• Journal of Magnetics
• /
• 제21권1호
• /
• pp.148-152
• /
• 2016

The main goal was to evaluate effectiveness of a modified TSE sequence compared with DIR (double inversion recovery) sequence in acquisition of fast flow brain vessel images using signal void effect. 32 healthy volunteers (10 men and 22 women; mean age of 31 years; ranging between 28-43 years) who underwent black blood DIR sequence (group A) and the modified TSE sequence (group B) were enrolled in our study. Signal to Noise Ratio (SNR) and Contrast to Noise Ratio (CNR) of the internal carotid arteries' lumen were compared in T1 and T2 weighted images for both group A and B. The images obtained from group B showed lower SNR values in internal carotid artery than the group A in both of the T1 and T2 weighted images (11.49% and 13.66% respectively). While the CNR values were higher in the group B than the group A in both of the T1 and T2 weighted images (8.69% and 7.55 % respectively). The qualitative score of all categories were not significantly different between the two groups. Furthermore approximately 49% of the total scan time was reduced from group B. Our study is to shorten the scanning time and minimize the inconveniences of the patients in acquisition of the black blood images of brain by using the signal void effect in the modified TSE technique while keeping the diagnostic value of the test.

• Journal of Korean Neurosurgical Society
• /
• 제45권6호
• /
• pp.381-385
• /
• 2009

The first case of intracranial metastases of a cervical intramedullary low-grade astrocytoma without malignant transformation in adult is presented in this report. Seven years ago, a 45 year-old male patient underwent biopsy to confirm pathologic characteristics and received craniocervical radiation and chemotherapy for a grade II astrocytoma in the cervical spinal cord. Two years later, posterior fusion was necessary for progressive kyphosis in the cervical spine. He was well for approximately 7 years after the primary surgery. Two months ago, he presented with partial weakness and incoordination with gait difficulty. MRI Scan demonstrated multiple small lesions in the cerebellar vermis and left hemisphere. After suboccipital craniectomy and posterior cervical exposure, the small masses in the cerebellar vermis and hemispheres were excised to a large extent by guidance of an intraoperative navigation system. The tumor at the cervical and brain lesions was classified as an astrocytoma (WHO grade II). When a patient with low-grade astrocytoma in the spinal cord has new cranial symptoms after surgery, radiaton, and chemotherapy, the possibility of its metastasis should be suspected because it can spread to the intracranial cavity even without malignant transformation as shown in this case.

• 동의생리병리학회지
• /
• 제33권4호
• /
• pp.219-225
• /
• 2019

The objective of this study is to observe the effectiveness of complex Korean Medicine treatments on pain reduction of patients after meniscal surgery. We analyzed 16 patients who have been diagnosed as Meniscal injury on Magnetic Resonance Imaging(MRI) scan and had admitted to Dunsan Korean Medical hospital from January 30, 2014 to April 30, 2019. The analysis was conducted as retrospective study which analyzes patient's medical records. Statistical analysis was performed using the IBM SPSS statistics 25 program. We used Numeric Rating Scale to evaluate pain reduction, Five-point likert scale to asses treatment satisfaction. The result showed that there were statistically significant pain reduction on the postoperative meniscal injury patients treated with complex Korean Medicine treatments. In conclusion, we found that the complex Korean Medicine treatments showed a positive effect on pain reduction of postoperative meniscal injury patients. Further research is required to confirm the effectiveness of Korean Medicine treatment.

• 고신대학교 의과대학 학술지
• /
• 제33권3호
• /
• pp.454-462
• /
• 2018

A 54-year-old man, suffering from severe headache and ophthalmoplegia after undergoing endoscopic sinus surgery was referred to a tertiary hospital. Computed tomography (CT) revealed soft tissue density lesions in the left sphenoid sinus. The internal carotid artery was shown to be occluded in brain magnetic resonance imaging (MRI) scans without any other cerebral lesion. Endoscopic view of left nasal cavity shows whitish hyphae in the ethmoid and the sphenoid sinuses. We diagnosed him with cavernous sinus syndrome caused by mucormycosis and conducted endoscopic sinus surgery to remove remaining lesions and decompress orbit and optic nerves. After the revision surgery the patient's headache and ophthalmoplegia were improved. However, multifocal cerebral infarctions were newly discovered in a postoperative CT scan. We experienced a case of mucormycosis of sphenoid sinus resulting in occlusion of internal carotid artery and multifocal cerebral infarction, and report it with a brief review of these disease entities.

• 대한인간공학회:학술대회논문집
• /
• 대한인간공학회 1996년도 추계학술대회논문집
• /
• pp.21-25
• /
• 1996

The Electomyographic (EMG) signals of flexor-extensor muscle pairs were investigated to identify the neural excitation pattern of low-back pain (LBP) patients during a repetitive bending motion. New parameters and EMG normalization technique were developed to quantitatively represent the difference of temporal EMG patterns between ten healthy subjects and ten LBP patients. Flexor-extensor muscle pairs such as rectus abdominis(RA)-erector spinae (ES at LS), external oblique(EO)-internal oblique(IO), rectus femois (quadriceps: QUD)-biceps femoris(hamstrings:HAM), and tibialis anterior(TA)-gastrocnemius(GAS) pairs of muscles were selected in this study. Results indicated that the temporal EMG pattern such as the peak timing difference of QUD-HAM muscle pair and the duration of coexcitation of ES-RA muscle pair showed a statistically isgnificant difference between healthy subjects and LBP patients. These results indicated that the new technique and parameters could be used as a diagnostic tool especially for LBP patients with soft tissue injuries that are rarely dentified by traditional imaging techniques such as X-ray, CT scan or MRI. Improtantly, the new EMG technique did not require the maximal volutary contraction(MVC) measure for normalization that helped patients minimize the pain experience during and after the session. Further study needs to be made to validate and refine this method for clinical application.

• Nuclear Engineering and Technology
• /
• 제55권1호
• /
• pp.222-228
• /
• 2023

This study aimed to analyze the applicability of the improved median filter in positron emission tomography (PET)/magnetic resonance (MR) fusion images based on parallel imaging using generalized autocalibrating partially parallel acquisition (GRAPPA). In this study, a PET/MR fusion imaging system based on a 3.0T magnetic field and ¹⁸F radioisotope were used. An improved median filter that can set a mask of the median value more efficiently than before was modeled and applied to the acquired image. As quantitative evaluation parameters of the noise level, the contrast to noise ratio (CNR) and coefficient of variation (COV) were calculated. Additionally, no-reference-based evaluation parameters were used to analyze the overall image quality. We confirmed that the CNR and COV values of the PET/MR fusion images to which the improved median filter was applied improved by approximately 3.32 and 2.19 times on average, respectively, compared to the noisy image. In addition, the no-reference-based evaluation results showed a similar trend for the noise-level results. In conclusion, we demonstrated that it can be supplemented by using an improved median filter, which suggests the problem of image quality degradation of PET/MR fusion images that shortens scan time using GRAPPA.

• International Journal of Computer Science & Network Security
• /
• 제23권11호
• /
• pp.183-189
• /
• 2023

A stroke is a medical disease where a blood vessel in the brain ruptures, causes damage to the brain. If the flow of blood and different nutrients to the brain is intermittent, symptoms may occur. Stroke is other reason for loss of life and widespread disorder. The prevalence of stroke is high in growing countries, with ischemic stroke being the high usual category. Many of the forewarning signs of stroke can be recognized the seriousness of a stroke can be reduced. Most of the earlier stroke detections and prediction models uses image examination tools like CT (Computed Tomography) scan or MRI (Magnetic Resonance Imaging) which are costly and difficult to use for actual-time recognition. Machine learning (ML) is a part of artificial intelligence (AI) that makes software applications to gain the exact accuracy to predict the end results not having to be directly involved to get the work done. In recent times ML algorithms have gained lot of attention due to their accurate results in medical fields. Hence in this work, Stroke disease identification system by using Machine Learning algorithm is presented. The ML algorithm used in this work is Artificial Neural Network (ANN). The result analysis of presented ML algorithm is compared with different ML algorithms. The performance of the presented approach is compared to find the better algorithm for stroke identification.

• 핵의학기술
• /
• 제19권1호
• /
• pp.12-16
• /
• 2015

주성분분석(Principal component analysis, PCA)은 고차원 변수들 사이의 복잡한 상관성 구조를 더 낮은 차원으로 단순화하여 상관성의 구조를 쉽게 설명하기 위한 다변량분석기법으로 뇌영상 분석에서 자주 사용되는 방법이다. 주성분분석의 기본개념은 서로 직교하는 변수들의 선형결합을 통해서 원래의 뇌영상 자료가 가지고 있는 전체정보를 최대한 설명할 수 있는 서로 독립적인 새로운 변수들을 유도하는 것이다. 뇌영상분석에서 주성분분석의 효율성과 유용성을 알아보기 위해서 C[11]-PIB 영상을 이용하여 분석하였다. 대상 및 방법으로는 평균나이가 같은 9명의 정상인, 10명의 알츠하이머/경도인지장애환자들의 C[11]-PIB 영상을 이용하였다. PET-CT 장비로는 Biograph 6 Hi-Rez (Siemens-CTI, Knoxville, TN)를 영상을 획득하였고 9.6 MBq/kg C[11]-PIB를 정맥주사 한 후 40분 후에 20분 동안 3D acquisition mode로 방출영상을 얻었다. Attenuation map은 X-ray CT scan을 이용하여 재구성하였다(130 kVp, 240 mA). PIB template을 만들기 위해서 정상인에서 3T MRI T1-weighted 영상을 동시에 얻었다. 주성분분석을 위한전처리과정으로서 공간정규화 및 공간편평화를 SPM8을 이용하여 실시하였고 주성분분석은 Matlab2012b를 이용하여 분석하다. 결과는 주성분분석을 통해서 서로 독립적인 주성분영상들을 얻을 수 있었다. 주성분분석을 통해서 얻어진주성분영상은 C[11]-PIB brain PET 영상의 패턴을 몇 개의 주성분으로 단순화 할 수 있었으며 주로는 neocortex를 변동 나타내는 영상, white matter의 변동을 나타내는 영상 그리고 pons등 deep brain의 변동을 나타내는 영상 등으로 단순화되었다. 결론으로는 주성분분석은 C[11]-PIB brain 영상을 단순화하여 영상의 패턴을 해석하는데 매우 유용하였다. 이러한 주성분분석은C[11]-PIB영상 분석뿐만 아니라 뇌의 포도당 대사를 측정하는 FDG-PET 또는 뇌기능영상등의 다변량분석 방법으로서 그 적용범위가 클 것으로 기대된다.

• 대한소아치과학회지
• /
• 제36권1호
• /
• pp.114-118
• /
• 2009

타석증은 대, 소타액선의 도관내에 석회화 물질이 형성되는 것이다. 타액의 점도가 높고 도관이 길고 구부러진 악하선에서 가장 호발한다. 어떤 나이에서도 발생할 수 있지만, 중년에서 호발하며 어린이에서는 드물다. 타석증의 임상 증상은 다양하지만, 부종이 가장 흔하며, 그 다음이 동통이다. 임상 검사와 방사선 검사(파노라믹 방사선 사진, 하악 교합면 방사선 사진, 타액선 조영술, 구강 내 및 구강 외 초음파, CT, MRI, 타액선 내시경)가 타석증의 진단 및 타석의 위치를 확인하는 데 도움을 준다. 치료는 도관의 절개에 의한 타석의 제거나 타액선의 절개를 포함하는 수술적 치료가 많다. 그러나, 일부는 쇄석술과 $CO_2$ 레이저, 내시경 등의 비침습적인 기술을 사용할 수 있다. 5세 여환이 구강저의 노란색 물질을 주소로 개인 병원에서 의뢰되었다. 4개월 전 처음 발견했을 때보다 3배 더 커졌으며 때때로 동통이 있었다고 하였다. 임상 검사 상, 노란색의 단단한 물질이 악하선 도관의 입구에서 관찰되었다. 와튼스 도관의 전방부에 발생한 악하선 타석증으로 진단내렸다. 국소마취하에 타석을 적출하였다.

• Journal of Yeungnam Medical Science
• /
• 제30권2호
• /
• pp.116-119
• /
• 2013

A burnt-out prostate cancer tumor is a very rare clinical entity. The term 'burnt-out' refers to a primary tumor that has spontaneously and nearly completely regressed without treatment. Since metastasis of prostate cancer is usually encountered in the presence of advanced disease, distant metastasis with an undetectable primary tumor is very rare. We report herein a case of a burnt-out prostate cancer tumor that metastasized to the thoracic (T) spine and caused cord compression. A 66-year-old man visited the Emergency Department due to weakness of both legs for the past two days. His blood and urine tests were normal at the time. His spine magnetic resonance imaging (MRI) scans looked like bone metastasis that involved the T-7 vertebral body and a posterior element, and caused spinal cord compression. Other images, including from the brain MRI, neck/chest/abdomino-pelvic computed tomography (CT) scan and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and endoscopy, revealed no lesions that suggested malignancy. After total corpectomy T-7 and screw fixation/fusion at T5 to T10, the pathology report revealed a metastatic carcinoma that was strongly positive for prostate-specific antigen (PSA). The serum PSA value was 1.5 ng/mL. The transrectal 12-core prostate biopsy and ultrasonography showed no definitive hypoechoic lesion, but one specimen had slight (only 1%) adenocarcinoma with a Gleason score of 6 (3+3). The final diagnosis was burned-out prostate cancer with an initial normal PSA value. Although metastatic disease with an unknown primary origin was confirmed, a more aggressive approach in seeking the primary origin could provide a more specific treatment strategy and greater clinical benefit to patients.