• Journal of the Korean Magnetic Resonance Society
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• v.19 no.3
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• pp.137-142
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• 2015

NMR-based structural studies on membrane proteins are appreciated quite challenging due to various reasons, generally including the narrow dispersion of NMR spectra, the severe peak broadening, and the lack of long range NOEs. In spite of the poor biophysical properties, structural studies on membrane proteins have got to go on, considering their functional importance in biological systems. In this review, we provide a simple overview of the techniques generally used in structural studies of membrane proteins by solution NMR, with experimental examples of a helical membrane protein, caveolin 3. Detergent screening is usually employed as the first step and the selection of appropriate detergent is the most important for successful approach to membrane proteins. Various tools can then be applied as specialized NMR techniques in solution that include sample deteuration, amino-acid selective isotope labeling, residual dipolar coupling, and paramagnetic relaxation enhancement.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.1-1
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• 2011

We developed a new generalized synthetic procedure, called as "heat-up process," to produce uniform-sized nanocrystals of many transition metals and oxides without a size selection process. We were able to synthesize uniform magnetite nanocrystals as much as 1 kilogram-scale from the thermolysis of Fe-oleate complex. Clever combination of different nanoscale materials will lead to the development of multifunctional nano-biomedical platforms for simultaneous targeted delivery, fast diagnosis, and efficient therapy. In this presentation, I would like to present some of our group's recent results on the designed fabrication of multifunctional nanostructured materials based on uniform-sized magnetite nanoparticles and their medical applications. Uniform ultrasmall iron oxide nanoparticles of <3 nm were synthesized by thermal decomposition of iron-oleate complex in the presence of oleyl alcohol. These ultrasmall iron oxide nanoparticles exhibited good T1 contrast effect. In in vivo T1 weighted blood pool magnetic resonance imaging (MRI), iron oxide nanoparticles showed longer circulation time than commercial gadolinium complex, enabling high resolution imaging. We used 80 nm-sized ferrimagnetic iron oxide nanocrystals for T2 MRI contrast agent for tracking transplanted pancreatic islet cells and single-cell MR imaging. We reported on the fabrication of monodisperse magnetite nanoparticles immobilized with uniform pore-sized mesoporous silica spheres for simultaneous MRI, fluorescence imaging, and drug delivery. We synthesized hollow magnetite nanocapsules and used them for both the MRI contrast agent and magnetic guided drug delivery vehicle.

• Journal of electromagnetic engineering and science
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• v.14 no.4
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• pp.329-331
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• 2014

A simple realization of an alignment-free wireless power transmission (WPT) system is presented in this letter. The WPT system consists of a transmitter with three reconfigurable modes corresponding to various controllable magnetic field directions in the azimuthal plane and an algorithm for the optimum mode selection carried by sensing the reflected voltage of the system. Twelve light emitting diodes (LEDs) are used to confirm the on- and off-state of LEDs powered wirelessly by the transmitter at every $15^{\circ}$ of the azimuthal plane. A criterion voltage from the reflected power of the system is found by using the correlation between the reflected voltage and the on- and off-state of the LEDs. Simply by continuous; monitoring of the voltage from the system, the system maintains power to the LEDs. The system is realized by MATLAB/Simulink and a National Instrument data acquisition device (DAQ) board. Measurements using the system show on-state LEDs in the azimuthal plane except at the angles of $60^{\circ}$, $75^{\circ}$, $180^{\circ}$, and $300^{\circ}$.

• Journal of Electrical Engineering and information Science
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• v.2 no.6
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• pp.95-105
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• 1997

In this paper, we have studied about design and fabrication of the actively shielded superconducting MRI magnet. Nonlinear optimization methods are usually used to find optimum coil configurations. However the selection of initial coil configurations is very difficult. In case bad initial data are used, it is even impossible to find optimum coil configurations which satisfy predefined constraints. We have developed computer optimization program which consists of two steps. Initial coil configurations are easily selected through linear optimization in the first step and optimum coil configurations are found through nonlinear optimization in the second step. We have also studied about superconducting shim coils to cancel error fields caused by coil fabrication errors. Many researchers published design concepts of shim coil. However all these studies are for shim coil design using filamentary coils with single turn, Shim coils with multi-turns should be used to produce enough field strength to cancel error fields. We have developed computer program for the design of shim coils which have proper thickness and length. An actively shielded superconducting MRI magnet with a small warm bore was fabricated and four sets of superconducting shim coils were equipped. The magnetic field distributions were measured and field correction was carried out using shim coils.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.7
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• pp.1311-1315
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• 2016

Induction motor requires a rotating magnetic field for rotation. Current required to generate the rotating magnetic field is immediately magnetizing current. This magnetizing current is associated with the reactive power. Induction motor is always required reactive power. If reactive power is supplied only to the power supply side, the power factor is low. Therefore, it is to compensate the power factor by connecting capacitors in parallel to the motor terminal. If the capacitor current is greater than the magnetizing current of the motor, there is a possibility that the self-excitation occurs. High voltage generated by the self-excitation leads to insulation failure on the motor. So it is necessary to calculate the power factor correction capacitor capacity the most suitable to the extent that the magnetizing current does not exceed the capacitor current. In this study, we first computed the magnetization current and the reactive power of the induction motor and then calculates a limit of the maximum power factor by comparing the magnetizing current and the capacitor current installed in order to achieve the target power factor.

• Korean Journal of Radiology
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• v.22 no.12
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• pp.1946-1963
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• 2021

Cardiac computed tomography (CT) and cardiac magnetic resonance imaging (CMR) can reveal the detailed anatomy and function of the tricuspid valve and right ventricle (RV). Quantification of tricuspid regurgitation (TR) and analysis of RV function have prognostic implications. With the recently available transcatheter treatment options for diseases of the tricuspid valve, evaluation of the tricuspid valve using CT and CMR has become important in terms of patient selection and procedural guidance. Moreover, CT enables post-procedural investigation of the causes of valve dysfunction, such as pannus or thrombus. This review describes the anatomy of the tricuspid valve and CT and CMR imaging protocols for right heart evaluation, including RV function and TR analyses. We also demonstrate the pre-procedural planning for transcatheter treatment of TR and imaging of postoperative complications using CT.

• Journal of Astronomy and Space Sciences
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• v.25 no.2
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• pp.113-128
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• 2008

Solar wind dynamic pressure enhancements are known to cause various types of disturbances to the magnetosphere. In particular, dynamic pressure enhancements may affect the evolution of magnetic storms when they occur during storm times. In this paper, we have investigated the statistical significance and features of dynamic pressure enhancements during magnetic storm times. For the investigation, we have used a total of 91 geomagnetic storms for 2001-2003, for which the Dst minimum $(Dst_{min})$ is below -50 nT. Also, we have imposed a set of selection criteria for a pressure enhancement to be considered an event: The main selection criterion is that the pressure increases by ${\geq}50%\;or\;{\geq}3nPa$ within 30 min and remains to be elevated for 10 min or longer. For our statistical analysis, we define the storm time to be the interval from the main Dst decrease, through $Dst_{min}$, to the point where the Dst index recovers by 50%. Our main results are summarized as follows. $(i){\sim}$ 81% of the studied storms indicate at least one event of pressure enhancements. When averaged over all the 91 storms, the occurrence rate is ${\sim}$ 4.5 pressure enhancement events per storm and ${\sim}$ 0.15 pressure enhancement events per hour. (ii) The occurrence rate of the pressure enhancements is about three times higher for CME-driven storm times than for CIR-driven storm times. (iii) Only 21.1% of the pressure enhancements show a clear association with an interplanetary shock. (iv) A large number of the pressure enhancement events are accompanied with a simultaneous change of IMF $B_y$ and/or $B_z$: For example, 73.5% of the pressure enhancement events are associated with an IMF change of either $|{\Delta}B_z|>2nT\;or\;|{\Delta}B_y|>2nT$. This last finding suggests that one should consider possible interplay effects between the simultaneous pressure and IMF changes in many situations.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.233-240
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• 1996

Analyses of the viscous and end effects on electromagnetic (EM) pumps of annular linear induction type for the sodium coolant circulation in Liquid Metal Fast Breeder Reactors have been carried out based on the MHD laminar flow analysis and the electromagnetic field theory. A one-dimensional MHD analysis for the liquid metal flowing through an annular channel has been performed on the basis of a simplified model of equivalent current sheets instead of three-phase currents in the discrete primary windings. The calculations show that the developed pressure difference resulted from electromagnetic and viscous forces in the liquid metal is expressed in terms of the slip, and that the viscous loss effects are negligible compared with electromagnetic driving forces except in the low-slip region where the pumps operate with very high flow velocities comparable with the synchronous velocity of the electromagnetic fields, which is not applicable to the practical EM pumps. A two-dimensional electromagnetic field analysis based on an equivalent current sheet model has found the vector potentials in closed form by means of the Fourier transform method. The resultant magnetic fields and driving forces exerted on the liquid metal reveal that the end effects due to finiteness of the pump length are formidable. In addition, a two-dimensional numerical analysis for vector potentials has been performed by the SOR iterative method on a realistic EM pump model with discretely-distributed currents in the primary windings. The numerical computations for the distributions of magnetic fields and developed pressure differences along the pump axial length also show considerable end effects at both inlet and outlet ends, especially at high flow velocities. Calculations of each magnetic force contribution indicate that the end effects are originated from the magnetic force caused by the induced current ( u x B ) generated by the liquid metal movement across the magnetic field rather than the one (E) produced by externally applied magnetic fields by three-phase winding currents. It is concluded that since the influences of the end effects in addition to viscous losses are extensive particularly in high-velocity operations of the EM pumps, it is necessary to find ways to suppress them, such as proper selection of the pump parameters and compensation of the end effects.

• Journal of Life Science
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• v.26 no.8
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• pp.943-947
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• 2016

The objective of this study was to see if fairly simple magnetic nano-particle treatment enhances boar semen qualities. Boar semen samples were prepared from the swine AI center and samples were divided by 4 different motility groups (1, >90%; 2. 80~90%; 3. 70~80%; 4. <70%) using computer assisted sperm analysis (CASA) evaluation. Boar semen was extended using BTS extender and same number of magnetic nano-particles as total number of spermatozoa in each sample was treated for 20 min and collected for 5 min at room temperature. Sperm qualities such as motility and viability were evaluated by the CASA before and after treatment. Sperm abnormality and degree of agglutination were also evaluated under the microscopic examination before and after treatment. There were significant changes (p<0.05) on sperm motility from all 4 different groups in the average of 7.11% after treatment. The enhancement of sperm motility changes was more clear in the groups of lower sperm motile groups (<70% and 70~80%; 19.12±1.08% and 5.67±0.71%, p<0.05). The sperm motility character in terms of curvilinear velocity (VCL), straight line velocity (VSL), average path velocity (VAP) and linearity (LIN, %) showed also similar pattern but motility enhancement wear more clear in below 70% motile group. Average sperm viability was increased to 4% by magnetic nano-particles (p<0.05). The percentage of sperm abnormality was also reduced significantly (p<0.05) to the range of 3.7~4.5% before after treatment. The degree of sperm agglutination was also reduced in lower motility groups by the magnetic nano-particle purification.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.40 no.5
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• pp.341-349
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• 2003

A real time interactive controller (spectrometer) for magnetic resonance imaging (MRI) system has been developed using high speed digital signal processors (DSP). The controller generates radio frequency (rf) waveforms and audio frequency gradient waveforms and controls multiple receivers for data acquisition. By employing DSPs having high computational power (e.g., TMS320C670l) real time generation of complicated gradient waveforms and interactive control of selection planes are possible, which are important features in real-time imaging of moving organs, e.g., cardiac imaging. The spectrometer was successfully implemented at a 1.5 Tesla whole body MRI system for clinical application. Performance of the spectrometer is verified by various experiments including high- speed imaging such as fast spin echo (FSE) and echo planar imaging (EPI). These high-speed imaging techniques reduce measurement time, however, usually intensify artifact if there is any systematic phase error or jitter in the synchronization between the transmitter, receiver, and gradients.