• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.8 no.4
• /
• pp.342-353
• /
• 1997

This paper presents an analytical evaluation of a hybrid direct-sequence/slow frequencyhopped code division multiple-access (DS/SFH-CDMA) system employing noncoherent M-ary frequency shift keying(MFSK) modulation in a multiple Nakagami fading (m) environment. Multipath interference (MPI) and multi-access interference (MAI) is taken into account and the spectral efficiency is calculated for uncoded as well as channel coding systems. Predetection multipath maximal ratio combining (MRC) diversity in conjunction with interleaved channel coding (Hamming(7,4) code, BCH(15, 7) code and RS (7, 4), (15, 9)) code ) is employed for improving the bit error rate (BER) performance. The BER of noncoherent hybrid system is obtained using a Gaussian interference approximation.

• Journal of electromagnetic engineering and science
• /
• v.12 no.4
• /
• pp.287-289
• /
• 2012

This paper proposes an alternate time-switched space-frequency block coding transmission technique for orthogonal frequency division modulation systems. There are two antennas in the transmitter but it still has only a baseband and RF and a switch that alternates between the antennas at every symbol timing. Alternating transmit symbols result in zeros that make maximal ratio receive combining possible in the receiver. Simulation results show that it provides better performance than the traditional algorithm at the expense of one additional antenna.

• Journal of Life Science
• /
• v.31 no.3
• /
• pp.266-279
• /
• 2021

The present study examined the cytotoxic effects of a Smilax china L. extract (SCLE) in human cancer (A-549, MCF-7, MDA-MB-231, U87-MG, AGS, MKN-74, and SNU-601) and normal MRC-5 fibroblasts, as well as in mesenchymal stem cells derived from dental tissue (DSC). The 50% inhibitory concentration (IC50) values for SCLE were significantly (p<0.05) lower in the cancer cell lines (A-549, MCF-7, MDA-MB-231, U87-MG, AGS, MKN-74 and SNU-601) than in the MRC-5 and DSC cells. Cell growth was significantly (p<0.05) more inhibited in the cancer cell lines treated with 200 ㎍/ml SCLE than in the normal MRC-5 and DSC, and anoikis-like floating cell morphology was observed in the SCLE-treated cancer cells. The cells detached by SCLE treatment were retrieved daily and assayed for viability and telomerase activity. Cells retrieved at 4 days showed significantly decreased viability and telomerase activity (p<0.05), as well as apoptosis-like abnormal morphology, when compared to cells retrieved in the previous 3 days. The ratio of apoptosis and cells in the G1 phase was significantly (p<0.05) increased in the A-549, AGS, and MCF-7 cancer cells treated with SCLE for 4 days compared to untreated controls. However, after SCLE treatment, cell adhesion was not increased by application of an inhibitor of the associated protein kinase (ROCK) that mainly contributes to the increase in cell attachment. This suggests that the cellular detachment by SCLE is probably controlled by a Rho-independent mechanism(s). These observations indicate that SCLE readily induces anoikis in cancer cells and could serve as a potent agent for cancer chemotherapy.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.12 no.5
• /
• pp.755-764
• /
• 2001

In this paper, we propose maximum likelihood (ML) decision feedback channel estimation (DFCE) for M-ary orthogonal modulation in direct sequence/code division multiple access (DS/CDMA) systems. The proposed DFCE uses the maximum combiner output in a RAKE receiver as decision feedback information, enabling M-ary orthogonal signals to be demodulated coherently and a RAKE receiver to use a em maximal ration combining (MRC) scheme. However, the performance of the proposed DFCE in the multiuser environment is severely degraded due to multiple access interference (MAI). To overcome this problem, a multistage parallel interference cancellation (PIC) scheme is combined with the proposed DFCE for multiuser environments. Accurate knowledge of the channel coefficient estimated by the proposed DFCE is used to regenerate the signal of each user for the multistage PIC scheme. According to the results of our simulations, the performance of coherent demodulation using the proposed system is significantly improved in comparison with conventional noncoherent demodulation.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.15 no.1
• /
• pp.22-32
• /
• 2011

In this paper, we first analyze the differences of underwater acoustic (UWA) orthogonal frequency division multiplexing (OFDM) systems and conventional terrestrial OFDM system, and give a simple introduction of the backgrounds. By considering the real UWA channel environments, the measured channel data is used to generate the UWA channel model and calculate the relative parameters for underwater OFDM systems. Practical least square (LS) based channel estimation with linear interpolation are adopted to obtain the channel state information (CSI) at receiver side. As multi-input multi-output (MIMO) processing techniques, Alamouti code is implemented and evaluated to perform for space time block coding (STBC) and space frequency block coding (SFBC) for UWA OFDM systems with the MIMO configuration of $2{\times}1$, at the same time, $1{\times}2$ maximum ratio combining (MRC) is performed for the purpose of comparison. The simulation results show that, with perfect channel estimation, SFBC failed to work duo to the serious frequency selectivity of UWA channel environments. When the practical channel estimation is applied, in the case of STBC, the proposed 4-column pilot pattern gives better performance about 7dB than SISO system.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.43 no.3 s.345
• /
• pp.1-9
• /
• 2006

In this paper, we propose a MIMO-OFDMA (Multi Input Multi Output-Orthogonal Frequency Division Multiple Access) system based on beamforming for performance improvement of downlink real-time traffic transmission in harsh channel conditions with low CIR (Carrier-to-Interference Ratio). In the proposed system, we first consider the M-GTA-SBA (Modified-Grouped Transmit Antenna-Simple Bit Allocation) using effective CSI (Channel State Information) calculation procedure based on spatial resource grouping, which is adequate for the combination of MRT (Maximum Ratio Transmission) in the transmitter and MRC (Maximum Ratio Combining) in the receiver. In addition, to reduce feedback information for the beamforming, we also apply QEGT (Quantized Equal Gain Transmission) based on quantization of amplitudes and phases of beam weights. Furthermore, considering multi-user environments, we propose the P-SRA (Proposed-Simple Resource Allocation) algorithm for fair and efficient resource allocation. Simulation results reveal that the proposed MIMO-OFDMA system achieves significant improvement of spectral efficiency in low CRI region as compared to a typical open-loop MIMO-OFDMA system using pseudo-orthogonal space time block code and H-ARQ IR (Hybrid-Automatic Repeat Request Incremental Redundancy).

• The Journal of Internal Korean Medicine
• /
• v.43 no.3
• /
• pp.396-412
• /
• 2022

Objective: The aim of this study was to identify the clinical features of post-acute COVID-19 syndrome and the efficacy and safety of Korean medicine treatment. Methods: This study was conducted on 15 patients with post-acute COVID-19 syndrome who visited the outpatient Allergy, Immune, and Respiratory System Department at Kyung Hee University Korean Medicine Hospital from January 10, 2021 to April 10, 2022. We retrospectively analyzed the charts of 15 patients and collected clinical characteristics, Korean medicine treatments, outcome variables (Numeral Rating Scale (NRS), modified Medical Research Council scale (mMRC), Leicester Cough Questionnaire (LCQ), Quality of Life Visual Analog Scale (QOL-VAS), The Post-COVID-19 Functional Status (PCFS)), adverse events, etc. Results: Of the 15 patients, seven (46.7%) were men, and the average age of all patients was 49.7±13 years. The most common symptom was cough (n=9, 60%), and it was followed by dyspnea or increased respiratory effort, fatigue, insomnia, anosmia, etc. The herbal medicine was prescribed for all 15 patients, and Saengmaek-san (n=8, 53.5%) was the most prescribed. Additionally, acupuncture and cupping were performed in four patients (26.7%) each, and electroacupuncture was applied to one patient (6.7%). As a result of Korean medicine treatment, NRS, mMRC, LCQ, QOL-VAS, and PCFS showed improvement, and adverse events were mild. Conclusions: This study presented the clinical features of post-acute COVID-19 syndrome and suggested that Korean medicine treatment may be effective in alleviating related symptoms and enhancing quality of life.

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.65 no.2
• /
• pp.136-141
• /
• 2016

This paper proposes an alternate time-switched multiplexed space-time block coding technique for orthogonal frequency division modulation systems. The traditional multiplexed space-time block coding technique can provide more data rate owing to multiple transmit and receive technique, which causes a lot of hardware burden. Alternate time-switched scheme of transmitting time-domain zeros can reduce this hardware burden by half with time-domain switches only. Simulation results show that alternate time-switched scheme has almost same performance with half of baseband and RF modules in comparison with a multiplexed space-time block coding for orthogonal frequency division modulation systems with twice repetitive transmission.

• Journal of Advanced Navigation Technology
• /
• v.10 no.3
• /
• pp.213-218
• /
• 2006

In this paper, we analyzed the performance of orthogonal frequency division multiplexing/ frequency hopping multiple access(OFDM/FHMA) hybrid system that in impulsive interference and broadband wireless communication channel then we applied the turbo code scheme to make satisfied in data and voice transmission service. Also, we compared the bit error rate(BER) performance of turbo coded diversity scheme in the OFDM/FHMA hybrid system. As a result of simulation, proposed OFDM/FHMA hybrid system shows the enhancement of 10 times compared to the general OFDM/FHMA system.

• IMMUNE NETWORK
• /
• v.4 no.1
• /
• pp.7-15
• /
• 2004

Background: The heat shock proteins (HSPs) play an important role in cellular protection mechanisms against physical or chemical stresses. In this study scFv antibodies specific for human HSP70.1 were isolated from a semi-synthetic human scFv library with the ultimate goal of developing anti-HSP70.1 intracellular antibody (intrabody) that may offer an attractive alternative to gene targeting to study the function of the protein in cells. Methods: A semi-synthetic human scFv display library ($5{\times}10^{8}$ size) was constructed using pCANTAB-5E vector and the selection of the library against bacterially expressed recombinant human HSP70.1 was attempted by panning. Results: Three positive clones specific for recombinant HSP70.1 were identified. All three clones used $V_{H}$ subgroup III. On the other hand, $V_{L}$ of two clones belonged to the kappa light chain subgroup I, but the other utilized $V_{k}$ subgroup IV Interestingly, these scFv molecules specifically reacted to the recombinant HSP70.1, yet failed to recognize native HSP70 induced in U937 human monocytic cells by heat treatment. Conclusion: Our results indicated that affinity selection of an scFv phage display library using recombinant antigens produced in E. coli might not guarantee the isolation of scFv antibody molecules specific for a native form of the antigen. Therefore, the source of target antigens needs to be chosen carefully in order to isolate biofunctional antibody molecules.