• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.310-313
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• 1996

In this study, we developed three dimensional FDG brain PET and MRI coregistration technique. The boundaries of the head in PET and MRI were segmented using sinogram of emission PET scan and T1-weighted MRI. We registered both boundaries by minimizing the mean Euclidean distance of those. To display the registered PET and MRI simultaneously, we used weighted normalization method and interleaving method.

• Investigative Magnetic Resonance Imaging
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• v.17 no.3
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• pp.169-180
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• 2013

Purpose : The purpose of this study was to setup a concuurent transcranial magnetic stimulation (TMS)-functional MRI (fMRI) system for understanding causality of the functional brain network. Materials and Methods: We manufactured a TMS coil holder using nonmagnetic polyether ether ketone (PEEK). We simulated magnetic field distributions in the MR scanner according to TMS coil positions and angles. To minimize image distortions caused by TMS application, we controlled fMRI acquisition and TMS sequences to trigger TMS during inter-volume intervals. Results: Simulation showed that the magnetic field below the center of the coil was dramatically decreased with distance. Through the MR phantom study, we confirmed that TMS application around inter-volume acquisition time = 100 miliseconds reduced imaging distortion. Finally, the applicability of the concurrent TMS-fMRI was tested in preliminary studies with a healthy subject conducting a motor task within TMS-fMRI and passive motor movement induced by TMS in fMRI. Conclusion: In this study, we confirmed that the developed system allows use of TMS inside an fMRI system, which would contribute to the research of brain activation changes and causality in brain connectivity.

• Proceedings of the KSMRM Conference
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• 2002.11a
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• pp.97-97
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• 2002

목적： MRI system에서 얻어지는 기초 data는 k-space 즉, 촬영대상의 Fourier Transform된 data이다. MRI를 이용한 단층 영상 촬영에서 촬영도중 촬영대상이 움직일 경우 움직임으로 인해 artifact가 발생하게 된다. 이것은 영상의 질을 떨어뜨림은 물론, 심한 경우에는 영상을 판독하지 못할 정도로 영상의 질에 영향을 미치게 된다. 이 연구에서는 촬영대상의 움직임이 방향성이 한 방향일 경우 그 움직이는 양을 검출하고, 그 결과를 이용하여 움직임으로 인해 생기는 artifact를 보정하는 방법을 제시하고자 한다.

• Investigative Magnetic Resonance Imaging
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• v.1 no.1
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• pp.51-57
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• 1997

MRI의 artifact는 대부분 신호의 부호화 방향에 따라서 방향성을 가지는데, 이를 요약해보면, 위상부호화 방향의 artifact에는 motion artifact, flow artifact, RF noise등이 있고, 주파수 부호화 방향의 artfact는 susceptibility artfact, chemical shift artifact, central line artifact등이 있으며, 양방향 모두 생길수 있는 것은 Aliasing artifact와 Gibb's phenomenon이고, 전체적으로 영샹의 질을 떨어뜨리는 것은 susceptibility artifact, Eddy current, cross talk등이 있다. 이런 artifact는 대부분은 MRI 자체의 물리적 특성에 다소간 기인하므로, artifact가 없는 양호한 영상을 얻기 위해서는 MRI의 설치 단계부터 관심이 필요하고, MRI의 기본원리와 다양한 artifact에 대해 이해함으로써, 제거 가능한 artifact는 제거하여 양질의 영상을 만들고 판독시의 오류를 피할 수 있도록 해야할 것이다.

• Journal of Biomedical Engineering Research
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• v.20 no.2
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• pp.165-172
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• 1999

An enhancement technique for phase dependent image contrast in MRI(Manetic Resonance Imaging) is proposed. Because the method can enhance inherent phase contrast it is suited for susceptibility imaging and flow imaging where intravoxel phase is a source of image contrast. In this paper, applying external phase in the voxel enhances phase contrast. The external phase is generated by a tailored RF pulse so that one can control the phase contrast and even produces phase only contrast. Signal intensity due to both inherent phase and external phase is analyzed and the proposed technique is applied to a susceptibility effect only imaging and a flow effect only imaging. To verify the proposed technique, computer simulations are performed and their results are given.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.2
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• pp.83-87
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• 2008

Diagnostic and functional imaging device have been developed independently. The recognition that combining of these two devices can provide better diagnostic outcomes by fusing anatomical and functional images. The representative examples of combining devices would be PET/CT and SPECT/CT. Development and their applications of animal imaging and instrumentation have been very active, as new drug development with advanced imaging device has been increased. The development of advanced imaging device resulted in researching and developing for detector technology and imaging systems. It also contributed to develop a new software, reconstruction algorithm, correction methods for physical factors, image quantitation, computer simulation, kinetic modeling, dosimetry, and correction for motion artifacts. Recently, development of MRI and PET by combining them together was reported. True integration of MRI and PET has been making the progress and their results were reported. The recent status of imaging and instrumentation in nuclear medicine is reported in this paper.

• Journal of Biomedical Engineering Research
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• v.22 no.2
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• pp.157-163
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• 2001

본 논문에서는 후취자극 제어장치를 이용하여 후각자극에 대한 인간의 뇌의 활성화 영역을 뇌기능자기공명영상(functional magnetic resonance imaging : fMRI)장치로 측정 또는 가시화하고 이의 임상적용에 대한 기초자료를 마련하고자 하였다. 우선 후각에 이상이 없고 코 수술 경험이 없는 오른손잡이 피험자 4명을 대상으로 5번에 걸쳐 Echo Plannar Imaging(EPI)에 의한 혈액산소농도의존(blood oxygen level dependent : BOLD)법을 이용하여 후각자극에 의한 뇌기능자기공명영상 실험을 수행하였다. 후각자극은 MRI 장치에서 사용할 수 있도록 제작된 후취제어장치를 사용하였으며, 제시된 향은 천연 향의 일종인 lavender-like fragrance를 사용하였다. 향의 제시는 후각의 피로도를 감안하여 3회의 휴식기관과 2회의 자극기간을 각 30초씩 번갈아 시행하였으며, 동시에 5초 간격으로 각 절편 당 30 영상을 연속적으로 획득하였다. Correlation법으로 0.4∼0.7의 문턱치(threshold)범위에서 통계 처리된 뇌의 활성화 영상은 EPI영상과 같은 부위의 T1 강조영상에 overlapping 시켰다. 호흡에 의한 artifact를 제거하기 위해 실험실에 만든 장치로 호흡을 측정하여 post-processing 할 때 반영하였다. 이렇게 얻어진 fMRI 영상의 신호변화를 관찰하여 활성 영역의 위치를 분석하였다. 그 결과 후각자극에 의해 뇌의 전두엽 피질(frontal cortex), 소뇌(cerebellum), 그리고 뇌교(pons)에서 활성화된 신호를 발견할 수 있었다. 또한, 측두엽(temporal lobe)과 뇌섬(insula)에서도 의미 있는 신호가 관찰되었다. 그러나, 일차 후각영역인 piriform cortex와 entorhinal cortex, amygdaloid complex, 그리고 이차후각영역인 orbitofrontal cotex에서는 그다지 많은 빈도로 신호가 발견되지 않았다. 결론적으로 BOLD법을 이용한 fMRI에 의하여 후각자극에 대한 뇌의 활성화영역을 관찰할 수 있었으며, 후각자극에 대한 뇌의 기능을 연구하는데 있어서 중요한 정량적 자료를 제공할 수 있다는 점을 확인할 수 있었다.

• Polymer Science and Technology
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• v.20 no.3
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• pp.239-244
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• 2009

• Smart Media Journal
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• v.5 no.1
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• pp.44-48
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• 2016

In a longitudinal neuroimaging study, the upgrades of a magnetic resonance imaging (MRI) scanner due to outdated hardwares and softwares make it difficult to maintain the same MRI conditions in the long-term research period. Particularly, high field MRI systems such 3T scanners become popular in recent years. However, it is still unclear whether an integrated analysis of 3T and 1.5T images is possible without consideration of the field strength. In this study, we evaluated the reproducibility of hippocampal volumes between brain images with different field strengths and slice orientations. 296 participants underwent both 3T and 1.5T MRI and both sagittal and axial scans for high resolution brain images, and their hippocampal volumes were measured using Freesurfer, a well-known software for neuroimaging analysis. Paired t-tests showed that the hippocampal volumes were significantly different between the image types. These results suggest that it is necessary to develop data analysis techniques for integrating diverse types of MRI images.

• Journal of the Korean Society of Radiology
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• v.81 no.5
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• pp.1234-1238
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• 2020

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is characterized by chondrocalcinosis, which mainly affects the knees, wrists, pelvis, and rarely, the spine. According to previous reports, CPPD crystal deposits display heterogeneous enhancement on MRI. When combined with inflammation of the surrounding soft tissue, strong enhancement by CPPD crystal deposition may appear similar to imaging features of other conditions such as infectious spondylitis. In these conditions, CT plays an important role in differential diagnosis. Here, we present a case of CPPD crystal deposition disease in the ligamentum flavum of the cervical spine that showed intense enhancement on MRI.