• Journal of Applied Biological Chemistry
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• v.54 no.3
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• pp.206-213
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• 2011

Hepatoprotective effects of Monascus pilosus mycelial ethanol extract (MPME) were examined in high-fat diet induced-obese rats. The rats were randomly divided into 2 groups; normal control (NC) and a high-fat and high cholesterol diet group (HFC). The HFC diet group was fed a 5L79 diet supplemented with 15% lard and 1% cholesterol for 3 weeks for induction of obesity. And then, the rats were divided into 4 groups (n=5); the NC, a HFC diet obesity control group (HF), 0.5% MPME supplemented HFC diet group (MPM), and 2% conjugated linoleic acid (CLA) supplemented HFC diet group for 7 weeks. Whereas the daily weight gain of NC and HFC groups were 3.48 g and 4.48 g, respectively, those of MPM and CLA were 3.09 g and 4.38 g, respectively. Furthermore, activity of serum alanine and aspartic aminotransferase in HF was markedly higher than those of NC group, but, the activity in MPM and CLA was significantly lower than HF. Hepatic reduced glutathione content in MPM and CLA was higher than HF. On the contrary, hepatic lipid peroxide content in MPM and CLA was significantly lower than HF. In conclusion, although the precise mechanisms of the hepatoprotective effects of the MPME in this study are unknown, our study provides experimental evidence that MPME may prevent obesity and hepatic damage by high-fat and high cholesterol diet via inhibition of lipid absorption and induction of reactive oxygen spices scavenging enzyme such as superoxide dismutase.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2017.06a
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• pp.254-255
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• 2017

HEVC(High Efficiency Video Coding) 보다 뛰어난 압축 성능을 갖는 차세대 비디오 부호화 표준 기술 탐색을 하고 있는 JVET(Joint Video Exploratory Team)에서는 기술 검증을 위한 참조 SW 코덱인 JEM(Joint Exploration Model)을 공개하고 있다. JEM 의 화면내 예측 부호화에서는 67 가지의 예측모드를 사용하고 6 개의 MPM(Most Probable Mode)을 이용하여 예측모드를 부호화 한다. 본 논문에서는 코딩블록에서의 화면내 예측모드의 선택 확률을 바탕으로 보다 효율적인 예측모드 부호화 기법을 제안한다. 실험결과 JEM 5.0 대비 MPM 을 포함한 예측모드 부호화 정보의 CABAC(Context Adaptive Binary Arithmetic Coding) 엔트로피 부호화를 제외하고, AI(All Intra) 부호화 구조에서 0.23% 정도의 BD-rate 감소를 보임을 확일 할 수 있었다.

• Tuberculosis and Respiratory Diseases
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• v.78 no.1
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• pp.36-40
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• 2015

Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant, and generally fatal disease. A 68-year-old male who was diagnosed with MPM at another hospital came to our hospital with dyspnea. We advised him to take combination chemotherapy but he refused to take the treatment. That was because he had already received chemotherapy with supportive care at another hospital but his condition worsened. Thus, we recommended photodynamic therapy (PDT) to deal with the dyspnea and MPM. After PDT, the dyspnea improved and the patient then decided to take the combination chemotherapy. Our patient received chemotherapy using pemetrexed/cisplatin. Afterwards, he received a single PDT treatment and then later took chemotherapy using gemcitabine/cisplatin. The patient showed a survival time of 27 months, which is longer than median survival time in advanced MPM patients. Further research and clinical trials are needed to demonstrate any synergistic effect between the combination chemotherapy and PDT.

• Korean Journal of Adult Nursing
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• v.17 no.3
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• pp.464-473
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• 2005

Purpose: The purpose of this study was to evaluate and compare the predictive ability of three mortality scoring systems; Acute Physiology and Chronic Health Evaluation(APACHE) III, Simplified Acute Physiology Score(SAPS) II, and Mortality Probability Model(MPM) II in discriminating in-hospital mortality for intensive care unit(ICU) patients with spontaneous intracerebral hemorrhage. Methods: Eighty-nine patients admitted to the ICU at a university hospital in Daejeon Korea were recruited for this study. Medical records of the subject were reviewed by a researcher from January 1, 2003 to March 31, 2004, retrospectively. Data were analyzed using SAS 8.1. General characteristic of the subjects were analyzed for frequency and percentage. Results: The results of this study were summarized as follows. The values of the Hosmer-Lemeshow's goodness-of-fit test for the APACHE III, the SAPS II and the MPM II were chi-square H=4.3849 p=0.7345, chi-square H=15.4491 p=0.0307, and chi-square H=0.3356 p=0.8455, respectively. Thus, The calibration of the MPM II found to be the best scoring system, followed by APACHE III. For ROC curve analysis, the areas under the curves of APACHE III, SAPS II, and MPM II were 0.934, 0.918 and 0.813, respectively. Thus, the discrimination of three scoring systems were satisfactory. For two-by-two decision matrices with a decision criterion of 0.5, the correct classification of three scoring systems were good. Conclusion: Both the APACHE III and the MPM II had an excellent power of mortality prediction and discrimination for spontaneous intracerebral hemorrhage patients in ICU.

• Acute and Critical Care
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• v.33 no.4
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• pp.216-221
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• 2018

Background: In this study, we analyze the performance of the Acute Physiology and Chronic Health Evaluation (APACHE) II, APACHE IV, Simplified Acute Physiology Score (SAPS) 3, and Mortality Probability Model $(MPM)_0$ III in order to determine which system best implements data related to the severity of medical intensive care unit (ICU) patients. Methods: The present study was a retrospective investigation analyzing the discrimination and calibration of APACHE II, APACHE IV, SAPS 3, and $MPM_0$ III when used to evaluate medical ICU patients. Data were collected for 788 patients admitted to the ICU from January 1, 2015 to December 31, 2015. All patients were aged 18 years or older with ICU stays of at least 24 hours. The discrimination abilities of the three systems were evaluated using c-statistics, while calibration was evaluated by the Hosmer-Lemeshow test. A severity correction model was created using logistics regression analysis. Results: For the APACHE IV, SAPS 3, $MPM_0$ III, and APACHE II systems, the area under the receiver operating characteristic curves was 0.745 for APACHE IV, resulting in the highest discrimination among all four scoring systems. The value was 0.729 for APACHE II, 0.700 for SAP 3, and 0.670 for $MPM_0$ III. All severity scoring systems showed good calibrations: APACHE II (chi-square, 12.540; P=0.129), APACHE IV (chi-square, 6.959; P=0.541), SAPS 3 (chi-square, 9.290; P=0.318), and $MPM_0$ III (chi-square, 11.128; P=0.133). Conclusions: APACHE IV provided the best discrimination and calibration abilities and was useful for quality assessment and predicting mortality in medical ICU patients.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2019.11a
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• pp.191-193
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• 2019

ISO/IEC JTC1 WG11 Moving Picture Expers Group 과 ITU-T SC16 은 Joint Video Experts Team 을 구성하여 차세대 비디오 부호화 표준으로서 Versatile Video Coding(VVC)를 표준화 중이다. VVC 는 현재 블록의 화면내 예측 모드일 가능성이 높은 모드의 집합인 Most Probable Mode(MPM) 리스트를 유도하고, MPM 을 이용하여 효율적으로 화면내 예측 모드를 부호화한다. VVC 참조 소프트웨어는 주변 블록의 화면내 예측 모드가 일치하는지 여부에 따라 1 개 또는 2 개의 모드를 최종 후보 선택을 위한 과정인 Rate-Distortion Optimization(RDO) 과정에 추가한다. 하지만 현재 MPM 은 항상 첫 번째 후보로 Planar 모드가 위치하며 이로 인하여, 주변 블록의 화면내 예측 모드가 RDO 에 추가되지 않는 경우가 존재한다. 따라서 본 논문은 VVC 의 부호화기에서 주변 블록의 화면내 예측 모드가 고려되지 않는 경우가 존재하는 문제를 해결하기 위한 방법을 제안한다. 제안 방법은 MPM 유도 과정에서 RDO 에 포함할 후보의 개수를 수정하여 RDO 과정에 항상 주변 블록의 화면내 예측 모드가 추가되도록 한다. 본 논문은 실험을 통해 제안 방법이 약 0.04%의 부호화 효율을 향상시켰음을 보인다.

• Korean Journal of Pharmacognosy
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• v.48 no.3
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• pp.213-218
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• 2017

In order to search for anticancer agent as therapy of oral squamous cell carcinoma (OSCC) and malignant pleural mesothelioma (MPM) from Korean traditional prescriptions, we selected 58 traditional prescriptions based on a review of the Korean traditional medicine books. Among the selected traditional prescriptions, only water extracts of paedoksan (敗毒散) showed relatively good cytotoxicity at the concentration of $50{\mu}g/ml$. Additionally, we evaluated cytotoxicity for various paedoksans and each herbal ingredient in paedoksans. The root of Anthriscus sylvestris exhibited more cytotoxic effect than any other ingredients in paedoksans. Bioactivity-guided fractionation of the MC layer of Anthriscus sylvestris led to the isolation of deoxypodophyllotoxin (DPT). DPT exhibited dose-dependently significant cytotoxicity against OSCC and MPM cell with nM range. Therefore, DPT from A. sylvestris might be a potential candidate as an effective anticancer therapeutic agent for OSCC and MPM.

• Journal of Pharmaceutical Investigation
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• v.2 no.1
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• pp.40-51
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• 1972

Water vapor sorption of corn starch in various protective film coated capsules in 100% RH chamber for 14 days were as follows: The percent of water vapor sorption were 28.63% in uncoated capsule, 25.16% in hydroxy propylcellulose(HPC) coated capsule, 15.59% in 2-methyl-5-vinyl pyridine-methyl acrylated-methacrylic acid (MPM) coated capsule and 15.50% in polyvinyl acetal diethyl amino acetate(AEA) coated capsule. 2. Water vapor sorotion of magnesium trisilicate in various protective film coated capsules in 100% RH chamber for 14 days were as follows. The percent of water vapor sorption were 13.91% in uncoated capsule, 13.30% in HPC-coated capsule, 10.87% in MPM-caated capsule and 9.9% in AEA-coated capsule. 3. Water vapor sorption of magnesium carbonate in various protective film coated capsules in 100% RH chamber for 14 days were as follows: The percent of water vapor sorption were 12.48% in uncoated capsule, 10.72% in HPC-coated capsule, 8.10% in MPM coated capsule and 7.8% in AEA-coated capsule. 4. MPM-coated capsules and AEA-canted capsules were mere effective to protect water vapor sorption than HPC-coated capsules.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9165-9170
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• 2014

Purpose: This study evaluated the effect of an Educational Program on Palliative Care for MPM for Nurses in Japan. Program: The 5-h program consisted of lectures and care planning group work. Materials and Methods: This study used a pretest-posttest design with a single cohort of nurses and included a Difficulties in Palliative Care for Patients with MPM (DPCMPM) Scale with 15 items. The pre- and posttest scores were compared using a t-test. Results: We included 27 female nurses with a mean of 14.4 years of nursing experience. In 12 of 15 DPCMPM items, the posttest difficulty scores were lower than the pretest scores. Participants highly evaluated the program for validity, clarity, clinical usefulness, and the facilitators. The Palliative Care for MPM Handbook for Nurses was developed as an educational tool for clinical settings. Conclusions: The Educational Program on Palliative Care for MPM for Nurses was effective in reducing nursing difficulties.

• Korean Chemical Engineering Research
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• v.49 no.2
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• pp.263-270
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• 2011

The aim of this paper is, through the experiment of Lithium-Ammonia solutions $(Li(NH_3)_n)$, to analyze and verify a thermoelectric-conversion property at near Ammonia-boiling point ($-40^{\circ}C$). The experiment results show that the solutions with 0.58 MPM~1.87 MPM generate thermoelectric power at temperature difference $({\Delta}T=0{\sim}15^{\circ}C)$ where Current is constantly proportional to Voltage. This paper provides a new insight into the development of a thermoelectric material.