• Title/Summary/Keyword: MPM응용

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Clinical Application of $^{18}F-FDG$ PET in Malignant Mesothelioma (악성중피종에서 $^{18}F-FDG$ PET의 임상응용)

  • Lee, Eun-Jeong
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.sup1
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    • pp.157-161
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    • 2008
  • Malignant pleural mesothelioma (MPM) has a poor prognosis and a strong association with exposure to asbestos. Although there are not generally accepted guidelines for treatment of MPM, recent reports suggest that multi modality therapy combining chemotherapy, radiotherapy, and surgery can improve the survival of patients with MPM. Therefore exact staging is required to decide the best treatment option. However, it is well known that there are many difficulties in determining precise preoperative stage, predicting prognosis, and monitoring response to therapy with conventional imaging modalities such as CT and MRI in MPM. Recently PET with $^{18}F-FDG$ comes into the spotlight as an important staging method. There is increasing evidence that PET is superior to other conventional imaging modalities in diagnosis and staging of MPM. Particularly PET/CT improves the diagnostic and staging accuracy over PET or CT alone in MPM because it provides anatomic imaging data as well as functional information. PET and PET/CT are also useful for monitoring response to therapy and SUV is reported as a prognostic factor in MPM.

Protective Effect of Monascus pilosus Mycelial Extract on Hepatic Damage in High-Fat Diet Induced-obese Rats (고지방식이로 유도한 비만 흰쥐에서 Monascus pilosus 균사체 추출물의 간 손상 예방효과)

  • Lee, Sang-Il;Kim, Jae-Won;Lee, Ye-Kyung;Yang, Seung-Hwan;Lee, In-Ae;Suh, Joo-Won;Kim, Soon-Dong
    • Journal of Applied Biological Chemistry
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    • v.54 no.3
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    • pp.206-213
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    • 2011
  • Hepatoprotective effects of Monascus pilosus mycelial ethanol extract (MPME) were examined in high-fat diet induced-obese rats. The rats were randomly divided into 2 groups; normal control (NC) and a high-fat and high cholesterol diet group (HFC). The HFC diet group was fed a 5L79 diet supplemented with 15% lard and 1% cholesterol for 3 weeks for induction of obesity. And then, the rats were divided into 4 groups (n=5); the NC, a HFC diet obesity control group (HF), 0.5% MPME supplemented HFC diet group (MPM), and 2% conjugated linoleic acid (CLA) supplemented HFC diet group for 7 weeks. Whereas the daily weight gain of NC and HFC groups were 3.48 g and 4.48 g, respectively, those of MPM and CLA were 3.09 g and 4.38 g, respectively. Furthermore, activity of serum alanine and aspartic aminotransferase in HF was markedly higher than those of NC group, but, the activity in MPM and CLA was significantly lower than HF. Hepatic reduced glutathione content in MPM and CLA was higher than HF. On the contrary, hepatic lipid peroxide content in MPM and CLA was significantly lower than HF. In conclusion, although the precise mechanisms of the hepatoprotective effects of the MPME in this study are unknown, our study provides experimental evidence that MPME may prevent obesity and hepatic damage by high-fat and high cholesterol diet via inhibition of lipid absorption and induction of reactive oxygen spices scavenging enzyme such as superoxide dismutase.

Prediction and Historical Analysis of Long-term Bed Elevation Change in the Mankyung-gang River (만경강의 장기하상변동 예측 및 이력분석)

  • Kim, Seung Ki;Kim, Ji Sung;Kim, Kyu Ho;Choi, Sung-Uk
    • Ecology and Resilient Infrastructure
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    • v.5 no.1
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    • pp.25-34
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    • 2018
  • This study presents prediction and historical analysis of the long-term bed elevation change in the Mankyung-gang River. The study area is a 25 km long reach including middle and lower courses of the Mankyung-gang River. HEC-RAS program was used for numerical predictions, and values of roughness coefficients were calibrated. Then, predictions were made in the two periods, seven years from 1986 to 1993 and twelve years from 1993 to 2005. Simulation results were compared with two sets of measured data for bed elevations. Four sediment transport formulas, namely MPM's, Toffaleti's, MPM-Toffaleti's, and Yang's formula, were tested. Simulation results showed that none of the four sediment transport formulas predicted the bed elevation change in the period of 1986 - 1993. This is related to the fact that dredging work was performed in the upstream reach in the period of 1986 - 1993, and sediment was deposited in this part severely later. However, it was found that MPM-Toffaleti's formula predicted properly the bed elevation change for the period of 1993 - 2005.

A Study of M2M Platform Technologies based on REST (REST 기반 M2M 플랫폼 기술 연구)

  • Lee, Chang-Yeol
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.9
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    • pp.4153-4159
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    • 2011
  • M2M can provide the bi-directional services between applications and objects which have the attached telecommunication module. It consists of the objects, platform, and (web based) applications. M2M can realize In-Transit Visibility and Asset Visibility combined with GIS. Although many applications of M2M, such as metering, monitoring, controlling, tracking et al., are being serviced, the interoperability among the M2Ms is not considered. In this paper, we described the interoperability. Specially, ROA, which is the state of art technology in mash-up, more than SOA, and URN, which is based on Open API in RESTful service, more than URL are studied. As the message protocol between platform and applications, MPM was defined.