• Journal of Acupuncture Research
• /
• v.25 no.1
• /
• pp.139-154
• /
• 2008

목적 : 홍화(紅花)는 활혈거어(活血祛瘀), 해독지통(解毒止痛)의 효능이 있어 관절염, 동맥경화(動脈硬化), 종양(腫瘍), 월경부조(月經不調), 뇌혈전(腦血栓)에 사용되어 왔다. 이에 홍화약침액(紅花藥鍼液)의 분자생물학적 효능 분석을 하고자 Lipopolysaccharide(LPS)로 염증을 유발한 RAW 264.7 cell의 유전자(遺傳子) 발현(發顯)에 미치는 영향을 Microarray를 통하여 관찰하였다. 방법 : RAW cell을 배양하고 홍화약침액(紅花藥鍼液)의 세포 독성을 확인한 후 (1) LPS, (2) 홍화약침액(紅花藥鍼液), (3) 홍화약침액(紅花藥鍼液)과 LPS를 처치했을 때의 유전자 발현양상을 microarray를 이용하여 관찰하였다. 대조군에 비해 2배 이상 발현의 차이가 있는 경우를 유의한 것으로 보았다. 결과 : 8,170개의 유전자 중 (1) LPS를 처치하였을 경우 35개의 유전자에서 발현이 상승되었고, (2) 홍화약침액(紅花藥鍼液)을 처치하였을 경우 11개의 유전자에서 발현이 상승되고 53개의 유전자에서 발현이 억제되었으며, (3) 홍화약침액(紅花藥鍼液)과 LPS를 동시에 처치하였을 경우에는 47개의 유전자에서 발현이 상승되었고 11개의 유전자에서 발현이 억제되었다. LPS 자극으로 발현이 상승되었지만 홍화약침액(紅花藥鍼液)을 처치할 때 발현이 억제되는 유전자는 SUMO1/sentrin specific protease 7(SENP7), Serine(or cysteine) proteinase inhibitor, clade B(ovalbumin), member 7(SERPINB7), M-phase phosphoprotein, mpp8(HSMPP8), Glycogenin 2(GYG2), InaD-like(Drosophila)(INADL), Copine III(CPNE3), Loss of heterozygosity, 11, chromosomal region 2, gene A(LOH11CR2A), Chromosome 9 open reading frame 33(SHC3), NADH dehydrogenase(ubiquinone) 1 beta subcomplex, 2, 8kDa(NDUFB2)로 9개가 있었다. 요약 : 홍화약침액(紅花藥鍼液)이 LPS로 염증을 유발시킨 RAW 264.7 cell의 유전자 발현에 미치는 영향을 Microarray를 통해 분석하였다. 홍화약침액(紅花藥鍼液)이 LPS로 발현을 항진시킨 35개의 유전자 중 9개를 효과적으로 억제하는 것을 확인하여 염증 치료 기전을 시사하는 유용한 자료를 얻을 수 있었으며 홍화약침액(紅花藥鍼液)이 발현을 항진시킨 유전자들을 통해 혈관생성과 종양억제 등 보다 넓은 범위에 대한 연구가 가능할 것으로 사료된다.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.36 no.7
• /
• pp.805-811
• /
• 2012

The reliability based design optimization (RBDO) approach requires high computing cost to consider uncertainties. In order to reduce the design cost, the single loop single vector (SLSV) approach has been developed for RBDO. This method can reduce the cost in calculating deign sensitivity by elimination of the nested optimization process. However, this process causes the increment of the instability or inaccuracy of the method according to the problem characteristics. Therefore, the method may not give accurate solution or the robustness of the solution is not guaranteed. Especially, when the function is concave, the process frequently diverges. In this research, the concept of the conjugate gradient method for unconstrained optimization is utilized to develop a new single loop single vector method. The conjugate gradient is calculated with gradient directions at the most probable points (MPP) of previous cycles. Mathematical examples are solved for the verification of the proposed method. The numeri cal performances of the obtained results are compared to those of other RBDO methods. The SLSV approach using conjugate gradient is not greatly influenced by the problem characteristics and improves its convergence capability.

• Journal of Food Hygiene and Safety
• /
• v.2 no.3
• /
• pp.121-136
• /
• 1987

As a part of continuing monitoring program since 1983, a study on pesticide residues on Korean agricultural products has been conducted to offer the tolerance of pesticide residues suiting Korean reality. The samples used in this experiment were collected from four areas in five provinces of Korea. The residue, levels of organochlorine pesticide (two kinds), organophosphoric pesticide (eight kinds) and carbamate pesticide (three kinds) on lettuce, garland chrysanthemum, radish Korean, potato, egg plant, green onion, persimmon and sweet potato, and the residue levels of captan and captafol on tomato, green pepper fresh, apple, peach, soybean, cucumber and cabbage Korean were determined by GC-NPD and ECD.

• Journal of Bio-Environment Control
• /
• v.10 no.2
• /
• pp.111-117
• /
• 2001

This experiment was conducted to elucidate the effects of foliar application of monopotassium phosphate on the acceleration of ind color and fruit quality of Satsuma mandarin cultivated in the plastic greenhouse. The 'a'value of peel chromaticity increased seasonably with the increasing frequency of foliar application of monopotassium phosphate, but became gradually irresponsive as the fruit approached to harvesting time. Glucose content increased with the number of foliar applications so did the fructose content. Content of reducing sugars tended to increase with the number of foliar applications by 0.32 to 0.41%.mL$^{-1}$ juice in treatment sof ive or more applications. Sucrose content increased gradually with the increasing number of foliar applications, but there was no significatn difference among treatments. Total sugar also increased with the increasing number of foliar applications Generally, the soluble solid level is considered to be representative of fruit quality. Sugar content increased with the number of foliar application up to 5 times in which sugar content increased by 0.93$^{\circ}$Bx as compared to the control. The fruit acidity of the treatment plots decreased as compared to that of the control, but there was no significant difference in fruit acidity among foliar application times.

• Land and Housing Review
• /
• v.4 no.2
• /
• pp.133-144
• /
• 2013

It is commonplace to refer to the Nordic countries of Sweden, Norway, Denmark, Finland and Iceland as a distinctive and homogenous welfare regime. As far as social housing is concerned, however, the institutional heritage of the respective countries significantly frames the ways in which social housing is understood, regulated and subsidized, and, in turn, how housing regimes respond to the general challenges to the national welfare states. The paper presents a historical institutionalist approach to understanding the diversity of regime responses in the modern era characterized by increasing marketization, welfare criticism and internationalization. The aim is to provide outside readers a theoretically guided empirical insight into Scandinavian social housing policy. The paper first lines up the core of the inbuilt argument of historical institutionalism in housing policy. Secondly, it briefly introduces the distinctive ideal typical features of the five housing regimes, which reveals the first internal distinction between the universal policies of Sweden and Denmark selective policies of Iceland and Finland. The Norwegian case constitutes a transitional model from general to selective during the past quarter of a decade. The third section then concentrates on the differences between Denmark, Sweden and Norway in which social housing is, our was originally, embedded in a universal welfare policy targeting the general level of housing quality for the entire population. Differences stand out, however, between finance, ownership, regulation and governance. The historical institutional argument is, that these differences frame the way in which actors operating on the respective policy arenas can and do respond to challenges. Here, in this section we lose Norway, which de facto has come to operate in a residual manner, due to contemporary effects of the long historical heritage of home ownership. The fourth section then discusses the recent challenges of welfare criticism, internationalization and marketization to the universal models in Denmark and Sweden. Here, it is argued that the institutional differences between the Swedish model of municipal ownership and the Danish model of independent cooperative social housing associations provides different sources of resistance to the prospective dismantlement of social housing as we know it. The fifth section presents the recent Danish reform of the governance model of social housing policy in which the housing associations are conceived of as 'dialogue partners' in the local housing policy, expected to create solutions to, rather than produce problems in social housing areas. The reform testifies to the strategic ability of the Danish social housing associations to employ their historically grounded institutional relative independence of the public system.

• Journal of KIISE:Information Networking
• /
• v.29 no.6
• /
• pp.595-612
• /
• 2002

One of the most important issues in guaranteeing the high degree of QoS on mobile computing is how to reduce hand-off drops caused by lack of available bandwidth in a new cell. Each cell can request bandwidth reservation to its adjacent cells for hand-off calls. This reserved bandwidth can be used only for hand-offs, not for new calls. It is also important to determine how much of bandwidth should be reserved for hand-off calls because reserving too much would increase the probability of a new call being blocked. Therefore, it is essential to develop a new mechanism to provide QoS guarantee on a mobile computing environment by reserving an appropriate amount of bandwidth and call admission control. In this paper. bandwidth reservation and call admission control mechanisms are proposed to guarantee a consistent QoS for multimedia traffics on a mobile computing environment. For an appropriate bandwidth reservation, we propose an adaptive bandwidth reservation mechanism based on an MPP and a 2-tier cell structure. The former is used to predict a next move of the client while the latter to apply our mechanism only to the client with a high hand-off probability. We also propose a call admission control that performs call admission test only on PNC(Predicted Next Cell) of a client and its current cell. In order to minimize a waste of bandwidth caused by an erroneous prediction of client's location, we utilize a common pool and QoS adaptation scheme. In order evaluate the performance of our call admission control mechanism, we measure the metrics such as the blocking probability of new calls, dropping probability of hand-off calls, and bandwidth utilization. The simulation results show that the performance of our mechanism is superior to that of the existing mechanisms such as NR-CAT2, FR-CAT2, and AR-CAT2.