• 제목/요약/키워드: MafK

검색결과 137건 처리시간 0.03초

Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells

  • Hwang, Yu-Jin;Song, Jaewhan;Kim, Haeng-Ran;Hwang, Kyung-A
    • BMB Reports
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    • 제47권9호
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    • pp.524-529
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    • 2014
  • Oxidative stress and inflammation are common to many pathological conditions. Defense mechanisms protect cells from oxidative stress, but can become over-activated following injury and inflammation. NF-${\kappa}B$ and Nrf2 transcription factors regulate proinflammatory and antioxidant gene expression, respectively. Studies have shown that many natural dietary compounds regulate NF-${\kappa}B$ and Nrf2, preventing inflammation and oxidative stress. Here, we report major compounds of Prunella vulgaris var. lilacina such as rosmarinic acid, oleanolic acid, ursolic acid and caffeic acid as a potential therapeutic for oxidative stress and inflammation. The major compounds exhibited high anti-inflammatory activity, inhibiting NO, PGE2 production, NF-${\kappa}B$ expression and activating Nrf2 expression. In addition, we examined the effect of major compounds on MafK expression. Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation. These findings suggest that oleanolic acid as NF-${\kappa}B$ inhibitors can potentially be used in therapeutic applications for the treatment of oxidative stress-induced diseases.

비육유에서 발생한 기종저의 병리학적 관찰 (A case report of blackleg in a Holstein bull)

  • 황의경;김재훈;윤순식;손현주;조윤상;유한상;박경애;진영화;최상호
    • 한국수의병리학회지
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    • 제2권1호
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    • pp.53-60
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    • 1998
  • A fourteen-month-old Holstein bull from a private cattle fattening farm at Ansung county in Kyunggi Province Korea was submitted on August 2nd 1997, for examination at the Pathology Division of the National Veterinary Research Institute. The bull died within 24 hours after developing clinical signs of abrupt inertia, complete anorexia high fever(40.3℃) diffuse severe emphysematous swelling of upper part of the right hind leg lateral recumbancy and paralysis. At necropsy diffuse severe subcutaneous redness and influx of serosanguinous exudate containing gas bubbles had accumulated under the thorax right hip and upper region of right hind leg. Muscles in upper right hind leg were blackish to dark red and yellowish brown in color. Muscle bundles were dry and separated by gas bubbles and serosanguinous fluids and muscles sections from affected regions floated in water. Histopathologically muscle fibers were partially or entirely degenerated fragmented and separated by exudate and gaseous substance mixed with polymorphonuclear cells. Blood vascular walls in affected regions showed severe acute fibrinoid necrosis. Typical large rod-shaped bacteria with or without oval central to subterminal spores were frequently observed in tissue sections stained with H-E and Gram stain. The large Gram-positive anaerobic endospore-producing rods were isolated from the suspension of muscle lesions. Isolated bacteria were identified as Clostridium(CL) chauvoei and CL. sordellii by biochemical tests. This case was diagnosed as blackleg based on the typical clinical signs gross finding histopathological observation and bacteriological results. This is the first case report on blackleg associated with Cl. chauvoei and Cl. sordellii in Holstein cattle in Korea.

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MAF(Multimedia Application File Format) 기반 멀티미디어 검색 시스템의 설계 및 구현 (A Design and Implementation of Multimedia Retrieval System based on MAF(Multimedia Application File Format))

  • 강영모;박주현;방형진;낭종호;김형철
    • 한국정보과학회논문지:시스템및이론
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    • 제33권9호
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    • pp.574-584
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    • 2006
  • 최근 MPEG-A(ISO/IEC 23000)에서는 MAF(Multimedia Application File Format)[1]라는 새로운 멀티미디어 파일 포맷을 제안하고 있다. MAF 파일포맷은 기존의 MPEG 압축 규격을 갖는 미디어 파일에 더해, 미디어 내용 정보를 기술하는 메타데이타를 MPEG-7을 사용하여 하나의 시스템 포맷 내에 포함할 수 있도록 해준다. 하지만 현재로서는 이러한 표준을 구현한 실제 시스템이 없기 때문에, 응용 측면에서 MAF가 얼마나 유용한지 검증하기 어렵다는 문제점을 가지고 있다. 본 논문에서는 PC와 모바일 단말기상에서 MPEG-A 표준을 기반으로 한 멀티미디어 검색 시스템을 설계 및 구현한다. 또한 MPEG-A에서는 아직 동영상에 관련된 메타데이타에 대해서는 제안된 바가 없기 때문에 MPEG-7 MDS(Multimedia Description Scheme)[2]와 TV-Anytime[3]을 기반으로 모바일 환경에서도 저작 및 사용하기 편리한 메타데이타들을 설계한다. 전체 시스템을 설계하기 위해서 MAF 검색 시스템이 가져야 할 5가지 요구사항인 이식성, 확장성, 호환성, 적응성, 효율성을 정의하고 이러한 요구사항을 바탕으로 하여 MAF 검색 시스템의 전체 구조를 응용 계층, 미들웨어 계층, 플랫폼 계층으로 설계한다. 제안하는 검색 시스템은 MAF 형식의 멀티미디어 데이타를 저작, 재생, 검색할 수 있는 클라이언트 파트와, 대용량의 MAF 형식의 멀티미디어 파일과 MAF 파일로부터 추출한 MPEG-7 형태의 메타데이타를 저장, 관리할 수 있는 서버 파트로 구성된다. 그리고 설계한 MAF 검색 시스템의 유용성을 검증하기 위하여, PC에서는 MS 윈도우 플랫폼 그리고 모바일 단말기에서는 WIPI 플랫폼 상에서 클라이언트 시스템을 구현하고 시스템 요구사항들을 모두 만족하는지 여부를 확인한다. 제안하는 검색 시스템은 MPEG-A 표준을 검증하고 그 유용성을 확인하기 위해 사용될 수 있다.

효율적인 비디오 브라우징 및 검색을 위한 통합 멀티미디어 응용 형식 (Integrated Multimedia Application Format for Active Video Browsing and Retrieval)

  • 조준호;진성호;양승지;노용만
    • 한국정보처리학회:학술대회논문집
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    • 한국정보처리학회 2005년도 추계학술발표대회 및 정기총회
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    • pp.155-158
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    • 2005
  • 본 논문에서는 MPEG 의 멀티미디어 응용 표준인 MAF(Multimedia Application Format)를 기반으로, 효율적인 비디오 콘텐츠의 검색 및 활용을 위한 통합 미디어 구조, 즉 비디오 MAF 를 제안한다. 제안하는 비디오 MAF 는 ISO 미디어 포맷을 기반으로 하고 단일의 비주얼 스트림과 다중 음성을 지원하기 위한 다수의 오디오 스트림, 내용기반의 정보를 포함하는 메타데이터, 그리고 비디오 콘텐츠의 대표 이미지를 동시에 포함하는 구조이다. 제안하는 파일포맷의 유용성을 검증하기 위해 비디오 MAF 로 생성 및 해석할 수 있는 부호기(encoder)와 복호기(decoder)를 설계하고 구현하여, 통합 미디어에 내재된 메타데이터를 이용한 효율적인 검색과 멀티트랙의 오디오 스트림을 활용한 다중 음성에 대한 지원이 가능함을 확인하였다. 또한 내재된 대표이미지는 비디오 콘텐츠에 대한 브라우징이 효과적으로 활용됨을 확인하였다.

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다중 영상 및 텍스트 동기화를 고려한 Music Player MAF 의 확장 포맷 연구 (A study on Extensions to Music Player MAF for Multiple JPEG images and Text data with Synchronization)

  • 양찬석;임정연;김문철
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2005년도 추계종합학술대회
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    • pp.967-970
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    • 2005
  • The Music Player MAF Player Format of ISO/IEC 23000-2 FDIS consists of MP3 data, MPEG-7 metadata and one optional JPEG image data based on MPEG-4 File Format. However, the current Music Player MAF format does not allow multiple JPEG image data or timed text data. It is helpful to use timed text data and multiple JPEG images in the various multimedia applications. For example, listening material for the foreign language needs an additional book which has text and images, the audio contents which can get image and text data can be helpful to understand the whole story and situations well. In this paper, we propose the detailed file structure in conjunction with MPEG-4 File Format in order to improve the functionalities, which carry multiple image data and text data with synchronization information between MP3 data and other resources.

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Authoring Tool of Musical Slide Show MAF Contents

  • ;김문철
    • 한국방송∙미디어공학회:학술대회논문집
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    • 한국방송공학회 2006년도 학술대회
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    • pp.289-295
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    • 2006
  • The Musical Slide Show MAF, which currently being standardized by MPEG, conveys the concept of combining several established standard technologies in a single file format. It defines the format of packing up MP3 audio data, along with MPEG-7 Simple Metadata Profile and MPEG-21 Digital Item Declaration metadata; with JPEC images and optional text, and synchronizes them all together to create a slideshow of JPEC image data associated to MP3 audio data during the audio playback. The implementation of Musical Slide Show MAF can be a music karaoke file where users can sing along while listening to the music, view the JPEG slideshow and reading the lyrics; or a story-telling file where users can listen to the narrated story by looking at the related illustration slideshow of the story In this paper we present the tool to producing the Musical Slide Show MAF contents. Regardless the knowledge of user on the MAF file format, the authoring tool simplify the manner of packaging several multimedia contents into single file.

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Performance Evaluations of Four MAF-Based PLL Algorithms for Grid-Synchronization of Three-Phase Grid-Connected PWM Inverters and DGs

  • Han, Yang;Luo, Mingyu;Chen, Changqing;Jiang, Aiting;Zhao, Xin;Guerrero, Josep M.
    • Journal of Power Electronics
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    • 제16권5호
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    • pp.1904-1917
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    • 2016
  • The moving average filter (MAF) is widely utilized to improve the disturbance rejection capability of phase-locked loops (PLLs). This is of vital significance for the grid-integration and stable operation of power electronic converters to electric power systems. However, the open-loop bandwidth is drastically reduced after incorporating a MAF into the PLL structure, which makes the dynamic response sluggish. To overcome this shortcoming, some new techniques have recently been proposed to improve the transient response of MAF-based PLLs. In this paper, a comprehensive performance comparison of advanced MAF-based PLL algorithms is presented. This comparison includes HPLL, MPLC-PLL, QT1-PLL, and DMAF-PLL. Various disturbances, such as grid voltage sag, voltage flicker, harmonics distortion, phase-angle and frequency jumps, DC offsets and noise, are considered to experimentally test the dynamic performances of these PLL algorithms. Finally, an improved positive sequence extraction method for a HPLL under the frequency jumps scenario is presented to compensate for the steady-state error caused by non-frequency adaptive DSC, and a satisfactory performance has been achieved.

Modified sorbitol MacConkey agar for the rapid isolation of Escherichia coli O157:H7

  • Jung, Byeong-yeal;Jung, Suk-chan;Lee, Na-kyung;Cho, Seong-kun;Cho, Dong-hee;Her, Moon;Yoon, Yong-dhuk;Kim, Bong-hwan
    • 대한수의학회지
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    • 제39권4호
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    • pp.765-771
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    • 1999
  • Unlike most Escherichia coli strains, E coli O157 : H7 didn't ferment sorbitol within 24h of incubation and showed a negative reaction for $\beta$-glucuronidase. We developed a new medium for the rapid isolation of E coli O157 : H7 using sorbitol MacConkey agar with cefixime, potassium tellurite and 4-methylumbelliferyl-${\beta}$-D-glucuronide (MUG) as a primary plating medium. The addition of $20{\mu}g/ml$ of vancomycin in enrichment broth for E coli O157 : H7 inhibited lots of Gram positive bacteria. Three strains (10.3%) of 29 non-O157 E coli strains and 3 strains (8.3%) of 36 Salmonella spp were inhibited at the $0.05{\mu}g/ml$ of cefixime and 23 strains (79.3%) of 29 non-O157 E coli strains and 12 strains (33.3%) of 36 Salmonella spp were inhibited at the $2.0{\mu}g/ml$ of potassium tellurite. But none of the E coli O157 : H7 was affected at these concentration. The addition of MUG at $100{\mu}g/ml$ level to sorbitol MacConkey agar with cefixime and potassium tellurite (CTM-SMAC) aided in the rapid isolation of E coli O157 : H7 from samples by checking sorbitol-negative and $\beta$-glucuronidase negative phenotypes simultaneously. In conclusion, inoculation of a positive in the O157 screening test from enrichment broth on CTM-SMAC appeared to be a rapid, cost-effective and sensitive method for the isolation of E coli O157 : H7.

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