Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anticancer Effect of Paedoksans for Oral Squamous Cell Carcinoma and Malignant Pleural Mesothelioma

패독산류의 구강편평세포암종 및 악성중피종에 대한 항암 활성

  • Oh, Ha-Na (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Kim, Hyun-Jung (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Chae, Jung-Il (Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University) ;
  • Shim, Jung-Hyun (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Yoon, Goo (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University)
  • 오하나 (목포대학교 약학대학 천연약물연구소) ;
  • 김현정 (목포대학교 약학대학 천연약물연구소) ;
  • 채정일 (전북대학교 치의학대학원 치과약리학교실(BK21 플러스사업단)) ;
  • 심정현 (목포대학교 약학대학 천연약물연구소) ;
  • 윤구 (목포대학교 약학대학 천연약물연구소)
  • Received : 2017.09.05
  • Accepted : 2017.09.20
  • Published : 2017.09.30
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Abstract

In order to search for anticancer agent as therapy of oral squamous cell carcinoma (OSCC) and malignant pleural mesothelioma (MPM) from Korean traditional prescriptions, we selected 58 traditional prescriptions based on a review of the Korean traditional medicine books. Among the selected traditional prescriptions, only water extracts of paedoksan (敗毒散) showed relatively good cytotoxicity at the concentration of $50{\mu}g/ml$. Additionally, we evaluated cytotoxicity for various paedoksans and each herbal ingredient in paedoksans. The root of Anthriscus sylvestris exhibited more cytotoxic effect than any other ingredients in paedoksans. Bioactivity-guided fractionation of the MC layer of Anthriscus sylvestris led to the isolation of deoxypodophyllotoxin (DPT). DPT exhibited dose-dependently significant cytotoxicity against OSCC and MPM cell with nM range. Therefore, DPT from A. sylvestris might be a potential candidate as an effective anticancer therapeutic agent for OSCC and MPM.

Keywords

References

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