• Clinical and Experimental Reproductive Medicine
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• v.27 no.2
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• pp.133-144
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• 2000

Objective: Several water channels (aquaporins; AQP) that belong to the MIP (major intrinsic protein) family have identified. In the selected tissues including red blood cells or renal tubules, water movements are abundant and/or physiologically important. Unexpectedly, a high water permeability of human and ram sperm has been reported. Recent studies showed that AQP7 and AQP8 are present in testes, so that the high water permeability of human sperm suggested to be mediated by AQPs. Method: To identify the identity of aquaporins expressed in testes, RT-PCR was performed using degenerative primers, which were designed to correspond to highly conserved sequences surrounding the Asn-Pro-Ala (NPA) motifs in the aquaporins. New expressed AQP series were reconfirmed by immunohistochemical study using rabbit polyclonal antibodies. Results: DNA sequencing of PCR products revealed that AQP2 and AQP3 mRNA as well as AQP7 and AQP8 are expressed in human and rat testes. In human and rat testes, AQP2 are expressed in spermatozoa, interstitial cells and myofibroblasts and AQP3 are expressed in myofibroblasts of semineferous tubules on immunocytochemical stain. Conclusion: These results indicate that multiple aquaporins are expressed in testes, and that they may have important roles in the spermatogenesis and the germ cell function of testis.

• Journal of Periodontal and Implant Science
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• v.26 no.2
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• pp.376-395
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• 1996

The neuropeptide substance P(SP) has been recognized to modulate immune systems, with close proximity between peptidergic sensory nerve endings and immune cells. These include the macrophage and neutrophil activation, IL-2 production in T cell, augmentation of Ig synthesis, mast cell degranulation, $PGE_2$ and collagenase secretion in synoviocytes. In this study I examined SP-induced various biological activities such as antimicrobial action, cytokine production, and mast cell degranulation in the presence or absence of other inflammatory cell activators. Antimicrobial studies showed that undifferentiated HL-60 cells were not affected by SP. However, SP significantly enhanced antimicrobial action of TPA-treated or dbcAMP-treated HL-60 cells which had been differentiated into PMN or macrophage/monocyte. I could not find synergistic relationship between SP and LPS in parallel experiments of the above. SP did not induce IL-l production from murine macrophage cell line RAW264.7 whether costimulated with LPS or not. Mast cell degranulation was occured only when stimulated with high dose ($10^{-5}M$) of SP and the degree of this activation was slightly reduced by simultaneous application of $MIP-1{\alpha}$. In addition, CGRP which is known to be a common coexisting neuropeptide with SP within specific fibers did not augment the function of SP on mast cell degranulation. These results suggest that immunoregulatory activities of SP could be mediated through direct upregulation of various functions of immune cells and also upregulation of responsiveness of immune cells to other immune activators.

• Korean Journal of Food Science and Technology
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• v.45 no.1
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• pp.25-33
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• 2013

Clenbuterol and ractopamine, which are ${\beta}$-agonists, have been misused as a growth promoting agent in meat producing animals. Clenbuterol was banned for veterinary drug in Korea because of its problems regarding safety. Due to their adverse effects, such as cardiovascular and central nervous diseases on human health proper control and monitoring should be conducted. The existing analytical method of clenbuterol and ractopamine in the Food code was improved through our present study. The bovine muscle samples were subjected to enzymatic hydrolysis, extracted with ethyl acetate and defatted by hexane-methanol partitioning. A molecular imprinted polymer (MIP) solid phase extraction cartridge was used for clean-up and LC-MS/MS was operated in positive multiple reaction monitoring (MRM). Clenbuterol-$d_9$ and ractopamine-$d_3$ were used as an internal standard. The renewed method was validated according to the CODEX guideline. The limits of quantitation for clenbuterol and ractopamine were 0.2 and 0.5 ${\mu}g/kg$, respectively. The mean recoveries ranged in 104.2-113.5% for clenbuterol and in 107.6-118.1% for ractopamine. The improved method was able to save both time and expenses.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2009.10a
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• pp.607-610
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• 2009

The abnormal combustion in the running engine results to knocking which increases the pressure and temperature in the cylinder, thereby decreasing the generated power by reducing the thermal efficiency. When the temperature and pressure in the cylinder increased rapidly by knocking, abnormal combustion takes place and the engine power is decreased. To investigate the knocking phenomenon, accelerometers are installed in the cylinder head to monitor and diagnose the vibration signal. As method of signal analysis, the time-frequency analysis method was adapted for acquisition of vibration signal and analyzes engine combustion in the short time. In this experiment, after analyzing time data which is stored in the signal recorder in one unit work (4 strokes: 2 revolutions), the signal with frequency and Wavelet methods with extracted one engine combustion data was also analyzed. Then, normal condition with no knocking signal is analyzed at this time. Hereafter, the experiments made a standard for distinguishing normal and abnormal condition to be carried out in acquisition of vibration signal at all cylinders and extracting knocking signal. In addition, analyzing methods can be diverse with Symmetry Dot Patterns (SDP), Time Synchronous Average (TSA), Wigner-Ville Distribution (WVD), Wigner-Ville Spectrum (WVS) and Mean Instantaneous Power (MIP) in the cold test [2]. With signal processing of vibration from engine knocking sensor, the authors adapted a part of engine /rotor vibration analysis and monitoring system for marine vessels to prevent several problems due to engine knocking

• The KIPS Transactions:PartC
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• v.11C no.2
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• pp.213-218
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• 2004

Recently MIP becomes more important for the macro mobility support in the emergence of the global system such as IMT-2000. However this Protocol suffers from many weaknesses on the location management. MIPv4 regional registration is presented for the local registration of MNs. MIPv6 can benefit from the reduced mobility signaling with external networks by employing a local MAP, that is called HMIPv6. The total signaling cost of HMIPv6 is rapidly increased by the number of CNs of an MN when the MN moves around between MAPs. In this paper, we propose a new location management scheme in MIPv6 that reduces the total signaling cost in the location update based on HMIPv6 Here the MN does not send the BU to CNs and HA when it moves around between MAPs. Instead it informs the current location by transferring the modified BU to the previous MAP. According to the results of the performance analysis, we determine the upper bound for the number of forwarding links allowed among adjacent MAPs without the BU information.

• The Journal of the Acoustical Society of Korea
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• v.23 no.3
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• pp.262-267
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• 2004

AMR-WB (Adaptive Multi Rate Wideband) speech codec, the most recent voice codec standardized by 3GPP, has the wider audio bandwidth of 50∼7000 Hz and operates on nine speech coding bit rates between 6.60 and 23.85 kbit/s. This Paper presents the real-time implementation of AMR-WB speech codec by using a 16 bit fixed-point TeakLite DSP. The implemented AMR-WB codec requires the complexity of 52.2 MIPS at 23.85 kbit/s mode and also needs the program memory of 17.9 kwords, data RAM of 11.8 kwords, and data ROM of 10.1kwords. It was verified through passing the all test vectors provided by 3GPP with maintaining bit exactness. Stable operations on the real-time testing board were also proved without any distortions and delays for the audio in/out.

• Journal of Magnetics
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• v.17 no.2
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• pp.138-144
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• 2012

3-dimensional magnetic resonance cholangiopancreatography (MRCP) images reconstructed using the maximum intensity projection technique were analyzed qualitatively in patients diagnosed with pancreatobiliary diseases to determine their diagnostic utility. Single shot fast spin echo (SSFSE), fast spin echo (FSE) and 3-dimensional reconstructive images were acquired from 20 patients diagnosed histologically with pancreatobiliary diseases using a 3.0T MR scanner. According to qualitative analysis, the fast spin echo images and 3-dimensional reconstructed images of the hepatic duct, gall bladder and common bile duct had a higher signal to noise ratio (SNR) than the single shot fast spin echo images. Fast spin echo images and 3-dimensional reconstructed images did not show any differences. The contrast to noise ratio of the hepatic duct, gallbladder and common bile duct on the fast spin echo images and 3-dimensional reconstructed images was higher than that of the single shot fast spin echo images. The fast spin echo images and 3-dimensional reconstructed images showed similar quality.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.37 no.11
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• pp.74-84
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• 2000

This paper deals with procedures for design and implementation of a DSP, which is compatible with TMS320C30 DSP. CBS(Cycle Based Simulator) is developed to study the architecture of the target DSP. The simulator gives us detailed information such as function block operation, control signal values, register condition, bus and memory values when a instruction is being carried out. RTL design is carried out by VHDL. Logic simulation and hardware emulation are employed to verify proper operation of the design. The DSP is fabricated with 0.6${\mu}m$ CMOS technology. The Chip has 450,000 gates complexity, $9{\times}9mm^2$ area, 20 MIPS operation speed. It is confirmed by running 109 instructions out of 114 instructions and 13 kinds of algorithm that the developed DSP has compatibility with TMS320C30.

• Journal of Korean Neurosurgical Society
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• v.45 no.5
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• pp.284-288
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• 2009

Objective : Our retrospective study aimed to determine whether 16-slice computerized tomography (CT) angiography optimized sharp kernel is suitable for the evaluation of visibility, luminal patency and re-stenosis of intracranial stents in comparison with conventional angiography. Methods : Fifteen patients with symptomatic intracranial stenotic lesions underwent balloon expandable stent deployment of these lesions (10 middle cerebral arteries, 2 intracranial vertebral arteries, and 3 intracranial internal carotid arteries). CT angiography follow-up ranged from 6 to 15 months (mean follow-up, 8 months) after implantation of intracranial stents and conventional angiography was confirmed within 2 days. Curved multiplanar reformations with maximal intensity projection (MIP) with optimal window settings for assessment of lumen of intracranial stents were evaluated for visible lumen diameter, stent patency (contrast distal to the stent as an indirect sign), and re-stenosis by two experienced radiologists who blinded to the reports from the conventional angiography. Results : All of stents deployed into symptomatic stenotic lesions. All stents were classified as patent and no re-stenosis, which was correlated with results of conventional angiography. Parts of the stent lumen could be visualized in all cases. On average, 57% of the stent lumen diameter was visible using optimized sharp kernel. Significant improvement of lumen visualization (22%, p<0.01) was observed using the optimized sharp kernel compared with the standard sharp kernel. Inter-observer agreements on the measurement of lumen diameter and density were judged as good, respectively (p<0.05). Conclusion : Sixteen-slice CT using the optimized sharp kernel may provide a useful information for evaluation of lumen diameter patency, and re-stenosis of intracranial stents.

• The KIPS Transactions:PartA
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• v.10A no.2
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• pp.123-130
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• 2003

This paper presents a new striped checkpointing scheme for serverless cluster computers, where the local disks are attached to the cluster nodes collectively form a distributed RAID with a single I/O space. Striping enables parallel I/O on the distributed disks and staggering avoids network bottleneck in the distributed RAID. We demonstrate how to reduce the checkpointing overhead and increase the availability by striping and staggering dynamically for communication intensive applications. Linpack HPC Benchamark and MPI programs are applied to these checkpointing schemes for performance evaluation on the 16-nodes cluster system. Benchmark results prove the benefits of the striped checkpointing scheme compare to the existing schemes, and these results are useful to design the efficient checkpointing scheme for fast rollback recovery from any single node failure in a cluster system.