• Archives of Pharmacal Research
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• v.21 no.5
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• pp.581-590
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• 1998

We developed a novel water-soluble camptothecin analobue, CKD602, and evaluated the inhibition of topoisomerase I and the antitumor activities against mammalian tumor cells and human tumor xenografts. CKD602 was a nanomolar inhibitor of the topoisomerase I enzyme in the cleavable complex assay. CKD602 was found to be 3 times and slightly more potent than topotecan and camptothecin as inhibitors of topoisomerase, respecitively. In tumor cell cytotoxicity, CKD602 was more potent than topotecan in 14 out of 26 human cancer cell lines tested, while it was comparable to camptothecin. CKD602 was tested for the in vivo antitumor activity against the human tumor xenograft models. CKD602 was able to imduce regression of established HT-29, WIDR and CX-1 colon tumors, LX-1 lung tumor, MX-1 breast tumor and SKOV-3 ovarian tumor as much as 80, 94, 76, 67, 87% and 88%, respectively, with comparable body weight changes to those of topotecan. Also the therapeutic margin (R/Emax: maximum tolerance dose/$ED-{58}$) of CKD602 was significantly higher than that of topotecan by 4 times. Efficacy was determined at the maximal tolerated dose levels using schedule dependent i.p. administration in mice bearing L1210 leukemia. On a Q4dx4 (every 4 day for 4 doses) schedule, the maximum tolerated dose (MTD) was 25 mg/kg per administration, which caused great weight loss and lethality in <5% tumor bearing mouse. this schedule brought significant increase in life span (ILS), 212%, with 33% of long-term survivals. The ex vivo antitumor activity of CKD602 was compared with that of topotecan and the mean antitumor index (ATI) values recorded for CKD602 were significantly higher than that noted for topotecan. From these results, CKD602 warrants further clinical investigations as a potent inhibitor of topoisomerase I.

• Journal of Korea Foresty Energy
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• v.22 no.3
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• pp.1-10
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• 2003

The successional status and potential natural vegetation were examined in the natural deciduous forest in Mt. Chombong area. The examination was based on the subsequent process of generation replacement by understory saplings for the dominant canopy trees within 106 20mx20m square sample plots. The transition matrix model, which was modified from mathematical theory of Markov chain, was employed to analyze the successional status of the study forest. The model suggests that study forest is still seral, and it is considered to be more than 500 years away from the steady state or climax in terms of species composition. The simulations predict a remarkable decrease in the proportion of species composition of the present dominant Quercus mongolica and Kalopanax pictus from current 42.6% and 8.1% to less than 13.3% and 0.5%, respectively, at the steady state. On the contrary, the proportions of Abies holophylla, Acer mono, Fraxinus mandshurica, Tilia amurensis, and Acer pseudo-sieboldianum will increase at the steady state. The change of predicted composition ratio was generally coincide with the result of tolerance index to be compared with the study model. The hypothesis and sensitivity of the model were also discussed to evaluate the applicability to the real situation. The overall results indicated that the present dynamics of the forest must reflect the seral state due to previous disturbance mainly by human related interference.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.1
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• pp.63-68
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• 1991

The author has arrived at the following result after having carried out multilateral study based on a total of 282 maxillofacial fracture patients who have receive treatment at the Euijeongbu general hospital and Shinchun general hospital in the northern district of Kyunggido from march 1988 to august 1990. 1. Sex distribution of Mx. facial fx. patient was higher in male by 4.6:1 and was predominant in the 3rd decade with 40.4% followed in decreasing order by the 2nd decade and the 4th. 2. A majority were in the Mn. with 40.2% followed in decreasing order by zygoma. nasal bone and maxilla. 3. For the sex distribution according to anatomy, make to female ratio was 6.2:1 in the mandible, followed in decreasing order by zygoma, and nasal bone with predominance in male. 4. Car accident with 42.8% was the most common cause of fx. followed in decreasing order by violence, workmen's accident, and fall down. 5. The involvement of other trauma areas are head. 79.0%, abdomen-thorax, and the extremities in decreasing order. 6. In the mandibular fx. a majority were in the symphysis with 73.9% followed in decreasing order by angle, Condyle, and body. 7. Maxillary fx. of the type LeFort II was estimated to be 41.2% 8. Fracture in the zygoma including zygomatic arch was estimated to be 72.5%

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.5
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• pp.511-517
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• 2007

Purpose: The aim of this study is to determine whether a difference in the amount of bone graft material is needed between edentulous patients and dentulous patients and to calculate the amount of augmentation for a sinus lift procedure. Methods: 19 patients(20 sinuses) were included to measure maxillary sinus volume. Facial CT scanning was performed using MX 8000 IDT CT devices(Philips, USA). And it was used for IDLvm(The IDL Virtual Machine) 6.0, CT Volume Analyzer Ver 2.3 program to measure maxillary sinus volumes Results: At edentulous patients, volumes(mean${\pm}SD$) of the inferior portion of the sinuses were $0.56{\pm}0.13cm^3$(5mm height), $2.35{\pm}0.57cm^3$(10mm height), $4.85{\pm}1.10cm^3$(15mm height). At dentulous patients, volumes(mean${\pm}SD$) of the inferior portion of the sinuses were $0.41{\pm}0.18cm^3$(5mm height), $1.76{\pm}0.42cm^3$(10mm height), $3.80{\pm}0.84cm^3$ (15mm height). A significant correlation was found between augmentation height(5mm, 10mm, 15mm) and the calculated sinus volume.(p=0.027, p=0.018, p=0.044) Conclusions: A significant correlation was found between augmentation height(5mm, 10mm, 15mm) and the calculated sinus volume. Detailed preoperative knowledge of sinus lift augmentation volume is helpful in determining the appropriate amount of the bone graft material.

• Journal of Technologic Dentistry
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• v.11 no.1
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• pp.35-45
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• 1989

This study was carried out from June, 20, to October 22, 1988, for the purpose of researching on the complaint ratio of Respiratory symptoms of the dental laboratory technicians in Seoul. In this study, aiming to find out complaint ratio of respiratory symptoms of the dental laboratory, SNU-81-AL were applied, at random, to 193 dental laboratory technicians at 39 dental laboratories, as the research group, and to 178 clinical laboratory technicians at 10 general hospitals, as the control group, and above two groups were compared with each other. The following results were obtained from this research. 1. The quantity of respirable dust under 5$\mu$m measured at the dental laborartories was, on an average as well, 5$mg/m^3$-minimum 1.56$mg/m^3$), and the density of CO was, on an average as well, 5.0ppm(Mx 7.0-Mn 3.0). 2. The complaint ratio of five main respiratory symptoms(cough, phlegm, wheezing, nasal catarrh & cold, breathlessness) was, on an average, 44.3% at the dental laboratory technicians, phlegm was the major symptom complained by the greatest number of the technicians. 22.4% of the clinical laboratory technicians complained above 5 main respiratory symptoms, nassal catarrh & cold was the mostly complained symptoms among them. There showed a consideraly significant difference at the complaint ratio between the above 2 occupations(P<0.005). 3. There showed no paticular significant difference between male and female, at the complaint ratio of the dental laboratory technicians. However, there showed a considerable significant difference according to their sexuality, in case of the clinical laboratory technicians. 4. Considered from th view point of age, the highest age group was 20-29 with its average 48.5%, in case of dental laboratory technicians. The highest age group among the clinical laboratory technicians was over 40 age with its 28.7%. There showed no particular significant differences between to tow occupations. 5. Considered from the view point of work period, the highest work period group was 0-3 years with average 47.8%, in case of dental laboratory The highest work period group among the clinical laboratory technicians was 16 years with its 25.2%. There showed no particuar significant differences between the two occupations. 6. Considered from the view point of smoking, phlegm was complained by much more smokers than non-smokers, in both occupations. In case of non-smokers, many complained about nassal catarrh & cold. There showed no particular significant differences between the smokers and the non-smokers.

• The Journal of the Korean dental association
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• v.47 no.11
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• pp.758-768
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• 2009

Purpose : Schulte introduced immediate implant cases in 1970s, since then many patients have been treated by immediate implants. The aim of this study was to evaluate the cumulative survival rate of immediate implant and to analyze various factors associated with survival of immediate implant in a 8-year period retrospectively. Materials and methods : From May, 2000 to October, 2007, 77 implants were placed in 63 patients immediately after tooth extraction at Department of Periodontology, Yonsei University Hospital. The implant survival rate was analyzed using a life-table analysis. After delivery of prosthesis, along 1 year of observation period, all implants were evaluated clinically and radiographically. Results : Among 77 implants, 59 were placed in maxilla and 18 in mandible. The most common site of the implantation was Mx anterior (65%). The overall survival rate was 94.8% over a mean follow-up period of $44.2{\pm}21$ months and the 8-year cumulative survival rate was 94.6%. Failure occurred in 4 implants, all of which were due to early failures. None of the following factors were significantly associated with the survival of immediate implants: advanced surgical technique including bone graft and guided bone regeneration, the types of implants, causes of tooth loss, and types of prosthesis. Conclusion : On the basis of 8-year life time analysis, immediate implant placement can be considered a safe and predictable treatment mordality.

• The korean journal of orthodontics
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• v.52 no.4
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• pp.287-297
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• 2022

Objective: To investigate the pattern of accuracy change in artificial intelligence-assisted landmark identification (LI) using a convolutional neural network (CNN) algorithm in serial lateral cephalograms (Lat-cephs) of Class III (C-III) patients who underwent two-jaw orthognathic surgery. Methods: A total of 3,188 Lat-cephs of C-III patients were allocated into the training and validation sets (3,004 Lat-cephs of 751 patients) and test set (184 Lat-cephs of 46 patients; subdivided into the genioplasty and non-genioplasty groups, n = 23 per group) for LI. Each C-III patient in the test set had four Lat-cephs: initial (T0), pre-surgery (T1, presence of orthodontic brackets [OBs]), post-surgery (T2, presence of OBs and surgical plates and screws [S-PS]), and debonding (T3, presence of S-PS and fixed retainers [FR]). After mean errors of 20 landmarks between human gold standard and the CNN model were calculated, statistical analysis was performed. Results: The total mean error was 1.17 mm without significant difference among the four time-points (T0, 1.20 mm; T1, 1.14 mm; T2, 1.18 mm; T3, 1.15 mm). In comparison of two time-points ([T0, T1] vs. [T2, T3]), ANS, A point, and B point showed an increase in error (p < 0.01, 0.05, 0.01, respectively), while Mx6D and Md6D showeda decrease in error (all p < 0.01). No difference in errors existed at B point, Pogonion, Menton, Md1C, and Md1R between the genioplasty and non-genioplasty groups. Conclusions: The CNN model can be used for LI in serial Lat-cephs despite the presence of OB, S-PS, FR, genioplasty, and bone remodeling.

• Korean Journal of Ichthyology
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• v.35 no.2
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• pp.141-147
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• 2023

The genus Cottiusculus Jordan and Starks 1904 (Cottoidei: Cottidae) comprises four species worldwide, three species in Japan, and two species in Korea. Cottiusculus species are characterized by a compressed head and body without scales, except for lateral-line scales, a preopercle with four spines, a curved uppermost preopercular spine with small dorsal spines, and teeth on the upper jaws, vomer, and palatines. Two Cottiusculus species have been recorded in Korea: Cottiusculus gonez and Cottiusculus nihonkaiensis. Among these, "jeom-jul-hoet-dae" specimens were initially identified as Cottiusculus schmidti by many Korean Ichthyologists. However, since C. nihonkaiensis was reported by Kai and Nakabo (2009), most such specimens have been identified as C. nihonkaiensis. To clarify the taxonomic status of "jeom-jul-hoet-dae", we conducted morphological and molecular analyses collected from the coasts of South Korea, and compared our findings with previous reports. Japanese and Korean C. nihonkaiensis specimens mostly consistent in some proportional measurements, our molecular results indicate that they are the same species. C. nihonkaiensis, "jeom-jul-hoet-dae" distinguished from other congers by combination of following characters: simple nasal spines, two branched cirri at the upper jaw, cirri at the opercular, preopercular, and lateral lines, and a number of blotches below the lateral line.

• Atmosphere
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• v.33 no.5
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• pp.477-492
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• 2023

Based on the new climate normals (1991~2020), annual mean, maximum and minimum temperature is 12.5℃, 18.2℃, and 7.7℃, respectively while annual precipitation is 1,331.7 mm, the annual mean wind speed is 2.0 m s^-1, and the relative humidity is 67.8% in the Republic of Korea. Compared to 1981~2010 normal, annual mean temperature increased by 0.2℃, maximum and minimum temperatures increased by 0.3℃, while the amount of precipitation (0.7%) and relative humidity (1.1%) decreased. There was no distinct change in annual mean wind speed. The spatial range of the annual mean temperature in the new normals is large from 7.1 to 16.9℃. Annual precipitation showed a high regional variability, ranging from 787.3 to 2,030.0 mm. The annual mean relative humidity decreased at most weather stations due to the rise in temperature, and the annual mean wind speed did not show any distinct difference between the new and old normals. With the addition of a warmer decade (2011~2020), temperatures all increased consistently and in particular, the increase in the maximum temperature, which had not significantly changed in previous decades, was evident. The increasing trend of annual and summer precipitation by the 2010s has disappeared in the new normals. Among extreme climate indices, MxT30 (Daily maximum temperature ≥ 33℃ days), MnT25 (Daily minimum temperature ≥ 25℃ days), and PH30 (1 hour maximum precipitation ≥ 30 mm days) increased while MnT-10 (Daily minimum temperature < -10℃ days) and W13.9 (Daily maximum wind speed ≥ 13.9 m/s days) decreased at a statistically significant level. It is thought that a detailed study on the different trends of climate elements and extreme climate indices by region should be conducted in the future.

• Journal of Korean Medical classics
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• v.6
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• pp.252-305
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• 1993

I have studied the relation between a Taoist(道家) and the oriental medicine(韓醫學), it is summerized as following. 1. According to the relation between a Taoist(道家) and the oriental medicine, Lao-tzu(老子)' mathematical principle that had an influence on Three yin-three yang(三陰三陽) theory of the oriental medicine, idea of natural philosopy(自然無爲) and the freedom from avarace(無慾) on the oriental medicine. 2. Vital essence and energy theory(精氣設) in a Taoist not only can be seen in Lao-tzu' Do dug gyung(老子道德經), Maengza(孟子), Guanza(管子), but also its principle has something to do with Nei Ching's Vital essence and energy theory(精氣設). 3. Danjungpa(丹鼎派) can be divided into Naedansul(內丹術) which preserves through the breath and Oedansul(外丹術) which makes one a Taoist hermit. If he takes magic portions(金丹), they had a great effect on Yangsanghak(養生學) and was actually concerned with oriental doctors who was known to us. 4. If medicine of Taoism is classified, it can be divided into three categories. Boiled solution(渴液), Pharmacopea "Ben cao"(本草), Acupuncture & moxibustion(針灸), Magic portions(外丹) are used in the first category. Chinese setting-up and Therapeutic exercises(導引), Josik(調息), Naedan(內丹), Byugok(辟榖), Naeshi(內視), Banjung(房中) belong to second category. The religious contents such as Bu(符), Jeum(占), Cheum(籤), Ju(呪), Je(齊), Gido(祈禱), taboo are implied in third category. 5. In the history of the medicine of Taoism and oriental medicine, they are called animism, shamanism, Mu(巫) or Ye(毉), not separated at first period. In the end of junguk(戰國時代), Ye(醫) was clearly distinguished from Mu(巫) and then Mu(巫) was developed into medicine of Taoism and ye(毉) into the present form of oriental medicine. 6. The oriental medicine doctors that are concerned with Taoism are Bakgo(伯高), Geyugu(鬼臾區), Soyu(少兪), Noigong(雷公), Pyujak(篇鵲), Sunuyi(淳于意), Hwata(華陀), Hwangbomil(皇甫謐), Hangang(韓康), Dongbong(童奉), Heuson(許遜), Galhong(葛洪), Dohongyung(陶弘景), Damlan(曇鸞), uyjajang(葦慈藏), Sonsanak(孫思邈), Wanguing(王氷), Jegonghwalbul(濟公活佛), Yuwanso(劉完素), Judonge(朱丹溪), Leesijin(李時珍), Johakmin(趙學敏), Ougu1(吳杰) etc. 7. The view of a human body in the medicine of Taoism affected the oriental medicine on the ground that man was regarded as a microcosm(小宇宙), so he was compared to a nation or heaven and earth. 8. The anatomy of medicine of Taoism gave a detail description of five visceras and each organs, the heart, center of mental function, Mirie(尾閭) which has an relationship to the training of Naedan(內丹修練). In this resrect, as it is accord with the acupunture point of oriental medicine, therefore we can find that Taoism influenced oriental medicine, also explicit study was achieved. 9. Acient people believed that the goo in the human lxxIy, one of the characteristics of the medicine of Taoism cured the patients and then protected him from the disease. If a man was taken ill, they had him cured by making the god's name which corresponded to its disease, calling him communicating with him, and asking him to deprive him of illness. This treatment was used to live and be kept young eternally. In this respects, we can see that they emphasized on the attitude of Bulchiyibeung chimibeung(不治己病治末病) and psychological treatment. 10. Samsi thoery(三尸說) that one's fortune, disaster, health, and disease in the world are at the mercy of his good or bad conduct, is concerned with Taoism and treatment with the oriental medicine. 11. Guchung(九蟲) is more closly associated with the religious aspect rather than with the medical aspect. Because of the similarity of the mcdern parasitism, its study has an important meaning. 12. The respect for the human life is reflected in jeunsi(傳屍), with Samsi-guchung theory(三尸九蟲說), which is considered as mxIern tuberculosis.