• Women's Health Nursing
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• v.28 no.2
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• pp.100-111
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• 2022

Purpose: Based on the theory of unpleasant symptoms (TOUS), this study aimed to examine the direct effect of antecedent factors on health-related quality of life (HRQoL) and its indirect effect via symptoms in Korean women during the late menopausal transition (MT) and early postmenopause. Methods: This cross-sectional survey employed a descriptive correlational research design. The respondents were 152 middle-aged women 40 to 60 years with an intermenstrual interval of 60 days or more (late MT) or less than 5 years from the last menstrual period (early postmenopause). The respondents were recruited through convenience sampling in Busan, Korea, from December 1, 2020, to January 31, 2021. Based on the TOUS, self-report data were collected on perceived health status, psychological distress, social support, menopausal symptoms, and HRQoL. The collected data were analyzed using descriptive statics, independent t-test, one-way analysis of variance, Pearson's correlation coefficient, and the Hayes' PROCESS macro. Results: TOUS was supported on this sample (n=152) of Korean women during the late MT and early postmenopause. Perceived health status, psychological distress, and social support had significant direct relationships with HRQoL. Menopausal symptoms had significant indirect relationships between antecedent factors (perceived health status, psychological distress, and social support) and partially mediated HRQoL. Conclusion: The findings of this study indicate that menopausal symptoms play an important role as an intervening factor of HRQoL in women during the late MT and early postmenopause. Therefore, women need an integrated program that manages antecedent factors and menopausal symptoms to improve HRQoL in these menopausal stages.

• Korean Chemical Engineering Research
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• v.61 no.2
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• pp.247-257
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• 2023

Precise counting of cell number stands in important position within clinical and research laboratories. Conventional methods such as hemocytometer, migration/invasion assay, or automated cell counters have limited in analytical time, cost, and accuracy., which needs an alternative way with time-efficient in-situ approach to broaden the application avenue. Here, we present simple coding-based cell counting method using image analysis tool, freely available image software (ImageJ). Firstly, we encapsulated RFP-expressing bacteria in a droplet using microfluidic device and automatically performed fluorescence image-based analysis for the quantification of cell numbers. Also, time-lapse images were captured for tracking the change of cell numbers in a droplet containing different concentrations of antibiotics. This study confirms that our approach is approximately 15 times faster and provides more accurate number of cells in a droplet than the external analysis program method. We envision that it can be used to the development of high-throughput image-based cell counting analysis.

• Journal of Venture Innovation
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• v.5 no.4
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• pp.117-133
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• 2022

Telecommuting is rapidly spreading because of the prevalence of Covid-19 but the research on the psychological characteristics of telecommuters and their attitudes(organizational commitment, job satisfaction, etc.) in the workplace is not abundant. We would like to verify whether the number of telecommuting affects social alienation and whether LMX moderates this relationship. Further, the alienation affects, in turn, job satisfaction and organizational commitment. A survey of 317 male and female workers aged 18 or older who are currently experiencing telework was conducted. The results are as follows. Firstlty, we confirmed that the number of telecommuting has a significant impact on social alienation and that LMX moderates this relationship. Secondly, we found that social alienation affects organizational commitment and that job satisfaction showed a mediating effect between social alienation and organizational commitment. Implications and limitations are discussed.

• The Journal of Korean Academic Society of Nursing Education
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• v.30 no.1
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• pp.71-81
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• 2024

Purpose: This study aimed to identify the relationship between nursing professionalism and nursing intention for patients with emerging infectious diseases of nursing students who had experienced coronavirus disease 2019 (COVID-19), with a focus on the mediating effect of e-Health literacy. Methods: The study surveyed 177 nursing students who had experienced COVID-19. The data were collected using self-reported questionnaires. The collected data were analyzed using IBM SPSS statistics 25.0, and the mediating effect was analyzed through the SPSS Process macro model 4. Results: Nursing professionalism (β=.26, p=.002) and e-Health literacy (β=.18, p=.021) were found to be significant predictors of nursing intention for patients with emerging infectious diseases. In addition, e-Health literacy partially mediated the relationship between nursing professionalism and nursing intention for patients with emerging infectious diseases. Conclusion: e-Health literacy was a mediating factor in the relationship between the nursing professionalism and nursing intention of nursing students for patients with emerging infectious diseases. In order to improve nursing intention of nursing students for patients with emerging infectious diseases, it is important to develop an education program that can enhance their e-Health literacy as well as nursing professionalism.

• Korean Journal of Childcare and Education
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• v.20 no.2
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• pp.145-167
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• 2024

Objective: This study aimed to investigate the moderated-moderated mediating effects of children's media content selection and parental restrictive media mediation on the relationship between children's screen media time and executive function difficulties. Methods: A total of 693 parents of children aged 5~6 years participated in this study and were asked to answer all survey questions. The data were analyzed by descriptive statistics and correlation analysis using SPSS 27.0. Model 11 of PROCESS macro 4.3 was used to examine the moderated-moderated mediation model. Children's gender, age, childcare enrollment status, and household income were included in the analyses as covariates. Results: The moderated-moderated mediating effects of children's media content selection and parental restrictive media mediation were found to be significant. Specifically, bedtime mediated the relationship between screen media time and executive function difficulties only when parents did not appropriately implement restrictive mediation and children freely selected media content. Conclusion/Implications: It is recommended that parents understand the importance of implementing restrictive media mediation and selecting appropriate media contents for their child to prevent executive function difficulties in early childhood. Also, child education or day-care centers should offer education program about appropriate media use to reach more parents.

• Journal of Korean Clinical Nursing Research
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• v.30 no.1
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• pp.24-34
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• 2024

Purpose: This study aimed to identify factors influencing nurses' intention to care for COVID-19 patients based on the theory of planned behavior, and to test the moderating effect of perceived behavior control between attitude, subjective norms, and nurses' intention to care. Methods: The participants were 167 nurses working at two designated hospitals for infectious diseases located in J and C city, South Korea. Data were collected from October 10th to 25th, 2020, and analyzed using independent t-test, ANOVA, and Pearson correlation coefficient, and hierarchical multiple regression analysis. The moderating effect was analyzed using the Process Macro model 1 (95% confidence interval, 10,000 bootstrapping), and a simple slope analysis was performed to identify the moderating effect of perceived behavior control. Results: The factors affecting nurses' intention to care for patients with COVID-19 were attitude toward the behavior (β=.32, p<.001) and perceived behavior control (β=.37, p<.001) in model 1, attitude toward the behavior (β=.28, p<.001) and perceived behavior control (β=.36, p<.001), and perspective taking (β=.26, p<.001) in model 2. The explanation power of this model was 65.0% (F=18.41, p<.001). The moderating effect of perceived behavioral control was statistically significant in the relationship between subjective norms and intention to care for patients with COVID-19 (F=16.37, p<.001). In the simple slope analysis, the reinforcement effect was greatest when the level of perceived behavioral control was at the mean (95% CI=0.46~0.67) and high (95% CI=0.70~1.08). Conclusion: Developing and applying a training program that enhances confidence and improves empathy is necessary to increase nurses' intention to care for COVID-19 patients.

• Interdisciplinary Bio Central
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• v.1 no.1
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• pp.3.1-3.6
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• 2009

Introduction: GTPases known as translation factor play a vital role as ribosomal subunit assembly chaperone. The bacterial Obg proteins ($Spo{\underline{0B}}$-associated ${\underline{G}}TP$-binding protein) belong to the subfamily of P-loop GTPase proteins and now it is considered as one of the new target for antibacterial drug. The majority of bacterial Obgs have been commonly found to be associated with ribosome, implying that these proteins may play a fundamental role in ribosome assembly or maturation. In addition, one of the experimental evidences suggested that Bacillus subtilis Obg (BsObg) protein binds to the L13 ribosomal protein (BsL13) which is known to be one of the early assembly proteins of the 50S ribosomal subunit in Escherichia coli. In order to investigate binding mode between the BsObg and the BsL13, protein-protein docking simulation was carried out after generating 3D structure of the BsL13 structure using homology modeling method. Materials and Methods: Homology model structure of BsL13 was generated using the EcL13 crystal structure as a template. Protein-protein docking of BsObg protein with ribosomal protein BsL13 was performed by DOT, a macro-molecular docking software, in order to predict a reasonable binding mode. The solvated energy minimization calculation of the docked conformation was carried out to refine the structure. Results and Discussion: The possible binding conformation of BsL13 along with activated Obg fold in BsObg was predicted by computational docking study. The final structure is obtained from the solvated energy minimization. From the analysis, three important H-bond interactions between the Obg fold and the L13 were detected: Obg:Tyr27-L13:Glu32, Obg:Asn76-L13:Glu139, and Obg:Ala136-L13:Glu142. The interaction between the BsObg and BsL13 structures were also analyzed by electrostatic potential calculations to examine the interface surfaces. From the results, the key residues for hydrogen bonding and hydrophobic interaction between the two proteins were predicted. Conclusion and Prospects: In this study, we have focused on the binding mode of the BsObg protein with the ribosomal BsL13 protein. The interaction between the activated Obg and target protein was investigated with protein-protein docking calculations. The binding pattern can be further used as a base for structure-based drug design to find a novel antibacterial drug.

• The Journal of Korean Society for Radiation Therapy
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• v.25 no.1
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• pp.87-90
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• 2013

Purpose: Introducing CR (Computed Radiography) system created a process of printing therapy irradiation images and converting the degree of enlargement. This is to increase job efficiency and contribute to work improvement using a computerized method with home grown software to simplify this process, work efficiency. Materials and Methods: Microsoft EXCEL (ver. 2007) and VISUAL BASIC (ver. 6.0) have been used to make the software. A window for each shield block was designed to enter patients' treatment information. Distances on the digital images were measured, the measured data were entered to the Excel program to calculate the degree of enlargement, and printouts were produced to manufacture shield blocks. Results: By computerizing the existing method with this program, the degree of enlargement can easily be calculated and patients' treatment information can be entered into the printouts by using macro function. As a result, errors in calculation which may occur during the process of production or errors that the treatment information may be delivered wrongly can be reduced. In addition, with the simplification of the conversion process of the degree of enlargement, no copy machine was needed, which resulted in the reduction of use of paper. Conclusion: Works have been improved by computerizing the process of block production and applying it to practice which would simplify the existing method. This software can apply to and improve the actual conditions of each hospital in various ways using various features of EXCEL and VISUAL BASIC which has already been proven and used widely.

• Journal of Distribution Science
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• v.12 no.11
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• pp.45-53
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• 2014

Purpose - Goal setting is effective in any domain in which an individual or group has some control over the outcomes. It applies not only to work tasks but also to sports and health, and in various other settings. Its success depends on considering the mediators and moderators determining its efficacy and applicability. This study investigates the individual factors influencing academic goal attainability. Unlike previous studies, we focused on the effect of the relationships between individual traits (passion, tenacity, self-control) and specific motivation (vision, self-efficacy, implementation intentions) with academic goal attainability, rather than the effects of the relationship between commitment and the goal shielding mechanism with goal attainability. Research design, data, and methodology - Data collected through questionnaires were analyzed by the SPSS program. A total of 293 school students, who participated in the TOEIC program, participated in the survey. Slightly more than half were female (male: n=145 vs. female: n=148). We verified nine hypotheses through various statistical methods (reliability analysis, exploratory factor analysis, confirmatory factor analysis, structural equation model for the hypothesis test, bootstrapping test for the mediation test). Results - Data was analyzed in three phases. The first phase involved measurement analysis (i.e., item purification and factor structure confirmation), involving the scales of the three variables of individual traits, three mechanism variables, and goal attainability. The second phase involved estimating the proposed structural relationships among the key constructs (see Figure 1), using the results to test H1 to H9. The final phase involved examining the mediating effects of the three variables (vision, implementation intention, and self-efficacy). The research model shows that the independent variable passion has a significant result with both the mediators-vision and self-efficacy. Further, vision and self-efficacy significantly affect goal attainability. The second variable, self-control, shows a significant effect when mediated by implementation intentions, but the direct relationship between implementation intension and goal attainability shows an insignificant result. However, when further mediated by self-efficacy, it showed a significant effect between self-efficacy and goal attainability. Similarly, the third variable, tenacity, shows an insignificant result when mediated by vision. In contrast, the mediator self-efficacy shows a positive effect between tenacity and goal attainability. Conclusions - This study shows how these individual traits, when mediated with the appropriate motivational factors, resulted significantly in the attainability of academic goals. We may identify several theoretical and practical contributions. Theoretically, we developed a step further in the research into consumer goals and related studies. Future research could examine the effects of different learning goal types and their combinations with performance goals (e.g., learning goals first, then performance goals), different types of goal framing (approach success vs. avoid failure), the relation between goals and cognition (which, by implication, entails all of cognitive psychology), goal hierarchies, and macro goal studies with organizations of different sizes. More studies on the relationship between conscious and subconscious goals would also be valuable.

• Journal of the Korean association of regional geographers
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• v.13 no.6
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• pp.651-673
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• 2007

In the studies on residential move, there has been tendency of dichotomy where short distance moves are largely caused by housing to adjust to changes in households while long distance moves are induced by shift in labor market. However, some empirical studies have proven that residential move is so complex process that the simple dichotomy should be elaborated. In this sense, the present study seeks to identify compounded course of residential move in Korea. In determining migration history, families with younger householders, renters, householders with higher educational attainment and smaller households show a higher probability to move. In case of mobility, women were more prone to move compared to man. Women compared to man, older age augmented the probability to own a house after migration. Families with householders following an occupation of sales and technical service showed lowest tendency to own houses while it marked the highest in the group of professionals. Higher land price of a region was negatively related to owning houses after migration. The present study revealed that factors in macro level as well as micro level significantly affect the move of individuals with varying effects in accordance with migration history.