• International Journal of Concrete Structures and Materials
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• v.2 no.2
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• pp.71-81
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• 2008

A macroscopic finite element model is applied to investigate the effect of fire induced spalling on the response of reinforced concrete (RC) beams. Spalling is accounted for in the model through pore pressure calculations in concrete. The principles of mechanics and thermodynamics are applied to compute the temperature induced pore pressure in the concrete structures as a function of fire exposure time. The computed pore pressure is checked against the temperature dependent tensile strength of concrete to determine the extent of spalling. Using the model, case studies are conducted to investigate the influence of concrete permeability, fire scenario and axial restraint on the fire induced spalling and also on the response of RC beams. Results from the analysis indicate that the fire induced spalling, fire scenario, and axial restraint have significant influence on the fire response of RC beams. It is also shown that concrete permeability has substantial effect on the fire induced spalling and thus on the fire response of concrete beams. The fire resistance of high strength concrete beams can be lower that that of normal strength concrete beams due to fire induced spalling resulting from low permeability in high strength concrete.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.4
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• pp.1437-1448
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• 1996

This paper presents a simplified model for approximate analysis of the solute redistribution in coarsening dendrite arms during solidification of binary metal alloys. By introducing a quadratic concentration profile with a time-dependent coefficient, the integral equation for diffusion in the solid phase is reduced to a simple differential relation between the coefficient and the solid-liquid interface position. The solid fraction corresponding to the system temperature is readily determined from the relation, phase equilibrium and the overall solute balance in which the liquid phase is assumed to be completely mixed. In order to validate the developed model, calculations are performed for the directional solidification of Al-4.9 mass Cu alloy. The predicted eutectic fractions for a wide range of the cooling rate reasonably agree with data from the well-known experiment as well as sophisticated numerical analyses. Also, the results for the back diffusion limits are consistent with available references. Additional calculations show that the characteristic parameters such as the coarsening, density variation and nonlinarity in the phase diagram significantly affect the microsegregation. Owing to the simplicity, efficiency and compatibility, the present model may be suitable for the micro-macroscopic solidification model as a microscopic component.

• Structural Engineering and Mechanics
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• v.5 no.1
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• pp.105-113
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• 1997

This paper proposes a model for simulating concrete shrinkage taking into account aggregate restraint. In the model, concrete is regarded as a two-phase material based on shrinkage property. One is paste phase which undergoes shrinkage. Another is aggregate phase which is much more volumetrically stable. In the concrete, the aggregate phase is considered to restrain the paste shrinkage by particle interaction. Strain compatibility was derived under the assumption that there is no relative macroscopic displacement between both phases. Stresses on both phases were derived based on the shrinking stress of the paste phase and the resisting stress of the aggregate phase. Constitutive relation of paste phase was adopted from the study of Yomeyama, K. et al., and that of the aggregate phase was adopted from the author's particle contact density model. The equation for calculating concrete shrinkage considering aggregate restraint was derived from the equilibrium of the two phases. The concrete shrinkage was found to be affected by the free shrinkage of the paste phase, aggregate content and the stiffness of both phases. The model was then verified to be effective for simulating concrete shrinkage by comparing the predicted results with the autogeneous and drying shrinkage test results on mortar and concrete specimens.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.6
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• pp.40-52
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• 1998

A good grasp of the failure mechanisms of resistance spot weld, widely used in joining the auto-panels, in essential to the structural/crashworthy analyses and integrity assessment of the whole auto-body. In this study, We provide an estimative model describing the failure behavior of resistance spotf weld, and apply the model to the finite element analysis of crashworthiness. First, in "Part 1-Failure Criteria", to be used for the finite element analysis of spot-welded structural panels of an auto-body, (i) a methodology for quantifying the spot weld failure and the accompanying failure criteria are presented, and (ii) the coefficients of the failure equation are determined by a munimum number of appropriate experimental tests. To achieve these, we derive the functional form of the failure envelop by limit analysis, and correlate it with the form in PAM-$CRASH^{TM}$ code, and also investigate the effect of the failure coefficients on the failure envelop form. An estimative model obtained in this Part1, as spot weld failure criteria is applied to the Macroscopic finite element analysis of autobody structural panels using PAM-$CRASH^{TM}$ code in Part 2.

• Journal of KIBIM
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• v.9 no.1
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• pp.42-51
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• 2019

Maintenance of aging structures has attracted societal attention. Maintenance of the aging structure can be efficiently performed with a digital twin. In order to maintain the structure based on the digital twin, it is required to accurately detect the damage of the structure. Meanwhile, deep learning-based damage detection approaches have shown good performance for detecting damage of structures. However, in order to develop such deep learning-based damage detection approaches, it is necessary to use a large number of data before and after damage, but there is a problem that the amount of data before and after the damage is unbalanced in reality. In order to solve this problem, this study proposed a method based on Generative adversarial network, one of Generative Model, for generating acceleration data usually used for damage detection approaches. As results, it is confirmed that the acceleration data generated by the GAN has a very similar pattern to the acceleration generated by the simulation with structural analysis software. These results show that not only the pattern of the macroscopic data but also the frequency domain of the acceleration data can be reproduced. Therefore, these findings show that the GAN model can analyze complex acceleration data on its own, and it is thought that this data can help training of the deep learning-based damage detection approaches.

• CELLMED
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• v.6 no.2
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• pp.11.1-11.7
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• 2016

The aimed of the presence study was to determine the antiulcer potential of virgin coconut oil (VCO), either extracted by wet process (VCO_A) or fermentation process (VCO_B), and to compare their effectiveness against the copra oil (CO) using the HCl/ethanol-induced gastric ulcer model. Earlier, the oils underwent chemical analysis to determine the free fatty acids composition, physicochemical properties and anti-oxidant capability. In the antiulcer study, rats (n=6) were pre-treated orally for 7 consecutive days with distilled water (vehicle), 100 mg/kg ranitidine (positive group) or the respective oils (10, 50, and 100% concentration). One hour after the last test solutions administration on Day 7^th, the animals were subjected to the gastric ulcer assay. Macroscopic and microscopic analyses were performed on the collected rat's stomachs. From the results obtained, the chemical analysis revealed i) the presence of high content of lauric acid followed by myristic acid and palmitic acid in all oils and; ii) the significant (^*p< 0.05) different in anisidine- and peroxide-value, percentage of free fatty acid, total phenolic content and total antioxidant activity among the oils. The animal study demonstrated that all oil possess significant (^*p< 0.05) antiulcer activity with VCO_B being the most effective oil followed by VCO_A and CO. The macroscopic observations were supported by the microscopic findings. Interestingly, all oils were more effective than 100 mg/kg ranitidine (reference drug). In conclusion, coconut oils exert remarkable antiulcer activity depending on their methods of extraction, possibly via the modulation of its antioxidant and anti-inflammatory activity.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.9
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• pp.1137-1143
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• 2011

The IHX (intermediate heat exchanger) of a VHTR (very high-temperature reactor) is a core component that transfers the high heat generated by the VHTR at $950^{\circ}C$ to a hydrogen production plant. Korea Atomic Energy Research Institute manufactured a small-scale prototype of a PCHE (printed circuit heat exchanger) that was being considered as a candidate for the IHX. In this study, as a part of high-temperature structural integrity evaluation of the small-scale PCHE prototype, we carried out high-temperature structural analysis modeling and macroscopic thermal and elastic structural analysis for the small-scale PCHE prototype under small-scale gas-loop test conditions. The modeling and analysis were performed as a precedent study prior to the performance test in the small-scale gas loop. The results obtained in this study will be compared with the test results for the small-scale PCHE. Moreover, these results will be used in the design of a medium-scale PCHE prototype.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.3
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• pp.613-619
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• 2009

The Efficacy of SHI-1909 was investigated in comparision with predinisolone in acetic acid and Picrylsulfonic acid solution (TNBS)-induced rat inflammatory bowel disease (IBD) for 5 days. 7% Acetic acid and 5% TNBS solution were administered with polyethylene (P.E) tube inserted to rats intracolon, which causing colitis to the rats. The acetic acid and TNBS control group (the saline treated colitic rat) exhibited ulceration and inflammation of the distal colon with formation of granuloma and pathologic connections. We checked the inflammatory parameters like rat's weight, food intake quantity change during administration. After 5 days, we sacrificed the rats and checked the colon's length, ulcer and pathologic condition. Oral treatment with SHI-1909 resulted in significant recovery of macroscopic parameters like weight and diet intake change. Especially, SHI-1909 had a more potent effect than prednisolone on macroscopic colonic damage score. We can suggest that SHI-1909 could be a promising drug in the treatment of IBD.

• Journal of Ginseng Research
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• v.45 no.6
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• pp.706-716
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• 2021

Background: Irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder, is characterized by chronic abdominal pain and bowel habit changes. Although diverse complicated etiologies are involved in its pathogenesis, a dysregulated gut-brain axis may be an important factor. Red ginseng (RG), a traditional herbal medicine, is proven to have anti-inflammatory effects and improve brain function; however, these effects have not been investigated in IBS. Methods: Three-day intracolonic zymosan injections were used to induce post-infectious human IBS-like symptoms in mice. The animals were randomized to receive either phosphate-buffered saline (CG) or RG (30/100/300 mg/kg) for 10 days. Amitriptyline and sulfasalazine were used as positive controls. Macroscopic scoring was performed on day 4. Visceral pain and anxiety-like behaviors were assessed by colorectal distension and elevated plus maze and open field tests, respectively, on day 10. Next-generation sequencing of gut microbiota was performed, and biomarkers involved in gut-brain axis responses were analyzed. Results: Compared to CG, RG significantly decreased the macroscopic score, frequency of visceral pain, and anxiety-like behavior in the IBS mice. These effects were comparable to those after sulfasalazine and amitriptyline treatments. Moreover, RG significantly increased the proliferation of beneficial microbes, including Lactobacillus johnsonii, Lactobacillus reuteri, and Parabacteroides goldsteinii. RG significantly suppressed expression of IL-1β and c-fos in the gut and prefrontal cortex, respectively. Further, it restored the plasma levels of corticosterone to within the normal range, accompanied by an increase in adrenocorticotropic hormone. Conclusion: RG may be a potential therapeutic option for the management of human IBS.

• Food Science of Animal Resources
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• v.42 no.2
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• pp.313-320
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• 2022

Brazil is considered as a great broiler feet exporter, especially for the Chinese trade. Contact lesions at the tibiotarsal region are responsible for economic losses and there is no model for its classification, thereby this study presents a fast and practical grade system to be used in the poultry industry and proposes these lesion characterizations into three different grades. For this, correlation was made between macroscopic, histological findings and microbiological quantification (Escherichia coli, Staphylococcus spp., Streptococcus spp. and sulphite-reducing clostridia) from contact lesions in the tibiotarsal region of 112 broiler carcasses, divided in four groups (n=28), accordingly to the lesion's intensity. There were no significant differences in microbiological quantification among the groups (p>0.05) except for the grade 3 group, as grade 1 and 2 lesions were in the early stages and histopathological changes such as ulceration were not observed. In grade 3 lesion group, it was observed bacterial cocci grume and ulceration at the articular region and significantly higher microbiological count (p<0.05) for E. coli and Staphylococcus spp. In conclusion, the visual standard proposed in this work, correlated and confirmed by the histopathologic, and microbiologic characterization, allows to precise and fast ascertainment of the contact lesion grade in the tibiotarsal regions of broiler carcasses. Moreover, it should be highlighted that grades 1 and 2 alterations are not caused by an inflammatory process caused by pathogenic agents and should not be considered a public health risk.