• Korean Journal of Clinical Pharmacy
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• v.19 no.1
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• pp.65-68
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• 2009

Disposal infusion device is known to be useful for chemotherapy. Anti-cancer drug can be released by the force of carbon dioxide or balloon. In this study, we compared the$Anapa^{(R)}$ (LC0020) with B Company (LV2 ml) in terms of infusion rate and stability. Infusion rate was determined every six minute using software, MSI08IH. Stability of 5-fluorouracil was examined periodically using a High Performance Liquid Chromatography. Infusion rates of gas-derived $Anapa^{(R)}$ device were 2.29, 1.86, 1.98 ml/hr and those of balloon-derived B Company device were 1.71, 1.58, 1.37 ml/min. There were no significant differences in stability of 5-fluorouracil between $Anapa^{(R)}$ and B Company devices. In summary, gas-derived $Anapa^{(R)}$ device is thought to be comparable or superior to balloon-derived B Company device as far as infusion rate and stability are concerned. We expect that $Anapa^{(R)}$ as a home infusion device can be employed to improve a quality of life and compliance of cancer patients.

• Journal of Korean Society of Rural Planning
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• v.16 no.1
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• pp.63-71
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• 2010

지난 수십 년 동안 형태지수는 패치의 복잡성을 정량화하여 생물종 다양성 보존과 같은 경관생태계획에 활용되어 왔다. 지역계획 연구자들이나 정책결정자들에게 경관구조와 패턴을 정량화하는 경관생태지수는 대상지역을 모니터링할 수 있는 하나의 수단으로 활용되어 왔다. 그러나 경관생태지수관련 연구를 살펴보면 연구 목적 및 범위에 따라 활용하는 경관생태지수의 종류가 매우 다양하고 복잡한 것을 알 수 있다. 또한 연구목적에 적합한 경관생태지수를 선정하는 것은 복잡한 수학분석과 함께 많은 주의가 필요한 것을 알 수 있다. 따라서 본 연구에서는 형태지수들을 도시지역, 도시외곽지역, 농촌지역 그리고 산림지역 등 4군데 사례지역에 적용하여 그 결과를 통해 형태지수들의 특성을 살펴보았다. 그 결과, 평균형태지수값(MSI)에서는 도시외곽지역이 가장 높게 나타났고, 평균프랙텔차원지수(MPFD)에서는 농촌지역이 높게 나타났다. 넓은 면적을 가진 패치에 가중점을 고려한 평균형태지수값(AWMSI)과 평균프랙텔차원지수값(AWMPFD)에서는 산림지역이 가장 높게 나타났다. 사용한 네 가지 형태지수값의 순위가 4군데 사례지역에서 다르게 나타났다. 특히 둘레와 면적의 로그전환을 이용하고 있는 프랙텔차원지수들의 경우, 도시와 도시외곽지역의 MPFD값은 같고, 도시외곽지역, 농촌지역과 산림지역의 AWMPFD값 차이는 적어 순위 분별력이 떨어졌다. 따라서 넓은 면적을 가진 패치에 가중점을 고려한 평균형태지수(AWMSI)가 지역별 산림패치의 복잡성을 잘 정량화할 수 있음을 본 연구결과에서 보여주고 있다.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.378-378
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• 2019

본 연구에서는 용담댐 유역을 대상으로 저수위/저수량 모니터링 및 예측을 위하여 고해상도 위성관측 자료를 이용하는 방법과 위성으로부터 추출한 강수량 자료로부터 가뭄지수를 이용한 저수위를 모니터링하고 SSA를 이용한 PCA방법으로 예측모델을 구축하여 가뭄을 예측하는 방법을 개발하였다. 용담댐 저수위와 SPI(3)와의 상관계수가 0.78로 매우 높은 상관성을 보였으며, 위성자료를 통하여 산정한 가뭄지수를 활용하여 댐 저수위/저수량 모니터링 및 예측 가능성을 진단하였다. SSA에 의한 주성분 분석결과 SPI(3)과 각 RC자료의 상관관계를 분석한 결과 CC=0.87~0.99의 높은 상관성을 보였으며, 표준화된 댐 저수위(N-W.S.L.)와 RC자료의 상관관계를 분석한 결과 CC=0.83~0.97의 비교적 높은 상관성을 보임을 확인하였다. 또한, Sentinel-2 위성의 MSI (Multi-Spectral Instrument) 센서로 댐수위의 변화를 모니터링하기 위해 지수 기법을 적용하여 수체 탐지 알고리즘을 개발하였으며, 용담댐유역에 대해 2016년부터 2018년까지의 수계 면적 변화를 분석하였다. 이를 기반으로 Sentinel-2 위성영상으로 추출한 수계 면적 변화를 이용하여 가뭄감시 분야에 대한 활용 가능성을 제시하였다. 본 연구의 결과는 다양한 위성관측자료로부터 미계측 지역의 저수량 모니터링과 수문학적 가뭄 모니터링/예측에 활용이 가능할 것이다.

• Korean Journal of Head & Neck Oncology
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• v.39 no.1
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• pp.1-9
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• 2023

Technological advancement in human genome analysis and ICT (information & communication technologies) brought 'precision medicine' into our clinical practice. Precision medicine is a novel medical approach that provides personalized treatments tailored to each individual by precisely segmenting patient populations, based on robust data including a person's genetic information, disease information, lifestyle information, etc. Precision medicine has a potential to be applied to treating a range of tumors, in addition to non-small cell lung cancer, in which precision oncology has been actively practiced. In this article, we are reviewing precision medicine in head and neck cancer (HNC) with focus on tumor agnostic biomarkers and treatments such as NTRK, MSI-H/dMMR, TMB-H and BRAF V600E, all of which were recently approved by U.S. Food and Drug Administration (FDA).

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.28-28
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• 2022

본 연구는 용담댐유역을 포함한 금강 유역 상류 지역을 대상으로 Sentinel-1 SAR (Synthetic Aperture Radar) 위성영상을 기반으로 한 토양수분 산정을 목적으로 하였다. Sentinel-1 영상은 2019년에 대해 12일 간격으로 수집하였고, 영상의 전처리는 SNAP (SentiNel Application Platform)을 활용하여 기하 보정, 방사 보정 및 Speckle 보정을 수행하여 VH (Vertical transmit-Horizontal receive) 및 VV (Vertical transmit-Vertical receive) 편파 후방산란계수로 변환하였다. 토양수분 산정에는 Water Cloud Model (WCM)이 활용되었으며, 모형의 식생 서술자(Vegetation descriptor)는 RVI (Radar Vegetation Index)와 NDVI (Normalized Difference Vegetation Index)를 활용하였다. RVI는 Sentinel-1 영상의 VH 및 VV 편파자료를 이용해 산정하였으며, NDVI는 동기간에 대해 10일 간격으로 수집된 Sentinel-2 MSI (MultiSpectral Instrument) 위성영상을 활용하여 산정하였다. WCM의 검정 및 보정은 한국수자원공사에서 제공하는 10 cm 깊이의 TDR (Time Domain Reflectometry) 센서에서 실측된 6개 지점의 토양수분 자료를 수집하여 수행하였으며, 매개변수의 최적화는 비선형 최소제곱(Non-linear least square) 및 PSO (Particle Swarm Optimization) 알고리즘을 활용하였다. WCM을 통해 산정된 토양수분은 피어슨 상관계수(Pearson's correlation coefficient)와 평균제곱근오차(Root mean square error)를 활용하여 검증을 수행할 예정이다.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.1
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• pp.19-23
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• 2010

Purpose: The aims of this paper are to assess the competitiveness about the spectacles industry of Korea against Japan. Methods: We use export competitiveness indexes such as market share index, trade specialization index and market comparative advantage index to evaluate the competitiveness of spectacles industry of Korea against Japan. Results: This paper shows that the comparative advantage of the Spectacles industry of Korea in MC(market comparative advantage) against Japan arc spectacles lenses and contact lenses. Furthermore, it can also be known that the spectacles lenses and contact lenses have export competitiveness in the TSI (trade specialization index) against Japan. Conclusions: We need to choose spectacles lenses and contacts lenses as the main export items against Japan in the spectacles industry of Korea. Along with this, we need to improve the image of the Spectacles industry in Korea; after that, we have to create a strategy that would strengthen export competition in other items.

• Journal of Nutrition and Health
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• v.36 no.10
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• pp.990-996
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• 2003

This study was conducted to investigate the effects of Forsythia viridissima Lindl. (FVL) on antioxidative defense system and lipid peroxidation of liver in rats fed high-cholesterol diet. Sprague-Dawley male rats weighing 100 $\pm$ 10 g were randomly assigned into five experimental groups fed 0.5％ cholesterol ; HC group which was not supplemented FVL extract, 0.05％ methanol extract diet group (MSI group), 0.1％ methanol extract diet group (MS2 group), 0.025％ ethylacetate-souble fraction diet group (ES1 group) and 0.05％ ethylacetate-souble fraction diet group (ES2 group). Experimental diets were fed ad libitum to the rats for 3 weeks. The hepatic xanthine oxidase (XOD) activity in the MS2 group was decreased to 20％ as compared to HC group. The activities of hepatic superoxide dismutase (SOD) and catalase (CAT) were not significantly different among all the high cholesterol diet groups. The hepatic glutathione peroxidase (GSHpx) activity in MS2, ES2 groups were significantly increased as compared to HC group. The hepatic glutathione S-transferase (GST) activity in the MS2 group was increased to 20％ as compared to HC group. The levels of hepatic TBARS in the MS1, MS2, ES1 and ES2 groups were reduced by 13％, 21％, 13％ and 21％, respectively, as compared with HC group. The contents of lipofuscin in liver tissue was not significantly different among all the experimental groups. The results indicate that FVL extract may reduce oxidative damage by activating antioxidative defense system of liver in rats fed high-cholesterol diets.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.50.2-50.2
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• 2017

Spatial distribution of atmosphereless bodies in the solar system provides an important clue as to their origins, namely asteroids from Mainbelt or comets from outer solar system. It is, however, difficult to distinguish asteroids and dormant comets due to their similar appearances. In this study, we conducted a unique observation to differentiate asteroids and dormant comets in terms of 'polarimetry'. We observed (331471) 1984 QY1 (hereafter QY1) at large phase angles using the Multi-Spectral Imager (MSI) on the 1.6-m Pirka Telescope from UT 2016 May 25 to June 24. QY1 is a dormant comet candidate in terms of the dynamical properties (i.e. the Tisserand parameter with respect to Jupiter, TJ = 2.68). We analyzed the polarization degree of QY1 as a function of phase angle and found its maximum polarization degree, $Pmax=8.68{\pm}0.28%$ and $8.72{\pm}0.38%$, in RC-and V-band, respectively, around the phase angle of ${\alpha}=100^{\circ}$. In addition, we obtained the geometric albedo, $pV=0.16{\pm}0.02$ by means of an empirical slope-albedo law. The polarimetric properties and the albedo value we acquired are similar to those of S-type asteroids rather than cometary nuclei. In this presentation, we introduce our observation and findings. In addition, we further discuss a dynamical transportation process from Mainbelt to the current orbit.

• Physical Therapy Korea
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• v.25 no.4
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• pp.27-36
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• 2018

Background: We developed a novel integrative lumbar stabilization technique that combines lumbar extension (LE) exercise with abdominal drawing-in maneuver (ADIM) to ameliorate low back pain (LBP) associated with neuromuscular imbalance and instability, based on the collective evidence of contemporary spinal rehabilitation. Objects: The specific aim of the present study was to investigate the effects of LE exercise with and without ADIM on core muscle strength, lumbar spinal instability, and pain, as well as functional characteristics in individuals with LBP using advanced radiographic imaging techniques. Methods: patients with mechanical LBP (N = 40, 6 males; $35.1{\pm}7.6years$) were recruited and randomly assigned either to the combined LE and ADIM (experimental group) or the LE alone (control group). Outcome measures included the visual analog scale, the modified Oswestry Disability Index, muscle strength imbalance (MSI), and radiographic imaging. The lumbar intervertebral displacement (LID), intervertebral (IV) and total lumbar extension (TLE) angles were calculated to evaluate the lumbar segmental instability. Results: The experimental group showed significant differences in the L3-L4, L5-S1 LIDs, L4-L5 and L5-S1 IV angles, and TLE angle as compared to the controls (p<.05). Immediate pain reduction and muscle strength imbalance ratio were significantly different between the groups (p<.05). Conclusion: These results suggest that the addition of ADIM significantly increased lumbar spinal stabilization in individuals with LBP, thereby reducing pain associated with functional lumbar flexion during daily activities.

• Journal of Families and Better Life
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• v.31 no.6
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• pp.97-112
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• 2013

This study was conducted to investigate the effect of sandplay therapy for couples on the self-differentiation, and heterosexual relationship satisfaction, of couples who are college students'. The subjects were four couples who are college students living in Seoul with low self-differentiation and heterosexual relationship satisfaction. I carried out sandplay therapy on four couples for once a week for 10 weeks, and each session was 70 minutes long. In this study, the self-differentiation scale was modified for Korea on the basis of Bowen's family systems theory (1976), and it was used as a research tool. Yu (2000) and Lee (2000) made a scale to measure heterosexual relationship satisfaction after they adjusted the Korea Marital Satisfaction Inventory (K-MSI). The scale was also used in order to compare pre-therapy and post-therapy traits and identify any changes. In addition, the group's behavior and interactions were observed and recorded in each session throughout the process of sandplay therapy with the couples, and the behanior and interactions were analyzed along with the change flow in the sand trays. The study's outcomes are summed up as follows. First, sandplay therapy with couples advances the level of self-differentiation in college students. Second, sandplay therapy with couples improves the heterosexual relationship satisfaction on college students. Third, the trays used in sandplay therapy with couples showed positive changes as the therapy progressed. As the sessions continued, negative factors in the trays decreased and the trays converged into one. As the sessions proceeded, it was observed that the couples became closer, felt more comfortable with each other, compromised and reflected on their relationship. The study's results show that sandplay therapy with couples increased the level of self-differentiation in college students and heterosexual relationship satisfaction, thus proving the therapy's effectiveness.