• Title/Summary/Keyword: Magnetic Resonance Method

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A Debate on the Use of Presaturation Method in NMR for Structure Determination of Polypeptides in $H_2O$

  • Lee, Chulhyun;Yi, Gwan-Su;Kim, Eun-Hee;Lee, Jo-Woong;Chagjoon Cheong
    • Journal of the Korean Magnetic Resonance Society
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    • v.1 no.1
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    • pp.21-29
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    • 1997
  • Three typical solvent suppression methods employed for measuring the NOE data that are used for structure determination of polypeptides by modeling were discussed and compared with one another. In the experiments with several peptides composed of 10 to 65 amino acids the presaturation method was found to give severely distorted signal intensities of exchangeable protons, thus making the results based on this method much less reliable.

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Synthesis and Characterization of a Receptor-Targeting Contrast Agent

  • Yang, Taegyun;Park, Ji-Hyung;Lee, Seung-Cheol;Kim, Cheol-Su;Cho, Jee-Hyun;Lee, Chul-Hyun;Cheong, Chae-Joon
    • Journal of the Korean Magnetic Resonance Society
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    • v.7 no.1
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    • pp.46-54
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    • 2003
  • We synthesized a contrast agent for MRI that is capable of binding to the ABP-1 receptor and enhancing the contrast of the targeted cells. We used a lysine dendrimer (G=3)DTPA[Gd] as the contrast agent and synthesized a biotinylated polyclonal antibody for ABP-1 as the first antibody. Lysine dendrimers were prepared using the solid phase peptide synthesis method.$^3$ Amino-terminated lysine dendrimers were then coupled to DTPA using the anhydride method. Gd was complexed with the DTPA-lysine dendrimer in an acidic solution of 3 eq GdCl$_3$ to one of DTPA. The lysine dendrimer-DTPA[Gd] and avidin were conjugated in MES solution, pH 6.0, using EDC as the coupling reagent. The biotin-avidin system was used to link the polyclonal antibody and contrast agent. K562 cells were used for imaging.

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Magnetic Resonance Imaging with Intermolecular Double Quantum Coherences

  • Ahn, Sang-Doo
    • Journal of the Korean Magnetic Resonance Society
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    • v.8 no.2
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    • pp.108-114
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    • 2004
  • Recently a new method for magnetic resonance imaging based on the detection of relatively strong signal from intermolecular multiple quantum coherences (iMQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in long-range dipolar couplings that are traditionally ignored. In this paper, we present the results of experimental studies to assess the feasibility of intermolecular double quantum coherences (iDQCs) imaging in humans. We show that the iDQC images are readily observable at 4T and that they do indeed provide different contrast than appears in conventional images.

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Comparative Evaluation of North American Symptomatic Carotid Endarterectomy Trial and Warfarin-Aspirin Symptomatic Intracranial Disease Methods for Measurement of Middle Cerebral Artery Stenosis in Digital Subtraction Angiography and Magnetic Resonance Angiography (디지털 감산 혈관조영술과 자기 공명 혈관조영술에서 중대뇌동맥의 협착 측정을 위한 North American Symptomatic Carotid Endarterectomy Trial 및 Warfarin-Aspirin Symptomatic Intracranial Disease 방법의 비교 평가)

  • Lee, Jung-Hoon;Kim, Sang-Hyun
    • Journal of radiological science and technology
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    • v.42 no.5
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    • pp.351-356
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    • 2019
  • This study aimed to determine whether there was a difference in measurements between North American Symptomatic Carotid Endarterectomy Trial(NASCET) and Warfarin-Aspirin Symptomatic Intracranial Disease(WASID) methods that measure the middle cerebral artery stenosis in Digital Subtraction Angiography (DSA) and Magnetic Resonance Angiography (MRA). It involved 24 patients who had completed both DSA and MRA among patients with Middle Cerebral Artery (MCA) stenosis. The Middle Cerebral Artery (MCA) stenosis was measured using the NASCET and WASID methods through a retrospective analysis. For the NASCET and WASID methods, they performed measurements on normal blood vessels located far from and close to the stenosis, respectively. The mean value and standard deviation of the Digital Subtraction Angiography (DSA) measured by the NASCET method were 59.23% and 13.27%. On the other hand, those of the Digital Subtraction Angiography (DSA) measured by the WASID method were 66.64% and 12.47%. And, the mean value and standard deviation of the Magnetic Resonance Angiography (MRA) measured by the NASCET method were 49.82% and 12.06%. By contrast, those of the Magnetic Resonance Angiography (MRA) measured by the WASID method were 56.63% and 10.67%. All the p-values obtained by the Pearson and Spearman correlation tests in the Digital Subtraction Angiography (DSA) and the Magnetic Resonance Angiography (MRA) were <0.01. In conclusion, this study suggests that both the NASCET and WASID methods to measure the middle cerebral artery stenosis in the Digital Subtraction Angiography (DSA) and the Magnetic Resonance Angiography (MRA) can be used if they are not used interchangeably.

Use of Nuclear Magnetic Resonance Spectroscopy in Analysis of Fennel Essential Oil

  • AbouZid, Sameh
    • Natural Product Sciences
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    • v.22 no.1
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    • pp.30-34
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    • 2016
  • A simple and rapid method based on proton nuclear magnetic resonance spectroscopy was developed for determination of trans-anethole content in fennel essential oil. Spectra of pure trans-anethole, of the pure essential oil of fennel, and of the pure oil of fennel with thymol internal standard were recorded. The signal of $H-1^/$ was used for quantification of trans-anethole. This proton signal is well separated in the proton magnetic resonance spectrum of the compound. No reference compound is needed and cheap internal standard was used. The results obtained from spectroscopic analysis were compared with those obtained by gas chromatography. Additionally, the developed method was used for determination of the type of vegetable oil used as a carrier in commercial products, which cannot be quantified as such by gas chromatography. This study demonstrates the application of proton nuclear magnetic resonance spectroscopy as a quality control method for estimation of essential oil components.

Analysis of the Efficiency According to Resonant Repeater Application in Magnetic Resonant Wireless Power Transfer System (자기공진방식의 무선전력전송 시스템에서 공진 중계기 적용 여부에 따른 전력전송 효율 분석)

  • Baek, Seung-Myung;Kim, Dong-Eun;Shon, Jin-Geun
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.67 no.4
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    • pp.221-226
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    • 2018
  • In this paper, the power transfer efficiency analysis based on the resonant repeater in a magnetic resonance wireless power transfer system is proposed. The efficiency of the magnetic resonance method was verified by comparing the general frequency with the resonance frequency. The resonance repeater was arranged to increase the efficiency and increase the transfer distance. When using resonant repeaters, the maximum efficiency increase is about 36.23[%] and the transfer distance was extended to more than 20[cm]. Through this study, confirmed the effect of using resonance repeaters in wireless power transfer system. As a result, it can be expected that the overall technology related to wireless power transfer system will be more valuable for energy-IT technology.

The Effects of Antenna Type and Frequency on Wireless Power Transmission (무선전력전송의 효율에 영향 미치는 안테나 구조와 주파수 효과)

  • Kim, Eung Soo
    • Journal of Korea Multimedia Society
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    • v.18 no.4
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    • pp.541-545
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    • 2015
  • Wireless power transmission which can transmit the electrical power through the air is the promise technology. In this paper, the effects of wireless power transmission using magnetic resonance method have been studied on coil material, resonance frequency, and antenna type. We have found copper tube as a coil material had the better characteristics than that of enameled wire, and the optimal resonance frequency was 13.6MHz in the range of from 1MHz to 20MHz. And the double square spiral type antenna as a load coil was the best. The power transmission distance by magnetic resonance method with 13.6MHz was 150 cm.

Thermodynamic and Physical Properties of (NH4)2MnCl4·2H2O by Nuclear Magnetic Resonance Relaxation Times

  • Kim, Yoo Young
    • Journal of the Korean Magnetic Resonance Society
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    • v.23 no.2
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    • pp.40-45
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    • 2019
  • The phase transition temperatures and thermodynamic properties of $(NH_4)_2MnCl_4{\cdot}2H_2O$ grown by the slow evaporation method were studied using differential scanning calorimetry and thermogravimetric analysis. A structural phase transition occurred at temperature $T_{C1}$ (=264 K), whereas the changes at $T_{C2}$ (=460 K) and $T_{C3}$ (=475 K) seemed to be chemical changes caused by thermal decomposition. In addition, the chemical shift and the spin-lattice relaxation time $T_{1{\rho}}$ were investigated using $^1H$ magic-angle spinning nuclear magnetic resonance (MAS NMR), in order to understand the role of $NH_4{^+}$ and $H_2O$. The rise in $T_{1{\rho}}$ with temperature was related to variations in the symmetry of the surrounding $H_2O$ and $NH_4{^+}$.

Principles of Magnetic Resonance Angiography Techniques

  • Shin, Taehoon
    • Investigative Magnetic Resonance Imaging
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    • v.25 no.4
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    • pp.209-217
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    • 2021
  • Magnetic resonance angiography (MRA) plays an important role in accurate diagnosis and appropriate treatment planning for patients with arterial disease. Contrast-enhanced (CE) MRA is fast and robust, offering hemodynamic information of arterial flow, but involves the risk of a side effect called nephrogenic systemic fibrosis. Various non-contrast-enhanced (NCE) MRA techniques have been developed by utilizing the fact that arterial blood is moving fast compared to background tissues. NCE MRA is completely free of any safety issues, but has different drawbacks for various approaches. This review article describes basic principles of CE and NCE MRA techniques with a focus on how to generate angiographic image contrast from a pulse sequence perspective. Advantages, pitfalls, and key applications are also discussed for each MRA method.