• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2005년도 공동학술대회 논문집
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• pp.273-280
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• 2005

MT 전달함수의 추정과정에서 로버스트 방법의 적용은 현재 전자탐사 분야에서 일반적이다. 적절하게 고안되고 적용된 로버스트 방법은 출력 채널인 전기장에 포함되어 있는 외치의 영향을 감소시킬 수 있으나, HLP(High leverage point)라 불리 우는 자기장(입력 채널)의 외치에 종종 민감하지 못하다. 이 문제를 해결하기 위해 HLP의 영향을 최소화할 수 있는 BI(Bounded Influence) 추정이 제안되었고, 전통적인 로버스트 방법보다 신뢰성 있는 전달함수를 제공하는 것으로 보고되었다. 이는 BI 추정이 M-추정을 적용함과 동시에 자기장 성분만으로 결정되는 모자행렬의 통계적인 특성을 고려하여 가중치를 부여하는 방법이기 때문이다. 본 연구에서는 전달함수 추정과정에 BI 추정을 적용하고, 이와 더불어 전처리 단계로서 전자기장의 통계적 분포를 이용해 주파수 영역에서 극단적인 전기장과 자기장 자료의 영향을 감소시키는 기법을 개발하였다. 개발된 전처리 기법은 BI 추정으로 제거될 수 없는 자료를 주파수 영역에서 효과적으로 제거하는 것으로 생각된다. 본 연구에서 개발된 기법의 효율성과 장점은 합성 자료와 현장 자료를 이용하여 도시될 것이다.

• 한국지구과학회:학술대회논문집
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• 한국지구과학회 2005년도 춘계학술발표회 논문집
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• pp.253-253
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• 2005

• Journal of Animal Science and Technology
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• 제65권4호
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• pp.767-778
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• 2023

The aim of the research is to identify that porcine oocytes can function as recipients for interspecies cloning and have the ability to develop to blastocysts. Furthermore each mitochondrial DNA (mtDNA) in interspecises cloned embryos was analyzed. For the study, mouse-porcine and porcine-porcine cloned embryos were produced with mouse fetal fibroblasts (MFF) and porcine fetal fibroblasts (PFF), respectively, introduced as donor cells into enucleated porcine oocytes. The developmental rate and cell numbers of blastocysts between intraspecies porcine-porcine and interspecies mouse-porcine cloned embryos were compared and real-time polymerase chain reaction (PCR) was performed for the estimate of mouse and porcine mtDNA copy number in mouse-porcine cloned embryos at different stages.There was no significant difference in the developmental rate or total blastocyst number between mouse-porcine cloned embryos and porcine-porcine cloned embryos (11.1 ± 0.9%, 25 ± 3.5 vs. 10.1 ± 1.2%, 24 ± 6.3). In mouse-porcine reconstructed embryos, the copy numbers of mouse somatic cell-derived mtDNA decreased between the 1-cell and blastocyst stages, whereas the copy number of porcine oocyte-derived mtDNA significantly increased during this period, as assessed by real-time PCR analysis. In our real-time PCR analysis, we improved the standard curve construction-based method to analyze the level of mtDNA between mouse donor cells and porcine oocytes using the copy number of mouse beta-actin DNA as a standard. Our findings suggest that mouse-porcine cloned embryos have the ability to develop to blastocysts in vitro and exhibit mitochondrial heteroplasmy from the 1-cell to blastocyst stages and the mouse-derived mitochondria can be gradually replaced with those of the porcine oocyte in the early developmental stages of mouse-porcine cloned embryos.

• The Plant Pathology Journal
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• 제38권5호
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• pp.541-549
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• 2022

Potato late blight caused by Phytophthora infestans is a destructive disease in Korea. To elucidate the genomic variation of the mitochondrial (mt) genome, we assembled its complete mt genome and compared its sequence among different haplotypes. The mt genome sequences of four Korean P. infestans isolates were revealed by Illumina HiSeq. The size of the circular mt genome of the four major genotypes, KR_1_A1, KR_2_A2, SIB-1, and US-11, was 39,872, 39,836, 39,872, and 39,840 bp, respectively. All genotypes contained the same 61 genes in the same order, comprising two RNA-encoding genes, 16 ribosomal genes, 25 transfer RNA, 17 genes encoding electron transport and ATP synthesis, 11 open reading frames of unknown function, and one protein import-related gene, tatC. The coding region comprised 91% of the genome, and GC content was 22.3%. The haplotypes were further analyzed based on sequence polymorphism at two hypervariable regions (HVRi), carrying a 2 kb insertion/deletion sequence, and HVRii, carrying 36 bp variable number tandem repeats (VNTRs). All four genotypes carried the 2 kb insertion/deletion sequence in HVRi, whereas HVRii had two VNTRs in KR_1_A1 and SIB-1 but three VNTRs in US-11 and KR_2_A2. Minimal spanning network and phylogenetic analysis based on 5,814 bp of mtDNA sequences from five loci, KR_1_A1 and SIB-1 were classified as IIa-6 haplotype, and isolates KR_1_A2 and US-11 as haplotypes IIa-5 and IIb-2, respectively. mtDNA sequences of KR_1_A1 and SIB-1 shared 100% sequence identity, and both were 99.9% similar to those of KR_2_A2 and US-11.

• Investigative Magnetic Resonance Imaging
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• 제22권1호
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• pp.26-36
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• 2018

Purpose: Children born with single ventricle physiology demonstrate poor growth rate and suffer from malnutrition, which lead to increased morbidity and mortality in this population. We assume that an anabolic steroid, oxandrolone, will promote growth in these infants by improving myocardial energy utilization. The purpose of this paper is to study the efficacy of oxandrolone on myocardial energy consumption in these infants. Materials and Methods: We modeled single ventricle physiology in a lamb by prenatally shunting the aorta to the pulmonary artery and then postnatally, we monitored cardiac energy utilization by quantitatively measuring the first order reaction rate constant, $k_f$ of the creatine-kinase reaction in the heart using magnetization transfer $^{31}P$ magnetic resonance spectroscopy, home built $^1H/^{31}P$ transmit/receive double tuned coil, and transmit/receive switch. We also performed cine MRI to study the structure and dynamic function of the myocardium and the left ventricular chamber. The spectroscopy data were processed using home-developed python software, while cine data were analyzed using Argus software. Results: We quantitatively measured both the first order reaction rate constant and ejection fraction in the control, shunted, and the oxandrolone-treated lambs. Both $k_f$ and ejection fraction were found to be more significantly reduced in the shunted lambs compared to the control lambs, and they are increased in oxandrolone-treated lambs. Conclusion: Some improvement was observed in both the first order reaction rate constant and ejection fraction for the lamb treated with oxandrolone in our preliminary study.

• 한국전자통신학회논문지
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• 제2권1호
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• pp.10-18
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• 2007

본 논문에서는 MTS(Multiple Time Scale) 트래픽 제어 프레임워크를 TCP(Transfer Control Protocol) 기반의 신뢰할 수 있는 전송 및 윈도우 기반 혼잡제어로 확대 적용한다. 이 작업은 TCP의 대역폭 소비 반응의 적극성을 LTS 네트워크 상태의 함수 형태, 즉 RTT(Round-Trip Delay Time)가 결정한 피드백 루프의 한계를 넘어서는 정보의 형태를 조정하는 LTS(Large Time Scale) 모듈과 TCP를 연계시키는 방법으로 수행된다. 혼잡 제어 성능 평가 방식은 자기 유사성 네트워크 트래픽의 물리적 모델링으로부터 얻은 시뮬레이션 기반 하에서 결과를 나타낸다. 자기 유사 버스트 환경 하에서 RTT가 450ms일 때 소스 트래픽이 초과되지 않는 경우에 TCP-SSC(Selective Slope Control)의 성능 이득은 각각 ${\alpha}$가 1.05일 45%정도 높아지는 반면에 ${\alpha}$가 1.95일 때는 20%정도의 성능 이득을 얻을 수 있다. 그러므로 비율 기반 피드백 혼잡 제어에 TCP-MTS를 적용함으로서 TCP-SCC 처리 이득의 성능이 약 2배정도의 개선이 이루어짐을 시뮬레이션 결과로부터 알 수 있다.