• Journal of the Korean Institute of Telematics and Electronics B
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• v.30B no.7
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• pp.1-13
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• 1993

In this paper, the problems of the conventional special-purpose array processor such as the deficiency of flexibility have been investigated. Then, a new modified methodology has been suggested and applied to obtain the common solution of the three typical App algorithms like SP(Shortest Path), TC(Transitive Closure), and MST(Minimun Spanning Tree) among the various APP algorithms using the similar method to obtain the solution. In the newly proposed APP parallel algorithm, real-time Processing is possible, without the structure enhancement and the functional restriction. In addition, we design 2-demensional bit-parallel low-triangular systolic array processor and the 1-PE in detail. For its evaluation, we consider its computational complexity according to bit-processing method and describe relationship of total chip size and execution time. Therefore, the proposed processor obtains, on which a large data inputs in real-time, 3n-4 execution time which is optimal o(n) time complexity, o(n$^{2}$) space complexity which is the number of total gate and pipeline period rate is one.

• Molecules and Cells
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• v.41 no.2
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• pp.83-92
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• 2018

The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.

• Journal of Acupuncture Research
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• v.20 no.3
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• pp.141-153
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• 2003

To study the effects of anti-cancer, anti-metastasis and immune response improvement of herbal-acupuncture with Eclipta prostrata diffuse herba infusion solution(ELP-HAS), we injected ELP-HAS into Chok-samni(St36) of C57BL/6 mice implanted intravenously with B16-F10 melanoma. We have reached the following conclusion through the effect on the number of $CD25^+/CD4^+$, $CD8^+/CD3e^+$, $CD69^+/B220^+$, $NK1.1+/CD3e^+$ cells in mouse PBMCs, the effect on the pulmonary colony number, and the effect on MST(Median Survival Time) and ILS(Increase of Life Span) of C57BL/6 mice implanted intravenously with B16-F10 melanoma The results were obtained as follows: 1. In the experiment groups treated with ELP(Eclipta prostrata) Herbal-Acupuncture, the spleen cell proliferation in Balb/c mouse was significantly increased compared with control group. 2. In the experiment groups treated with ELP(Eclipta prostrata) Herbal-Acupuncture, the percentage of $CD25^+/CD4^+$, $CD8^+/CD3e^+$, $CD69^+/B220^+$, $NK1.1^+/CD3e^+$ cells in C57Bl/6 mouse PBMCs was increased compared with control group. 3. In the experiment groups treated with ELP(Eclipta prostrata) Herbal-Acupuncture, the pulmonary colony number of C57BL/6 mice implanted intravenously with B16-F10 melanoma was decreased significantly compared with control group. 4. In the experiment groups treated with ELP(Eclipta prostrata)Herbal-Acupuncture, MST(Median Survival Time) and ILS(Increase of Life Span) of C57BL/6 mice implanted intravenously with B16-F10 melanoma were increased significantly compared with control group.

• Journal of Acupuncture Research
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• v.21 no.6
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• pp.63-84
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• 2004

Objective & Methods : To study the effects of anti-cancer, anti-metastasis and immune response improvement of herbal-acupuncture with Eclipta prostrata diffusae herba infusion solution(ELP-HAS), we injected ELP-HAS into Chung-wan(CV12) of C57BL/6 mice implanted intravenously with B16-F10 melanoma. We have reached the following conclusion through the effect on the percentage of $CD25^+/CD4^+$, $CD8^+/CD3e^+$, $CD69^+/B220^+$, $NK1.1^+/CD3e^+$cells in mouse PBMCs, the effect on the pulmonary colony formation number, and the effect on MST(Median Survival Time) and ILS(Increase of Life Span) of C57BL/6 mice implanted intravenously with B16-F10 melanoma. Results : The results were obtained as follows : 1. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, the spleen cell proliferation in BALB/c mouse was significantly increased compared with control group. 2. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, the percentage of $CD25^+/CD4^+$, $CD8^+/CD3e^+$, $CD69^+/B220^+$, $NK1.1^+/CD3e^+$cells in C57BL/6 mouse PBMCs was increased compared with control group. 3. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, the pulmonary colony formation number of C57BL/6 mice implanted intravenously with B16-F10 melanoma was decreased significantly compared with control group. 4. In the experiment groups treated with ELP(Ecliptae Herba) Herbal acupuncture, MST(Median Survival Time) and ILS(Increase of Life Span) of C57BL/6 mice implanted intravenously with B16-F10 melanoma were increased significantly compared with control group. Conclusions : ELP Herbal acupuncture injection into Chung-wan(CV12) of C57BL/6 mice is considered to be effective in anti-cancer, anti-metastasis and immune response improvement.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.24 no.2
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• pp.65-69
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• 2014

Crystallographic phases of Plasma electrolytic oxidized Al alloy, A1100, A5052, A6061, A6063, A7075, were investigated. Two types of electrolyte $Na_2Si_2O_3$ and Na2P2O7 were also compared. Bipolar pulse, $2000{\mu}sec$ with $400{\mu}sec+420V$ impulse and $300{\mu}sec$ - impulse were applied for 20 min. ${\alpha}-alumina$, ${\gamma}-alumina$, ${\eta}-alumina$, $Al_{4.95}Si_{1.05}O_{9.52}$, and $(Al_{0.9}Cr_{0.1})_2O_3$ were mainly observed. Si, component of electrolyte, were moved into the PEO layer by bipolar pulse. Glassy phase was also observed at the surface of $Na_2Si_2O_3$ electrolyte treated PEO layer, and increased with the Mg content of Al alloy. It is concluded that at first glassy phase was formed by the micro plasma, and the high temperature of plasma turns glassy phase to several crystalline phases. And we could expect that many other crystalline phase could be formed by PEO process.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1261-1270
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• 2006

This study was done to investigate the effect of anti-cancer, anti-metastasis and immune response improvement of herbal-acupuncture with Evodiae Fructus herbal infusion solution(EF-HAS). To study the effects of anti-cancer, anti-metastasis and immune response improvement of EF-HAS, we injected EF-HAS into Chung-wan(CV12) of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma. Then, we have examined the effect on the increasing of spleen cells, the effect on the number of CD25$^+$/CD4$^+$, CD8$^+$/CD3e$^+$, CD69$^+$/B220$^+$, NK1.1$^+$/CD3e$^+$ cells in mice's PBMCs, the effect on the pulmonary colony number, and the effect on median survival time(MST) and increase of life span(ILS) of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma. The following results were obtained; in the experiment groups treated with EF-HAS, the spleen cell proliferation in C57BL/6 mice, the percentage of CD25$^+$/CD4$^+$, CD8$^+$/CD3e$^+$, CD69$^+$/B220$^+$, NK1.1$^+$/CD3e$^+$ cells in C57BL/6 mice's PBMCs, and MST and ILS of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma were significantly increased compared with that of the control group. And in the experiment groups treated with EF-HAS, the pulmonary colony number of C57BL/6 mice implanted intravenously with Bl6-Fl0 melanoma was decreased significantly compared with that of the control group. These results support a role for EF-HAS might De usefully applied in treatment of cancer.

• 한국체육학회지인문사회과학편
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• v.54 no.5
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• pp.829-840
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• 2015

The purpose of this study was to investigated into the kinematics and ground reaction force for gait on induced stereoacuity in normal subjects with normal sight. Eighteen subjects who passed the stereoacuity testing were participated in the experiment(age: 22.1±2.7 years, height: 176.8±4.4 cm, weight: 67.6±5.8 kg). The study method adopted 3D analysis with six cameras and ground reaction force with two force-plates. The results were as follows; In gait velocity, obstacle crossing gait was slower than flat gait. In angular displacement of hip joint, mostly obstacle crossing gait was more flexed than flat gait. In angular displacement of knee joint, obstacle crossing gait was more flexed than flat gait, and stereoacuity reduction gait in TO and FC2 were more flexed than normal vision gait. In angular displacement of ankle joint, obstacle crossing gait in FC2 was more flexed than flat gait. In trunk tilt, obstacle crossing gait in MSt, TO and MSw were more extended than flat gait. In GRF, there was no significant in Fx, obstacle crossing gait in right and left foot were bigger propulsion force than flat gait, obstacle crossing gait in right and left foot were bigger braking force than normal vision gait in Fy, and obstacle crossing gait in right and left foot were bigger than flat gait in peak F1 and peak F2 of Fz, and stereoacuity reduction gait in right foot was lower than normal vision gait in valley force of Fz.

• Natural Product Sciences
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• v.13 no.3
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• pp.234-240
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• 2007

The present study investigated the anti-tumor activity of ethyl acetate extract of Acanthospermum hispidum DC against daltons ascites lymphoma in mice. The extract was prepared by cold maceration with ethyl acetate for 3 - 7 days and evaporated in vacuum to dry. (Yield : 14.2 g, 1.42% w/w). The extract was fractionated by column chromatography by using gradient elution technique and the diterpenes fraction isolated (0.649 g). Both extract and the fraction were administered as oral suspension with tween 20 in water to tumor bearing mice (DAL) and changes in dead cell count, histopathology of tumor cells, hematological parameters and median survival time (MST) were examined and compared with that of tumor control or 5-Fluorouracil (5-FU). The results indicate that both ethyl acetate extract and fraction possess anti-tumor activity. The study suggests that Acanthospermum hispidum DC seems promising as a source of diterpenes for potential anti-tumor activity.

• Journal of Korean Society for Quality Management
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• v.11 no.1
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• pp.2-9
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• 1983

For the optimal achievement of system goals through a systematic analysis of the complex problems, systems engineering provides us the concepts and methodology that include comprehensive interpretability (or understandability), universal applicability, and feasibility. Under this aspect, the main objective of this study is that it introduces mathematical system theory (MST) as the fundamental tool of SE into the Inventory Control among the related parts with IE, and review it's applicability. Through its work, we can find that it has the alternative aspects with which it can replace other existing methods for problem-solving in understanding and analyzing structurally systems in themselves as well as being considerable of the time evolutionary process of a given system.

• Annual Conference on Human and Language Technology
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• 2010.10a
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• pp.73-77
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• 2010

본 논문은 의존 구조 분석기를 통합하기 위해 입력 문장의 단어 특성을 활용하는 단어 단위 분배기를 제안한다. 본 모델은 기존의 문장 수준 분배기와는 달리 입력 문장의 단어 특성에 따라 가장 적절한 의존 구조 분석기를 선택하고, 선택된 의존 구조 분석기의 결과를 최종 결과로 사용한다. 기존의 문장 단위 분배기보다 단어 수준의 풍부한 특질을 활용할 수 있다는 장점과 큰 크기의 코퍼스를 사용할 수 있다는 장점이 있다. 총 6개 언어의 LAS를 측정했는데, MALT 보다는 평균 1.98%, MST 보다는 0.54%의 성능 향상이 있었다.