• Journal of Genetic Medicine
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• v.6 no.1
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• pp.8-24
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• 2009

Understanding the genetic background of hearing loss is important since almost 50% of the cases of profound hearing loss are caused by genetic factors. Until now, more than 150 causative genes have been identified. In this review, classification of genetic hearing loss (syndromic versus non-syndromic, recessive versus dominant, X-linked and mitochondrial), pitfalls in elucidating causative genes, anatomy of the inner ear, introduction of the most common syndromic hearing loss, introduction of the most common non-syndromic hearing loss-causing genes, mitochondrial and multifactorial hearing losses were discussed. Moreover, clinical approaches to the patients with hereditary hearing loss and genetic counseling were also explained briefly. Finally, future directions of the hereditary hearing loss research in Korean population were presented.

• Journal of Korea Multimedia Society
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• v.21 no.12
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• pp.1363-1369
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• 2018

Breast cancer is one of the most common cancers in women worldwide. In Korea, breast cancer is most common cancer in women followed by thyroid cancer. The purpose of this study is to evaluate the possibility of using deep - run model for segmentation of breast masses and to identify the best deep-run model for breast mass segmentation. In this study, data of patients with breast masses were collected at Asan Medical Center. We used 596 images of mammography and 596 images of gold standard. In the area of interest of the medical image, it was cut into a rectangular shape with a margin of about 10% up and down, and then converted into an 8-bit image by adjusting the window width and level. Also, the size of the image was resampled to $150{\times}150$. In Deconvolution net, the average accuracy is 91.78%. In U-net, the average accuracy is 90.09%. Deconvolution net showed slightly better performance than U-net in this study, so it is expected that deconvolution net will be better for breast mass segmentation. However, because of few cases, there are a few images that are not accurately segmented. Therefore, more research is needed with various training data.

• Nuclear Engineering and Technology
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• v.55 no.11
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• pp.4159-4166
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• 2023

Laser decontamination of radioactive surfaces is an innovative technology. Our contribution to improving this technology includes studies on laser beam decontamination with a pulsed laser of an average power of 150 W, equipped with a hand guided working head. Our investigations are focused on metallic surfaces typical in nuclear power plants, such as stainless steel, bright and rusted mild steel, galvanized steel, and painted steel. As typical nuclides of contaminated surfaces we chose Co-60 and Cs-137, the most frequently occurring nuclides in many nuclear plant components; Sr-85 as a representative of Sr-90, the potentially most harmful fission nuclide; and Am-241 as a representative of the minor alpha-radiation emitting actinides. Here, we present our results of decontamination and recovery ratios. Decontamination ratios of 90-100% were achieved on different surfaces.

• Microbiology and Biotechnology Letters
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• v.24 no.3
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• pp.331-335
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• 1996

Characteristics of ethanol fermentation were investigated during the stationary culture of a killer yeast, Saccharomyces cerevisiae B15-1. Specific ethanol production rate reached the maximum level, 1.203 g-EtOH/g-cell-hr, at 150 g/l of the initial glucose concentration. No big differences were obtained in ethanol fermentability based on the initial sugar concentration below 150 g/l. When 200 g/l of sugar was used, fermentability dropped significantly. Although the final cell mass and the amount of ethanol produced were increased, their increase rates were declined according to the increase of initial sugar concentration. It was found that most of the sugar used below 150 g/l of concentration could be changed to ethanol. However, when 200 g/l of sugar was used, some of them remained in the media even after increase of cell mass and fermentation stopped. The ethanol yield was decreased when initial sugar concentration was high, and were increased when the amount of ethanol produced was increased and finally reached the plateau over 60 g/l of ethanol concentration.

• Applied Microscopy
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• v.26 no.2
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• pp.157-175
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• 1996

The development of flexor digital tendon of the hand was studied by electron microscopy in human fetuses ranging from 9 mm to 260 mm crown rump length. The primordium of tendons was first identified as discrete collection of mesenchymal cells at 25 mm fetus. Synovial sheath formation had commenced by 40 mm fetus and was complete by 70 mm fetus. Cell junction or adhesion sites at all ages were noted between the tendon cells. When dilatation of the synovial cavity occurred, two types of synovial cells were observed. A-type cells had numerous vesicles and large vacuoles. In contrast, B-type cells were characterized by abundant rough endoplasmic reticulum and well-developed Golgi complex. By $150mm{\sim}260mm$ fetuses, a mojority of the synovial cells were type B. The most remarkable difference between the synovial cells of full-term fetus and adult was the larger amount of collagen fibers in the latter. The vascular buds were first observed between the individual fibril bundles in the interfascicular space at 150 mm fetus. At 25 mm fetus, collagen fibrils were first noted within narrow cytoplasmic recesses which were continued with the extracellular space. Collagen fibrils were filled in almost entire extracellular space at 150 mm fetus. Besides collagen fibrils in the extracellular space small elastic fibers were also identified and followed in their development.

• Tunnel and Underground Space
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• v.9 no.3
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• pp.221-229
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• 1999

Parameters of failure criteria, compressive strength and elastic modulus are most important for design and stability analysis of rock structure using numerical analysis. In this study, it suggests that the application of input data for numerical analysis by the literature study and the result of the 150 sets of triaxial compressive test. There was much different between parameters of failure criterion suggested by Hoek-Brown and parameters resulted from the analysis using 150 sets of triaxial compressive test. But the converting equations of compressive strength have had an interrelation with RMR. However, the converting of elastic of elastic modulus were different as chosen of equation, and the equation by Nicholson et at was more useful than others.

• Korean Journal of Clinical Pharmacy
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• v.25 no.3
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• pp.178-186
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• 2015

Objective: Clinical practice guidelines (CPGs) are systematically developed statements aimed at helping optimal care of the patient in a given clinical circumstance. Because of the increasing evidence that active implementation of CPGs improve health outcomes, there is a growing awareness of the importance of guideline development and dissemination. The objective of this study was to investigate the status of CPG development and availability of the CPGs in Korea. Method: We searched in the Web sites of 180 organizations to identify CPGs which were developed and/or published in Korea until 1 July 2014. The data of titles, published year, publisher, distributer, and accessibility at the internet web of all CPGs were collected and analyzed. Results: A total of 172 CPGs were developed and 80% had been released since 2009. Most (51.2%) were developed for management of 4 diseases: 28 for digestive system disease; 27 for infectious disease; 18 for endocrine and metabolic diseases; and 15 for neoplasms. Of the 172 CPGs, 150 CPGs were publicly available. Among the 150 CPGs, 78.7% (118/150) were developed by only one organization. Conclusion: To ensure the production of high-quality CPGs, it is necessary to collaborate with other relevant professional societies in guideline development process. In addition, stronger efforts on wider dissemination of CPGs must be employed at the country levels to promote implementation of CPGs in clinical settings.

• The Research Journal of the Costume Culture
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• v.14 no.2
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• pp.310-319
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• 2006

This study intended to compare and analyze marking efficiencies of tailored jacket based on different cloth and production conditions, 'the width of cloth', 'the number of marking pieces' and 'the direction for marking deployment'. The results were as follows. For the two pieces of markers, the efficiency of the cloth width of 110cm was higher than that of 150cm. As the number of markers increased, the efficiency of cloth width of 150cm was higher than that of 110cm. In the case of one-directional deployment, the results obtained was that the efficiency of two markers was higher than that of three markers, while, in the case of bi-directional deployment, the efficiency of three markers was higher than that of two markers. In the case of one-directional deployment for each size, the marking efficiencies were higher in two markers at the cloth width of 110 cm and higher in three markers at the cloth width of 150 cm. Then, in marking efficiencies according to the direction for marking deployment, bi-direction marker was the most efficient marker, followed by one-direction for each size marker and one-direction marker.

• Environmental Analysis Health and Toxicology
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• v.17 no.1
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• pp.1-6
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• 2002

Effects on nonylphenol (NP) treatment on early development of fertilized eggs and survival of larvae in olive flounder, Paralichthys olivaceus were investigated. Fertilized eggs and hatched larvae were exposed to aqueous solutions of NP at nominal concentrations of 50, 100, 150 and 200 $\mu\textrm{g}$/L. In the control I and II (methanol-carrier control) groups, the hatchability of fertilized eggs were 90.7$\pm$7.02 and 90.0$\pm$5.29％ (P <0.05), respectively. However, treatments of NP concentrations at 50, 100, 150 and 200 ug/L were reduced to 78.7$\pm$4.16, 46.0$\pm$9.17, 48.0$\pm$3.46 and 33.3$\pm$11.02% (P<0.05), respectively. The time to hatching of fertilized eggs was delayed in high-dose NP treatment groups rather than control groups. Fertilized eggs of NP immersed group could not hatch normally, and also vertebra of the larvae observed as abnormal shape. Cumulative mortality of hatched larvae after 26hr NP treatment was 38.3, 78.3, 88.3 and 100% in NP 50, 100, 150 and 200 ug/L treatment groups, respectively. Whereas, control I and II were 11.7, 16.7% (P<0.05). Hatched larvae showed most death at the embryonic development stage with abnormalities. These results suggest that NP treatment in fertilized eggs and larvae was inhibited as normally development for fertilized egg and growing of larvae.

• Journal of The Korean Society of Grassland and Forage Science
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• v.14 no.3
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• pp.223-229
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• 1994

To find out the effects of phosphatic fertilizer application levels on the botanical composition, mineral contents and mineral nutrient deprivation of grasses and the chemical properties of soil, this expriment was arranged as a randomized complete block design with six treatments(0, 50, 100, 150, 200 and 250kg $P_2O_5$/ha) and conducted at hilly land in Gwangju, Gyeonggi Province from September, 1989 to October, 1992. The results obtained are summarized as follows: The botanical composition of grasses without posphatic fertilizer application was poor but with 150kg $P_2O_5$/ha application, remarkably increased in legume of grasses and decreaed in weed. As the phophatic fertilizer levels increase, P, Ca and Mg content of grasses were increased but N and K content tended not to be regular, and Ca/p and K/Ca+ Mg equivalent ratio were lowered. Up to 150kg $P_2O_5$/ha application level, the mineral nutrient content deprived by dry matter yield was increased but with that over application, tend not to be increased. Most of applied mineral elements were accumulated at a subsurface of grassland and as the phosphatic fertilizer application levels increase, the available $P_2O_5$ and exchangeable Mg contents of the soil tended to be remarkably increased and exchangeable K content tended to be decreased, but pH, OM and exchangeable Ca content tended not to be regular.