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Effect of Forsythia Viridissima Extracts on Antioxidative System and Lipid Peroxidation of Liver in Rats Fed High-Cholesterol Diet  

이정민 (대구가톨릭대학교 식품영양학과)
최상원 (대구가톨릭대학교 식품영양학과)
조성희 (대구가톨릭대학교 식품영양학과)
이순재 (대구가톨릭대학교 식품영양학과)
Publication Information
Journal of Nutrition and Health / v.36, no.10, 2003 , pp. 990-996 More about this Journal
Abstract
This study was conducted to investigate the effects of Forsythia viridissima Lindl. (FVL) on antioxidative defense system and lipid peroxidation of liver in rats fed high-cholesterol diet. Sprague-Dawley male rats weighing 100 $\pm$ 10 g were randomly assigned into five experimental groups fed 0.5％ cholesterol ; HC group which was not supplemented FVL extract, 0.05％ methanol extract diet group (MSI group), 0.1％ methanol extract diet group (MS2 group), 0.025％ ethylacetate-souble fraction diet group (ES1 group) and 0.05％ ethylacetate-souble fraction diet group (ES2 group). Experimental diets were fed ad libitum to the rats for 3 weeks. The hepatic xanthine oxidase (XOD) activity in the MS2 group was decreased to 20％ as compared to HC group. The activities of hepatic superoxide dismutase (SOD) and catalase (CAT) were not significantly different among all the high cholesterol diet groups. The hepatic glutathione peroxidase (GSHpx) activity in MS2, ES2 groups were significantly increased as compared to HC group. The hepatic glutathione S-transferase (GST) activity in the MS2 group was increased to 20％ as compared to HC group. The levels of hepatic TBARS in the MS1, MS2, ES1 and ES2 groups were reduced by 13％, 21％, 13％ and 21％, respectively, as compared with HC group. The contents of lipofuscin in liver tissue was not significantly different among all the experimental groups. The results indicate that FVL extract may reduce oxidative damage by activating antioxidative defense system of liver in rats fed high-cholesterol diets.
Keywords
Forsythia viridissima Lindl; extract; high cholesterol diet; antioxidative system; lipid peroxidation;
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1 /
[ Kim,T.J. ] / Korean resources plants
2 Screening of antioxidant and antimicrobial activity in native plants /
[ Rim,Y.S.;Park,Y.M.;Park,M.S.;Kim,K.Y.;Kim,M.J.;Choi,Y.H ] / Korean J Medicinal Crop Sci
3 The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart disease: expert group recommendations /
[ Sacks,F.M. ] / Am J Cardiol   DOI   ScienceOn
4 Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats /
[ Bok,S.H.;Park,S.Y.;Park,Y.B.;Lee,M.K.;Jeon,S.M.;Jeong,T.S.;Choi,M.S. ] / Int J Vitam Nutr Res   DOI   ScienceOn
5 Antioxidant activity of anti-inflammatory plant extracts /
[ Schinella,G.R.;Tournier,H.A.;Prieto,J.M.;Mordujovich,D.;Rios,J.L. ] / Life Sci   DOI   ScienceOn
6 Protein measurement with the folin phenol reagent /
[ Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.;Randall,R.J. ] / J Bio Chem
7 /
[ Sreel,R.G.D.;Torrie,J.H. ] / Principles and procedures of statistics
8 Rapid automated analysis of glutathione reductase, peroxidase and S-transferase activity: application to cisplatin-induced toxicity /
[ Bompart,G.J.;Prevot,D.S.;Bascands,J.L. ] / Clin Biochim   DOI   ScienceOn
9 Chemicals, drugs, and lipid peroxidation /
[ Plaa,G.L.;Witscri,H. ] / Annu Rev Pharmacol Toxicol   DOI   ScienceOn
10 The effect of cholesterol feeding on lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in the liver of rats /
[ Uysai,M.;Kutalp,G.;Seckin,S. ] / Int J Vitam Nutr Res
11 Antiinflammatory effect of Forsythia suspensa V (AHL) and its active principle /
[ Ozaki,Y.;Rui,J.;Tang,Y.T. ] / Biol Pharm Bull   DOI   ScienceOn
12 Improving effect of dietary taurine supplementation on the oxidative stress and lipid levels in the plasma, liver and aorta of rabbits fed on a high-cholesterol diet /
[ Balkan,J.;Kanbagli,O.;Hatipoglu,A.;Kucuk,M.;Cevikbas,U.;Aykac-Toker,G.;Uysal,M.;Uysal,M. ] / Biosci Biotechnol Biochem   DOI   ScienceOn
13 The regulation of rat liver xanthine oxidase. Conversion in vitro ofthe enzyme activity from dehydrogenase (type D) to oxidase (type O) /
[ Stirpe,F.;Della Corte E. ] / J Bio Chem
14 Quantitative effects of dietary fat on serum cholesterol in man /
[ Hegsted,D.M.;McGandy,R.B.;Myers,M.L.;Stare,F.J. ] / Am J Clin Nutr
15 Antioxidative activity of green tea polyphenol in cholesterol-fed rats /
[ Yokozawa,T.;Nakagawa,T.;Kitani,K. ] / J Agric Food Chem   DOI   ScienceOn
16 The glutathione S-transferases: a group of multi-functional detoxification proteins /
[ Jacoby,W.B. ] / Adv Enzymol Relat Areas Mol Biol
17 Aortic antioxidant defence mechanisms: time-related changes in cholesterol-fed rabbits /
[ Del Boccio G;Lapenna,D.;Porreca,E.;Pennelli,A.;Savini,F.;Feliciani,P.;Ricci,G.;Cuccurullo,F. ] / Atherosclerosis   DOI   ScienceOn
18 Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits /
[ Jeon,S.M.;Bok,S.H.;Jang,M.K.;Lee,M.K.;Nam,K.T.;Park,Y.B.;Rhee,S.J.;Choi,M.S. ] / Life Sci   DOI   ScienceOn
19 Investigation on antibacterial activity of Forsythia suspense Vahl in vitro with Mueller-Hinton agar /
[ Li,Z.X.;Wang,X.H.;Zhao,J.H.;Yang,J.F.;Wang,X. ] / Zhongguo Zhong Yao Za Zhi
20 Effect of saturated and polyunsaturated fat diet in the chemical composition and metabolism of low density lipoprotein in man /
[ Shepherd,J.;Packard,C.J.;Grundy,S.M.;Yeshumin,P.;Gotto,A.M.;Taunton,O.D. ] / J Lipid Res
21 Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method /
[ Satho,K. ] / Clin Chim Acta   DOI   ScienceOn
22 Antioxidative Activity of Ethanol Extract from Korean Medicinal Plants /
[ Lim,D.K.;Choi,U.;Shin,D.H. ] / Korean J Food Sci Technol
23 Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase /
[ Marklund,S.;Marklund,G. ] / Eur J Biochem
24 Measurement of fluorescent lipid peroxidation products in biological systems and tissues /
[ Fletcher,B.L.;Dillard,C.J.;Tappel,A.L. ] / Anal Biochem   DOI   ScienceOn
25 Pharmacological stodies on Forsythae Fructus /
[ Lee,E.B.;Keum,H.J. ] / Kor J Pharmacogn
26 Glutathione S-transferases. The first enzymatic step in mercapturic acid formation /
[ Habig,W.H.;Pabst,M.J.;Jakoby,W.B. ] / J Bio Chem
27 The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits /
[ Naito,M.;Wu,X.;Nomura,H.;Kodama,M.;Kato,Y.;Kato,Y.;Osawa,T. ] / J Atheroscler Thromb   DOI   ScienceOn
28 Glutathione peroxidase activity in selenium-deficient rat liver /
[ Lawrence,R.A.;Burk,R.F. ] / Biochem Biophys Res Commun   DOI   ScienceOn
29 Heterogeneity of erythrocyte catalase Ⅱ. Isolation and characterization of normal and variant erythrocyte catalase and their subunits /
[ Aebi,H.;Wyss,S.R.;Scherz,B.;Skvaril,F. ] / Eur J Biochem   DOI   ScienceOn
30 Characterization of alternative molecular forms of xanthine oxidase in the mouse /
[ Duke,E.J.;Joyce,P.;Ryan,J.P. ] / Biochem J
31 Effects of probucol on hyper cholesterolemia-induced changes in antioxidant enzymes /
[ Mantha,S.V.;Kalra,J.;Prasad,K. ] / Life Sci   DOI   ScienceOn