Browse > Article
http://dx.doi.org/10.22246/jikm.2022.43.3.396

Effects of Korean Medicine Treatment in Post-acute COVID-19 Syndrome: A Retrospective Case Series of 15 Patients  

Park, Jiwon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University)
Hong, Sung-eun (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University)
Shin, Jeong-Won (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University)
Kim, Kwan-Il (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University)
Lee, Beom-Joon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University)
Jung, Hee-Jae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.43, no.3, 2022 , pp. 396-412 More about this Journal
Abstract
Objective: The aim of this study was to identify the clinical features of post-acute COVID-19 syndrome and the efficacy and safety of Korean medicine treatment. Methods: This study was conducted on 15 patients with post-acute COVID-19 syndrome who visited the outpatient Allergy, Immune, and Respiratory System Department at Kyung Hee University Korean Medicine Hospital from January 10, 2021 to April 10, 2022. We retrospectively analyzed the charts of 15 patients and collected clinical characteristics, Korean medicine treatments, outcome variables (Numeral Rating Scale (NRS), modified Medical Research Council scale (mMRC), Leicester Cough Questionnaire (LCQ), Quality of Life Visual Analog Scale (QOL-VAS), The Post-COVID-19 Functional Status (PCFS)), adverse events, etc. Results: Of the 15 patients, seven (46.7%) were men, and the average age of all patients was 49.7±13 years. The most common symptom was cough (n=9, 60%), and it was followed by dyspnea or increased respiratory effort, fatigue, insomnia, anosmia, etc. The herbal medicine was prescribed for all 15 patients, and Saengmaek-san (n=8, 53.5%) was the most prescribed. Additionally, acupuncture and cupping were performed in four patients (26.7%) each, and electroacupuncture was applied to one patient (6.7%). As a result of Korean medicine treatment, NRS, mMRC, LCQ, QOL-VAS, and PCFS showed improvement, and adverse events were mild. Conclusions: This study presented the clinical features of post-acute COVID-19 syndrome and suggested that Korean medicine treatment may be effective in alleviating related symptoms and enhancing quality of life.
Keywords
COVID-19; sequelae; post-acute COVID-19 syndrome; herbal medicine; Korean medicine;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Hartley DM, Perencevich EN. Public health interventions for COVID-19: emerging evidence and implications for an evolving public health crisis. Jama 2020;323(19):1908-9.   DOI
2 Willi S, Luthold R, Hunt A, Hanggi NV, Sejdiu D, Scaff C, et al. COVID-19 sequelae in adults aged less than 50 years: A systematic review. Travel Med Infect Dis 2021;40:101995.   DOI
3 Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nature medicine 2021;27(4):601-15.   DOI
4 Logue JK, Franko NM, McCulloch DJ, McDonald D, Magedson A, Wolf CR, et al. Sequelae in adults at 6 months after COVID-19 infection. JAMA network open 2021;4(2):e210830.   DOI
5 Ryu HS, Oh HK, Lee JY, Yoon SW. An Overview on the Traditional Chinese Medicine Treatment Guidelines for Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The Journal of Internal Korean Medicine 2015;36(3):335-47.
6 Jang SB, Kim DS, Yi EH, Choi GH, Son MD, Lee EK, et al. Telemedicine and the Use of Korean Medicine for Patients With COVID-19 in South Korea: Observational Study. JMIR Public Health and Surveillance 2021;7(1):e20236.   DOI
7 Shah W, Hillman T, Playford ED, Hishmeh L. Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline. bmj 2021;372:n136.
8 Li F, Lv YN, Tan YS, Shen K, Zhai KF, Chen HL, et al. An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases. Acta Pharmacologica Sinica 2015;36(11):1337-48.   DOI
9 Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, et al. Attributes and predictors of long COVID. Nature medicine 2021;27(4):626-31.   DOI
10 李東垣. 東垣十書. Seoul: Daesung Munhwa-sa; 1983.
11 Luo X, Ni X, Lin J, Zhang Y, Wu L, Huang D, et al. The add-on effect of Chinese herbal medicine on COVID-19: a systematic review and meta-analysis. Phytomedicine 2021;85:153282.   DOI
12 Al-Aly Z, Xie Y, Bowe B. High-dimensional characterization of post-acute sequelae of COVID-19. Nature 2021;594(7862):259-64.   DOI
13 World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) Swiss: World Health Organization; 2020.
14 Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet 2021;397(10270):220-32.   DOI
15 Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al. Extrapulmonary manifestations of COVID-19. Nature medicine 2020;26(7):1017-32.   DOI
16 Greenhalgh T, Knight M, Buxton M, Husain L. Management of post-acute covid-19 in primary care. bmj 2020;370:m3026.   DOI
17 Yin CS, Ko SG. Introduction to the history and current status of evidence-based Korean medicine: a unique integrated system of allopathic and holistic medicine. Evidence-Based Complementary and Alternative Medicine 2014;2014:740515.   DOI
18 Tao W, Luo X, Cui B, Liang D, Wang C, Duan Y, et al. Practice of traditional Chinese medicine for psycho-behavioral intervention improves quality of life in cancer patients: a systematic review and meta-analysis. Oncotarget 2015;6(37):39725-39.   DOI
19 Tenforde MW, Kim SS, Lindsell CJ, Rose EB, Shapiro NI, Files DC, et al. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network-United States, March-June 2020. Morbidity and Mortality Weekly Report 2020;69(30):993.   DOI
20 Lee KE, Jeong SH, Jeong MJ, Choi YM, Song MD, Jang IS. Review on Herbal Medicine Treatment for Late Complications of COVID-19 Patients. The Journal of Internal Korean Medicine 2021;42(1):53-66.   DOI
21 Su Y, Yuan D, Chen DG, Ng RH, Wang K, Choi J, et al. Multiple early factors anticipate post-acute COVID-19 sequelae. Cell 2022;185(5):881-95.e20.   DOI
22 Ji K, Ma J, Wang L, Li N, Dong S, Shi L. Efficacy and safety of traditional Chinese medicine in idiopathic pulmonary fibrosis: a meta-analysis. Evidence-Based Complementary and Alternative Medicine 2020;2020:1-11.
23 Central Disease Control Headquarters, Central Disaster Management Headquarters. The COVID-19 At-home Treatment Guideline (ver. 7). Korea: Korea Disease Control and Prevention Agency; 2022.
24 Klok FA, Boon GJ, Barco S, Endres M, Geelhoed JM, Knauss S, et al. The Post-COVID-19 Functional Status scale: a tool to measure functional status over time after COVID-19. European Respiratory Journal 2020;56(1):2001494.   DOI
25 Datta SD, Talwar A, Lee JT. A proposed framework and timeline of the spectrum of disease due to SARS-CoV-2 infection: illness beyond acute infection and public health implications. Jama 2020;324(22):2251-2.   DOI
26 Li L, Gou CY, Li XM, Song WY, Wang XJ, Li HY, et al. Effects of chinese medicine on symptoms, syndrome evolution, and lung inflammation absorption in COVID-19 convalescent patients during 84-day follow-up after hospital discharge: a prospective cohort and nested case-control study. Chinese journal of integrative medicine 2021;27(4):245-51.   DOI
27 張介賓. 景岳全書. Seoul: HANMI Medical Publishing Co.; 2006.
28 Tian Y, Li R, Ren H, Li D, Ju A, He Y, et al. Feasibility of Shengmai Powder in convalescent patients with novel coronavirus pneumonia. Drug Evaluation Research 2020;43(3):378-83.
29 Liu WH, Guo SN, Fang W, Yang H. Understanding of guidance for acupuncture and moxibustion interventions on COVID-19 issued by CAAM. World journal of acupuncture-moxibustion 2020;30(1):1-4.   DOI
30 Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clinical immunology 2020;215:108427.   DOI