption. In order to identify the characteristics of the energy absorption, a set of finite element analysis was conducted with Abaqus Explicit. Moreover, the ISCD-II sampling method and a first order polynomial were used to build a response surface. As a result, we demonstrated that the impact energy could be controlled by four main design variables, namely an expansion pipe's thickness, inner radius, pressing die's expansion angle and expansion ratio. Additionally, we observed the relationship between the four main design variables and the impact energy absorbing time, displacement, and maximum impact force.

• Journal of Korean Academy of Nursing
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• v.8 no.1
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• pp.85-98
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• 1978

This study was designed to investigate the elderly people's attitude toward death for the purpose of identifying the issues needed in the planning of health management and care activities for the aged. The total number of subjects in this study was 354 elderly people who were accommodated in house for elderly people (185) and school for elderly people (169). The scale for the attitude toward death of aged persons as an instrument of this study was mainly constructed with reference to Schneidman's attitude questioners toward death modified of adjust the Korean cultural characteristics and attitudes concerning death. Theresultsofthisstudywereasfollows: - 1. Out of total 45.8% of the respondents consider that death is a natural phenomena and ending of life. The responses on the meaning of death appeared differently : non-religions (48.1%) and oriental religions (50.3%) consider death as a natural phenomena however western religions (47.4%) consider that death is God's call. This difference was statistically significant. (x$^2$= 56.6419. df = 10. p<0.01). Respondents with a spouses (52.4%) think death is a natural phenomena opposed to respondent without spouses (33.3%). This was statistically significant. (x$^2$= 14.7134. df= 5 p<0.05). 2. Respondents in the house for aged persons (51.9%) replied. They do not wanted death because it meant a separation from their family as compared to those from school for aged persons (26.0%). 57.9% responded that they want to be told when death is confronted. 3. 51.2% of the respondents replied that the main factor to influence their attitude toward concept of death was the dying of their friends & relatives. 79.9% of respondents expressed that wished to die. The main reason for dying was economic shortage (28.3%). 4. 70.1% of the respondents want their body to be hurried while only 1.1% of the respondents want to donate their body to a medical research. 5. Over two thirds of the respondents replied that they do not believe in a life in heaven or that they will be rebirth. 6. The questioners of this study stimulated 56.8% of the respondents to feel that they should spend the leu of their life more effectively and 15.5% of the respondents felt it gave them the opportunity to think about their death seriously.

• Korean Journal of Agricultural Science
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• v.22 no.1
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• pp.11-23
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• 1995

The CAD/CAM system for the manufacturing automation is the newest technology in mechanical engineering area and becomes the important research subject nowadays. Most of all hardwares and softwares for the CAD/CAM system used in the our manufacturing companies such as automobile company are developed by the foreign country and the purchasing price of them is very expensive but their applicability to a certain area is very limited. This study was conducted to develope a CAD/CAM system for the design and the automatic manufacturing of the iron pattern shaped with 3 - dimensional free curved surface, and to test its applicability to the design and the manufacturing of the rotary blade. The results obtained from the study are as follow; 1. The CAD system which can process graphic procedures from the free curved surface shaped data was developed with personal computer. 2. The CAM main program was developed. This main program could produce CL data from CAD data file by checking the tool interference according to the cutting mode. 3. The sub. program which can simulate the tool trace from the CL data was developed. 4. The post processor for the Deckel FP2NC NC milling machine from CL data file was developed and the sub program could transmit NC program through modem to NC milling machine was developed. 5. The developed CAM system seemed to be applicable to any other system. Because the measuring results of the cross sectional thickness of the plastic model from the manufacturing iron pattern by the system showed that this system could properly check the tool interference. 6. In took 75~90 hours to manufacture two iron patterns of rotary blade. For the sake of convenience in applying to the other systems, this system was developed in BASIC and FORTRAN computer language and minimum portion of machine language as possible.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2006.10a
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• pp.166-175
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• 2006

Since many years ago and in spite of the existence of national regulations and international conventions ratified by the countries that are conformed the Central American Region (CAR), the seagoing maritime sector of this Region, has developed its activity without any type of safety measures. Therefore, a large number of people are known to die, disappear and suffer from serious injuries each year. These maritime casualties devastate the families affected by these events, and severely impact the local social and economic well-being. While all these accidents occurred in this Region, non government or any other official records are available recording these casualties Due to the lack of any historical written reports about maritime casualties occurred in this Region, the compilation of this type of accidents information and data was carried out directly by the researchers in the field. Also, all the information about the CAR Maritime Organization Components was too compiled by the authors from the respective National Maritimes Authorities. From the compiled information was elaborated the CAR maritime casualties data base and from the analysis of the above data base were determined the main causes of the maritime accidents occurred in the CAR. The lack of safety measures onboard and the ignorance of the presence and influence of atmospheric phenomena were among main factors that had been caused the maritime casualties in this Region. By other hand, from the analysis of the CAR maritime organization components, the existence of one level of organization very similar among them was determinate. The objective of this research was to analyze the role of the CAR maritime organization in the prevention of the occurrence of maritime casualties. The results of this study provides general understanding of the causes of this type of accidents in the CAR and basis for support in improving safety navigation system and measures so that the number of fatalities and maritime accidents may be reduced in the future.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.4
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• pp.177-182
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• 2023

Korea is currently an aging society with a population of about 15 percent over the age of 65. Accordingly, the government is currently working on a number of measures. However, the problem that is rapidly increasing rather than decreasing is the traffic accident of the elderly. It has increased so much that we can check it out in multiple media right away. An average of 110 elderly people die or are injured in traffic accidents a day, or about 40,000 a year. The National Police Agency reported a 25 percent increase in elderly traffic accidents from five years ago. This paper analyzes traffic accidents of senior citizens through the Big Data analysis and R programming language to present the main causes of traffic accidents of senior citizens and areas where measures are needed to prevent them.

• Journal of Mechanical Science and Technology
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• v.16 no.12
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• pp.1687-1692
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• 2002

The problem analyzed here is a sheet metal forming process which requires a drawbead. The drawbead provides the sheet metal enough tension to be deformed plastically along the punch face and consequently, ensures a proper shape of final products by fixing the sheet to the die. Therefore, the optimum design of drawbead is indispensable in obtaining the desired formability. A static-explicit finite element analysis is carried out to provide a perspective tool for designing the drawbead. The finite element formulation is constructed from static equilibrium equation and takes into account the boundary condition that involves a proper contact condition. The deformation behavior of sheet material is formulated by the elastic-plastic constitutive equation. The finite element formulation has been solved based on an existing method that is called the static-explicit method. The main features of the static-explicit method are first that there is no convergence problem. Second, the problem of contact and friction is easily solved by application of very small time interval. During the analysis of drawbead processes, the strain distribution and the drawing force on drawbead can be analyzed. And the effects of bead shape and number of beads on sheet forming processes were investigated. The results of the static explicit analysis of drawbead processes show no convergence problem and comparatively accurate results even though severe high geometric and contact-friction nonlinearity. Moreover, the computational results of a static-explicit finite element analysis can supply very valuable information for designing the drawbead process in which the defects of final sheet product can be removed.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.10
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• pp.115-121
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• 2008

This paper presents bisymmetric dual iron core lineal motor stage for heavy-duty high precision applications such as large area micro-grooving machines or high precision roll die machines. In this stage, two iron core linear motors are installed in laterally symmetric way to cancel out the attractive forces. Main focus was given to analyzing the effect of cogging force and moment for two different layouts, which are symmetric and half-pitch shifted ones. Experimental results showed that the symmetric layout is more adequate for high precision applications because of its clear moment cancellation effect. It was also verified that the effect of the residual cogging moment can be suppressed further by increasing the bearing stiffness. One problem of the symmetric layout is added cogging force which hinders smooth motion, but its effect was relatively small compared with that of moment cancellation.